Latest news with #PDE5
Scottish Sun
18-07-2025
- Health
- Scottish Sun
New SUPER-Viagra pill is stronger and could have fewer side effects, scientists find
NHS prescriptions for erection drugs are at a record high LITTLE BLUE THRILL New SUPER-Viagra pill is stronger and could have fewer side effects, scientists find Click to share on X/Twitter (Opens in new window) Click to share on Facebook (Opens in new window) SCIENTISTS are developing a new super-Viagra that is stronger than the little blue pill at just a tenth of the dose. Experimental drug simenafil was tested on 706 men by a team at the Peking University First Hospital in China. Sign up for Scottish Sun newsletter Sign up 1 NHS prescriptions for erection pills are at record highs (stock image) Credit: Getty Results showed that 12 weeks of treatment improved men's erectile function by an average of 12.3 per cent. The scientists said original Viagra, known as sildenafil, caused an approximately 11.8 per cent improvement in studies and other brands are less effective. The real catch is that the dose is tiny in comparison, they added – just 5mg compared to a standard 50mg dose of Viagra. This could make it cheaper or reduce the risk of side effects. The drugs are called PDE5 inhibitors and work by blocking an enzyme that restricts blood flow to the penis, causing it to relax and function normally for sex. Unwanted side effects might include headaches, sickness, hot flushes, indigestion, a stuffy nose or feeling dizzy. 'Effective at low doses' Writing in the Journal of Sexual Medicine, study author Dr Hui Jiang said: 'Owing to these adverse events, novel and alternative therapies are needed for patients with erectile dysfunction. 'The results so far show oral simenafil was effective and well-tolerated in male patients. 'Therefore, we believe that it will provide an additional reliable treatment option. 'Overall, the evaluation indicated that simenafil was as effective as other PDE5 inhibitors even at very low doses. 'It showed that intercourse satisfaction, orgasmic function, sexual desire and overall satisfaction increased.' Erectile dysfunction is common and becomes more likely with age, illness and weight gain. What is Erectile Dysfunction? At least half of men are expected to suffer once they get into middle and old age. NHS doctors last year prescribed record amounts of bedroom-boosting drugs like Viagra, dishing out 4.7million prescriptions at a cost of £17.6million.
Time Business News
13-06-2025
- Health
- Time Business News
Beyond the Little Blue Pill: Exploring Generic Sildenafil for ED
1. Understanding Erectile Dysfunction 2. The Rise of Sildenafil 3. Differences Between Brand Name and Generic Sildenafil 4. How Generic Sildenafil Works 5. Benefits of Choosing Generic Sildenafil 6. Potential Side Effects and Precautions 7. Who Can Use Generic Sildenafil? 8. Availability and Accessibility 9. Comparing Costs: Brand Name vs. Generic 10. Real-Life Success Stories 11. Future Innovations in ED Treatment — Erectile dysfunction (ED) is a common condition that affects millions of men worldwide, leading to significant emotional and psychological distress. It is characterized by the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. While occasional difficulties are normal, persistent issues warrant attention. ED can stem from various causes, which can be broadly categorized into physical and psychological factors: – Physical Causes: These include cardiovascular disease, diabetes, hormonal imbalances, obesity, and certain medications. – Psychological Causes: Stress, anxiety, depression, and relationship issues can contribute to ED. Understanding these causes is crucial as they inform the treatment approach, which may include lifestyle changes, therapy, or medication. — The introduction of sildenafil in the late 1990s revolutionized the treatment landscape for ED. Marketed initially under the well-known brand name Viagra, sildenafil quickly became synonymous with ED treatment. Before sildenafil's approval by the FDA in 1998, options for treating ED were limited and often invasive, such as penile injections or implants. Sildenafil offered a non-invasive alternative that was both effective and easy to use, leading to widespread adoption. — While Viagra remains a popular choice, many patients are now turning to generic sildenafil due to its affordability and accessibility. Generic sildenafil contains the same active ingredient as Viagra—sildenafil citrate—and works in the same way. It is subject to stringent regulations to ensure it matches the efficacy and safety profile of its branded counterpart. – Cost: Generic versions are typically less expensive due to reduced marketing and development costs. – Brand Variability: Multiple pharmaceutical companies produce generic sildenafil, which may lead to variations in inactive ingredients. — Understanding the mechanism of action is essential for appreciating how generic sildenafil alleviates symptoms of ED. Sildenafil belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. It works by enhancing blood flow to the penis by relaxing blood vessels—a process triggered during sexual stimulation. – Onset: Typically begins working within 30 to 60 minutes. – Duration: Effects can last up to four hours, providing ample time for sexual activity. — Opting for generic sildenafil offers several advantages beyond cost savings. – Affordability: Significantly cheaper than branded alternatives. – Wide Availability: Accessible at most pharmacies with a prescription. – Proven Efficacy: Clinical trials confirm its effectiveness in treating ED across various populations. Choosing generic sildenafil allows patients to manage their condition without financial strain, making it an attractive option for many men worldwide. — As with any medication, it's essential to be aware of potential side effects when using generic sildenafil. – Headaches – Flushing – Indigestion – Nasal congestion Though rare, severe side effects such as vision or hearing loss require immediate medical attention. Patients should disclose their full medical history to their healthcare provider to avoid contraindications with other medications or conditions such as heart disease or high blood pressure. — Generic sildenafil is suitable for most men experiencing ED; however, some individuals may require additional considerations. Men over the age of 18 who experience difficulty achieving or maintaining an erection may consider this treatment option after consulting with a healthcare provider. Special caution is advised for those with underlying health conditions or those taking medications that could interact negatively with sildenafil. — The availability of generic sildenafil has expanded significantly since its introduction into the market. In most countries, including the UK where sites like Post My Meds operate, a prescription is required to purchase sildenafil legally. This ensures proper medical oversight and reduces the risk of misuse. Online pharmacies have made accessing this medication more convenient than ever while ensuring privacy and discretion for users seeking treatment. — One of the most compelling reasons patients opt for generic sildenafil is its cost-effectiveness compared to brand-name versions. – Brand Name (Viagra): Generally priced higher due to brand recognition and initial research investments. – Generic Versions: Provide substantial savings without compromising on quality or efficacy. This price difference enables broader access among diverse socioeconomic groups who need effective ED treatment but may have budget constraints. — Real-life testimonials provide valuable insights into how generic sildenafil impacts users' lives positively beyond clinical statistics alone. Consider John, a 55-year-old office worker who struggled with ED due to stress-related factors: – Pre-treatment: Experienced anxiety affecting relationships. – Post-treatment with Generic Sildenafil: Regained confidence; improved personal relationships; reported satisfaction with both effectiveness & affordability aspects. Such stories underscore both practical benefits & emotional relief offered by generics like these. — The field continues evolving beyond traditional methods like oral medications towards holistic approaches integrating lifestyle interventions alongside pharmaceutical advancements such as: – Gene Therapy: Ongoing studies explore potential gene editing techniques targeting root causes directly within affected tissues. – Regenerative Medicine: Utilization stem cells show promise restoring function naturally over time rather than merely symptom management alone. These innovations hold exciting potential reshaping future therapeutic landscapes offering hope those seeking comprehensive solutions tailored individual needs. In conclusion, exploring beyond little blue pills reveals promising opportunities improve quality life countless individuals globally facing challenges associated erectile dysfunction today tomorrow alike. TIME BUSINESS NEWS
