Latest news with #Padhi
Time of India
a day ago
- Health
- Time of India
IIT-BHU scientists' technology to check drug resistance of viruses
Varanasi: Scientists at Indian Institute of Technology (BHU) have developed new framework to help understand how virus evolves to evade drugs and treatments. While the technology focuses primarily on Coronavirus (SARS-CoV-2), it can also be applied to other pathogens and infectious diseases. The study, led by assistant professor at the School of Biochemical Engineering, Aditya Kumar Padhi, was published in the Biophysical Journal. The 'integrated multi-scale computational framework' combines several advanced computer-based methods including protein design, machine learning, hybrid QM/MM, and multi-scale simulations. It helps identify mutations or changes in viral proteins leading to drug resistance. The discovery comes at a time when Covid-19 cases are being reported. As the virus continues to mutate rapidly, the framework can help anticipate how it might resist treatment in future. While the current study focuses on resistance to sotrovimab, a monoclonal antibody used against SARS-CoV-2, the framework is applicable to other diseases too, including cancer and urinary tract infections. The team members of Laboratory for Computational Biology & Biomolecular Design (LCBD) contributed significantly to understanding resistance mechanisms against several other antiviral drugs and monoclonal antibodies against SARS-CoV-2. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like USDJPY đang đi lên không? IC Markets Đăng ký Undo Padhi said there were plans to make this framework freely available to scientists and doctors worldwide to support global fight against drug resistance. The research also aligns with India's national health initiatives, such as Integrated Disease Surveillance Programme (IDSP) and National Programme on Containment of Antimicrobial Resistance (AMR). "We developed this framework to address complex healthcare problems like antimicrobial resistance using integrated computational methods. Its modular design makes it suitable for a wide range of biomedical and healthcare challenges," said Padhi. IIT-BHU Director prof Amit Patra said, "Such advanced technologies reflect the scientific leadership of Indian institutions like IIT- BHU in research and innovation, particularly in tackling infectious diseases and major public health challenges. This also significantly contributes to the objectives of the key programme of the govt of India."
Time of India
7 days ago
- Health
- Time of India
IIT-BHU develops breakthrough tool to track and predict drug-resistant viruses
VARANASI: Scientists at the Indian Institute of Technology ( BHU ), Varanasi, developed a new framework that helps understand how viruses evolve to evade drugs and treatments. While the technology primarily focuses on the coronavirus (SARS-CoV-2), it can also be applied to other pathogens and infectious diseases. The study, led by Aditya Kumar Padhi, Assistant Professor at the School of Biochemical Engineering, was published in the renowned Biophysical Journal. This "integrated multiscale computational framework" combines several advanced computer-based methods. These include protein design, machine learning, hybrid QM/MM, and multiscale simulations to study how viruses evolve. It helps identify mutations or changes in the viral proteins that may reduce the effectiveness of drugs. This discovery comes at a time when COVID-19 cases are once again rising in India and across the globe due to the emergence of new viral variants. As the virus continues to mutate rapidly, this framework can help anticipate how it might resist treatments in the future. While the current study focuses on resistance to sotrovimab, a monoclonal antibody used against SARS-CoV-2, the framework is also applicable to other diseases, including cancer and urinary tract infections. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Doutora: 'Um hábito simples antes de dormir me fez perder 1kg a cada 7 dias!' Revista Saúde Saiba Mais Undo The team members of the Laboratory for Computational Biology & Biomolecular Design (LCBD) also significantly contributed to understanding resistance mechanisms against several other antiviral drugs and monoclonal antibodies against SARS-CoV-2. Padhi said that there are plans to make this framework freely available to scientists and doctors worldwide to support the global fight against drug resistance. This will especially benefit regions with limited resources by giving them access to cutting-edge predictive tools. The research also aligns with India's national health initiatives, such as the Integrated Disease Surveillance Programme (IDSP) and the National Programme on Containment of Antimicrobial Resistance (AMR), both of which aim to strengthen the country's pandemic preparedness. 'We developed this framework to address complex healthcare problems like antimicrobial resistance using integrated computational methods. Its modular design makes it suitable for a wide range of biomedical and healthcare challenges,' said Padhi. Prof. Amit Patra, Director of IIT (BHU), said, 'Such advanced technologies reflect the scientific leadership of Indian institutions like IIT (BHU) Varanasi in research and innovation, particularly in tackling infectious diseases and major public health challenges. This also significantly contributes to the objectives of the key programme of the government of India.'
News18
17-05-2025
- Business
- News18
From Budget Drones To Hypersonic Missiles: India's Defence Sector Enters A New Era
Last Updated: India is soon to get an indigenous hypersonic missile that can fly at a speed of Mach 5. This will mark a significant boost in Indian defence sector. Army drones that can hit the target are available in India for just Rs 1 lakh, said Major General Ramesh Chandra Padhi (retd), Senior Vice President of IG Drones, at the Network18 Powering Bharat Summit. His remarks are notable as they challenge the conventional belief that defence technologies are expensive. Speaking at the Defending Bharat panel at the summit, Padhi spoke about FPV Kamikaze — small drones with the capacity to fly at 140 km/hr before hitting the target. 'We have got very small drones, FPV Kamikaze, where you see your target, the speed goes up to 140 km/hr and then it drops directly and hits the target," he said. Padhi's remarks also indicate that made-in-India defence technologies can be more affordable. IG Drones recently gained significant attention after being listed in a government release as one of the four drone companies involved in Operation Sindoor. India carried out the operation in response to the 22 April Pahalgam attack that claimed 26 lives. During the attack, India targeted nine terror camps across Pakistan and Pakistan-occupied Kashmir. In another significant development in the defence sector, India is soon to get an indigenous hypersonic missile that can fly at a speed of Mach 5, marking a major achievement in the defence sector, informed Dr Sudhir Kumar Mishra, veteran DRDO scientist, who was speaking at the Powering Bharat Summit. In conversation with Moneycontrol's Managing Editor Nalin Mehta, the ex-DRDO chief said that DRDO recently conducted a hypersonic engine test, and soon it will come out with a hypersonic missile that will reach Mach 5 speed. 'All the technologies for BrahMos were developed in-house by DRDO. We even built the world's largest launcher ourselves," Mishra said. First Published: May 17, 2025, 08:37 IST
Hans India
22-04-2025
- Business
- Hans India
ISWAI commends state govts for implementing progressive excise policies
Vijayawada: The International Spirits and Wines Association of India (ISWAI) praised state governments for their progressive excise policies aimed at modernising retail formats, increasing revenue, and enhancing consumer experiences. Key innovations include Uttar Pradesh's composite retail formats, Andhra Pradesh's privatised model, Rajasthan's premium mall-based stores, and Madhya Pradesh's single-bottle billing system, among others. These initiatives are reshaping the alcohol retail landscape across the country. Sanjit Padhi, CEO of ISWAI, remarked, 'The reforms signal a paradigm shift in the alcobev sector, reflecting the commitment of state governments. These policies are improving compliance and transparency while fostering sustainable, consumer-focused growth.' He highlighted Uttar Pradesh's impressive revenue growth from Rs 24,000 crore in FY 18/19 to a target of Rs 55,000 crore in FY 25/26, attributing this success to ISWAI members, who contribute over 55% of the state's IMFL revenue. New outlets and investments in retail infrastructure are expected to enhance the consumer experience further. The reforms also stabilise vendor operations by offering two-year licenses through an e-lottery system, capping ownership at two outlets, and promoting fair competition. Padhi added, 'We are seeing the rise of a modern alcobev ecosystem that aligns with global best practices, providing consumers with quality brands and deterring counterfeit products.' In Andhra Pradesh, the privatised retail model supports 3,736 liquor vends and has led to a Rs 1,800 crore increase in revenue. Padhi also stressed the need for deregulation in pricing, stating that market forces should dictate prices to prevent businesses from pricing themselves out of the market. ISWAI advocates for removing pricing controls to encourage investment and enhance contributions to state revenues. As more states adopt these successful practices, India's alcobev landscape will continue to evolve toward a balanced and consumer-centric ecosystem.
