Latest news with #PREVAIL
Sharjah 24
5 days ago
- Health
- Sharjah 24
Royal Marsden hails Jawaher Al Qasimi's role in cancer treatment
The report underscored that Her Highness's support has empowered the lab's scientific team to fast-track diagnostics and treatments, bringing hope to thousands of patients. This was achieved through the introduction of state-of-the art facilities to the Sharjah Clinical Genomics Laboratory; including the UK's first robotic genome testing facility; and bringing together world experts in molecular pathology, bioinformatics, translational research. A humanitarian grant has been driving rapid progress The Sharjah Laboratory was launched in 2018 as a humanitarian initiative by Her Highness Sheikha Jawaher Al Qasimi, who donated £500,000 to support its establishment within the CMP at The Royal Marsden in the UK. This donation reflects Her Highness's strong belief that investing in scientific research is foundational in the fight against cancer and that such research can make a genuine global impact, benefiting patients far beyond the institution itself. Founded in 1851, The Royal Marsden in London is the world's first and most renowned cancer centers. It specialises in the diagnosis, treatment, and research of all types of cancer, with a highly experienced medical team and a dedicated department for paediatric and adolescent care. The hospital serves more than 50,000 patients annually and works in close collaboration with its academic partner, The Institute of Cancer Research, London, cementing its position as a global leader in cancer treatment innovation. Recent advancements enhancing cancer care Recent advancements at the CMP are enhancing cancer care and were reflected in a comprehensive report. The 'Marsden360' service, developed in partnership with Guardant Health, uses liquid biopsy (a blood test for cancer) to identify the genetic changes in DNA, allowing patients to be matched to targeted treatments. The testing was offered as part of an NHS England national study for patients with suspected late-stage lung cancer, as well as providing a commissioned NHS ctDNA service to guide treatment decisions for eligible patients with suspected late-stage breast cancer. The report also noted the Sharjah Clinical Genomics Laboratory is on track to become the first facility in the UK to offer fully automated genomic testing, with the capacity to conduct 5000 tests monthly. This is being achieved through collaboration with Automata, a global biotech company providing robotic automation solutions to the life sciences industry. The advancement has improved early detection of genetic mutations and enabled proactive care for high-risk cancer patients. Cutting-edge technology includes the Nanopore PromethION device for precise long-read DNA sequencing, already analyzing 110 whole genomes to yield new insights for treatment development. The CMP also plays a vital role in key clinical trials like 'ENABLE-NGS', 'PREVAIL', and 'ICED' (targeting leukemia, lung, and rare cancers), 'SIGNIFIED' (offering annual scans for Li-Fraumeni Syndrome), 'INOVATE' (blood-based monitoring for head/neck cancers), and 'RECUT Plus' (studying radiotherapy resistance). Further amplifying its impact, the lab contributed to over 24 peer-reviewed studies in 2024, presented at major conferences like ESMO and ASCO, exploring molecular profiling to redefine cancer risk and reshape treatment strategies. A UAE humanitarian vision for the world The Sharjah Clinical Genomics Laboratory reflects the UAE's vision of investing in human potential and scientific research, transforming humanitarian efforts into tangible impact in patients' lives. It serves as a prime example of successful collaboration between philanthropy and science, through which Sharjah has become an active partner and contributor to the future of genomic medicine worldwide. The laboratory's success in the UK exemplified the vision and commitment of Her Highness Sheikha Jawaher Al Qasimi commitment to supporting cancer patients. Her Highness's efforts have directly supported several specialised institutions such as Children's Cancer Hospital Egypt 57357, the Children's Cancer Center of Lebanon (CCCL), the National Cancer Institute in Egypt (Sheikha Jawaher Al Qasimi Building), and the Union for International Cancer Control's (UICC) Fund for Childhood Cancer Patients. Through these efforts, Her Highness Sheikha Jawaher Al Qasimi champions a UAE global humanitarian mission that transcends borders.
Yahoo
12-06-2025
- Business
- Yahoo
NewAmsterdam Pharma Company N.V. (NAMS) Initiated with a Buy at Stifel
NewAmsterdam Pharma Company N.V. (NASDAQ:NAMS) is one of the 13 Biotech Stocks with Huge Upside Potential. It is now under Stifel's coverage, with a buy rating and a $44 price target. A scientist in a lab coat standing in a research lab examining biopharmaceuticals. According to the firm, NewAmsterdam Pharma Company N.V. (NASDAQ:NAMS) is a distinct late-stage cardiovascular company with a short-term trajectory toward regulatory filings. Its core asset, obicetrapib, has the potential to differentiate itself in the growing lipid-lowering market, according to Stifel. The analyst points out that obicetrapib potentially differs from earlier attempts in the CETP inhibitor market due to the company's cardiovascular outcomes trial, PREVAIL. Stifel anticipates significant upside even under cautious commercial assumptions. The CETP inhibitor obicetrapib, which is being developed by NewAmsterdam Pharma Company N.V. (NASDAQ:NAMS), is intended to decrease cholesterol in the treatment of cardiovascular disease. Stifel cites the PREVAIL study and an extensive amount of supporting data to show that obicetrapib differs significantly from previous CETP failures. New Amsterdam has a legitimate route to market access due to this distinction and impending regulatory milestones. Stifel's $44 price estimate shows that they are confident in the drug's clinical uniqueness and market potential. While we acknowledge the potential of NAMS as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you're looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock. READ NEXT: 10 High-Growth EV Stocks to Invest In and 13 Best Car Stocks to Buy in 2025. Disclosure. None. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
12-06-2025
- Business
- Yahoo
NewAmsterdam Pharma Company N.V. (NAMS) Initiated with a Buy at Stifel
NewAmsterdam Pharma Company N.V. (NASDAQ:NAMS) is one of the 13 Biotech Stocks with Huge Upside Potential. It is now under Stifel's coverage, with a buy rating and a $44 price target. A scientist in a lab coat standing in a research lab examining biopharmaceuticals. According to the firm, NewAmsterdam Pharma Company N.V. (NASDAQ:NAMS) is a distinct late-stage cardiovascular company with a short-term trajectory toward regulatory filings. Its core asset, obicetrapib, has the potential to differentiate itself in the growing lipid-lowering market, according to Stifel. The analyst points out that obicetrapib potentially differs from earlier attempts in the CETP inhibitor market due to the company's cardiovascular outcomes trial, PREVAIL. Stifel anticipates significant upside even under cautious commercial assumptions. The CETP inhibitor obicetrapib, which is being developed by NewAmsterdam Pharma Company N.V. (NASDAQ:NAMS), is intended to decrease cholesterol in the treatment of cardiovascular disease. Stifel cites the PREVAIL study and an extensive amount of supporting data to show that obicetrapib differs significantly from previous CETP failures. New Amsterdam has a legitimate route to market access due to this distinction and impending regulatory milestones. Stifel's $44 price estimate shows that they are confident in the drug's clinical uniqueness and market potential. While we acknowledge the potential of NAMS as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you're looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock. READ NEXT: 10 High-Growth EV Stocks to Invest In and 13 Best Car Stocks to Buy in 2025. Disclosure. None. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
10-04-2025
- Health
- Yahoo
AAN 2025: Lundbeck highlights sustained efficacy of Vyepti for migraine prevention
On 9 April, at the American Academy of Neurology (AAN) 2025 annual meeting, three posters highlighting the sustained long-term efficacy and real-world impact of Lundbeck's anti-calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) Vyepti (eptinezumab) for migraine prevention were presented. Vyepti was approved by the FDA for the prevention of migraine in adults in 2020. As the last of the anti-CGRP mAbs to enter the migraine market, Vyepti has seen moderate uptake since its approval, with the majority of key opinion leaders (KOLs) previously interviewed by GlobalData indicating that one of the subcutaneously administered anti-CGRP mAbs would be their first choice, highlighting the intravenous administration of Vyepti as a logistical challenge. The posters show that early response to Vyepti can be predictive of sustained treatment response, as well as highlighting meaningful benefits of Vyepti treatment. Post hoc analysis of the long-term, open-label Phase III PREVAIL (NCT02985398) study evaluating two-year safety and patient-reported outcomes with Vyepti in adults with chronic migraine was presented in a poster at AAN 2025. The analysis showed that the majority of the participants who achieved 50% or greater headache response or 75% or greater headache response in the first 12 weeks after receiving their first dose of Vyepti were able to maintain that level of response up to Week 84. Sustained treatment response was further demonstrated in another poster presenting post hoc analysis of data from the randomized, placebo-controlled Phase III DELIVER (NCT04418765) trial. In this study, patients had either chronic migraine or high-frequency episodic migraine, and they had failed to respond to two to four prior migraine preventive treatments. Up to 83% of patients who responded to Vyepti treatment within the first one to 24 weeks of the trial (i.e., having received the first two doses of Vyepti) were able to maintain that response over the 72-week trial. These analyses highlight that early treatment response with Vyepti may be able to predict long-term sustained treatment response. A third poster focused on patient-reported impact of Vyepti treatment in adults with chronic migraine. It presented a post hoc analysis of the impact of a 75% or greater increase in good days/month in patients treated with Vyepti from a real-world, observational, US-based study. Approximately two-thirds of the patients in the study reported a 75% or greater increase in good days/month, and this was correlated with higher satisfaction regarding the effects of Vyepti on migraine symptom severity, frequency, and duration; daily activities, such as being able to participate in social/family life, being productive, and ability to plan; and overall wellbeing when compared with patient with less than 75% increase in good days/month. Prior to treatment, the prevalence of brain fog was similar across the treatment response subgroups; however, following Vyepti treatment, 76.6% of the patients with a 75% or greater increase in good days/month reported moderate-to-complete improvement in brain fog, compared with 42.3% of patients with less than 75% increase in good days/month. These results highlight the meaningful benefits that patients experience following Vyepti treatment and will help Lundbeck with its focus on 'raising the bar around preventive treatment expectations in migraine.' Historically, migraine prevention has been managed with a wide variety of drug classes, such as beta-adrenergic receptor blockers, calcium antagonists, antidepressants, and anti-epileptics. However, many of these oral preventive treatments have been associated with poor side-effect profiles, and KOLs previously interviewed by GlobalData reported that low efficacy of oral preventive treatment was common among patients, meaning that patients often cycle through the different drug classes of oral preventive treatments. The first preventive therapies developed specifically for the treatment of migraine were the anti-CGRP mAbs, followed by the oral gepants; however, they are typically prescribed as second- or third-line options for many patients due to reimbursement restrictions requiring failure with the oral preventives before they can be prescribed. In the US, a 2024 statement was published by the American Headache Society recommending that the anti-CGRP mAbs and gepants should be used as first-line preventive options due to their superior efficacy and tolerability compared with the oral preventive options. Long-term sustained efficacy data and demonstration of meaningful benefit for patients, such as was presented for Vyepti at AAN 2025, are likely to further cement the case for first-line adoption of the anti-CGRP mAbs; however, given the comparative costs of the oral preventives and the mAbs, whether this recommendation will be implemented by insurance companies remains to be seen. Vyepti faces significant competition from three other anti-CGRP mAbs: Amgen's Aimovig (erenumab), Eli Lilly's Emgality (galcanezumab), and Teva's Ajovy (fremanezumab). Additional competition also comes from two orally administered gepants: Pfizer's Nurtec (rimegepant) and AbbVie's Qulipta (atogepant). KOLs agreed that the CGRP mAbs had similar efficacy profiles, with treatment choice often based on side effects, dosing schedule, or patient preference. As the only intravenously administered mAb, Vyepti may be at a disadvantage among patients who prefer to self-administer one of the other mAbs, and therefore highlighting the long-term efficacy, particularly with a focus on some of the patient-reported meaningful benefits, will be crucial in helping Vyepti to remain competitive in the migraine prevention market. "AAN 2025: Lundbeck highlights sustained efficacy of Vyepti for migraine prevention" was originally created and published by Clinical Trials Arena, a GlobalData owned brand. 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