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New Indian Express
5 days ago
- Health
- New Indian Express
RMRC Bhubaneswar develops advanced malaria vaccine, ready for tech transfer
BHUBANESWAR: In a significant breakthrough, a team of researchers led by the Regional Medical Research Centre (RMRC), Bhubaneswar, has developed a novel and advanced malaria vaccine that can prevent Plasmodium falciparum infection in humans and community transmission. The new recombinant, chimeric multi-stage vaccine code-named AdFalciVax has been designed to protect against the deadliest malaria parasite in humans. It is now ready for technology transfer to manufacturers for production, clinical trials and its commercialisation. Currently, two malaria vaccines are available and cost in a range of `250 to `830 per dose. The efficacy rate is between 33 per cent and 67 per cent. Unlike existing WHO-recommended vaccines RTS,S/AS01 (Mosquirix) and R21/Matrix-M, AdFalciVax offers dual-stage protection and is cost-effective. Scientist-D at RMRC Dr Susheel Singh said the new vaccine can prevent human infection and interrupt transmission in the community. 'AdFalciVax uses a full-length PfCSP, a major protein found in Pf, for broader protection and includes a novel fusion of Pfs230 and Pfs48/45 proteins to produce strong antibodies that stop the transmission,' he said. What makes AdFalciVax stand out among the existing vaccines is its exceptional pharmaceutical stability. The formulation remains potent for over nine months at room temperature, eliminating the need for costly cold chain logistics, which continue to be a major bottleneck in vaccine distribution across remote and resource-limited regions. According to the researchers, the vaccine has been developed with the help of cutting-edge protein engineering using Lactococcus lactis, a safe bacterial host. The pre-clinical validation of the technology has been conducted by RMRC in collaboration with National Institute of Malaria Research (NIMR) and National Institute of Immunology (NII), New Delhi. RMRC director Dr Sanghamitra Pati said, 'The vaccine's efficacy was sustained for over four months post-boost, which translates to over a decade of protection in humans.' Meanwhile, Indian Council of Medical Research (ICMR), New Delhi has invited expressions of interest from the eligible organisations, companies and manufacturers for transfer of technology and commercialisation.
Time of India
5 days ago
- Health
- Time of India
ICMR to transfer tech for production of malaria vaccine
Bhubaneswar: The Indian Council of Medical Research (ICMR), New Delhi, on Thursday invited expressions of interest from eligible organisations, companies, and manufacturers for undertaking the 'transfer of technology' for commercialisation of a malaria vaccine developed by ICMR-Regional Medical Research Centre (RMRC), Bhubaneswar. This technology, "A recombinant chimeric multi-stage malaria vaccine (AdFalciVax) against Plasmodium falciparum", is useful in preventing Plasmodium falciparum infection in humans and minimising its community transmission, said RMRC, Bhubaneswar, director Sanghamitra Pati. ICMR-RMRC, Bhubaneswar, led the development of this technology and possesses the technical know-how of the process to produce this malaria vaccine. The pre-clinical validation of this technology was conducted in collaboration with ICMR-National Institute of Malaria Research (ICMR-NIMR) and National Institute of Immunology (NII), New Delhi. The aim of the expression of interest (EoI) is to license the 'technology' for the vaccine, which is useful in preventing Plasmodium falciparum infection in humans and minimising its community transmission, for commercialisation and marketing activities. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Villas For Sale in Dubai Might Surprise You Dubai villas | search ads Get Deals Undo According to the EoI letter, ICMR is willing to collaborate with eligible organisations, companies, and manufacturers for undertaking the transfer of technology for commercialisation of the malaria vaccine. The company would be granted rights to undertake further development, manufacture, sell, and commercialise the technology/product. "RMRC, Bhubaneswar, has expertise in various techniques, methods, and information relating to the aforesaid technology, which could be used for the production of the malaria vaccine. It will provide expert guidance and technical support for the production of this vaccine. ICMR will provide technical support to the producing company," said the official sources.
Time of India
31-05-2025
- Health
- Time of India
RMRC joins WHO network to reduce ‘health inequities'
1 2 3 Bhubaneswar: The Regional Medical Research Centre (ICMR-RMRC) in the city has been selected to join the WHO's 'Health Inequality Monitoring Network', a global initiative dedicated to advancing health equity through better data and evidence. Through the network, RMRC will contribute to developing tools, strengthening data systems and guiding policy interventions to reduce health inequities, official sources said. ICMR director Sanghamitra Pati said Odisha and the rest of the eastern region face significant health challenges, particularly among tribal, rura, and underserved populations. "Being a part of the network will allow RMRC to generate disaggregated data to better understand who is being left behind, support evidence-informed policies to reduce health gaps, and enhance regional health monitoring systems and capacity-building," she added. "This recognition places ICMR-RMRC Bhubaneswar among key institutions worldwide working to identify and address health disparities. The WHO's recently published report, 'Health Inequality Monitoring: Harnessing Data to Advance Health Equity', emphasises the critical role of monitoring in shaping inclusive health policies," read a press statement from RMRC. "By collaborating with WHO and other global partners, RMRC will play a critical role in shaping strategies that promote universal health coverage and equity-oriented health reforms," said Pati. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Use an AI Writing Tool That Actually Understands Your Voice Grammarly Install Now Undo As a participant in the network, she said the RMRC will support WHO in identifying training needs and organising capacity-building workshops for member states. "Our multidisciplinary team of experts will familiarise themselves with WHO's methods and tools on health inequality monitoring and help teams adhere to the shared guidelines," she added. Pati said RMRC will contribute technical inputs to enhance training programmes, support integration of data disaggregation into health systems and promote best practices. "RMRC will also share knowledge and help develop context-specific training resources to strengthen monitoring capacity across member states," she added.
