Latest news with #PPMI
Associated Press
29-04-2025
- Health
- Associated Press
The Michael J. Fox Foundation Expands Landmark Parkinson's Research Study toward Better Treatments and Prevention
NEW YORK, April 29, 2025 /PRNewswire/ -- The landmark Parkinson's disease study from The Michael J. Fox Foundation for Parkinson's Research (MJFF) today announces a new expansion with additional cohorts and updated technologies to further explore the intricacies and etiology of this complex neurological disease. First launched in 2010, the Parkinson's Progression Markers Initiative (PPMI) has become a cornerstone of Parkinson's research with the aim of accelerating personalized treatments, cures and one day a world without Parkinson's disease (PD). Now offering additional ways to participate, PPMI has lowered its screening age eligibility and is remotely screening individuals aged 40 or older without PD and people with PD diagnosed within the last seven years for potential longitudinal enrollment at one of 50 sites in 12 countries. Additionally, anyone aged 18 or older in the United States can contribute data on health and wellbeing through the newly relaunched myPPMI study participant platform. This expansion builds on PPMI's longstanding commitment to drive and deepen understanding of the biological fingerprint and clinical footprint of Parkinson's disease. 'Since PPMI began, the study has risen to meet current scientific needs while looking forward to anticipate the infrastructure and novel data required for future research. Partnering with more participants, in the clinics and online, offers new opportunities to develop more tools and learnings to speed therapies while also engaging a broader audience of potential volunteers for the clinical trials to come,' said PPMI's principal investigator and distinguished scientist at the Institute for Neurodegenerative Disorders, Kenneth Marek, MD. PPMI's latest expansion comes as The Michael J. Fox Foundation recognizes extraordinary research progress and an innovative high-risk, high-reward model that has generated more than $2.5 billion dollars to support global research programs. The unprecedented opportunity to speed cures is matched only by the urgency of the need: PD is now the second most common and fastest-growing neurological disease in the world. An estimated 6 million or more people around the world, including over 1 million Americans, live with Parkinson's today. With no way to prevent, stop or slow the disease, PD is projected to double globally by 2040. Expanded Eligibility for In-Clinic Study Population Aims to Answer Key Questions In 2023, PPMI data validated a biomarker test for a key Parkinson's pathology — the aggregation of the protein alpha-synuclein. This groundbreaking new test, the alpha-synuclein seed amplification assay (a-syn SAA), allowed scientists, for the first time, to detect this Parkinson's pathology in living people. The results from PPMI data analysis showed remarkable findings. Firstly, the a-syn SAA test was positive in many people aged 60 or older who were not yet diagnosed with clinical PD and correlated with severe smell loss (≥10% of expected smell ability controlled for age and sex). Six to ten percent of participants in the diagnosed PD cohort had a negative a-syn SAA result. This was most common in people with normal smell ability, and in individuals who carried a PD-associated mutation in the LRRK2 gene. These findings have pointed to a deeper biological understanding of Parkinson's and have led PPMI to adjust its cohorts. Enrolling people aged 40 or older with smell loss and a-syn SAA positivity will allow scientists to study how early this pathology appears, which could help design prevention trials and further understand younger disease onset. PPMI will also further examine the biology of individuals later in disease with a Parkinson's diagnosis within the past seven years and robust smell ability, many presumably negative on the a-syn SAA, to understand the biological markers present in these individuals. 'In science, each answer begets more questions. PPMI is iterating to build on past success and drive to the next breakthrough. These quick pivots are possible only with the trust and commitment of the initiative's many partners. We are grateful for the efforts and contributions of the study team, the scientists, the sites and most importantly the study's generous volunteers who have helped change what we know about this disease and how research is moving to stop it,' said MJFF Chief Program Officer Sohini Chowdhury. Eligible participants — over age 40 and not diagnosed with Parkinson's or over age 30 and diagnosed with Parkinson's in the past seven years — can request a smell test at Online Data Capture Complements In-Clinic Research to Elucidate Brain Health and Disease PPMI has also updated its online experience for participants. In 2020, the study launched an English-language online platform to capture data on health and wellbeing over time from anyone aged 18 or older in the United States, with or without PD. To date, more than 46,000 participants have completed more than 222,000 online study visits, contributing data in over 3.3 million surveys. This data is pointing scientists to predictive features and varied progression profiles, which may help improve care and research practices. The online capture part study has been folded into the myPPMI participant platform. Introduced in 2023, myPPMI provides opportunities for participants to contribute in varied ways to the initiative (e.g., online, in-person) and to contribute study data virtually and, in some cases, individuals' personal research information. In 2024, PPMI began offering access to personal data from the a-syn SAA test, dopamine transporter (DAT) brain imaging scan, and a physician assessment of movement issues. One of the first Parkinson's studies to share back this volume of research information directly to trial volunteers, PPMI provides education and counseling around these tests as well. myPPMI is available in the U.S., Austria, England, Canada, Germany, Spain, the Netherlands, with additional countries starting later in 2025; content is currently translated into German, Dutch and Spanish. The integration of online data collection into myPPMI enhances the participant experience as well as widens the pool of contributors. 'I am grateful for the opportunity to be part of this study community. Joining PPMI has been an empowering step in my Parkinson's journey, and I'm glad that the new platform will make it easy to contribute more to the study,' said PPMI Community Advisory Board member Marty Acevedo, 65, of Oceanside, California. 'Furthermore, I'm glad that the study is now returning some personal research information back to us participant partners. This knowledge on our own disease can help navigate care and research decisions.' PPMI's Continuing Collaborations to Grow Study Impact Today, MJFF is convening hundreds of academic, research and industry leaders from around the world for its PPMI Annual Investigators Meeting held in New York City. Hosted by MJFF, the annual meeting features reports on promising avenues of exploration in the study and advancements in our understanding around disease progression and biomarkers, while addressing challenges and opportunities in clinical trial innovations, including new approaches to integrating patient perspectives. Heralded as 'the study that's changing everything' about how Parkinson's is diagnosed, managed and treated, PPMI and its data are made possible by the nearly 4,000 volunteers — people with PD, disease risk factors and control volunteers — at PPMI clinics and more than 45,000 in its online study. All de-identified data is shared in real-time with qualified scientists to speed scientific discovery and validation of findings toward broad application. While iterating its current protocols, PPMI is also collaborating to grow the impact of its dataset, biosample library and engaged participant base. PPMI is a $750-million public-private partnership. Major funding for PPMI comes from ASAP, a global research initiative focused on accelerating the pace of discovery for Parkinson's disease. ASAP support is enabling expanded PPMI recruitment efforts and remote testing as well as assay development efforts to enable breakthroughs such as αSyn-SAA. This infrastructure provides a ready platform for future discoveries. In addition to ASAP, PPMI is supported by the Edmond J. Safra Foundation, the Farmer Family Foundation, Connie and Steven Ballmer, and Susan and Riley Bechtel. The study is additionally funded by a consortium of more than 40 biotech and pharmaceutical firms providing financial and in-kind support, and by tens of thousands of individual donors to The Michael J. Fox Foundation. About The Michael J. Fox Foundation for Parkinson's Research (MJFF) As the world's largest nonprofit funder of Parkinson's research, The Michael J. Fox Foundation is dedicated to accelerating a cure for Parkinson's disease and improved therapies for those living with the condition today. The Foundation pursues its goals through an aggressively funded, highly targeted research program coupled with active global engagement of scientists, Parkinson's patients, business leaders, clinical trial participants, donors and volunteers. In addition to funding $2.5 billion in research to date, the Foundation has fundamentally altered the trajectory of progress toward a cure. Operating at the hub of worldwide Parkinson's research, the Foundation forges groundbreaking collaborations with industry leaders, academic scientists and government research funders; creates a robust open- access data set and biosample library to speed scientific breakthroughs and treatment with its landmark clinical study, PPMI; increases the flow of participants into Parkinson's disease clinical trials with its online tool, Fox Trial Finder; promotes Parkinson's awareness through high-profile advocacy, events and outreach; and coordinates the grassroots involvement of thousands of Team Fox members around the world. For more information, visit us at Facebook, Instagram and LinkedIn. View original content to download multimedia: SOURCE The Michael J. Fox Foundation for Parkinson's Research
Yahoo
03-04-2025
- Health
- Yahoo
Planned Parenthood shutting down 4 Michigan clinics after Trump administration cuts funding
Planned Parenthood clinic in Marquette, the only abortion care clinic in the U.P., on Dec. 9, 2021 | Allison R. Donahue Planned Parenthood of Michigan announced Wednesday that it will be closing its health centers in Jackson, Petoskey and Marquette at the end of the month and consolidating the two health centers in Ann Arbor into one location after the Trump administration cut millions of dollars in federal funding for family planning. In order to ensure long-term sustainability amid funding cuts and expected future restrictions on reproductive health care enacted by President Donald Trump's administration, Planned Parenthood of Michigan, or PPMI said in a news release that it is eliminating some clinics and cutting its staffing by 10 percent. 'Our decision to restructure reflects months of strategic planning and careful financial analysis,' Paula Thornton Greear, President and CEO of PPMI said in a news release. 'These necessary changes strengthen PPMI's ability to adapt quickly in a challenging political landscape. While implementing difficult decisions is never easy, they are essential to protect our long-term capacity to fulfill our mission and serve Michigan communities for generations to come.' Trump himself for years has articulated his interest in defunding Planned Parenthood for providing abortion care, and the Department of Health and Human Services, or HHS announced this week that it is placing a freeze on millions of dollars to a federal program dedicated to family planning for low-income patients known as Title X. Nine Planned Parenthood state affiliates that receive federal money from the 55-year-old Title X family planning program got notices Monday, informing them that their funding is being 'temporarily withheld.' The notice pointed to 'possible violations' of federal civil rights law and President Donald Trump's executive orders — including prohibitions on promotion of diversity, equity and inclusion and 'taxpayer subsidization of open borders.' Whitmer orders state departments to review Trump executive orders on DEI, transgender policies The cut comes as a devastating blow to health care providers like PPMI, Thornton Greear said in the news release. And though PPMI plans on expanding hours for its Virtual Health Center for telehealth services like birth control, medicated abortions and gender affirming health care, the current administration's attitude towards reproductive health care has PPMI preparing for further challenges. 'And in the coming weeks and months, additional attacks against sexual and reproductive health care providers are expected, including restricting access to medication abortion, restricting Medicaid coverage of Planned Parenthood health services, further restrictions on Title X funding, or even ending the program altogether, as the administration has already done to so many other lifesaving Federal funding streams and agencies,' Thornton Greear said. With the Marquette and Petoskey locations set to be permanently closed by the end of April, Michigan's Upper Peninsula and much of Northern Michigan will be more than 100 miles from a Planned Parenthood, with the next closest Planned Parenthood clinic to Marquette nearly five hours away, in Traverse City. The closing of the Marquette clinic is a sad affair, the Marquette County Democratic Party said in a news release Thursday, adding that the group stands ready to advocate for those in the Upper Peninsula to continue to receive the services they had been accessing through the Planned Parenthood clinic. 'We are outraged by the partisan Republican federal funding freeze that caused the loss of the local clinic. Planned Parenthood has long put into practice values that Democrats hold dear, such as personal autonomy, women's rights, LGBTQIA+ rights, and affordable access to health care services,' the party said in a news release. SUBSCRIBE: GET THE MORNING HEADLINES DELIVERED TO YOUR INBOX
