Latest news with #SILC
Business Wire
7 days ago
- Health
- Business Wire
Long Covid Patients Can Sign up for Remote Clinical Trial Notification, Announces CareEvolution
BUSINESS WIRE)--Long Covid patients around the U.S. looking to participate in a clinical trial from home can sign up to be notified when an upcoming study conducted by scientists at Scripps Research and supported by the Schmidt Initiative for Long Covid (SILC) opens. Patients can sign up on the Long Covid Treatment Trial (LoCITT) website. 'For people with severe Long Covid, travel can be dangerous,' said Julia Moore Vogel, senior program director at the Scripps Research Translational Institute. 'LoCITT enables even patients with the most severe symptoms to join the search for answers.' The upcoming study, powered by the MyDataHelps platform from CareEvolution, is a fully remote clinical trial investigating the efficacy of a repurposed drug for treating Long COVID. It will enroll 1,000 Long Covid patients from across the U.S. The app-based study enables participants to enroll and participate in all trial activities without having to visit a trial clinic. 'Decentralized trials broaden reach, speed timelines and yield richer real-world evidence,' said Vik Kheterpal, MD, a principal at CareEvolution. 'LoCITT will help advance how efficiently we can run trials as we seek treatments for complex, heterogeneous conditions like Long Covid.' Long Covid, which has affected the lives of 400 million people worldwide and costs the global economy an estimated $1 trillion per year, can often cause symptoms that make mobility and travel challenging for patients who want to participate in trials. The forthcoming Scripps Research-led trial will rely on the LoCITT platform to enroll patients, distribute drug candidates and placebos, as well as collect and evaluate trial data. 'For people with severe Long Covid, travel can be dangerous,' said Julia Moore Vogel, senior program director at the Scripps Research Translational Institute. 'LoCITT enables even patients with the most severe symptoms to join the search for answers.' Moore Vogel is co-principal investigator of the study alongside Scripps Research executive vice president Eric Topol. Remote trials, which eliminate the need for patients to report to clinics, enable easier and broader participation. Conducting a Long Covid trial remotely will also allow more representative cohorts—potentially leading to more generalizable findings. 'We need aggressive, rapid efforts to turn the tide on this very difficult condition for all the patients who struggle with it,' said John Redd, CEO of SILC. 'We're hopeful that a remote trial will help us find effective treatments more quickly.' CareEvolution adapted its existing MyDataHelps decentralized clinical trial platform specifically for the LoCITT trial, with the potential for it to be used by other research efforts. The platform will allow for patients to be screened, enrolled and randomized more swiftly. Potential treatments and placebos will be mailed directly to the participant's home, along with wearable devices and other technologies to collect patient data. CareEvolution's user-friendly platform allows patients to check their eligibility, provide consent electronically and respond to baseline and ongoing surveys about their symptoms. Patients selected for the study will receive wrist devices to monitor their heart rates, activity and sleep, potentially enabling the development of digital biomarkers for Long Covid and related conditions like myalgic encephalomyelitis (ME), which can cause debilitating fatigue, and postural orthostatic tachycardia syndrome (POTS), which can cause dizziness, fatigue and a rapid heart rate upon standing up. The data from the devices will be uploaded to LoCITT. Prospective participants who are 18 years of age or older and who believe they have Long Covid can sign up at to be notified when the Scripps clinical trial opens. About CareEvolution We Connect Healthcare. MyDataHelps®, our digital clinical trials platform, accelerates healthcare innovation by empowering researchers to configure and launch studies in hours. We enable anyone, anywhere to be able to participate in research using participant centric design that integrates surveys, wearable and sensor data, EHR connectivity, and participant engagement tools to generate robust real-world longitudinal data. Trusted by over 2.5 million participants enrolled in longitudinal initiatives sponsored by health systems, academic institutions, life science companies, foundations, and public health agencies, CareEvolution advances precision health and helps close critical gaps in our collective understanding of complex conditions. For more information please visit About the Schmidt Initiative for Long Covid The Schmidt Initiative for Long Covid (SILC) advances clinical care for Long Covid patients globally. The nonprofit organization, founded in 2023 by philanthropists Eric and Wendy Schmidt, works to raise the level of Long Covid care and understanding around the world, connecting specialists and primary care providers to support patients and share knowledge virtually, in real time. For more information, visit About Scripps Research Scripps Research is an independent, nonprofit biomedical institute ranked one of the most influential in the world for its impact on innovation by Nature Index. We are advancing human health through profound discoveries that address pressing medical concerns around the globe. Our drug discovery and development division, Calibr-Skaggs, works hand-in-hand with scientists across disciplines to bring new medicines to patients as quickly and efficiently as possible, while teams at Scripps Research Translational Institute harness genomics, digital medicine and cutting-edge informatics to understand individual health and render more effective healthcare. Scripps Research also trains the next generation of leading scientists at our Skaggs Graduate School, consistently named among the top 10 US programs for chemistry and biological sciences. Learn more at
ITV News
30-07-2025
- Business
- ITV News
A fifth of people deemed at risk of poverty in eight-year period, says study
Almost a fifth of people were deemed at risk of poverty at least once between 2015 and 2023, according to a study. The Economic and Social Research Institute (ESRI) published research examining the complexities of income poverty and deprivation and how they intertwine. On average, 22% of the population experienced deprivation at least once in two consecutive years from 2016 to 2023: almost half of these were in persistent deprivation, slightly less than a third were exiting deprivation and about a quarter were entering deprivation. The study noted that there was a post-pandemic spike observed amongst lone-parent families, 30 to 65-year-old single people, adults above 65, and especially amongst single people over 65. It said the stronger effect for the older population could be explained by the fact that the State pension was frozen in cash terms in 2020 and 2021. The ESRI report, published in partnership with the Department of Social Protection, used longitudinal data from the Survey on Income and Living Conditions (SILC) – the study explores the dynamics of poverty. It found that the annual at-risk-of-poverty (AROP) rate declined from 16% in 2016 to 11% in 2023, while the persistent AROP rate declined from 10% in 2015-2016 to 7% in 2022-2023. The latter shows the share of the population who were AROP two years in a row. Material deprivation increased in the recent period from 14% in 2021 to 17% in 2023. Over the period 2016 to 2023, an average of 5% of people were both AROP and deprived. Lone parent families, large families, and households with a working-age adult with a disability faced the highest risks of persistent AROP and deprivation, it said. Children in lone parent families, in particular, are most at risk, with an average 33% of them being persistently deprived, and 21% being persistently AROP, between 2016 and 2023. The report said that implementing 'targeted' policy measures to support lone parents, large families, and households with a person with disabilities is essential to help those at high risk of poverty. It said timely adjustments to social welfare payments, including pensions, would be 'critical' to protect vulnerable groups from inflation. Co-author Anousheh Alamir said the report highlighted 'the complex nature of poverty' and how different groups face different risks over various time periods. 'Over two year stretches, lone parent families and households with a disabled adult are found to be the most at risk of income poverty and/or material deprivation for one year only. 'And while they are also the most likely to be materially deprived two years in a row (i.e persistently), large families are the most at risk of income poverty during that time. 'Thus, different groups are vulnerable to different forms and durations of poverty, an insight that should be key for effective policy.'
Irish Times
08-05-2025
- General
- Irish Times
Families who rent are four times less likely to take holidays
Children in one-parent families and those in private rented housing are less likely to be able to pursue hobbies such as swimming or go on an annual one-week holiday than their peers in two-parent families who own their home, according to research from the Central Statistics Office (CSO). One in eight (12 per cent) single-parent households were unable to afford regular leisure activities such as swimming, playing an instrument or youth organisation membership for their children, compared with 4.3 per cent of two-parent households, the study published on Thursday finds. Overall, more than one in six (18 per cent) Irish households with children could not afford a one-week holiday for their children, but this rate increases to 33 per cent for children in single-parent households. 'When analysed by the number of parents in the household, one in three single-parent households could not afford a seven-day holiday for their children, more than double the rate for two-parent households (14 per cent),' says the CSO. READ MORE Looking at household tenure type, it says: 'One in three (33.2 per cent) households in rented accommodation could not afford a one-week holiday for their children, four times higher than the rate for owner-occupied households (8.6 per cent).' The findings are taken from a module in the annual Survey on Income and Living Conditions (SILC) report, which was published on Thursday. It finds more than half (55 per cent) of households with no working adult – whether due to unemployment, long-term illness or disability – could afford a one-week holiday for their children, compared with one in four (26 per cent) of households with one working adult and 10 per cent of those with two working adults. The SILC survey data are collected by the CSO from households using computer-assisted interviews and data collection. These latest data were gathered in 2023. Asked about ability to afford a regular leisure activity for their children, 6 per cent of households said they could not afford this. However, one in four (25 per cent) households where there was no working adult could afford it, compared with 8 per cent where one adult was working and 3 per cent where two were. [ Third of households with single adult and children went into debt to meet ordinary living costs last year Opens in new window ] 'A higher percentage of households without an Irish-born parent (17 per cent) reported that they could not afford leisure activities for their children when compared with households with at least one Irish-born parent (2 per cent).' Parents were asked about their ability to afford new – as opposed to second-hand – clothes for their children. In 2023, 2.5 per cent of households with children could not afford this. 'Looking at the impact of tenure status on this ... shows that households in rented accommodation were more likely to be deprived of new clothes when compared with owner-occupied households – 5.6 per cent versus 0.6 per cent,' it says. On school trips and school events, almost 2 per cent of households could not afford these for their children. Among single-parent households the rate was 10times higher (6.2 per cent) than for two-parent families (0.6 per cent). Across the population one in 50 households with children reported not being able to afford to invite their children's friends to play or eat occasionally. 'Households with no working adult were more likely to be unable to afford this activity at 7 per cent of such households, compared with 0.5 per cent of those with two working adults.'
The Journal
08-05-2025
- General
- The Journal
More than one in six households can't afford a one-week holiday with their children
OVER ONE IN six households cannot afford to take their children on a one-week holiday away from home, CSO figures have revealed. More than a third of renters can't afford the family holiday, four times higher than the rate among parents who own their own home. According to the CSO figures, which were reocrded last year, almost a third (31.1%) of children living in rented accommodation experienced 'material deprivation' – an indicator meaning the inability to afford certain basic goods and services that are considered essential for a decent standard of living. One in twenty homes reported that they were unable to afford new (not second-hand) clothes for their children. Single-parent households, households that rent, had no Irish-born parent, or working adult were more likely to experience child deprivation #CSOIreland #Ireland #SILC #EUSILC #SocialInclusion #PovertyIndicator #PovertyRate #Deprivation #EnforcedDeprivation — Central Statistics Office Ireland (@CSOIreland) May 8, 2025 Advertisement Many single-parent households were found to be struggling – one in eight (12.1%) households with one parent reported that they were unable to afford to pay for regular leisure activities (sports, playing an intrument, youth clubs) for their children. The rate was three times the corresponding figure of 4.3% for two-parent households. For immigrant families, the rates increased again - 17.1% were unable to afford regular leisure activities for their children in 2024. Seperately, one in twenty (5.2%) single-parent households said that they could not afford to invite friends of their children to their household to play or eat from time to time, and a similar percentage (6.2%) could not afford school trips and school events (that cost money). The comparable rates for two-parent households were 1.1% and 0.6% respectively. Immigrant households are more likely to experience poverty, with 17.1% of those without an Irish-born parent unable to afford regular leisure activities for their children, compared to just 2.1% of households where at least one parent is Irish-born. Readers like you are keeping these stories free for everyone... A mix of advertising and supporting contributions helps keep paywalls away from valuable information like this article. Over 5,000 readers like you have already stepped up and support us with a monthly payment or a once-off donation. Learn More Support The Journal
India.com
04-05-2025
- Health
- India.com
Scientists Launch Trial To Test Long-Acting Antibody For Long Covid
New Delhi: US scientists are undertaking a clinical trial to decode the efficacy of a long-acting antibody against Long Covid -- a condition that affects at least 65 million people worldwide. Long Covid affects people after an infection caused by the SARS-CoV-2 virus. The condition not properly defined yet presents with more than 200 symptoms. The team from the Nova Southeastern University (NSU) and the Schmidt Initiative for Long Covid (SILC) announced that a clinical trial is underway to assess the effectiveness and safety of sipavibart -- a long-acting monoclonal antibody designed by British drugmaker AstraZeneca's to protect the condition. The team enrolled 100 patients in the multi-year research, reviewed and cleared by the FDA earlier this year. It aims to improve patients Long Covid symptoms and restore them to full health. 'Like many multi-symptom, post-viral conditions, Long Covid is incredibly complicated and thus little understood,' said Nancy Klimas, director of the Institute for Neuro-lmmune Medicine at NSU. 'Finding a treatment will be life-changing for patients suffering from the myriad symptoms of Long Covid,' she added. The study will test whether the monoclonal antibody sipavibart -- approved for the pre-exposure prophylaxis (prevention) of Covid-19 in Japan and the EU -- is effective in treating Long Covid. The trial is one of three Long Covid treatment trials expected to begin in 2025. 'Long Covid affects at least 65 million people worldwide, and with more than 200 symptoms, the health impacts of the disease can be debilitating,' said Dr. John Redd, CEO of SILC. 'This trial represents our overall commitment to addressing the most pressing health challenges of our time. We're leveraging our research expertise to potentially transform treatment options for millions suffering from Long Covid, advance knowledge, and improve patient outcomes through innovative clinical research,' added Dr. Ken Dawson-Scully, NSU's senior vice president for research and associate provost.
