26-03-2025
Yale researchers use lupus antibody to possibly treat glioblastoma
NEW HAVEN, Conn. (WTNH) — Researchers at Yale Cancer Center have made a breakthrough finding that could lead to a therapies for glioblastoma and other aggressive cancers that are extremely difficult to treat.
Dr. James Hansen, a Yale Cancer Center researcher, and his team discovered that using an antibody related to lupus they can breach the tumor and trigger an immune response to fight it.
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He says that this has not been possible in these tumors previously because they have a way to cloak themselves and remain invisible to the body's immune system.
Now, these antibodies can get into the tumor and trigger an attack.
'These antibodies rush in and they say whoa wait a second this is not all good because they've got that ability to really fire up an immune system from lupus then that awakens the bodies own defenses to come in and fight off those tumors,' Hansen said.
The findings have proven successful in the lab and his team plans to work as fast as they can to study this treatment further.
'What lupus antibodies can do that make them so magically mysterious is cross through a live cell membrane to fight things from the inside,' Hansen said.
'We're excited about this new way to engage the immune system to treat brain tumors,' Hansen said. 'Equally exciting is the discovery that this lupus antibody delivers genes to cells without needing any help from a virus, meaning it could be used to transform gene therapy strategies.'
This was recently published in Scince Signaling.
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