Latest news with #SimonVincent
Gulf Today
2 days ago
- Health
- Gulf Today
New breast cancer therapy can slow advance of disease, prolong survival
A new triple therapy for aggressive, advanced breast cancer slows the progression of the disease, delays the need for further chemotherapy and helps patients live longer, research revealed. The combination treatment is made up of two targeted drugs: inavolisib and palbociclib, and the hormone therapy fulvestrant. It improved overall survival by an average of seven months, compared with the patients in the control group, who were given palbociclib and fulvestrant. It also delayed progression of the disease by 17.2 months, on average, compared with 7.3 months in the control group, and patients taking inavolisib were able to delay subsequent chemotherapy treatment by almost two years longer than the patients in the control group. The results of the study, funded by Roche, were presented at the American Society of Clinical Oncology (Asco) annual meeting in Chicago and published in the New England Journal of Medicine. The international trial involved 325 patients from 28 countries, including the US, UK, Australia, Singapore, Brazil, France and Germany. Experts said it demonstrated the potential of the triple therapy for targeting PIK3CA-mutated HR+, HER2- breast cancer - a common form of the disease. About 70 percent of patients have HR+, HER2- breast cancer. PIK3CA mutations are found in 35 to 40 percent of HR+ breast cancers, and are linked to tumour growth, disease progression and treatment resistance. "The INAVO120 trial has identified a targeted treatment regimen that meaningfully improves survival in patients with untreated PIK3CA-mutated hormone receptor-positive metastatic breast cancer - a big step forward for these patients,' said Dr Jane Lowe Meisel, Co-Director of Breast Medical Oncology at Winship Cancer Institute of Emory University, and an Asco expert in breast cancer. The results also showed a substantial shrinking in cancer growth in about 62.7 percent of patients in the triple therapy group compared with 28 percent in the control group. Dr. Simon Vincent, Director of Research, support and influencing at Breast Cancer Now, said the findings were a "significant breakthrough'. Dr. Nisharnthi Duggan, a research information manager at Cancer Research UK, said, "The trial showed that adding inavolisib to targeted treatment plans improved survival. On top of this, it also delayed the progression of people's cancer and the need for chemotherapy, which could improve quality of life. We hope that more research like this will help to give people kinder cancer treatment options, and more time with their loved ones.' In the trial, more than half of the patients had disease that had already spread to three or more organs. The researchers used circulating tumour DNA (ctDNA) liquid biopsy blood tests to determine whether patients had a PIK3CA mutation. Participants were then allocated to receive either the inavolisib-based regimen or a combination of palbociclib, fulvestrant and a dummy pill. The new drug inavolisib works by blocking the activity of the PIK3CA protein. The inavolisib combination was generally well tolerated with only a few patients experiencing side-effects that led them to discontinue the treatment. Nick Turner, Professor of Molecular Oncology at the Institute of Cancer Research, London, and consultant medical oncologist at the Royal Marsden NHS Foundation Trust, led a UK arm of the trial. "The key findings from this study showed that the inavolisib-based therapy not only helped patients live longer but it more than doubled the time before their cancer progressed or worsened. It also gave them more time before needing subsequent chemotherapy which we know is something that patients really fear and want to delay for as long as possible," he stated. WAM
Hospitality Net
6 days ago
- Business
- Hospitality Net
Hilton's LXR Brand Debuts in Paris
Hilton (NYSE: HLT) announces the recent opening of Sax Paris, LXR Hotels & Resorts. Located in Paris's elegant 7th arrondissement, the 118-room property is housed in a historic neo-Gothic building, boasting panoramic rooftop views. Marking the debut of the LXR Hotels & Resorts brand in France, Sax Paris joins a global collection of luxury hotels in sought-after destinations that invite guests on a journey of discovery and adventure. Sax Paris is owned and developed by Compagnie de Phalsbourg, a French real estate company. Sax Paris transforms a landmark 1899 building, formerly home to the Ségur telephone exchange, into a refined gathering place where travellers and Parisians come together to connect, converse, and experience the authentic lifestyle of the renowned Rive Gauche (Left Bank). Designed in the spirit of the 7th arrondissement - where art, culture, and sophistication converge - the hotel invites guests to relax and soak up its elegant atmosphere. Sax Paris offers contemporary rooms and suites, two distinctive restaurants, a stylish cocktail bar, and versatile event spaces. Guests can relax in the outdoor pool and garden, and the fitness and spa club provide a luxurious retreat. From this stylish base, guests can easily explore nearby treasures such as the Eiffel Tower, Musée d'Orsay, and Jardin du Luxembourg. Simon Vincent CBE, president, Europe, Middle East & Africa, Hilton, said: "Sax Paris, LXR Hotels & Resorts epitomises modern luxury, elevating the guest experience within the beautiful surroundings of this reimagined Parisian landmark. As we surpass the milestone of 1,000 operating hotels across Europe, the Middle East, and Africa, this latest addition to our portfolio marks our first luxury hotel in the heart of Paris. The opening also symbolises our continued commitment and growing presence in the French market and exemplifies our dedication to delivering unique and exceptional hotels in the world's most iconic destinations." Feisal Jaffer, global head, LXR Hotels & Resorts added: "Sax Paris, LXR Hotels & Resorts marks a significant moment for our brand as we debut in France. Paris is a city of timeless allure, making it the perfect setting for LXR's expansion into new, culturally rich destinations. As we continue to grow our global portfolio, we remain dedicated to curating independent, one-of-a-kind hotels that offer deeply personal and transformative experiences." Philippe Journo, founder and executive chairman of Compagnie de Phalsbourg, also commented: "We are delighted with the recent opening of Sax Paris, LXR Hotels & Resorts, which has already set itself as one of the trendiest venues in Paris, fully embodying our vision of what luxury lifestyle should stand for in the heart of the city's prestigious 7th arrondissement. The hotel offers a unique view of Paris's iconic monuments that no one should miss when coming to the City of Light!" Unrivalled hospitality steeped in Left Bank culture The hotel's design studio, led by Karine Journo, reinterprets Left Bank sophistication through a modern lens, uniting talented artists, decorators, and designers. Guests are welcomed via The Galerie, a vibrant social hub adorned with 200 mirrors and Baccarat chandeliers. Beyond the gallery lies the SAX Garden, a city centre oasis designed by Studio Ravn, inspired by romantic French-style gardens, and featuring a heated outdoor pool and jacuzzi. Sax Paris also showcases creations from renowned contemporary artists, including Arik Levy's crystal sculpture 'Rockstone' at the garden entrance and a restaurant ceiling mural by street artist Sto, referencing the building's historic République Française insignia. The hotel's 118 rooms and suites feature a contemporary design of neutral colours and natural materials, including marble bathrooms and wood panelling. Many offer connecting options for families, while others open onto private terraces. Three signature suites - The Studio, The Winter Garden Suite, and The Signature Suite - feature in-room cocktail stations. Minibars are stocked with Parisian favourites curated through a partnership with the iconic Le Bon Marché's La Grande Épicerie de Paris. Sax Paris presents distinctive dining concepts. Restaurant Le SAX is an all-day bar and restaurant for hotel guests and Parisians alike to socialise and dine over brunch, lunch or dinner. Presided over by Executive Chef, David Maroleau, who has previously led Michelin-starred restaurants, Restaurant Le SAX showcases the best of 'all that we love.' The celebrated Kinugawa brand brings its acclaimed Franco-Japanese dining experience to the top of Sax Paris. Kinugawa Rive Gauche, a two-story rooftop restaurant, blends Parisian elegance with Japanese culinary artistry. The cocktail bar reinterprets Parisian classics with Japanese elements such as yuzu and shiso. Exclusive adventures and amenities The experienced concierge team is ready to tailor each guest's stay. As part of the LXR Hotels & Resorts Pursuit of Adventure programme, guests can explore the essence of the Rive Gauche through intimate and specially curated experiences. These include a gourmet picnic with a stunning view of Les Invalides, a behind-the-scenes tour of the Eiffel Tower, and a private pontoon cruise on the Seine for a memorable Parisian adventure. The Fitness & Spa SAX Le Club, open 24/7 for hotel guests and members, offers Technogym equipment, a sauna, a hammam, and treatment rooms for massages and facials. Designer bicycles and personalised pet-friendly services are also available. Sax Paris, LXR Hotels & Resorts is part of Hilton Honors, the award-winning guest-loyalty programme for Hilton's 24 distinct hotel brands. Members who book directly have access to instant benefits, including a flexible payment slider that allows members to choose nearly any combination of Points and money to book a stay, an exclusive member discount, free standard Wi-Fi and the Hilton Honors mobile app. Sax Paris, LXR Hotels & Resorts is located at 55 Avenue de Saxe, Paris, 75007, France, close to the Sèvres-Lecourbe and Duroc metro stations. Hotel website
