Latest news with #SPEAR
Business Wire
15-07-2025
- Business
- Business Wire
Spear Bio Announces Strategic Partnership with Bio-Techne to Accelerate the Deployment of Its Next-Generation Immunoassay Technology
WOBURN, Mass.--(BUSINESS WIRE)--Spear Bio, a biotechnology company pioneering homogeneous ultrasensitive immunoassay technology, is pleased to announce a strategic distribution partnership with Bio-Techne Corporation (NASDAQ: TECH), a global leading provider of innovative reagents, instruments, and solutions for life-science research and clinical diagnostics. The partnership significantly expands global access to Spear Bio's groundbreaking SPEAR UltraDetect™ immunoassays, focusing initially on the neurology research market. The introductory SPEAR UltraDetect offering targets biomarkers pivotal to neurodegenerative diseases, such as phosphorylated tau 231 (pTau 231), phosphorylated tau 217 (pTau 217), glial fibrillary acidic protein (GFAP), and neurofilament light (Nf‑L). This partnership follows Bio-Techne's participation in Spear Bio's $45 million Series A funding round in 2024. Early detection of protein biomarkers is essential for understanding historically challenging disease mechanisms, developing early interventions, and advancing clinical trials. Spear Bio's Successive Proximity Extension Amplification Reaction (SPEAR) platform, based on breakthrough technology licensed from Harvard University, and amplified using conventional qPCR instrumentation, offers sensitivity two to three orders of magnitude higher than current immunoassay platforms. "Partnering with Spear Bio marks an exciting step in our mission to advance biomarker detection in neurodegenerative disease research," said Will Geist, President of Bio-Techne's Protein Sciences Segment. "By leveraging Bio-Techne's global reach and immunoassay expertise with Spear Bio's ultrasensitive technology, we are equipping researchers with innovative tools to detect and study critical biomarkers with unmatched precision and sensitivity." With Bio-Techne's global reach, Spear Bio is well-positioned to accelerate the deployment of its next-generation assay technology, enabling researchers to detect biomarkers in historically challenging conditions. Spear Bio's initial focus is neurodegenerative diseases, with the technology relevant for inflammation, oncology and additional fields. In addition, Spear Bio's advanced detection technology expands applications in high-growth markets, including early neurodegenerative disease diagnosis, enhancing patient access to critical interventions. 'Our strategic partnership with Bio-Techne represents a transformative opportunity for neurodegenerative disease research,' said Feng Xuan, PhD, Founder and CEO of Spear Bio. 'By combining Bio-Techne's global distribution network and market leadership with Spear Bio's next-generation immunoassay technology, we are empowering researchers worldwide to investigate earlier disease mechanisms, improve patient stratification in clinical trials, and accelerate the development of new treatments for neurological disorders.' This partnership underscores the promise of Spear Bio's SPEAR technology and reinforces Bio-Techne's commitment to advancing biomarker detection. About Bio-Techne Bio-Techne Corporation (NASDAQ: TECH) is a global life sciences company providing innovative tools and bioactive reagents for the research and clinical diagnostic communities. Bio-Techne products assist scientific investigations into biological processes and the nature and progress of specific diseases. They aid in drug discovery efforts and provide the means for accurate clinical tests and diagnoses. With hundreds of thousands of products in its portfolio, Bio-Techne generated approximately $1.2 billion in net sales in fiscal 2024 and has approximately 3,100 employees worldwide. For more information on Bio-Techne and its brands, please visit or follow the Company on social media at: Facebook, LinkedIn, Twitter or YouTube. About Spear Bio Founded in 2021 and headquartered in Woburn, Massachusetts, Spear Bio is dedicated to its mission of revolutionizing biomarker research and diagnostics through innovation and accessibility. Leveraging its unique homogeneous assay format, SPEAR technology consistently delivers highly sensitive and precise protein measurements. Spear Bio envisions a future where high-performance assays democratize access to critical insights, accelerating progress in research and medicine worldwide. To learn more about the company, please visit the Spear Bio website.
Yahoo
13-06-2025
- Yahoo
Law enforcement recovers stolen vehicle in suspected string of break-ins
GARFIELD COUNTY, Colo. (KREX) – A man was arrested Wednesday after authorities spotted him and his allegedly stolen vehicle outside a gas station. This initial incident started when the Rifle Police Department received a report that a 2022 black Ford Bronco Sport was stolen, according to the Garfield County Sheriff's Office. A few days later, a Rifle police officer saw the stolen car and described the driver to law enforcement. The vehicle was later located by SPEAR investigators at the Golden Gate Gas Station near Silt. SPEAR, GCSO and Silt Police Department members approached the driver, Soloman Holliday, and placed him under arrest before he was transported to the Garfield County Jail. During the arrest, law enforcement discovered Holliday was allegedly carrying a stolen handgun. He is also suspected of breaking into several vehicles in western Garfield County. Holliday was charged with motor theft and carrying a concealed weapon, but more charges are expected as the investigation continues. SPEAR is a multi-jurisdictional task force based in Garfield County comprised of local and federal law enforcement agencies. Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
Yahoo
22-05-2025
- Business
- Yahoo
The UK's 'missile of the future' for its F-35s has been delayed again
The UK's SPEAR 3 air-to-surface cruise missile is facing further delays. The UK MOD called the missile, designed for F-35B Lightnings, the "cruise missile of the future." But its expected timeline for in-service capability has been pushed to the early 2030s. The UK's new missile, which its defense ministry has called the "cruise missile of the future," has been further delayed. The SPEAR 3 air-to-surface cruise missile is intended for use by F-35B Lightnings in both the Royal Air Force and the Royal Navy. Its manufacturer, European multinational MBDA, says it will be the "primary air launched, precision effects, surface attack weapon" of the RAF. But the missile's expected timeline for in-service capability has now been pushed back to the early 2030s, Maria Eagle, the UK's minister of state for defense procurement and industry, said. In response to an opposition lawmaker, Eagle said the weapon program was "undergoing re-baselining," which means its progress is being reconsidered. She said that a Review Note was expected toward the end of 2025, and "until that is approved, dates are considered draft and of low confidence." "The estimated current timeline for in-service capability is expected to be early 2030s," she added. This represents another in a series of delays for the project. The missiles were once expected to be integrated by 2025, which was then pushed back to the last quarter of 2028. The SPEAR 3 missile was successfully launched from an aircraft for the first time last year, the RAF said. It was launched by a Eurofighter Typhon jet in a test over Sweden. The RAF described the SPEAR missile as "a next generation turbojet-powered miniature cruise missile," to be used by both Royal Air Force and Royal Navy pilots. It said each F-35B will be able to carry up to eight SPEAR missiles at a time. The UK chose to develop its own cruise missile with MBDA after considering purchasing an available model from US defense company Raytheon. The RAF said the missiles can hit targets at a distance of 62 miles, and MBDA said they will be effective against naval vessels, main battle tanks, ballistic missile launchers, and fast-moving vehicles, among other targets. The missile also has a semi-active laser mode, which allows operators to designate a target using a laser, which the missile's seeker then follows. Gustav Gressel, a missile expert at the National Defence Academy of the Austrian Armed Forces, described the latest SPEAR delay as part of a pattern. "Aircraft armament in Europe, unfortunately, is a story of delays and cost overruns," he told Business Insider. The UK has purchased 48 F-35Bs, made by Lockheed Martin, for use by both its air force and navy, though not all have been delivered. It intends to buy a total of 138 jets, though some reports have suggested that number could be reassessed amid cost concerns. Some countries have said they are reconsidering their commitment to the F-35, as the US distances itself from longtime allies and amid speculation the US could make the jets ineffective by removing critical support. But a UK Ministry of Defence spokesperson told Business Insider in March that the UK "maintains the freedom of action to operate the F-35 Lightning at a time and place of our choosing." The RAF described SPEAR last year as part of a portfolio that supports $8.7 billion of planned investment in the UK weapons industry by the MOD over the next decade. It said this included Brimstone, CAMM, Sea Viper, Sea Venom, and Storm Shadow. Read the original article on Business Insider
Business Insider
22-05-2025
- Business
- Business Insider
The UK's 'missile of the future' for its F-35s has been delayed again
The UK's new missile, which its defense ministry has called the "cruise missile of the future," has been further delayed. The SPEAR 3 air-to-surface cruise missile is intended for use by F-35B Lightnings in both the Royal Air Force and the Royal Navy. Its manufacturer, European multinational MBDA, says it will be the "primary air launched, precision effects, surface attack weapon" of the RAF. But the missile's expected timeline for in-service capability has now been pushed back to the early 2030s, Maria Eagle, the UK's minister of state for defense procurement and industry, said. In response to an opposition lawmaker, Eagle said theweapon program was "undergoing re-baselining," which means its progress is being reconsidered. She said that a Review Note was expected toward the end of 2025, and "until that is approved, dates are considered draft and of low confidence." "The estimated current timeline for in-service capability is expected to be early 2030s," she added. This represents another in a series of delays for the project. The missiles were once expected to be integrated by 2025, which was then pushed back to the last quarter of 2028. The SPEAR 3 missile was successfully launched from an aircraft for the first time last year, the RAF said. It was launched by a Eurofighter Typhon jet in a test over Sweden. The RAF described the SPEAR missile as "a next generation turbojet-powered miniature cruise missile," to be used by both Royal Air Force and Royal Navy pilots. It said each F-35B will be able to carry up to eight SPEAR missiles at a time. The UK chose to develop its own cruise missile with MBDA after considering purchasing an available model from US defense company Raytheon. The RAF said the missiles can hit targets at a distance of 62 miles, and MBDA said they will be effective against naval vessels, main battle tanks, ballistic missile launchers, and fast-moving vehicles, among other targets. The missile also has a semi-active laser mode, which allows operators to designate a target using a laser, which the missile's seeker then follows. Gustav Gressel, a missile expert at the National Defence Academy of the Austrian Armed Forces, described the latest SPEAR delay as part of a pattern. "Aircraft armament in Europe, unfortunately, is a story of delays and cost overruns," he told Business Insider. The UK has purchased 48 F-35Bs, made by Lockheed Martin, for use by both its air force and navy, though not all have been delivered. It intends to buy a total of 138 jets, though some reports have suggested that number could be reassessed amid cost concerns. Some countries have said they are reconsidering their commitment to the F-35, as the US distances itself from longtime allies and amid speculation the US could make the jets ineffective by removing critical support. But a UK Ministry of Defence spokesperson told Business Insider in March that the UK "maintains the freedom of action to operate the F-35 Lightning at a time and place of our choosing." The RAF described SPEAR last year as part of a portfolio that supports $8.7 billion of planned investment in the UK weapons industry by the MOD over the next decade. It said this included Brimstone, CAMM, Sea Viper, Sea Venom, and Storm Shadow.
Time of India
22-05-2025
- Entertainment
- Time of India
How to defeat Illuminate Leviathans in Helldivers 2
(Image via Arrowhead Game Studios) Illuminate Leviathans in Helldivers 2 loom over the battlefields of Super Earth , raining chaos with the relentless plasma barrages. To defeat them could feel like an impossible task, as airborne fortresses need much more than brute force. They need precision, smart Helldivers 2 loadouts , and teamwork. While the durability of these Leviathans is quite daunting, the use of a strategic approach could bring the giants crashing down. Here is all you need to know to dismantle them and bring the odds to your favor easily. Target the weak points of Illuminate Leviathans in Helldivers 2 EVERYTHING U NEED TO KNOW TO DESTROY LEVIATHAN & NEW ILLUMINATES - Helldivers 2 indepth guide & tips Illuminate Leviathans are not invincible, but the weak spots of theirs is an important key. So, focus on glowing blue rings that are beneath the hull of it or the joints that connect the segmented bodies. The well-aimed shot from the SPEAR or the Recoilless Rifle could capture the areas, causing some structural damage that could destabilize the ship. Destroying all three 3 rings will trigger catastrophic descent, but if even one wing is disabled, it will expose the vulnerable flaming zones for follow-up attacks. The heavy armor-piercing weapons are non-negotiable. Anti-Tank Emplacement, which can be unlocked through Urban Legends Warbond, delivers devastating hits. However, the positioning here needs foresight due to the mobility of the Leviathans. Pair it with the teammates for the rapid reloads and team reload mechanics; it can turn slow-firing SPEAR into a relentless threat. Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like 2025년 최고의 전설적인 로봇 전투를 경험해보세요 기계 경기장 Undo The Exosuits pack enough of the punch, but they drain the ammo reserves. Use them sparingly at the time of critical phases. Adapt the strategy to evade or fight Leviathans thrive in the chaos. However, engaging them is not always required. Outside the Evacuate Assets missions, the Leviathans erratic aim and the urban terrain quite often let the players bypass them. However, during the generator-defense objectives, the bombardment of Leviathans cannot be ignored. So, give priority to taking them down early on in such cases to protect the mission-critical structures. If the weaker spots remain inaccessible, ensure to switch the tactics. The Railguns and Autocannons chip away at the exposed hull breaches, while the Laser Cannons can target the joints— though to have consistent hits does demand patience. Just avoid the orbital strikes like Railcannon or the Orbital Laser. They lack tracking. Instead, save the stratagems for crowd control to manage the smaller foes while the squad remains on the focused fire on Leviathans. Best Helldivers 2 loadouts for the Leviathans hunts Not all missions need to take down the Leviathans, but in the Evacuate Assets mission, they are a huge threat. So, give priority to the heavy anti-armor weapons like the SPEAR or the Recoilless Rifle. The team reload will help to maintain the firepower. So, coordinate with the allies. For the secondary options, Railguns and Autocannons work once the armor gets stripped. So, avoid wasting the Orbital Strikes, as the Leviathans dodge most of the stratagems. Instead, try to focus on the direct-fire weapons and also positioning—to fight near the skyscrapers limits Leviathans line of sight. Helldivers 2 tips to ensure efficiency for survival Leviathans test resource management just as much as combat skills. So, stockpile the ammo near objectives and ensure that the reload duties are communicated to avoid downtime. Remain mobile and use the skyscrapers to take cover when repositioning to exploit the weaker points. Know that the victory here is not just about the glory. At times, evasion can buy the time needed to secure the objectives. So, focus, adapt, and bring the sky crashing down on the enemies. Get IPL 2025 match schedules , squads , points table , and live scores for CSK , MI , RCB , KKR , SRH , LSG , DC , GT , PBKS , and RR . Check the latest IPL Orange Cap and Purple Cap standings.
