Latest news with #PFM
Yahoo
2 days ago
- Health
- Yahoo
Rectify Pharma Presents Translational Data Demonstrating Improvements in Kidney Function and Reductions in Vascular Calcification at ERA 2025
Potent, selective ABCC6-targeting positive functional modulator (PFM) improved multiple markers of renal function in animal models of chronic kidney disease (CKD) PFM improved inorganic pyrophosphate (PPi) efflux via on-target engagement of the ABCC6 membrane transporter and reduced vascular calcification in animal models of CKD BOSTON, June 06, 2025 (GLOBE NEWSWIRE) -- Rectify Pharmaceuticals, Inc., ('Rectify') a biotechnology company pioneering positive functional modulators (PFMs) that restore and enhance membrane protein function, today showcased new data from its cardiorenal program with its ABCC6-targeting PFM, RTY-822. The results were presented in an oral presentation during the European Renal Association (ERA) 2025 Congress, taking place in Vienna, Austria, June 4 – 7, 2025. 'These translational results demonstrate that Rectify's PFM reduces vascular calcification and kidney injury and improves kidney function through enhancement of ABCC6 function,' said Rajesh Devraj, Ph.D., President and Chief Executive Officer of Rectify. 'We believe the strength of these data underscores the potential of our approach to offer a novel and differentiated therapeutic strategy to treat renal dysfunction and injury, as well as address vascular calcification driving cardiovascular disease. We are committed to continuing to advance meaningful therapies for patients with CKD and serious cardiovascular conditions.' Robert Hughes, Ph.D., Chief Scientific Officer of Rectify, added, 'Enhancing the function of ABCC6 holds the potential to address key drivers of vascular calcification and tubular dysfunction seen in CKD. With demonstrated on-target engagement, RTY-822 shows significant promise to reduce CKD-associated calcium deposits in arterial walls, a well-established contributor to cardiovascular morbidity and mortality seen in patients with CKD, and remarkably, also improves glomerular function and tubular injury. The translational readiness of this program makes it a compelling de-risked asset with the potential to address CKD and multiple cardiovascular indications.' Title: A Positive Functional Modulator of ABCC6 Decreases Vascular Calcification and Improves Kidney Function in a Rat Adenine Diet Model of Chronic Kidney DiseaseAbstract Number: 1723 Presenter: John Miller, Ph.D. Session: Chronic Kidney Disease, Focused Oral Room 4Date and Time: Friday, June 6, 2025, 8:51 a.m. – 8:57 a.m. CEST In CKD, reduced ABCC6 activity or expression may lead to lower PPi levels, contributing to pathological calcification in blood vessels and kidneys. Restoring ABCC6 function or enhancing its expression offers a new and compelling therapeutic strategy to prevent the progression of CKD towards end-stage renal disease in addition to reducing large vessel calcification, a major driver of cardiovascular complications in CKD. Key findings RTY-822, an orally administered PFM targeting ABCC6 increased both ABCC6 protein expression and plasma PPi levels in primary human hepatocytes, supporting its proposed mechanism of action In a rat model of CKD and vascular calcification induced by an adenine-enriched diet with calcitriol supplementation: RTY-822 treatment led to statistically significant reductions in vascular calcification in the aorta and the femoral arteries After a six-week treatment course, RTY-822 improved glomerular and tubular kidney functions, with statistically significant reductions in serum creatinine, urea, and cystatin C, and an improved estimated glomerular filtration rate (eGFR) Calcium accumulation in the kidney was also significantly reduced Kidney injury biomarkers were reduced, including a significant decrease in plasma KIM-1 and urinary Lipocalin-2 (NGAL) levels In rats fed an adenine-rich diet without calcitriol supplementation, treatment with RTY-822 resulted in: Improved glomerular and tubular kidney functions Reduced serum creatinine and cystatin C levels Increased eGFR Reduced urinary NGAL levels, a biomarker of acute kidney injury The presentation is available on the Rectify website at About Rectify Pharmaceuticals, Inc. ('Rectify') Rectify is advancing Positive Functional Modulators (PFMs), a novel class of oral, small molecules that restore and enhance membrane protein function to address the underlying cause of serious diseases. Rectify's PFMs have potential to modulate the activity of wild-type and mutated membrane-bound proteins, a historically difficult challenge with a small molecule approach. The Company's breakthrough product platform enables efficient and rapid discovery of first- and best-in-class small molecule therapies with the potential to address membrane protein dysfunction for treatment of rare and common diseases, including liver, cardio-renal-metabolic, and neurodegenerative diseases. Rectify was founded and seeded by Atlas Venture who co-led the $100M Series A round with Omega Funds and were joined by Forbion and Longwood Fund. For more information, please visit or follow us on X and LinkedIn. ContactMediaJonathan PappasLifeSci Communicationsjpappas@ in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
2 days ago
- Health
- Yahoo
Rectify Pharma Presents Translational Data Demonstrating Improvements in Kidney Function and Reductions in Vascular Calcification at ERA 2025
Potent, selective ABCC6-targeting positive functional modulator (PFM) improved multiple markers of renal function in animal models of chronic kidney disease (CKD) PFM improved inorganic pyrophosphate (PPi) efflux via on-target engagement of the ABCC6 membrane transporter and reduced vascular calcification in animal models of CKD BOSTON, June 06, 2025 (GLOBE NEWSWIRE) -- Rectify Pharmaceuticals, Inc., ('Rectify') a biotechnology company pioneering positive functional modulators (PFMs) that restore and enhance membrane protein function, today showcased new data from its cardiorenal program with its ABCC6-targeting PFM, RTY-822. The results were presented in an oral presentation during the European Renal Association (ERA) 2025 Congress, taking place in Vienna, Austria, June 4 – 7, 2025. 'These translational results demonstrate that Rectify's PFM reduces vascular calcification and kidney injury and improves kidney function through enhancement of ABCC6 function,' said Rajesh Devraj, Ph.D., President and Chief Executive Officer of Rectify. 'We believe the strength of these data underscores the potential of our approach to offer a novel and differentiated therapeutic strategy to treat renal dysfunction and injury, as well as address vascular calcification driving cardiovascular disease. We are committed to continuing to advance meaningful therapies for patients with CKD and serious cardiovascular conditions.' Robert Hughes, Ph.D., Chief Scientific Officer of Rectify, added, 'Enhancing the function of ABCC6 holds the potential to address key drivers of vascular calcification and tubular dysfunction seen in CKD. With demonstrated on-target engagement, RTY-822 shows significant promise to reduce CKD-associated calcium deposits in arterial walls, a well-established contributor to cardiovascular morbidity and mortality seen in patients with CKD, and remarkably, also improves glomerular function and tubular injury. The translational readiness of this program makes it a compelling de-risked asset with the potential to address CKD and multiple cardiovascular indications.' Title: A Positive Functional Modulator of ABCC6 Decreases Vascular Calcification and Improves Kidney Function in a Rat Adenine Diet Model of Chronic Kidney DiseaseAbstract Number: 1723 Presenter: John Miller, Ph.D. Session: Chronic Kidney Disease, Focused Oral Room 4Date and Time: Friday, June 6, 2025, 8:51 a.m. – 8:57 a.m. CEST In CKD, reduced ABCC6 activity or expression may lead to lower PPi levels, contributing to pathological calcification in blood vessels and kidneys. Restoring ABCC6 function or enhancing its expression offers a new and compelling therapeutic strategy to prevent the progression of CKD towards end-stage renal disease in addition to reducing large vessel calcification, a major driver of cardiovascular complications in CKD. Key findings RTY-822, an orally administered PFM targeting ABCC6 increased both ABCC6 protein expression and plasma PPi levels in primary human hepatocytes, supporting its proposed mechanism of action In a rat model of CKD and vascular calcification induced by an adenine-enriched diet with calcitriol supplementation: RTY-822 treatment led to statistically significant reductions in vascular calcification in the aorta and the femoral arteries After a six-week treatment course, RTY-822 improved glomerular and tubular kidney functions, with statistically significant reductions in serum creatinine, urea, and cystatin C, and an improved estimated glomerular filtration rate (eGFR) Calcium accumulation in the kidney was also significantly reduced Kidney injury biomarkers were reduced, including a significant decrease in plasma KIM-1 and urinary Lipocalin-2 (NGAL) levels In rats fed an adenine-rich diet without calcitriol supplementation, treatment with RTY-822 resulted in: Improved glomerular and tubular kidney functions Reduced serum creatinine and cystatin C levels Increased eGFR Reduced urinary NGAL levels, a biomarker of acute kidney injury The presentation is available on the Rectify website at About Rectify Pharmaceuticals, Inc. ('Rectify') Rectify is advancing Positive Functional Modulators (PFMs), a novel class of oral, small molecules that restore and enhance membrane protein function to address the underlying cause of serious diseases. Rectify's PFMs have potential to modulate the activity of wild-type and mutated membrane-bound proteins, a historically difficult challenge with a small molecule approach. The Company's breakthrough product platform enables efficient and rapid discovery of first- and best-in-class small molecule therapies with the potential to address membrane protein dysfunction for treatment of rare and common diseases, including liver, cardio-renal-metabolic, and neurodegenerative diseases. Rectify was founded and seeded by Atlas Venture who co-led the $100M Series A round with Omega Funds and were joined by Forbion and Longwood Fund. For more information, please visit or follow us on X and LinkedIn. ContactMediaJonathan PappasLifeSci Communicationsjpappas@ in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
30-05-2025
- Business
- Yahoo
Should Invesco Dividend Achievers ETF (PFM) Be on Your Investing Radar?
The Invesco Dividend Achievers ETF (PFM) was launched on 09/15/2005, and is a passively managed exchange traded fund designed to offer broad exposure to the Large Cap Value segment of the US equity market. The fund is sponsored by Invesco. It has amassed assets over $680.20 million, making it one of the average sized ETFs attempting to match the Large Cap Value segment of the US equity market. Companies that fall in the large cap category tend to have a market capitalization above $10 billion. Overall, they are usually a stable option, with less risk and more sure-fire cash flows than mid and small cap companies. Value stocks have lower than average price-to-earnings and price-to-book ratios. They also have lower than average sales and earnings growth rates. When you look at long-term performance, value stocks have outperformed growth stocks in nearly all markets. But in strong bull markets, growth stocks are more likely to be winners. Cost is an important factor in selecting the right ETF, and cheaper funds can significantly outperform their more expensive counterparts if all other fundamentals are the same. Annual operating expenses for this ETF are 0.52%, putting it on par with most peer products in the space. It has a 12-month trailing dividend yield of 1.56%. Even though ETFs offer diversified exposure that minimizes single stock risk, investors should also look at the actual holdings inside the fund. Luckily, most ETFs are very transparent products that disclose their holdings on a daily basis. This ETF has heaviest allocation to the Information Technology sector--about 23.10% of the portfolio. Financials and Healthcare round out the top three. Looking at individual holdings, Microsoft Corp (MSFT) accounts for about 4.60% of total assets, followed by Broadcom Inc (AVGO) and Apple Inc (AAPL). The top 10 holdings account for about 30.61% of total assets under management. PFM seeks to match the performance of the NASDAQ US Broad Dividend Achievers Index before fees and expenses. The NASDAQ US Broad Dividend Achievers Index is designed to identify a diversified group of dividend-paying companies which have increased their annual dividend for 10 or more consecutive fiscal years. The ETF has added about 1.70% so far this year and it's up approximately 13.15% in the last one year (as of 05/30/2025). In the past 52-week period, it has traded between $41.05 and $48.20. The ETF has a beta of 0.81 and standard deviation of 14.23% for the trailing three-year period, making it a medium risk choice in the space. With about 434 holdings, it effectively diversifies company-specific risk. Invesco Dividend Achievers ETF carries a Zacks ETF Rank of 3 (Hold), which is based on expected asset class return, expense ratio, and momentum, among other factors. Thus, PFM is a good option for those seeking exposure to the Style Box - Large Cap Value area of the market. Investors might also want to consider some other ETF options in the space. The Schwab U.S. Dividend Equity ETF (SCHD) and the Vanguard Value ETF (VTV) track a similar index. While Schwab U.S. Dividend Equity ETF has $67.93 billion in assets, Vanguard Value ETF has $133.01 billion. SCHD has an expense ratio of 0.06% and VTV charges 0.04%. An increasingly popular option among retail and institutional investors, passively managed ETFs offer low costs, transparency, flexibility, and tax efficiency; they are also excellent vehicles for long term investors. To learn more about this product and other ETFs, screen for products that match your investment objectives and read articles on latest developments in the ETF investing universe, please visit Zacks ETF Center. Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report Invesco Dividend Achievers ETF (PFM): ETF Research Reports Apple Inc. (AAPL) : Free Stock Analysis Report Microsoft Corporation (MSFT) : Free Stock Analysis Report Broadcom Inc. (AVGO) : Free Stock Analysis Report Vanguard Value ETF (VTV): ETF Research Reports Schwab U.S. Dividend Equity ETF (SCHD): ETF Research Reports This article originally published on Zacks Investment Research ( Zacks Investment Research Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Business Wire
28-05-2025
- Business
- Business Wire
Veryon Expands Strategic App Integrations with Airplane Manager Partnership
SAN FRANCISCO--(BUSINESS WIRE)-- Veryon, a leading provider of information services and software solutions for the aviation industry, today announced a new integration with Airplane Manager, a premier platform for flight operations, scheduling, and trip planning. This strategic move is part of Veryon's broader commitment to improving real-time coordination across aviation functions and giving customers even more options to choose from when it comes to premier Flight Operations vendors. "With our integration with Airplane Manager, we are adding another partner to our integration portfolio and empowering our operators with accurate, up-to-the-minute aircraft status data without the need for additional technology integration." Share The integration enables automatic synchronization of aircraft status, maintenance schedules, and crew coordination between Airplane Manager and Veryon Tracking, delivering real-time visibility and faster operator decision-making. It reduces manual updates, improves dispatch accuracy, and ensures maintenance and flight departments are always aligned. "Simplifying how our customers operate and giving them choices as they look to integrate products across their ecosystem remains a core principle at Veryon," said Kris Volrath, Senior Vice President of Product of Veryon. "With our integration with Airplane Manager, we are adding another partner to our integration portfolio and empowering our operators with accurate, up-to-the-minute aircraft status data without the need for additional technology integration." Strategic Integration Portfolio Continues to Grow This new capability adds to Veryon's growing portfolio of integrations with leading scheduling and operations platforms, including Skylegs, FlightBridge, Professional Flight Management (PFM), Business Aircraft Records and Tracking (BART), Professional Flight Management (PFM), and Avianis. Powered by Veryon's open API architecture, these integrations allow maintenance tracking, scheduling, and operational systems to share data seamlessly, eliminating rework, increasing reliability, and reducing the time it takes to go from maintenance sign-off to wheels up. "Integrating Airplane Manager with Veryon Tracking helps improve the efficiency between maintenance and flight operations and ensures that blind spots that may have existed before between maintenance and scheduling are eliminated," said Aaron Zampaglione, Senior Engineer at Airplane Manager. "It's improved our customer satisfaction, reliability, and dispatch speed, leading to a higher level of confidence in aircraft readiness across the board." Solving a Long-Standing Industry Challenge Disconnected systems have long been a source of inefficiency in business aviation. Veryon's latest integration directly addresses operators losing time reconciling maintenance and flight scheduling data across platforms, helping flight departments recover time, reduce friction, and optimize aircraft utilization. "Our customers want technology that fits into their operation, not the other way around," said Volrath. "With Airplane Manager and our other integrations, we're helping operators adapt faster and fly smarter." About Veryon Veryon is the leading provider of aviation software and information services, supporting a global network of more than 75,000 aircraft maintenance professionals and over 7,600 customers in nearly 175 countries worldwide. We help everyone from business aviation teams and MROs to airlines and OEMs get their aircraft more uptime. Challenges like unscheduled repairs, part availability, and excessive paperwork lead to too many aircraft spending too much time on the ground. And that leads to needless delays, endless back and forth, and lots of wasted dollars. The key to more uptime is having a better technology platform to manage everything from maintenance and operations to manuals and diagnostics. That's why thousands of aircraft operators, 25% of the worldwide commercial fleet, and over 100 OEMs all rely on Veryon. And it's why customers have been able to achieve an average 23% improvement in aircraft downtime cost. Veryon. Let's get you more uptime. Learn more at About Airplane Manager Airplane Manager is a comprehensive flight scheduling and management software designed exclusively for the private jet industry and air charter operators. Since pioneering web-based scheduling software in 2009, Airplane Manager continues to lead by providing advanced solutions that seamlessly connect pilots, passengers, owners, and executive assistants. The platform offers features such as flight scheduling, crew management, and real-time data synchronization, enhancing operational efficiency for over 1,295 flight departments and managing 5,443 aircraft. Learn more at
Yahoo
28-05-2025
- Business
- Yahoo
Veryon Expands Strategic App Integrations with Airplane Manager Partnership
New partnership with Airplane Manager bridges the gap between maintenance tracking and flight scheduling for business aviation operators. SAN FRANCISCO, May 28, 2025--(BUSINESS WIRE)--Veryon, a leading provider of information services and software solutions for the aviation industry, today announced a new integration with Airplane Manager, a premier platform for flight operations, scheduling, and trip planning. This strategic move is part of Veryon's broader commitment to improving real-time coordination across aviation functions and giving customers even more options to choose from when it comes to premier Flight Operations vendors. The integration enables automatic synchronization of aircraft status, maintenance schedules, and crew coordination between Airplane Manager and Veryon Tracking, delivering real-time visibility and faster operator decision-making. It reduces manual updates, improves dispatch accuracy, and ensures maintenance and flight departments are always aligned. "Simplifying how our customers operate and giving them choices as they look to integrate products across their ecosystem remains a core principle at Veryon," said Kris Volrath, Senior Vice President of Product of Veryon. "With our integration with Airplane Manager, we are adding another partner to our integration portfolio and empowering our operators with accurate, up-to-the-minute aircraft status data without the need for additional technology integration." Strategic Integration Portfolio Continues to Grow This new capability adds to Veryon's growing portfolio of integrations with leading scheduling and operations platforms, including Skylegs, FlightBridge, Professional Flight Management (PFM), Business Aircraft Records and Tracking (BART), Professional Flight Management (PFM), and Avianis. Powered by Veryon's open API architecture, these integrations allow maintenance tracking, scheduling, and operational systems to share data seamlessly, eliminating rework, increasing reliability, and reducing the time it takes to go from maintenance sign-off to wheels up. "Integrating Airplane Manager with Veryon Tracking helps improve the efficiency between maintenance and flight operations and ensures that blind spots that may have existed before between maintenance and scheduling are eliminated," said Aaron Zampaglione, Senior Engineer at Airplane Manager. "It's improved our customer satisfaction, reliability, and dispatch speed, leading to a higher level of confidence in aircraft readiness across the board." Solving a Long-Standing Industry Challenge Disconnected systems have long been a source of inefficiency in business aviation. Veryon's latest integration directly addresses operators losing time reconciling maintenance and flight scheduling data across platforms, helping flight departments recover time, reduce friction, and optimize aircraft utilization. "Our customers want technology that fits into their operation, not the other way around," said Volrath. "With Airplane Manager and our other integrations, we're helping operators adapt faster and fly smarter." About Veryon Veryon is the leading provider of aviation software and information services, supporting a global network of more than 75,000 aircraft maintenance professionals and over 7,600 customers in nearly 175 countries worldwide. We help everyone from business aviation teams and MROs to airlines and OEMs get their aircraft more uptime. Challenges like unscheduled repairs, part availability, and excessive paperwork lead to too many aircraft spending too much time on the ground. And that leads to needless delays, endless back and forth, and lots of wasted dollars. The key to more uptime is having a better technology platform to manage everything from maintenance and operations to manuals and diagnostics. That's why thousands of aircraft operators, 25% of the worldwide commercial fleet, and over 100 OEMs all rely on Veryon. And it's why customers have been able to achieve an average 23% improvement in aircraft downtime cost. Veryon. Let's get you more uptime. Learn more at About Airplane Manager Airplane Manager is a comprehensive flight scheduling and management software designed exclusively for the private jet industry and air charter operators. Since pioneering web-based scheduling software in 2009, Airplane Manager continues to lead by providing advanced solutions that seamlessly connect pilots, passengers, owners, and executive assistants. The platform offers features such as flight scheduling, crew management, and real-time data synchronization, enhancing operational efficiency for over 1,295 flight departments and managing 5,443 aircraft. Learn more at View source version on Contacts Veryon Media ContactKim Welch Director, Corporate MarketingVeryon kwelch@ Error while retrieving data Sign in to access your portfolio Error while retrieving data
