Latest news with #ReAltaLifeSciences
Yahoo
29-07-2025
- Business
- Yahoo
ReAlta Life Sciences Appoints Ellen Lubman as Chief Business Officer
By Karen Roman ReAlta Life Sciences, Inc. said it designated Ellen Lubman as Chief Business Officer to supervise business development, capital formation and corporate strategy. Ms. Lubman has nearly 25 years of experience across small to large-cap private and public biopharmaceutical companies with a track record in strategic, transactional, and operational roles, the company stated. She previously served as Chief Business Officer at Werewolf Therapeutics, Inc. (Nasdaq: HOWL), taking the company through multiple financings including an IPO, it said. 'Ellen is a highly respected executive with a strong track record of building partnerships, raising capital, and developing successful corporate strategies for biotech and pharmaceutical companies,' said David Marek, ReAlta's CEO. 'We are excited to welcome Ellen at such a pivotal moment for our business with all three clinical programs reading out this year.' Ms. Lubman holds an M.B.A. from Stanford Graduate School of Business and a B.A. in Biology from Rutgers College. READ MORE ReAlta Drug Shows Promise in Protecting Newborn Brains from Oxygen Deprivation Injuries Never Miss our Weekly Highlights Contact: Exec Edge Editor@ Click to follow us on LinkedIn Sign in to access your portfolio
Yahoo
28-07-2025
- Business
- Yahoo
ReAlta Life Sciences Strengthens Management Team with the Appointment of Biotechnology Business Leader Ellen Lubman, MBA as Chief Business Officer
Accomplished biopharma executive brings nearly 25 years of experience in business development, capital formation, and enterprise strategy to this role NORFOLK, Va., July 28, 2025--(BUSINESS WIRE)--ReAlta Life Sciences, Inc. ("ReAlta" or the "Company"), a clinical-stage biopharmaceutical company dedicated to saving lives by rebalancing the inflammatory response to address rare and acute inflammatory diseases, today announced the appointment of Ellen Lubman, MBA as Chief Business Officer. In this role, Ms. Lubman will oversee business development, capital formation and corporate strategy. "Ellen is a highly respected executive with a strong track record of building partnerships, raising capital, and developing successful corporate strategies for biotech and pharmaceutical companies," said David Marek, Chief Executive Officer of ReAlta. "We are excited to welcome Ellen at such a pivotal moment for our business with all three clinical programs reading out this year. Her deep strategic and transactional expertise strengthens our team, and she will play a key leadership role as we forge partnerships with pharmaceutical companies and investors alike to advance our transformative therapies for patients across numerous severe inflammatory diseases with high unmet need." "I am thrilled to join ReAlta and build on the company's accomplishments in developing the EPICC platform and its lead asset pegtarazimod, which has the potential for clarity this year on a path to approval in hypoxic ischemic encephalopathy (HIE), a devastating disease where no pharmacologic treatment exists," said Ms. Lubman. "It is a privilege to contribute to the advancement of this differentiated approach to support the delivery of innovative therapies treating neuroinflammation in newborns with HIE, acute graft-versus-host disease (aGvHD), and acute Chronic Obstructive Pulmonary Disease (COPD)." Ms. Lubman brings seasoned leadership and broad experience across small to large-cap private and public biopharmaceutical companies, with a strong track record in strategic, transactional, and operational roles to ReAlta. She joins ReAlta from Werewolf Therapeutics where she was Chief Business Officer, ushering the company through multiple financings, including an Initial Public Offering, as well as business development transactions. Prior to Werewolf, she was Chief Business Officer of Impel Pharmaceuticals and Vice President of External Science & Innovation at Allergan, where she was responsible for strategic expansion of the company's diverse pipeline of therapeutics in a variety of disease areas. Ms. Lubman has held numerous other executive and leadership roles at Kadmon Pharmaceuticals, Bristol Myers Squibb, Celtic Pharma Management, L.P., Robertson Stephens Investment Bank, and Abbott Labs. She serves on the Board of Directors of Reunion Neuroscience and Cytovation ASA and is a Strategic Advisor to Two Bear Capital. Ms. Lubman earned her M.B.A. from Stanford Graduate School of Business with a focus on Global Management and her B.A. in Biology from Rutgers College. About ReAlta Life Sciences ReAlta Life Sciences, Inc. is a clinical mid-stage biopharmaceutical company dedicated to addressing life threatening rare and acute inflammatory diseases by rebalancing the inflammatory response. The Company's EPICC peptide platform leverages discoveries from the human astrovirus (HAstV-1), which uniquely inhibits components of the innate immune system. ReAlta's therapeutic peptides employ the dual-targeting mechanisms of HAstV-1 to modulate both complement and innate inflammatory pathways by inhibiting complement cascade activation and two key neutrophil-driven mechanisms: myeloperoxidase (MPO) and neutrophil extracellular traps (NETs). The Company's lead candidate, RLS-0071 (pegtarazimod), has received FDA Orphan Drug Designation and Fast Track Designations for hypoxic ischemic encephalopathy (HIE), a devastating disease that causes brain damage and high mortality in oxygen-deprived newborns; Orphan Drug Designation by the European Medicines Agency for HIE; FDA Orphan Drug and Fast Track Designations for acute graft-versus-host disease (aGvHD) associated with bone marrow and stem cell transplants; and FDA IND clearance for acute exacerbations of chronic obstructive pulmonary disease (COPD). Founded in 2018, ReAlta operates in Norfolk, Virginia and Aguadilla, Puerto Rico. For more information, please visit View source version on Contacts Investors John RickmanChief Financial Officerjrickman@ Media Harrison WongICR HealthcareReAltaPR@ Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Business Wire
28-07-2025
- Business
- Business Wire
ReAlta Life Sciences Strengthens Management Team with the Appointment of Biotechnology Business Leader Ellen Lubman, MBA as Chief Business Officer
NORFOLK, Va.--(BUSINESS WIRE)-- ReAlta Life Sciences, Inc. ('ReAlta' or the 'Company'), a clinical-stage biopharmaceutical company dedicated to saving lives by rebalancing the inflammatory response to address rare and acute inflammatory diseases, today announced the appointment of Ellen Lubman, MBA as Chief Business Officer. In this role, Ms. Lubman will oversee business development, capital formation and corporate strategy. 'Ellen is a highly respected executive with a strong track record of building partnerships, raising capital, and developing successful corporate strategies for biotech and pharmaceutical companies,' said David Marek, Chief Executive Officer of ReAlta. 'We are excited to welcome Ellen at such a pivotal moment for our business with all three clinical programs reading out this year. Her deep strategic and transactional expertise strengthens our team, and she will play a key leadership role as we forge partnerships with pharmaceutical companies and investors alike to advance our transformative therapies for patients across numerous severe inflammatory diseases with high unmet need.' 'I am thrilled to join ReAlta and build on the company's accomplishments in developing the EPICC platform and its lead asset pegtarazimod, which has the potential for clarity this year on a path to approval in hypoxic ischemic encephalopathy (HIE), a devastating disease where no pharmacologic treatment exists,' said Ms. Lubman. 'It is a privilege to contribute to the advancement of this differentiated approach to support the delivery of innovative therapies treating neuroinflammation in newborns with HIE, acute graft-versus-host disease (aGvHD), and acute Chronic Obstructive Pulmonary Disease (COPD).' Ms. Lubman brings seasoned leadership and broad experience across small to large-cap private and public biopharmaceutical companies, with a strong track record in strategic, transactional, and operational roles to ReAlta. She joins ReAlta from Werewolf Therapeutics where she was Chief Business Officer, ushering the company through multiple financings, including an Initial Public Offering, as well as business development transactions. Prior to Werewolf, she was Chief Business Officer of Impel Pharmaceuticals and Vice President of External Science & Innovation at Allergan, where she was responsible for strategic expansion of the company's diverse pipeline of therapeutics in a variety of disease areas. Ms. Lubman has held numerous other executive and leadership roles at Kadmon Pharmaceuticals, Bristol Myers Squibb, Celtic Pharma Management, L.P., Robertson Stephens Investment Bank, and Abbott Labs. She serves on the Board of Directors of Reunion Neuroscience and Cytovation ASA and is a Strategic Advisor to Two Bear Capital. Ms. Lubman earned her M.B.A. from Stanford Graduate School of Business with a focus on Global Management and her B.A. in Biology from Rutgers College. About ReAlta Life Sciences ReAlta Life Sciences, Inc. is a clinical mid-stage biopharmaceutical company dedicated to addressing life threatening rare and acute inflammatory diseases by rebalancing the inflammatory response. The Company's EPICC peptide platform leverages discoveries from the human astrovirus (HAstV-1), which uniquely inhibits components of the innate immune system. ReAlta's therapeutic peptides employ the dual-targeting mechanisms of HAstV-1 to modulate both complement and innate inflammatory pathways by inhibiting complement cascade activation and two key neutrophil-driven mechanisms: myeloperoxidase (MPO) and neutrophil extracellular traps (NETs). The Company's lead candidate, RLS-0071 (pegtarazimod), has received FDA Orphan Drug Designation and Fast Track Designations for hypoxic ischemic encephalopathy (HIE), a devastating disease that causes brain damage and high mortality in oxygen-deprived newborns; Orphan Drug Designation by the European Medicines Agency for HIE; FDA Orphan Drug and Fast Track Designations for acute graft-versus-host disease (aGvHD) associated with bone marrow and stem cell transplants; and FDA IND clearance for acute exacerbations of chronic obstructive pulmonary disease (COPD). Founded in 2018, ReAlta operates in Norfolk, Virginia and Aguadilla, Puerto Rico. For more information, please visit
Yahoo
19-05-2025
- Health
- Yahoo
ReAlta Life Sciences Announces New Inflammatory Biomarker Data from Acute Exacerbations of Chronic Obstructive Pulmonary Disease Program at American Thoracic Society 2025 International Conference
NORFOLK, Va., May 19, 2025--(BUSINESS WIRE)--ReAlta Life Sciences, Inc. ("ReAlta" or the "Company"), a clinical-stage biopharmaceutical company dedicated to saving lives by rebalancing the inflammatory response to address rare and acute inflammatory diseases, today announced a poster presentation featuring new analysis of clinical data from its acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) program at the American Thoracic Society (ATS) 2025 International Conference, taking place May 18-21, 2025 in San Francisco. The new findings, presented today in a poster titled "Effect of RLS-0071 on Airway Neutrophilia Following Inhaled Endotoxin Challenge Assessed by ChipCytometry," were from additional analysis of samples from ReAlta's previously reported Phase 1b study of RLS-0071 (pegtarazimod). Pegtarazimod is a 15-amino-acid peptide that uniquely targets both humoral and cellular inflammation. The analysis, conducted using ChipCytometry, extends the original proof-of-mechanism findings regarding inhibition of lung neutrophils and inflammatory cytokines, and reveals cellular-level mechanisms. Airway neutrophilia is associated with several lung diseases, including acute exacerbations of COPD and severe asthma, and related lung damage is a result of neutrophil-mediated release of toxic myeloperoxidase (MPO) and neutrophil elastase (NE). In this ChipCytometry analysis, pegtarazimod prevented lipopolysaccharide (LPS)-driven increases in neutrophil activation markers (CD89, CD11a, CD11b) as well as intracellular levels of MPO and NE. In ReAlta's Phase 1b study, healthy participants received inhaled LPS to induce temporary neutrophil-mediated inflammation in the lungs, followed by intravenous administration of pegtarazimod at different dose levels. Pegtarazimod demonstrated powerful inhibition of neutrophil migration into the lungs by half (~50%), with significant reductions in key inflammatory markers including MPO and NE, and pro-inflammatory cytokines IL-1β and IL-8. "These new data further reinforce pegtarazimod's potential to address neutrophil-driven inflammation in the lungs by meaningfully reducing detrimental neutrophil activation," said Kenji M. Cunnion, MD, MPH, Chief Medical Officer at ReAlta. "We look forward to completing our Phase 2 trial in patients with AE-COPD (NCT06175065) later this year and exploring opportunities for our novel dual-targeting peptide platform to deliver effective new therapies for respiratory diseases." Prof. Dr. Jens M. Hohlfeld, Division Director of Airway Research at the Fraunhofer Institute for Toxicology and Experimental Medicine in Hannover, Germany and lead investigator for the study, commented, "ChipCytometry analysis offers various advantages over conventional flow cytometry and differential cell counts that allowed us to visualize how pegtarazimod impacts neutrophil activation markers and intracellular components, which had not been directly observable in our previous analyses. These new insights into pegtarazimod's cellular-level mechanisms of action strengthen the scientific foundation for its development and will inform other upcoming clinical trials in patients with neutrophil-driven inflammatory conditions." About ReAlta Life Sciences ReAlta Life Sciences, Inc. is a clinical mid-stage biopharmaceutical company dedicated to addressing life threatening rare and acute inflammatory diseases by rebalancing the inflammatory response. The Company's EPICC peptide platform leverages discoveries from the human astrovirus (HAstV-1), which uniquely inhibits components of the innate immune system. ReAlta's therapeutic peptides employ the dual-targeting mechanisms of HAstV-1 to modulate both complement and innate inflammatory pathways by inhibiting complement cascade activation and two key neutrophil-driven mechanisms: myeloperoxidase (MPO) and neutrophil extracellular traps (NETs). The Company's lead candidate, RLS-0071 (pegtarazimod), has received FDA Orphan Drug Designation and Fast Track Designations for hypoxic ischemic encephalopathy (HIE), a devastating disease that causes brain damage and high mortality in oxygen-deprived newborns; Orphan Drug Designation by the European Medicines Agency for HIE; FDA Orphan Drug and Fast Track Designations for acute graft-versus-host disease (aGvHD) associated with bone marrow and stem cell transplants; and FDA IND clearance for acute exacerbations of chronic obstructive pulmonary disease (COPD). Founded in 2018, ReAlta operates in Norfolk, Virginia and Aguadilla, Puerto Rico. For more information, please visit View source version on Contacts Investors John RickmanChief Financial Officerjrickman@ Media Harrison WongICR HealthcareReAltaPR@ Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
19-05-2025
- Health
- Yahoo
ReAlta Life Sciences Announces New Inflammatory Biomarker Data from Acute Exacerbations of Chronic Obstructive Pulmonary Disease Program at American Thoracic Society 2025 International Conference
NORFOLK, Va., May 19, 2025--(BUSINESS WIRE)--ReAlta Life Sciences, Inc. ("ReAlta" or the "Company"), a clinical-stage biopharmaceutical company dedicated to saving lives by rebalancing the inflammatory response to address rare and acute inflammatory diseases, today announced a poster presentation featuring new analysis of clinical data from its acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) program at the American Thoracic Society (ATS) 2025 International Conference, taking place May 18-21, 2025 in San Francisco. The new findings, presented today in a poster titled "Effect of RLS-0071 on Airway Neutrophilia Following Inhaled Endotoxin Challenge Assessed by ChipCytometry," were from additional analysis of samples from ReAlta's previously reported Phase 1b study of RLS-0071 (pegtarazimod). Pegtarazimod is a 15-amino-acid peptide that uniquely targets both humoral and cellular inflammation. The analysis, conducted using ChipCytometry, extends the original proof-of-mechanism findings regarding inhibition of lung neutrophils and inflammatory cytokines, and reveals cellular-level mechanisms. Airway neutrophilia is associated with several lung diseases, including acute exacerbations of COPD and severe asthma, and related lung damage is a result of neutrophil-mediated release of toxic myeloperoxidase (MPO) and neutrophil elastase (NE). In this ChipCytometry analysis, pegtarazimod prevented lipopolysaccharide (LPS)-driven increases in neutrophil activation markers (CD89, CD11a, CD11b) as well as intracellular levels of MPO and NE. In ReAlta's Phase 1b study, healthy participants received inhaled LPS to induce temporary neutrophil-mediated inflammation in the lungs, followed by intravenous administration of pegtarazimod at different dose levels. Pegtarazimod demonstrated powerful inhibition of neutrophil migration into the lungs by half (~50%), with significant reductions in key inflammatory markers including MPO and NE, and pro-inflammatory cytokines IL-1β and IL-8. "These new data further reinforce pegtarazimod's potential to address neutrophil-driven inflammation in the lungs by meaningfully reducing detrimental neutrophil activation," said Kenji M. Cunnion, MD, MPH, Chief Medical Officer at ReAlta. "We look forward to completing our Phase 2 trial in patients with AE-COPD (NCT06175065) later this year and exploring opportunities for our novel dual-targeting peptide platform to deliver effective new therapies for respiratory diseases." Prof. Dr. Jens M. Hohlfeld, Division Director of Airway Research at the Fraunhofer Institute for Toxicology and Experimental Medicine in Hannover, Germany and lead investigator for the study, commented, "ChipCytometry analysis offers various advantages over conventional flow cytometry and differential cell counts that allowed us to visualize how pegtarazimod impacts neutrophil activation markers and intracellular components, which had not been directly observable in our previous analyses. These new insights into pegtarazimod's cellular-level mechanisms of action strengthen the scientific foundation for its development and will inform other upcoming clinical trials in patients with neutrophil-driven inflammatory conditions." About ReAlta Life Sciences ReAlta Life Sciences, Inc. is a clinical mid-stage biopharmaceutical company dedicated to addressing life threatening rare and acute inflammatory diseases by rebalancing the inflammatory response. The Company's EPICC peptide platform leverages discoveries from the human astrovirus (HAstV-1), which uniquely inhibits components of the innate immune system. ReAlta's therapeutic peptides employ the dual-targeting mechanisms of HAstV-1 to modulate both complement and innate inflammatory pathways by inhibiting complement cascade activation and two key neutrophil-driven mechanisms: myeloperoxidase (MPO) and neutrophil extracellular traps (NETs). The Company's lead candidate, RLS-0071 (pegtarazimod), has received FDA Orphan Drug Designation and Fast Track Designations for hypoxic ischemic encephalopathy (HIE), a devastating disease that causes brain damage and high mortality in oxygen-deprived newborns; Orphan Drug Designation by the European Medicines Agency for HIE; FDA Orphan Drug and Fast Track Designations for acute graft-versus-host disease (aGvHD) associated with bone marrow and stem cell transplants; and FDA IND clearance for acute exacerbations of chronic obstructive pulmonary disease (COPD). Founded in 2018, ReAlta operates in Norfolk, Virginia and Aguadilla, Puerto Rico. For more information, please visit View source version on Contacts Investors John RickmanChief Financial Officerjrickman@ Media Harrison WongICR HealthcareReAltaPR@ Sign in to access your portfolio
