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Time of India
24-05-2025
- Health
- Time of India
NIT-R develops biosensor for early detection of breast cancer
1 2 Rourkela: In a significant breakthrough, researchers at the National Institute of Technology, Rourkela (NITR) have developed a bio-sensor capable of detecting and distinguishing between cancerous and healthy breast cells. The research team led by Prof. Prasanna Kumar Sahu from the department of electrical engineering and his scholar Priyanka Karmakar, has published their findings in the prestigious Microsystem Technologies journal. The new technology utilises a tunnel field effect transistor (TFET)-based biosensor that detects cancer cells by measuring their dielectric properties. "Cancer cells like T47D have a higher dielectric constant than healthy ones like MCF-10A. The sensor picks up these differences quickly and with high precision," said Prof. Sahu. The biosensor features a small cavity etched into the transistor under the gate area, where biological samples are placed for analysis. The device then measures changes in electrical signals to determine whether cells are cancerous or healthy. This development comes at a crucial time when India has witnessed a significant rise in breast cancer cases over the past few decades. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Giao dịch vàng CFDs với mức chênh lệch giá thấp nhất IC Markets Đăng ký Undo While conventional diagnostic methods like X-ray, mammography, and MRI exist, they require specialised equipment and trained personnel, making them inaccessible to many, particularly in remote areas. The TFET-based biosensor offers several advantages over traditional testing methods. While there is no requirement for additional chemicals or labels, it has higher sensitivity in detecting cancer cells. It would be more affordable than conventional testing methods and has the potential for use in mobile testing units and home settings. The research team is currently seeking collaborations for fabrication and scientific validation of technology, which could revolutionise early breast cancer detection in clinical and home settings, they said. Get the latest lifestyle updates on Times of India, along with Brother's Day wishes , messages and quotes !
Hans India
24-05-2025
- Health
- Hans India
NIT Rourkela designs a novel semiconductor device-based biosensor
Researchers at the National Institute of Technology (NIT) Rourkela have designd a novel semiconductor device-based biosensor that can identify breast cancer cells without the need for complicated or expensive laboratory procedures. The device 'TFET' (Tunnel Field Effect Transistor) is based on TCAD (Technology Computer-Aided Design) simulation results, that can effectively detect breast cancer cells. FETs are commonly used in electronics, but here they have been adapted to function as a sensitive detector of biological materials. Unlike many traditional tests, this biosensor does not need any added chemicals or labels to work. It uses the physical properties of cancer cells to detect them. Cancerous breast tissues, which hold more water and are denser than healthy tissues, interact differently with microwave radiation. These differences, known as dielectric properties, make it possible to distinguish between healthy and cancerous cells. The findings of the research published in the Microsystem Technologies journal, showed that the sensor is sensitive in detecting T47D cancer cells due to their high density and permittivity. It is also highly effective at distinguishing cancerous cells from healthy breast cells, offering improved sensitivity compared to existing technologies. 'A small cavity is etched into the transistor under the gate area, and an equivalent material of biological sample of cells is placed in the cavity to check the sensitivities of the device. The sensor then reads changes in electrical signals based on the properties of the sample, essentially 'sensing' whether the cells are cancerous or healthy,' said Prof. Prasanna Kumar Sahu, Department of Electrical Engineering, NIT Rourkela. 'Because cancer cells like T47D have a higher dielectric constant than healthy ones like MCF-10A, the sensor picks up these differences quickly and with high precision,' Sahu added. Another key feature of the developed technology is its affordability. TFET-based biosensors are affordable compared to conventional testing methods and other existing FET-based biosensors. The developed technology holds significant promise for future medical applications, resulting in low-cost, easy-to-use diagnostic devices that bring early breast cancer detection to clinics, mobile testing units, and home settings. As the next step, the research team is exploring potential collaborations for fabrication and scientific validation of the developed technology.
Time of India
23-05-2025
- Health
- Time of India
NIT Rourkela develops biosensor to detect breast cancer cells without expensive lab procedures
New Delhi: Researchers at National Institute of Technology (NIT), Rourkela have developed a novel semiconductor device-based biosensor that can identify breast cancer cells without the need for complicated or expensive laboratory procedures, according to officials. The developed biosensor does not require any added chemicals to work. It is highly effective in distinguishing the cancerous cells from the healthy breast cells, offering improved accuracy compared to the existing methods of biosensing devices for breast cancer diagnosis, they said. The research has been published in the prestigious Microsystem Technologies journal. According to Prasanna Kumar Sahu, Professor at the Department of Electrical Engineering, the rise of potentially fatal illnesses has drawn attention in recent years to the global emphasis on biomolecule evaluation and Point-of-Care (POC) testing. Among these diseases, cancer is a significant global public health concern. In this context, India has seen a significant rise in breast cancer cases in the past few decades. "Since cancer cells often do not show any initial signs of progression, it is crucial to diagnose them at an early stage for prevention and cure. While several diagnostic procedures such as X-ray, mammography, Enzyme-Linked Immunosorbent Assay Test (ELISA), Ultrasonography and Magnetic Resonance Imaging (MRI) are used to identify the disease, they require specialised equipment and trained personnel. "Additionally, these diagnostic methods are often inaccessible to people in remote areas," Sahu said. The COVID-19 pandemic further highlighted these challenges due to the relocation of medical resources, resulting in delayed cancer screenings and treatments, he said. "This underscores the urgent need for simpler, faster, and more affordable diagnostic tools that do not rely on complex infrastructure," Sahu added. The NIT team has designed a novel approach that uses the physical properties of cancer cells to detect them. Cancerous breast tissues, which hold more water and are denser than healthy tissues, interact differently with microwave radiation. These differences, known as dielectric properties, make it possible to distinguish between healthy and cancerous cells. The research team has proposed an electronic device, Tunnel Field Effect Transistor (TFET), based on TCAD simulation results that can effectively detect breast cancer cells. FETs are commonly used in electronics but here they have been adapted to function as a sensitive detector of biological materials. Unlike many traditional tests, this biosensor does not need any added chemicals or labels to work. "A small cavity is etched into the transistor under the gate area and an equivalent material of biological sample of cells is placed in the cavity to check the sensitivities of the device. The sensor then reads changes in electrical signals based on the properties of the sample, essentially 'sensing' whether the cells are cancerous or healthy. "Because cancer cells like T47D have a higher dielectric constant than healthy ones like MCF-10A, the sensor picks up these differences quickly and with high precision," Sahu said. The findings show that the sensor is sensitive in detecting T47D cancer cells due to their high density and permittivity. It is also highly effective in distinguishing cancerous cells from healthy breast cells, offering improved sensitivity compared to existing technologies. Another key feature of the developed technology is its affordability. "TFET-based biosensor is affordable compared to the conventional testing methods and other existing FET-based biosensors. The developed technology holds significant promise for future medical applications, resulting in low-cost and easy-to-use diagnostic devices that bring early breast cancer detection to clinics, mobile testing units and home settings," said Priyanka Karmakar, research scholar. As the next step, the research team is exploring potential collaborations for fabrication and scientific validation of the developed technology.
