Latest news with #SDGR
Yahoo
6 days ago
- Business
- Yahoo
Schrödinger Announces Discontinuation of SGR-2921 Program
NEW YORK, August 14, 2025--(BUSINESS WIRE)--Schrödinger, Inc. (Nasdaq: SDGR) today announced the discontinuation of the clinical development program for SGR-2921, its CDC7 inhibitor, which was being evaluated in a Phase 1 dose-escalation study in patients with relapsed/refractory acute myeloid leukemia or high-risk myelodysplastic syndromes. Despite early evidence of monotherapy activity observed in the Phase 1 study, based on the profile observed to date, including two emergent events where SGR-2921 was considered to have contributed to two deaths in patients with AML, Schrödinger believes the path to development as a combination therapy would be difficult to pursue. The Phase 1 study was supported by preclinical data which had demonstrated that CDC7 inhibition resulted in monotherapy and combination anti-leukemic responses in patient-derived AML models, suggesting that SGR-2921 could ultimately be used in combination with standard of care agents. "Patient safety is our first priority, and in light of two treatment-related deaths in the Phase 1 dose-escalation study, we have made the decision to discontinue further development of SGR-2921. While disappointing given the early clinical activity observed, we believe this is the right decision for patients," stated Margaret Dugan, M.D., chief medical officer at Schrödinger. "We had hoped to advance this investigational agent for acute myeloid leukemia as relapse rates are high, the disease progresses rapidly and there are limited therapies available. We are very grateful to the investigators, patients and families who have participated in this clinical study." About SchrödingerSchrödinger is transforming molecular discovery with its computational platform, which enables the discovery of novel, highly optimized molecules for drug development and materials design. Schrödinger's software platform is built on more than 30 years of R&D investment and is licensed by biotechnology, pharmaceutical and industrial companies, and academic institutions around the world. Schrödinger also leverages the platform to advance a portfolio of collaborative and proprietary programs. Founded in 1990, Schrödinger has approximately 800 employees operating from 15 locations globally. To learn more, visit follow us on LinkedIn and Instagram, or visit our blog, Cautionary Note Regarding Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995 including, but not limited to the benefits of its computational platform. Statements including words such as "aim," "anticipate," "believe," "contemplate," "continue," "could," "estimate," "expect," "goal," "intend," "may," "might," "plan," "potential," "predict," "project," "should," "target," "will," "would" and statements in the future tense are forward-looking statements. These forward-looking statements reflect Schrödinger's current views about its plans, intentions, expectations, strategies and prospects, which are based on the information currently available to the company and on assumptions the company has made. Actual results may differ materially from those described in these forward-looking statements and are subject to a variety of assumptions, uncertainties, risks and important factors that are beyond Schrödinger's control, including the uncertainties inherent in drug development, such as the conduct of research activities and the timing of and its ability to initiate and complete preclinical studies and clinical trials, whether results from preclinical and early clinical studies will be predictive of the results of later preclinical studies and clinical trials, whether initial data from clinical results will be predictive of the final results of the clinical trials, uncertainties associated with the regulatory review of clinical trials, and the ability to retain and hire key personnel and other risks detailed under the caption "Risk Factors" and elsewhere in the company's Securities and Exchange Commission filings and reports, including its Quarterly Report on Form 10-Q for the quarter ended June 30, 2025, filed with the Securities and Exchange Commission on August 6, 2025, as well as future filings and reports by the company. Any forward-looking statements contained in this press release speak only as of the date hereof. Except as required by law, Schrödinger undertakes no duty or obligation to update any forward-looking statements contained in this press release as a result of new information, future events, changes in expectations or otherwise. View source version on Contacts Jaren Madden (Investors and Media) 617-286-6264 Matthew Luchini (Investors) 917-719-0636 Allie Nicodemo (Media) 617-356-2325
Reuters
6 days ago
- Business
- Reuters
Schrödinger stops development of blood cancer therapy after two patient deaths
Aug 14 (Reuters) - Schrödinger (SDGR.O), opens new tab said on Thursday it has stopped the development of an experimental drug after the death of two patients with a type of blood cancer in an early-stage trial, sending its shares down nearly 17% before the bell. The company was testing the therapy, SGR-2921, in patients with high-risk myelodysplastic syndromes, a group of blood cancers in which the bone marrow doesn't produce enough healthy blood cells, and its more serious form - acute myeloid leukemia. The drug was considered to have contributed to the deaths of two AML patients in the trial, the company said. "While disappointing given the early clinical activity observed, we believe this is the right decision for patients," Chief Medical Officer Margaret Dugan said. In pre-clinical trial, the therapy showed responses against the cancer, which suggested SGR-2921 could ultimately be used in combination with standard of care treatments, the company said. The experimental drug was designed to work by blocking CDC7, a protein that helps cancer cells repair DNA damage during replication. By inhibiting this protein, the drug causes cancer cells to accumulate fatal levels of DNA damage.
Globe and Mail
25-07-2025
- Business
- Globe and Mail
Schrödinger to Announce Second Quarter 2025 Financial Results on August 6
Schrödinger (Nasdaq: SDGR) will report its second quarter 2025 financial results on Wednesday, August 6, 2025, after the financial markets close. The company will host a conference call and webcast at 4:30 p.m. ET. The live webcast can be accessed in the 'Investors' section of Schrödinger's website and will be archived for approximately 90 days following the event. About Schrödinger Schrödinger is transforming molecular discovery with its computational platform, which enables the discovery of novel, highly optimized molecules for drug development and materials design. Schrödinger's software platform is built on more than 30 years of R&D investment and is licensed by biotechnology, pharmaceutical and industrial companies, and academic institutions around the world. Schrödinger also leverages the platform to advance a portfolio of collaborative and proprietary programs and is advancing three clinical-stage oncology programs. Founded in 1990, Schrödinger has approximately 800 employees operating from 15 locations globally. To learn more, visit follow us on LinkedIn and Instagram, or visit our blog,
Yahoo
22-05-2025
- Business
- Yahoo
Leadership Transition at Schrödinger: Richie Jain Named CFO
On May 20, Schrödinger, Inc. (NASDAQ:SDGR) announced the departure of Chief Financial Officer Geoffrey Porges, MBBS., who is stepping down to pursue other opportunities. Richie Jain, previously Senior Vice President of Strategic Finance and Head of Corporate and Business Development, will succeed him. Dr. Porges will continue as an advisor until June 6, 2025, to facilitate a seamless transition. A trader in a financial institution using fundamentals analysis to select stocks for a portfolio. CEO Ramy Farid, Ph.D., acknowledged Dr. Porges for his contributions, emphasizing his role in strengthening the company's financial profile and guiding key strategic initiatives. He expressed confidence in Jain, highlighting his strong financial skills and ability to build important partnerships. As CFO, Jain will oversee Schrödinger's financial operations, investor relations, corporate development, and business transactions. Before joining Schrödinger, he was a Managing Director at Morgan Stanley, specializing in healthcare investment banking and mergers & acquisitions. Earlier, he worked as an electrical engineer at Boston Scientific's cardiac rhythm management division. He holds a B.S. in Electrical Engineering from the University of Michigan and an MBA from the University of Chicago Booth School of Business. Schrödinger reaffirmed its financial expectations for 2025, maintaining its second-quarter software revenue guidance. The company is well known for its advanced computational platform for molecular discovery, continues to drive innovation in drug development and materials science. While we acknowledge the potential of Schrödinger, Inc. (NASDAQ:SDGR) as an investment, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than SDGR and that has 100x upside potential, check out our report about the . READ NEXT: 20 Best AI Stocks To Buy Now and 30 Best Stocks to Buy Now According to Billionaires. Disclosure: None. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
