Latest news with #Poletti
Hans India
10-06-2025
- Health
- Hans India
Childhood trauma can have lasting brain consequences, cause psychiatric disorders
Childhood adversity may have a profound connection with lifelong vulnerability causing psychiatric disorders and other brain consequences, according to a study. The study showed that early life experiences become biologically embedded and create lasting changes in brain structure and immune function. "The immune system doesn't just fight infections -- it plays a crucial role in shaping our mental health throughout life," said Sara Poletti, senior researcher at IRCCS Ospedale San Raffaele Milan, Italy. "Childhood trauma can fundamentally reprogramme these immune responses, creating vulnerability to depression, bipolar disorder, and other psychiatric conditions decades later," she added. By identifying specific inflammatory markers associated with childhood trauma, the study provides potential targets for novel interventions. The research calls for precision medicine approach to transform psychiatric treatment from symptom management to addressing underlying biological mechanisms. The paper, published in the journal Brain Medicine focussed on the use of an immunomodulatory agent (interleukin 2) to treat mood disorders. Mood disorders have been recognised by the World Health Organization (WHO) as a major source of disability, morbidity, and mortality worldwide. Among mood disorders, major depressive disorder (MDD) and bipolar disorders (BD) are the most frequent and disabling ones. The lifetime prevalence is about 12 per cent for MDD and 2 per cent for BD. Recent years have seen evidence increasing for the role of immune dysregulations in mood disorders with a focus on the inflammatory response system (IRS). It suggests that an activation of the IRS should be considered as one of the main pathological underpinnings of mood disorders. "I aim to further elucidate the role of the immune system and its interaction with the environment in psychiatric disorders," Poletti said. Her vision includes developing prevention strategies to reduce mental illness odds, particularly for individuals with trauma histories. This preventive focus represents a paradigm shift from reactive to proactive psychiatric care.
Montreal Gazette
25-04-2025
- Montreal Gazette
Man who attacked retired police detective pleads guilty to lying to cops while on probation
Montreal Crime By One of three men who attacked a retired Montreal police detective inside his home in LaSalle a few years ago was ordered to carry out 200 hours of community service after he pleaded guilty to lying to the police and drug possession while he was serving his sentence for the assault. Sandel Pierre, 23, received his new sentence Friday at the Montreal courthouse after he pleaded guilty to obstructing a police officer in the line of duty and the simple possession of a drug. The Criminal Code offences occurred on March 29, 2024, while Pierre was on probation. It was part of the sentence he received in 2023 for taking part in the attack on Pietro Poletti, a retired Montreal police detective and an expert on the Mafia. On the morning of June 12, 2020, four men arrived at Poletti's home in a car. Three of the men got out of the vehicle, rang the doorbell and forced their way in when Poletti opened the door. The three men, who were wearing surgical masks, used a metal bar, a winter shovel and a brick to strike the retired detective several times in the face and stomach. Poletti's mother, who was 87 at the time, was also inside the residence. She heard her son shouting while he was attacked and headed up the stairs from the basement when one of the assailants closed the door on her. She managed to leave the home by the garage and asked neighbours to call 911. Pierre admitted he used a brick to strike Poletti during the attack. When he was sentenced on Jan. 20, 2023, he was left with a six-week prison term to serve to be followed by two years of probation. When the guilty pleas were entered in 2023, the prosecutor in the case said Pierre didn't appear to be the leader in the assault. The two other men who took part were later sentenced to prison terms of eight and nine years. On Friday, Quebec Court Judge Martin Chalifour was told that Pierre was on probation last year when Montreal police approached a vehicle he was seated in, near a park in the Rivière-des-Prairies district, because they suspected a man behind the wheel of the same car was a known criminal. While reading from a joint statement of facts entered into the court record, one of the lawyers in the case said Pierre told the police his name was Sheldon when he was asked to identify himself. The officers noted he uttered the fake name in the form of a question. 'The police informed him that he had the right to remain silent and to a lawyer. Mr. Pierre got out of the vehicle and asked several times, nervously, if he was going to be returned to jail,' the lawyer said. 'He started to run and the police caught up to him.' Chalifour agreed with a joint recommendation that Pierre be sentenced to another two years of probation and that he carry out 50 hours of community service for lying to the police and another 150 hours for possessing a controlled substance. Pierre has 18 months to carry out the community service.
Yahoo
26-02-2025
- Business
- Yahoo
Marketside Restaurant expansion work starting next month
When Marketside Restaurant started operations in 1939, Tony Poletti's great-grandmother would cook the food served in a neighboring house and bring it to the small dining area. Subsequent generations of owners expanded it to include more dining space and a proper kitchen. Now, having worked here for 22 years and becoming owner in 2023, Tony will be making his mark. The restaurant will start expansion work next month that will transform the former Goodfella's Pizzeria at 716 E. Market St. into a new 800-square-foot dining room with a 2,000-square-foot outdoor patio by the summer. The new dining areas will double the restaurant's capacity to 140 seats and enable it to eventually serve dinner four nights a week instead of just breakfast and lunch. 'I'm gonna use it for in the summertime,' Poletti said, with the new space better suited for large groups of tourists. 'I'm limited to 50 people, then you get a little crowded.' Poletti, a member of the Pine Avenue Redevelopment Project, has been planning this expansion since 2011 when he first purchased the vacant space next door. When a city small business property improvement grant came along, reimbursing him up to $100,000 of project costs, he had to pause to make sure that everything he did for it would qualify for it. The expansion's total cost would be around $350,000, with Poletti also securing a loan from Keybank to help cover the costs. This expansion comes at a time of transition for other restaurants that line Pine Avenue. The Como Restaurant changed ownership in early 2024 while other restaurants like Michael's, La Hacienda, and Goodfella's Pizzeria are all listed for sale. 'I have been granted a family business that's been established that a lot of people don't have,' Poletti said. 'Most people don't have that benefit. They're either starting from new or they're coming in and buying old businesses, and then they're forced to adapt.' Poletti hopes that this addition can inspire other nearby business owners to invest in Pine Avenue, whether that is improving the current stores or by bringing in more outsiders to buy and grow businesses. The oldest of his children is six, so he does not know yet if they want to continue the family business or expand further.
