Latest news with #Roskilde
Medscape
13-06-2025
- Health
- Medscape
HS Genetics Point Toward the Hair Growth Cycle
A missense variant in WNT10A detected by a recent genome-wide association study (GWAS) in hidradenitis suppurativa (HS) suggested that drug-development efforts should target hair follicle biology, said the authors of a recent letter responding to the study. Increasing providers' and patients' knowledge about the genetic underpinnings of HS also could help reduce stigma around the disease, an expert told Medscape Dermatology . The GWAS meta-analysis, published online on December 5, 2024, in the Journal of the American Academy of Dermatology ( JAAD ), included 4814 HS cases and 1.2 million control patients. RNA sequencing and other tools enabled authors led by Rune Kjærsgaard Andersen, MD, PhD, of the Department of Dermatology, Zealand University Hospital in Roskilde, Denmark, to identify eight independent HS-associated variants, including four previously unreported variants that all mapped to signaling pathways crucial in epidermal keratinization. Ultimately, the authors highlighted rs121908120-A, a missense variant in the WNT10A pathway, as protective against HS. Noteworthy Discovery The discovery of rs121908120-A is notable, wrote authors led by Olivia D. Perez, MD, of the Department of Dermatology, New York University School of Medicine in New York City, because of its clinical implications derived from previously reported disease associations at the WNT10A locus. A 2023 British Journal of Dermatology publication showed that the rs121908120-A variant is elevated in patients with hair miniaturization disorders. Because the clinical effects of WNT10A deficiency on hair have been validated in a mouse model, added Perez and colleagues, 'a shortened hair follicle growth phase could be protective of HS, which has clinical implications for HS trials.' Their letter was published in the JAAD Notes and Comments section on May 5, 2025. In the absence of functional genomic studies elucidating the mechanism(s) of the WNT10A pathway in HS, Perez and coauthors used data from a study published in Immunity in 2024 to investigate where this gene is expressed in lesional skin. Single-cell RNA sequencing showed that WNT10A is expressed in keratinocytes, including hair follicle infundibulum, proliferative cells, basal cells, and immune cells, including regulatory T cells. Spatial transcriptomics confirmed that WNT10A is expressed in both surface and tunnel epithelium, along with the immune cell-rich dermis of HS lesions. The latter findings suggest potential WNT10A involvement in immune responses and augment its known roles in follicular biology, wrote Perez and colleagues. With few treatments approved by the US Food and Drug Administration for HS, trials to date largely have attempted to repurpose existing drugs that target the inflammatory cascade. Conversely, Perez and colleagues wrote that the GWAS findings highlighted the potential of targeting hair follicle biology and that a shorter follicular growth phase may explain the success of laser hair removal in HS management. A Developing Story Lasers appeared to address HS through ablation rather than targeting any specific cytokine or gene, Christopher Sayed, MD, professor of dermatology at the University of North Carolina School of Medicine, Chapel Hill, North Carolina, said in an interview. 'If the initial event in disease development is centered on the hair follicle, then reducing the number of follicles present should help slow down the development of new lesions and progression.' He was not involved with JAAD studies but was asked to comment. Christopher Sayed, MD More broadly, Sayed said, Perez and colleagues' paper resonates with prior research, including a study published in JAMA Dermatology in 2023 that he co-authored, all suggesting that HS involves follicular dysregulation that probably also affects processes such as wound healing and inflammatory responses. 'That's potentially another thread that we should be pulling on, beyond the inflammatory process, when it comes to treatment, to see if there's a way to improve how the follicles differentiate and how the chronic wounds in HS could perhaps be coaxed into healing better,' he said. Perez and colleagues' findings also could counter the long-standing misconception that HS stems largely from modifiable factors such as hygiene issues, infection, or obesity, Sayed noted. 'There's a very strong genetic correlation, and multiple genes now implicated have to do with follicular regulation and epidermal differentiation,' he explained. 'While environmental factors may play a role, it's probably a much smaller role than people used to think.' As with other inflammatory conditions such as rheumatoid arthritis or inflammatory bowel disease, said Sayed, probably the biggest HS risk factor is heredity. 'So, when we talk to patients and the public about hidradenitis suppurativa, we can describe it as a chronic inflammatory condition with a strong genetic component — rather than something where there should be blame and stigma placed on patients.' Regarding new therapeutics, Sayed said he is unaware of any HS drugs in development that specifically target hair follicle biology. 'It's an area that has just started to come into focus over the last couple of years as genome-wide association studies have highlighted a role for these pathways that are intertwined with inflammatory processes and wound healing.' Regardless of what triggers HS, he added, the process results in inflammation, which is the target of many drugs in HS trials. 'As we understand hidradenitis suppurativa and how pathways around epidermal and follicular differentiation are dysregulated,' Sayed said, 'it will hopefully present opportunities for more deliberate drug development.' The letter authors reported funding from the National Institutes of Health, Sanofi-Aventis US, and the Irma T. Hirschl Charitable Trust. These authors reported no relevant conflicts of interest. GWAS authors reported financial relationships with more than a dozen pharmaceutical companies, including Eli Lilly, LEO Pharma, Novartis, and others. Additionally, several of these authors are employees of deCODE genetics/Amgen. Sayed reported no relevant conflicts of interest.
Forbes
29-05-2025
- Business
- Forbes
Lizzo's New Single Finally Becomes A Hit, With Some Help From A Major Pop Star
Lizzo's 'Still Bad' debuts at No. 11 on Digital Song Sales after a duet with Kelly Clarkson, marking ... More her first chart hit in over a year. ROSKILDE, DENMARK - JULY 01: Lizzo performs at Roskilde Festival 2023 on July 01, 2023 in Roskilde, Denmark. (Photo by Joseph Okpako/WireImage) It's been well over two months since Lizzo released her most recent single, "Still Bad." The track was a commercial disappointment in its earliest days, as the singer, songwriter and rapper was surely hoping it would become a major hit and kick off her latest album campaign, as she's currently hyping the world for her forthcoming Love in Real Life. But sadly, that didn't turn out to be the case. Long after the tune was shared with the public, it finally becomes a bestseller in America, thanks to an assist from another one of the most successful women in pop music. "Still Bad" debuts at No. 11 on Billboard's Digital Song Sales chart this week. That tally ranks the bestselling cuts on platforms like iTunes and Amazon, and this time around, that includes Lizzo's most recent offering. Luminate reports that in the past tracking period, "Still Bad" sold just under 2,700 copies. "Still Bad" may be new to the Digital Song Sales chart, but as mentioned, it's not actually very new as far as pop music goes. Lizzo's cut experiences a 286% gain in pure purchases from one frame to the next. Just days ago, it ended a tracking period with 700 sales — and the following stint, it adds about 2,000 to that sum. "Still Bad" experiences such a boom after Kelly Clarkson invited Lizzo onto her daytime talk show to perform the tune. The singers turned it into a duet earlier this month, but it's Lizzo who enjoys the spoils on the Billboard rankings, as Clarkson doesn't earn credit on the cut. "Still Bad" earns Lizzo her twelfth placement on the Digital Song Sales tally, and her first since 2023. In August of that year, "Pink," the song she wrote and recorded for the Barbie soundtrack, peaked at No. 22. "Still Bad" has already been present on one Billboard ranking for more than two months. This frame, it drops seven spaces to No. 37 on the Adult Pop Airplay chart in its tenth stay on that radio roster. The tune previously peaked at No. 21.
Scotsman
21-05-2025
- Entertainment
- Scotsman
The 10 most searched for music festivals in 2025
These are the 10 music festivals that revellers have been searching for in 2025 - have you been to any of them previously? Sign up to our Arts and Culture newsletter Sign up Thank you for signing up! Did you know with a Digital Subscription to The Scotsman, you can get unlimited access to the website including our premium content, as well as benefiting from fewer ads, loyalty rewards and much more. Learn More Sorry, there seem to be some issues. Please try again later. Submitting... What are the music festivals that people have searched for in 2025? A study shows that no less than two UK festivals have appeared in the top ten list provided after a recent study. But who came out on top - and where did Glastonbury end up in the top ten, if at all? The bulk of the UK's summer festivals are about to kick off very shortly, with Bearded Theory and Slam Dunk Festival due to take place this week and Download next month. But are these the music festivals that most people on the internet are searching for? And is Glastonbury the most searched-for event, owing to its popularity and hotly coveted tickets each year? Advertisement Hide Ad Advertisement Hide Ad What festivals are people searching for the most in 2025, and is Glastonbury top of the list, by chance? | Canva/Getty Images The team at QR Code Generator wondered just that, and issued a study to determine which festivals around the world people are searching for the most. Is there as much interest in Isle of Wight as there is Roskilde, or are fans more entranced by the stunning visuals at Tomorrowland than the iconic burning at Burning Man? Here's the top ten most searched-for music festivals this year, including their search volumes (based on the search terms used, detailed below). Are any set to be added to your 2025 calendar, especially since Glastonbury is taking a fallow year in 2025? Methodology To determine the most searched-for festivals, the team analysed Google Keyword Planner data for average monthly search volumes over the 12-month period from April 2024 to March 2025. This involved compiling search data for each festival across various related terms, including specific queries like '[festival] 2025 dates,' '[festival] lineup,' and '[festival] tickets,' as well as broader searches such as '[festival] festival,' '[festival] location,' and 'When is [festival].' Advertisement Hide Ad Advertisement Hide Ad The combined average monthly search volume for each festival was then calculated and used to rank them from the highest to the lowest number of searches." The 10 most searched for musical festivals in 2025 10. Bonnaroo - June 12 - 15 2025 Josh Dun (L) and Tyler Joseph of Twenty One Pilots perform on stage during the 2015 Bonnaroo Music & Arts Festival - Day 4 on June 14, 2015 in Manchester, Tennessee. |Monthly Searches: 252,527 9. Roskilde Festival - June 28 - July 5 2025 Spectators cheer as they attend a concert of US rock band Foo Fighters performing on the Orange Stage at Roskilde Festival on July 5, 2024 in Roskilde, Denmark. | Helle Arensbak / Ritzau Scanpix / AFP Monthly Searches: 276,798 8. Rolling Loud - Rolling Loud California: March 15 - 16 2025 A Boogie wit da Hoodie attends Rolling Loud Los Angeles 2019 Fueled by West Coast Cure on December 15, 2019 in Los Angeles, California. |for West Coast Cure Monthly Searches: 376,549 Rolling Loud California transformed Hollywood Park in LA into the ultimate hip-hop haven earlier this year, with over 75 artists spanning two epic days. This year's headliners included A$AP Rocky, Playboi Carti, and a special guest spot from Peso Pluma. Advertisement Hide Ad Advertisement Hide Ad 7. Rock in Rio - Lisbon: Mid to Late June 2025 (speculated June 20-28) People walk next to a Ferris wheel during the Rock in Rio Lisboa music festival at Bela Vista Park in Lisbon, on June 24, 2018. | MIGUEL RIOPA/AFP via Getty Images Monthly Searches: 388,644 This iconic festival, with roots in Brazil and a strong presence in Lisbon, is gearing up for another monumental edition in 2025 at Parque Tejo Lisboa. While the official line-up is a closely guarded secret, expect a show-stopping array of international talent, reflecting past headliners like Ed Sheeran, Foo Fighters, and Queen. Rock in Rio is more than just music; it's a multiverse of entertainment promising an unforgettable experience. 6. Isle of Wight Festival - June 19 - 22 2025 View of the crowd during Day 3 at The Isle of Wight Festival at Seaclose Park on June 15, 2014 in Newport, Isle of Wight. | Tim P. Whitby/Getty Images Monthly Searches: 390,957 The legendary Isle of Wight Festival returns to Seaclose Park, Newport , from June 19th to 22nd, 2025! Get ready to make friends for life and memories that last a lifetime with an incredible line-up. Headliners already announced include music icons Sting , Stereophonics and Justin Timberlake . 5. Burning Man - August 24 - September 1 2025 A security guard keeps people back during the annual Burning Man Festival on September 4, 2023 after the sun shone on the colourful makeshift community of 70,000 people called Black Rock City. | AFP via Getty Images Monthly Searches: 539,490 Step into Black Rock City, Nevada, for the world's most unique and inclusive arts festival, Burning Man! From August 24 to September 1, 2025, immerse yourself in a vibrant metropolis dedicated to radical inclusion, self-expression, and communal effort. This year's theme, "Tomorrow Today," invites participants to imagine and create the future. While headliners in the traditional sense aren't announced, expect countless immersive art installations, performances, and spontaneous collaborations from a global community. 4. Glastonbury - June 25 - 29 2025 Nigerian singer Burna Boy performs on the pyramid stage on the fifth day of the Glastonbury festival at Worthy Farm in the village of Pilton in Somerset, southwest England, on June 30, 2024. | OLI SCARFF/AFP via Getty Images Monthly Searches: 1,042,466 Glastonbury Festival returns to Worthy Farm, Pilton, from June 25th to 29th, 2025, for another legendary celebration of contemporary performing arts! This world-renowned event promises an electrifying mix of music and culture. The headlining acts confirmed to grace the iconic Pyramid Stage are The 1975, Neil Young and Olivia Rodrigo, with the legendary Rod Stewart confirmed for the Sunday 'Legends' slot. Advertisement Hide Ad Advertisement Hide Ad 3. Lollapalooza - July 31 - August 3 2025 A 'Wheel of Fortune' mechanical attraction is seen during the sunset of the third day of the Lollapalooza music festival. | PABLO PORCIUNCULA/AFP via Getty Images Monthly Searches: 1,307,167 Lollapalooza is back for four days of non-stop music and fun in Grant Park, Chicago, from July 31st to August 3rd, 2025! This genre-defying festival will once again showcase the music industry's biggest names alongside emerging artists across nine stages. Confirmed headliners include Olivia Rodrigo, Tyler, the Creator, Sabrina Carpenter, Rüfüs du Sol, Luke Combs, Twice, A$AP Rocky, Korn, Gracie Abrams and Doechii. Beyond the music, explore Chow Town's diverse food vendors and family-friendly activities at Kidzapalooza. 2. Coachella - April 11 - 13 & April 18 - 20 2025 Charli XCX performs with Mí onstage during 2018 Coachella Valley Music And Arts Festival Weekend 1 at the Empire Polo Field on April 14, 2018 in Indio, California. |for Coachella Monthly Searches: 1,447,589 The iconic Coachella Valley Music and Arts Festival returned for two incredible weekends: April 11-13 and April 18-20, 2025, at the Empire Polo Club in Indio, California! The star-studded line-up spanning rock, pop, hip-hop, electronic, and indie included Lady Gaga, Green Day, Post Malone, and Travis Scott. Thanks to their fantastic YouTube streaming coverage, the vibrant world of music, art installations, and unforgettable performances across multiple stages were broadcast to the wider world - for those who missed out on tickets. 1. Tomorrowland - July 18 - 20 & July 25 - 27 2025 Visitors attend the first day of the Tomorrowland electronic music festival in Boom on July 21, 2023. | HATIM KAGHAT/Belga/AFP via Getty Images Monthly Searches: 1,698,347
The Guardian
06-05-2025
- Health
- The Guardian
Denmark's museum objects at risk from ‘extreme' new mould, say conservators
A new type of 'extreme' mould is sweeping through Denmark's museums, threatening some of the nation's most important paintings and cultural objects, conservators have warned. Described as an 'epidemic for Golden Age paintings', the highly resistant mould covers objects in a white coating and has been detected in 12 of the country's museums, including the National Museum of Denmark and Skagens Museum. Known as aspergillus section restricti , it belongs to a group of fungi that can survive in extreme environments such as the deep ocean or near volcanoes. 'It's quite a large problem because these fungi they deteriorate museum artefacts, materials, they decimate enzymes and assets, deteriorating museum objects, so it will damage them,' said Camilla Jul Bastholm, who is the head of conservation and collection storage at the National Museum of Denmark. The white mould has grown on a wooden box with ornate carvings held at the Museum Romu in Roskilde. Photograph: Camilla Jul Bastholm Preliminary studies are now under way at 150 other cultural sites in Denmark to see if the mould is present there too. Jul Bastholm, who first noticed the substance when she was working at a museum in Roskilde, believes the white transparent mould is a global phenomenon, but usually goes undetected because it is difficult to find. By the time it is visible, she said, it was 'too late'. She added: 'I think it is worldwide. If we start looking for it with the right methods we will find it. I don't think it's just a Danish thing.' Unlike most fungi, which prefer a very high humidity, and will come as a result of water damage or humid buildings, this variety prefers dry environments. Jul Bastholm's research centred around museums, but she has also seen the mould in churches, archives and libraries. 'It seems they [the fungi] prefer cultural heritage. I've never seen them anywhere else,' she said. The mould is feared to be a potential health hazard, which means affected objects may then not be able to be exhibited to the public. 'If you have a museum collection that can give health hazards to people then you can't use it,' she said. 'And then the collection will become a dead resource for the museums.' Skagens Museum, home to the work of members of the Skagen painters, a 19th-century Scandinavian artists' colony, also reported finding the mould, describing it to broadcaster DR as a 'whitish coating, a kind of bloom'. The Danish Museums Association said they were waiting for the results of further research at the end of the year to decide on how to tackle the problem. The National Museum is in the process of moving 116,000 shelf metres of cultural objects into a new staffed warehouse near Copenhagen which they hope will help fight the mould problem. But it is not known exactly what the humidity needs to be for it to stop growing.
