Latest news with #SIRS
Business Wire
28-05-2025
- Health
- Business Wire
Resolve Therapeutics and Duke Medical School Initiate Observational Study of Cell-free RNA in Polytrauma Patients
MIAMI--(BUSINESS WIRE)--Resolve Therapeutics, a leader in the emerging field of cell-free nucleic acid therapeutics, today announced a collaboration with the Department of Surgery, Duke University School of Medicine to analyze the role of cell-free RNA (cfRNA) in polytrauma A significant number of trauma patients admitted to the hospital each year suffer from polytrauma, with multiple, life-threatening injuries requiring immediate surgical intervention. Many of these patients experience poor clinical outcomes due to Systemic Inflammatory Response Syndrome (SIRS). The mechanism of SIRS in polytrauma patients is not completely understood but the current view holds that that massive tissue injury results in the release of large amounts of RNA into the blood overwhelming the activity of circulating RNase, which protects cells from the inflammatory effects of cfRNA under normal circumstances. The accumulating cfRNA activates several key mechanisms driving local and systemic inflammation which leads to increased morbidity and mortality. 'Preventing systemic inflammation in polytrauma would be a large step forward in the treatment paradigm for these patients,' said Allan D. Kirk, MD, PhD, Chair of the Department of Surgery at Duke University. Share Working closely with the world's foremost trauma surgeons at Duke University, Resolve and Duke will conduct an observational study to analyze the presence, structure, and drug targeting of cfRNA in a selected population of polytrauma patients. Based on the results of this work, a proof-of-concept clinical trial with RSLV-132 (a fully human, catalytically active, RNase Fc fusion protein) may be undertaken seeking to improve clinical outcomes for polytrauma patients by removing circulating inflammatory nucleic acids. 'We are thrilled to work with the world class physician scientists within the Duke University School of Medicine and are hopeful our work together may lead to an improvement in the outcome for patients with polytrauma,' commented Dr. James Posada chief executive officer of Resolve Therapeutics. 'Duke Surgery offers a unique environment, coupling state of the art patient care with basic research expertise and infrastructure to enable systematic molecular analysis of plasma-borne inflammatory nucleic acids.' 'Preventing systemic inflammation in polytrauma would be a large step forward in the treatment paradigm for these patients,' said Allan D. Kirk, MD, PhD, Chair of the Department of Surgery at Duke University. 'We look forward to the collaboration with Resolve and learning more about the underlying mechanisms of inflammation in critically injured patients,' he added. About RSLV-132 RSLV-132 is a safe, fully-human, non-immunosuppressive, non-immunogenic, biologic drug with a three-week serum half-life. The drug is comprised of catalytically active human RNase fused to an engineered Fc region of human IgG1. It is designed to remain in circulation and digest extracellular pathogenic RNA in diseases where the presence of cfRNA drives the inflammatory process. RSLV-132 has proven safe in five clinical trials and has demonstrated improvement in autoimmune symptoms in phase 2 clinical trials in both systemic lupus erythematosus and Sjogren's syndrome. About Resolve Therapeutics Resolve is a biopharmaceutical company at the forefront of the emerging field of cell-free nucleic acids in disease. We are developing RSLV-132 and RSLV-145 in a broad range of acute and chronic diseases that are driven by cell-free RNA, cell-free DNA, and Neutrophil Extracellular Traps (NETs). For more information or to discuss our programs please visit:
Yahoo
03-05-2025
- Business
- Yahoo
Financial Advisor: Wealthy Americans Are Flocking To Florida, but They Shouldn't Be
Many of the richest people in American have relocated to Florida, known for its lack of income taxes. Among the billionaire residents of the Sunshine State are Amazon founder Jeff Bezos and Ken Griffin, the financier behind the Citadel hedge fund. Learn More: Read Next: However, relocating for the tax savings doesn't always pay off for the super wealthy. GOBankingRates spoke with Henry Silva, wealth management advisor at Apollon Wealth Management, about why the ultra-rich should think twice before uprooting their lives and moving to Florida. Although Silva himself lives in Miami, he noted that moving to Florida won't be the right choice for everyone. 'For high-net-worth families, Florida's no state income tax alone shouldn't be the deciding factor when considering a major relocation,' he said. 'The financial picture here is far more complex than a single tax line item.' For one, there are certain necessities high-net-worth individuals will likely pay more for in Florida. 'Home insurance premiums have skyrocketed,' Silva said. 'Whether it's clients, friends or family, nearly everyone I know has faced a significant increase in their premiums, sometimes unexpectedly. And it's not just in Miami — this is impacting properties across the state. 'Add to that the cost of property taxes, flood zone assessments and limited public school options depending on the area, and suddenly, the move doesn't feel quite as tax-efficient,' he said. Silva believes that the move 'has to make sense beyond taxes.' 'It should align with your lifestyle and long-term vision,' he said. 'Without that, you're just chasing trends, and trends can be expensive.' Find Out: It's not just costly home insurance and property taxes that potential Florida homebuyers need to be aware of. 'One of the biggest surprises, especially for folks looking to buy near the beach or in older high-rise condominiums, is the Structural Integrity Reserve Study (SIRS) requirement,' Silva said. 'After the tragic Champlain Towers collapse, Florida has cracked down on how condos maintain reserves for structural repairs. Now, homeowners are suddenly being hit with massive special assessments or monthly increases to catch up.' These extra payments are often unanticipated. 'These fees vary widely, but they're often significant and can come with little warning,' Silva said. 'Without a well-informed team guiding you, what looks like a dream condo can quickly become a financial and emotional burden, simply because the true cost of ownership was buried in deferred maintenance.' High-net-worth Americans shouldn't assume moving to Florida is a good decision just because other people in their income bracket are doing it. 'Wealthy individuals didn't build their success by following the herd,' Silva said. 'But right now, I'm seeing a lot of families make emotional or reactive decisions — whether it's relocating for a tax break, buying in trendy ZIP codes or moving assets based on headlines.' The best financial decision for you is always the one that makes sense for your individual circumstances. 'What I remind my clients is this — just because a move is popular doesn't mean it's right for you,' Silva said. 'You need a personal strategy, not a crowd mentality. A move like this is more than a tax decision — it impacts your estate plan, asset protection, real estate exposure, cost of living and even how your legacy plays out.' Before making any big moves, Silva recommended seeking the advice of a professional. 'That's exactly where a skilled wealth advisor makes a difference,' he said. 'We help families go beyond surface-level planning and build a strategy designed around their life, values and long-term goals.' More From GOBankingRates 5 Types of Vehicles Retirees Should Stay Away From Buying How Far $750K Plus Social Security Goes in Retirement in Every US Region 4 Things You Should Do if You Want To Retire Early 12 SUVs With the Most Reliable Engines Sources Henry Silva, Apollon Wealth Management This article originally appeared on Financial Advisor: Wealthy Americans Are Flocking To Florida, but They Shouldn't Be Sign in to access your portfolio
CBS News
06-03-2025
- Business
- CBS News
Florida legislative bill could strip insurance from non-compliant condo buildings
A new bill in the Florida Legislature could leave thousands of condo owners without state-run insurance if their buildings fail to meet structural safety requirements. The proposed measure, introduced by State Rep. Vicki Lopez, would strip Citizens Property Insurance from condominiums that have not completed a required structural integrity reserve study (SIRS), a move that has some residents concerned about affordability and coverage. Condo owners struggle with compliance Tony Fratianni, who lives in the Sunrise Lakes condo community, said his homeowners association has yet to complete the study, which was required by Dec. 31. The SIRS mandate forces condo associations to assess their buildings, establish reserves and fund necessary repairs, costs that fall directly on unit owners. "Our board is doing everything they can to keep us afloat and at the same time, the people in the buildings that don't attend these meetings just don't understand," Fratianni said. "I don't know if you can get water from a stone." Walter Raser, another condo owner, worries the bill could financially devastate elderly residents. "We're not asking for safety to be ignored. We're asking for elderly communities to be listened to," Raser said. "In this situation, safety should not override the cost. It's literally going to cost people their homes." Widespread non-compliance raises risks A study by the Miami Association of Realtors found that as of last month, only 44% of condo buildings in Miami-Dade County and 41% in Broward County had completed the required study. Peter Zalewski, a South Florida condo market analyst and founder of said the bill's impact could be far-reaching, even for buildings that don't currently rely on Citizens coverage. "If Citizens is saying, 'No, we're not going to insure you,' I can bet the house the private sector is not going to insure," Zalewski said. Citizens Property Insurance covers 18,468 condo buildings with associations, more than half of them in Miami-Dade, Broward and Palm Beach counties. Zalewski warned that if a large number of condo owners lose their coverage, those who remain insured could face steep premium increases to offset the financial risk.
Yahoo
05-02-2025
- Yahoo
Seattle mom beat teen son to death with extension cord, caused over 1,100 injuries: docs
Newly released court documents detail the horrific beating of a 14-year-old boy at the hands of his mother that led to the teen's death at the end of January. On Jan. 30, Seattle Police responded to a call for an unresponsive boy in a south Seattle apartment. Denaya Young, the boy's mother, called 911. When officers responded, she told them that she 'went too far' during an hour-long beating of the teen for not doing his chores, according to court documents. The teen was temporarily resuscitated by first responders but died shortly after arriving at Harborview Medical Center. According to court documents, Young, 29, beat the teen with an extension cord until his heart gave out. The medical examiner said the boy had 1,172 fresh injuries from the beating, and likely died from Sudden Inflammatory Response Syndrome (SIRS) or Distributive Shock. Court documents define SIRS as 'when the body sends blood and blood serum to so many different injuries around the body, attempting to heal them, that it draws enough blood out of the muscles and other vital areas that there is not enough to sustain the heart.' Young said she lost count of how many times she hit her child. He told her that he was dizzy and kept falling down, but she told officers that she thought he was pretending to get out of cleaning the mess he made, according to court documents. She also admitted to hitting the teen in the past with a closed fist and 'probably' put her hands around his neck during a previous beating, court documents detail. 'I cut his a** a little too hard. He was supposed to be doing chores, he didn't,' she told responding officers. 'He was supposed to do them last night. It's a recurring thing, and then I let my anger get the best of me with the extension cord.' While the 14-year-old enduring the beating, his three siblings, a 5-month old, and a 4- and 6-year-old, were present. The teen's stepfather was also present during the beating, but did nothing to stop it, according to court documents. The stepfather told officers that he didn't intervene with the teen's previous beatings because the child is not his and he felt it wasn't his place, saying it was best to mind his own business in 'these situations,' court documents say. The 14-year-old boy came to his mother's home in August of 2024 for a visit, but she did not return him to his aunt, who is his legal guardian. Young has been charged with second-degree murder. Prosecutors are asking that she be held on $3 million bail. It's unclear if the stepfather will face charges in connection to this incident.
