Latest news with #STAT1
Business Insider
18-07-2025
- Health
- Business Insider
Telomir says data show Telomir-1 reversed epigenetic silencing
In a regulatory filing, Telomir Pharmaceuticals (TELO) reported new preclinical results evaluating the effects of its lead candidate, Telomir-1, in a murine xenograft model using PC3 human prostate cancer cells. The data demonstrated that Telomir-1 reversed epigenetic silencing by DNA methylation of the STAT1 gene, a tumor suppressor and immune response regulator, in a dose-dependent manner. STAT1 is frequently silenced in advanced cancers via promoter hypermethylation, disrupting immune detection and apoptotic pathways. In this study, Telomir-1 administered orally daily for 21 days resulted in full reversal of STAT1 hypermethylation in tumor tissue. No such reversal was observed in the Paclitaxel group, and only partial demethylation was observed with Rapamycin In addition to STAT1, Telomir-1 also reduced hypermethylation of TMS1, a pro-apoptotic tumor suppressor commonly silenced in prostate cancer. While PTX and Rapamycin showed comparable or greater effects on TMS1 methylation, Telomir-1 is unique in its ability to modulate both STAT1 and TMS1-two genes that together regulate immune response and apoptosis. Importantly, TMS1 also plays a central role in inflammasome activation, which not only contributes to tumor cell death but also supports the immune system's ability to detect and clear abnormal cells. When TMS1 is hypermethylated, this immune signaling pathway is disrupted-reducing caspase-1 activation and inflammatory cytokine release. This can impair immune surveillance and allow cancer cells to persist undetected. By reducing TMS1 hypermethylation, Telomir-1 may help restore immune recognition and enhance the tumor's sensitivity to both chemotherapy and immunotherapy. Telomere length analysis in PC3 tumor tissue showed no measurable elongation following Telomir-1 administration. This finding is relevant given concerns that telomere-targeting compounds may promote tumor progression through telomere extension in malignant cells. In contrast, Telomir-1 demonstrated selective activity without altering telomere length in this model. Telomir is conducting ongoing research to evaluate Telomir-1 across multiple therapeutic areas, including oncology, Wilson's disease, age-related macular degeneration, autism spectrum disorder, and dysphonia. The company is continuing preclinical development across these programs and plans to announce its initial IND indication at a future date. 'We remain encouraged by the preclinical data and continue to explore Telomir-1's potential across several disease areas. Our team is committed to advancing this program thoughtfully and strategically as we move toward clinical development,' said Erez Aminov, CEO of Telomir. Elevate Your Investing Strategy:
Yahoo
04-04-2025
- Health
- Yahoo
Piatt Co. girl with gene mutation celebrating 4th birthday, how to donate gifts:
PIERSON STATION, Ill. (WCIA) — Amelia, a girl from Pierson Station born with a gene mutation, is getting ready to celebrate her fourth birthday in a St. Louis hospital. Even though she can't have any visitors, she can still receive gifts. Amelia was diagnosed with a STAT1 gene mutation and HLH, a rare immune system disorder, in March 2024. Her father, Shane, fought a 36-year battle with STAT1 and died from STAT1 and HLH complications on Jan. 23, 2025. New leadership 'amped up' to change Danville for the better She is currently undergoing treatment at Barnes Children's Hospital in St. Louis. Amelia underwent an extensive week of chemotherapy at the beginning of March in order to receive a bone marrow transplant. The transplant is scheduled to take place April 14 and is expected to cure both her STAT1 gene mutation and her HLH. The St. Louis hospital will be her home for three months during her treatment, which means she will be spending her 4th birthday, on April 28, in the hospital. 'With this being her first birthday without her dad I couldn't just stand by and let a hard day go without attempting to bring joy to her,' Teresa Ely said. Ely also said that while Amelia is not allowed to have visitors currently, she is hoping that cards, pictures, will wishes and other small gifts will bring her excitement during this time. She provided the following guidelines for gifts sent to Amelia: Stuffed animals must be able to be machine washed Toys that can easily be disinfected such as Pop-It art toys Gift cards for iPad games Slime Books Coloring supplies Pink peeps Bunny toys Bubbles Minnie mouse toys 'Bluey' products Monticello Bowl & Lounge closes permanently Gift donations are asked to be sent by April 23 to Laura Chimel c/o McDonald House at 4321 Chouteau Ave. in St. Louis, MO 63103. For additional information, you can contact Ely at 217-766-1859 or teresamnorman91@ Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
