Latest news with #SelectiveSerotoninReuptakeInhibitors
Time of India
23-05-2025
- Politics
- Time of India
UK chancellor considers mandating chemical castration for serious sex offenders
Lord high chancellor of Great Britain, Shabana Mahmood is considering introducing mandatory chemical castration for the most dangerous sex offenders in England and Wales, United Kingdom. Tired of too many ads? go ad free now According to government sources, the proposal is part of a broader effort to address prison overcrowding and reform the criminal justice system. Justice secretary exploring mandatory chemical castration for some sex offenders Chemical castration involves the use of drugs to reduce sexual urges. These drugs include Selective Serotonin Reuptake Inhibitors (SSRIs) that reduces intrusive sexual thoughts and anti-androgens that lowers testosterone levels. Currently, the programme is voluntary, but Mahmood is looking at whether it could be made compulsory for high-risk offenders. A pilot programme using these drugs began in 2022 in south-west England and is due to end next year. Officials are planning to expand the trial to 20 more regions before considering a national rollout. The proposal is part of recommendations made by former conservative justice secretary David Gauke. He suggested that the government should gather more evidence on the effectiveness of these drugs and study the application in countries like Germany, Denmark and Poland. Mahmood is expected to address the issue in Parliament this week. At the end of March 2025, sexual offences made up to 21 per cent of all adult prison sentences, as reported by the Guardian. Gauke recommended that short prison sentences of under 12 months should be used only in rare cases. Instead, courts should have more options, like longer suspended sentences, delayed sentencing for low-risk offenders, and greater use of fines or bans (such as travel or driving restrictions). Tired of too many ads? go ad free now To support victims, expand courts that deal with domestic abuse and increase the use of electronic tags for those who commit violence against women and girls. It also calls for better training for judges and legal professionals on these issues. Additionally, change the statutory purpose of sentencing so judges and magistrates must consider protecting victims as much as they consider punishment and rehabilitation when passing sentences. He warned that these reforms will only succeed with more funding including expanding the availability of electronic monitoring equipment like tags. The Conservative Party has strongly criticised Gauke's recommendations. Shadow justice secretary Robert Jenrick said, 'By scrapping short prison sentences Starmer is effectively decriminalising crimes like burglary, theft and assault. This is a gift to criminals who will be free to offend with impunity,' as reported by the Guardian.
Associated Press
25-04-2025
- Health
- Associated Press
MindScape Retreat in Cozumel, Mexico, Offers Innovative Ibogaine Therapy to Address Long-Term SSRI Effects and Serotonin Syndrome Risks
Miami, FL April 25, 2025 --( )-- MindScape Retreat, a licensed ibogaine treatment center located in Cozumel, Mexico, is pioneering a holistic approach to assist individuals in safely discontinuing Selective Serotonin Reuptake Inhibitors (SSRIs) and addressing associated long-term effects, including the risk of serotonin syndrome. Through medically supervised ibogaine therapy, an Ibogaine Retreat at MindScape Retreat aims to restore neurochemical balance and promote overall well-being. Understanding the Challenges of Long-Term SSRI Use While SSRIs are commonly prescribed for depression and anxiety, prolonged use has been associated with several adverse effects: Emotional Blunting: A diminished ability to experience emotions, affecting personal relationships and quality of life. Cognitive Impairments: Difficulties with memory, concentration, and decision-making. Sexual Dysfunction: Persistent issues such as decreased libido and anorgasmia, even after discontinuation. Withdrawal Symptoms: Challenges in tapering off SSRIs, including mood disturbances and physical discomfort. Moreover, SSRIs can increase the risk of serotonin syndrome, a potentially life-threatening condition resulting from excessive serotonin activity in the central nervous system. Symptoms can range from mild (tremors, sweating, confusion) to severe (high fever, seizures, loss of consciousness). The syndrome is more common than many realize, especially when SSRIs are combined with other serotonergic agents or supplements. Ibogaine: A Potential Path to Neurochemical Restoration Ibogaine, a naturally occurring alkaloid derived from the African iboga plant, offers a unique approach to addressing the neurochemical imbalances associated with long-term SSRI use. Unlike SSRIs, which increase serotonin levels by blocking its reuptake, ibogaine acts as a non-competitive inhibitor of the serotonin transporter (SERT), potentially helping to reset and rebalance neurotransmitter systems without causing excessive serotonin accumulation. Additionally, ibogaine has been shown to stimulate the release of neurotrophic factors such as Brain-Derived Neurotrophic Factor (BDNF) and Glial cell line-Derived Neurotrophic Factor (GDNF). These proteins support neuronal growth, differentiation, and survival, playing a crucial role in neuroplasticity—the brain's ability to reorganize and form new neural connections. By enhancing neuroplasticity, ibogaine may help reverse the structural and functional changes associated with long-term SSRI use. MindScape Retreat's Comprehensive Approach At MindScape Retreat, patients undergo thorough medical evaluations to ensure safety and suitability for ibogaine therapy. The retreat's programs integrate ibogaine treatment with supportive practices, including NAD+ infusions, to promote mitochondrial health and neurotransmitter balance. The serene setting of Cozumel provides an ideal environment for individuals seeking a transformative healing experience. About MindScape Retreat MindScape Retreat is dedicated to providing safe and effective ibogaine therapy for individuals seeking to overcome the challenges associated with long-term SSRI use. With a focus on holistic healing and neurochemical restoration, the retreat offers personalized care in a tranquil setting. For more information about MindScape Retreat and its ibogaine therapy programs, please visit Contact Information: MindScape Retreat Dr. Omar Calderon 786-761-7729 Contact via Email Read the full story here: MindScape Retreat in Cozumel, Mexico, Offers Innovative Ibogaine Therapy to Address Long-Term SSRI Effects and Serotonin Syndrome Risks Press Release Distributed by
Time Business News
24-04-2025
- Health
- Time Business News
Lexapro vs Zoloft: Which is Better for Emotional Blunting Symptoms?
When managing depression and anxiety, many people turn to SSRIs (Selective Serotonin Reuptake Inhibitors), a class of antidepressants known for their effectiveness and generally tolerable side effect profiles. Two of the most commonly prescribed SSRIs are zoloft vs lexapro. While both medications are effective for treating anxiety and depression, a growing concern among patients is emotional blunting — a symptom characterized by a reduction in emotional responsiveness, or feeling emotionally 'numb.' In this blog post, we'll explore how Lexapro and Zoloft compare in terms of emotional blunting, what clinical and anecdotal evidence suggests, and which might be a better choice depending on individual needs. Managing mental health requires a tailored strategy, especially for adults juggling both ADHD and anxiety. It's crucial to work closely with a healthcare provider to determine the most effective treatment. For many, the best adhd medication for adults with anxiety tends to be non-stimulant options like atomoxetine or guanfacine, which can help manage symptoms without exacerbating anxious feelings. Stimulants such as methylphenidate might still be prescribed in certain cases but require careful monitoring. Combining medication with cognitive-behavioral therapy often leads to the best results, ensuring both focus and emotional regulation are addressed holistically. Emotional blunting, also known as emotional numbing, refers to the experience of feeling detached from emotions, whether positive or negative. People who suffer from emotional blunting may describe feeling like a 'zombie,' unable to feel happiness, sadness, or even love. While this symptom can be part of depression or anxiety itself, it is also a well-documented side effect of SSRIs. Emotional blunting can significantly impact quality of life and may cause patients to discontinue treatment if it becomes too distressing. Both Lexapro and Zoloft are SSRIs that work by increasing serotonin levels in the brain. Serotonin is a neurotransmitter that plays a key role in mood regulation, and increasing its availability can help alleviate symptoms of depression and anxiety. However, while they belong to the same class of drugs, they have subtle differences in their pharmacological profiles. Lexapro is often considered a more 'pure' SSRI, mainly targeting serotonin receptors. Zoloft, on the other hand, not only influences serotonin but also has mild effects on dopamine reuptake and sigma-1 receptors. These differences might contribute to variations in side effects, including emotional blunting. Lexapro is generally praised for its tolerability and relatively low side effect burden. However, emotional blunting is one of the more common side effects reported by users. Some patients on Lexapro find themselves feeling emotionally flat, even if their anxiety and depressive symptoms have improved. This trade-off can be frustrating. The drug's strong serotonin-targeting effect might contribute to this emotional flattening. Clinical research supports the notion that higher serotonergic activity can suppress both positive and negative emotional responses, potentially leading to blunting. Zoloft also carries the risk of emotional blunting, but it's often perceived differently than Lexapro by some patients. Because Zoloft slightly affects dopamine pathways and sigma-1 receptors, it may provide a more balanced emotional profile in certain individuals. Some users report that Zoloft helps with mood stabilization without making them feel numb. That said, others do report significant emotional blunting with Zoloft, especially at higher doses. The effects can be highly individual, and some patients may even experience increased emotional sensitivity instead of blunting. Research comparing emotional blunting across different SSRIs is still limited, but there are some findings worth noting. A 2016 study published in the journal Psychiatry Research found that emotional blunting was a common side effect across SSRIs, but the intensity and frequency varied. Lexapro showed a higher incidence of emotional numbing in that specific study compared to Zoloft, though the difference was not statistically overwhelming. Anecdotal evidence from patient forums and online communities supports these findings, with some individuals claiming that switching from Lexapro to Zoloft helped reduce their emotional blunting symptoms. One of the most important things to remember is that how someone responds to Lexapro or Zoloft can vary significantly from person to person. Genetic differences, brain chemistry, lifestyle, concurrent medications, and even diet can influence how a person experiences emotional side effects. What feels numbing for one person on Lexapro may feel perfectly manageable to another. Similarly, someone might feel emotionally distant on Zoloft while another might thrive on it. That's why personalized treatment and open communication with a healthcare provider are crucial when addressing these kinds of symptoms. If you're experiencing emotional blunting while on Lexapro or Zoloft, there are several strategies that can help. First, speak to your doctor about adjusting the dose. Sometimes reducing the dosage can alleviate blunting without compromising the therapeutic effects. In other cases, switching medications might be necessary. Some patients find relief by augmenting their SSRI with another drug, such as bupropion, which targets dopamine and norepinephrine rather than serotonin. Non-pharmaceutical strategies such as therapy, mindfulness, and regular exercise can also improve emotional awareness and mitigate some of the numbing effects. When it comes to emotional blunting specifically, Zoloft may have a slight advantage for some individuals due to its broader receptor activity, which might help maintain more emotional responsiveness. However, Lexapro is still a very effective and often well-tolerated medication for many people. It's not necessarily that one is better than the other universally — it really depends on the individual. If emotional numbness becomes a serious issue on Lexapro, Zoloft could be worth trying, and vice versa. Both medications have helped millions manage anxiety and depression effectively, but trial and error is often necessary to find the best fit. Emotional blunting is a frustrating and sometimes overlooked side effect of antidepressant treatment. Both Lexapro and Zoloft can cause this symptom, though the likelihood and severity vary from person to person. While Zoloft might offer a more dynamic emotional experience for some due to its slightly different chemical activity, others may find Lexapro more calming and better suited to their needs. The most important takeaway is that if you're experiencing emotional blunting, you're not alone — and there are options. Talk to your healthcare provider about what you're feeling and explore adjustments that might help you feel more like yourself again. TIME BUSINESS NEWS
