Latest news with #Solve
Yahoo
3 days ago
- General
- Yahoo
The Underrated Power of Aunts in Raising Strong, Confident Girls
The right aunt can make a young girl feel safe, seen, and loved exactly as she is. When I became an aunt I found out in the most unexpected way, through a frantic mid-workday phone call from my brother, his voice trembling with equal parts excitement and fear. I ducked into a private room, heart racing, and joined a video call to see him and his wife in the hospital. She smiled and said calmly, "She's coming." In that moment, I didn't know what kind of aunt I'd be, but I knew I wanted to show up. Since then, I've learned so much—how to cradle a newborn just right, how to make the tiniest moments feel big, and how to be present even when I'm not the one doing the day-to-day parenting. I didn't have a blueprint for being an aunt, but I quickly learned how much my presence mattered. And according to Steve Biddulph, psychologist and author of Raising Girls and 10 Things Girls Need Most, aunts play a crucial role in the lives of girls. The Special Role of Aunts On ABC's Parental as Everything podcast, Biddulph explained that girls often need someone aside from their parents to turn to, especially during the tricky phases in adolescence when they may be reluctant to speak to their primary caregivers but still need to be heard. "They don't want to listen to you, but they still need lots of help," he said. That's where an aunt, or an aunt-like figure, comes in. According to Biddulph, an aunt can offer a less emotionally charged, more approachable ear, free of the pressure a child might feel from their parent. Biddulph even mentions that aunts don't need to be related by blood to hold this special role, he describes anyone who is "around your [parent's] age who loves you too" as being capable of providing this necessary support. These women, Biddulph says, are "pillars of mental health for girls." Building Bonds Early Biddulph encourages parents to nurture the child-aunt relationship early, before the teen years, so that trust and closeness are already in place when life gets complicated. Australian parenting author and Parental as Everything host Maggie Dent, agrees. She points out that young people today face immense mental and emotional pressures, making it essential to have caring adults beyond parents to turn to. Research supports this, too, sometimes just one consistent, caring adult can positively change a child's life. Ultimately, aunts, by blood or bond, can provide trust, emotional refuge, and guidance during moments where girls might feel misunderstood or overwhelmed. And one day, when my niece is old enough to navigate her own teenage storms, I hope she'll remember the woman who once answered a frantic phone call in the middle of the workday just to see her arrive in the world, and know she can always call me, too. Read the original article on Parents Solve the daily Crossword
Yahoo
07-08-2025
- Health
- Yahoo
Camilla Luddington Diagnosed with Hashimoto's After Feeling ‘Slothy'
"Truly when they said autoimmune disease, I was a little freaked out," the 'Grey's Anatomy' actress admitted Solve the daily Crossword
Yahoo
17-06-2025
- Health
- Yahoo
Solve M.E. Selects Simmaron Research As Recipient of ME/CFS Catalyst Award to Accelerate Low-Dose Rapamycin Trial for ME/CFS, Long COVID, and IACCs
The Catalyst Award will expedite the hunt for a validated test-to-treat model for ME/CFS, a disease for which there is currently no FDA-approved treatment. LOS ANGELES, June 17, 2025 /PRNewswire/ -- Solve M.E. is proud to announce the second recipient of its 2025 ME/CFS Catalyst Award: Simmaron Research. Simmaron will receive targeted funding to accelerate their study, "Low Dose Rapamycin in ME/CFS, Long-COVID, and Other Infection Associated Chronic Conditions (NCT06257420)." The study hypothesizes that mTOR inhibition through rapamycin may address observed findings of autophagy impairment and symptoms in a subset of patients with ME/CFS and other infection-associated chronic conditions and illnesses (IACCIs). Solve M.E. is a national nonprofit dedicated to making ME/CFS, Long Covid, and associated conditions widely understood, diagnosable, and treatable. Solve invests in translational research essential to turning biological discoveries into real-world therapies. Simmaron is a non-profit research center dedicated to developing treatments for ME/CFS and Long Covid. Simmaron is focused on developing 1st-in-kind animal models, finding key treatable mechanisms, and defining subsets aimed at changing the lack of evidence-based treatments for patients. Leading its Catalyst Award-winning project will be Dr. C. Gunnar Gottschalk (Simmaron, PI and chief executive officer), Dr. David Kaufman (Center for Complex Diseases, founder), Dr. Stephanie Grach, MD (Mayo Clinic), and Dr. Avik Roy (Simmaron, chief scientific officer). The Solve ME/CFS Catalyst Awards are a focused initiative to ensure that promising research doesn't lose momentum—especially in the face of unpredictable federal funding cycles. These awards provide strategic support to help studies reach key milestones such as publication, translation to clinical application, or advancement to the next phase of investigation. Solve President and CEO Emily Taylor noted, "We are so proud to support this bold and rigorously designed study that not only builds on promising biological insights but also advances an already FDA-approved drug as a potential treatment. This is exactly the kind of patient-centered, translational science our community needs. Our Catalyst Award will enable Simmaron to enroll more participants and collect more samples from more time points, making real movement toward meaningful care." In 2022, Solve awarded Dr. Avik Roy a Ramsay Research Grant to study how symptoms of ME/CFS relate to problems with autophagy. Autophagy is the cellular process of clearing unwanted debris (like unnecessary proteins or damaged mitochondria). With Dr. Roy's Ramsay Research Grant funds, follow-up funds from the NIH, and substantial investment by Simmaron's private donors, the Simmaron team showed that a subset of people with ME/CFS have problems with muscle-cell autophagy and that these problems increase post-exertional malaise. They established animal models for studying autophagy and post-exertional malaise (PEM) in the context of ME/CFS and started a multicenter clinical trial to test whether they could repurpose the drug rapamycin (an FDA-approved drug that reverses problems with autophagy) for reducing post-exertional malaise and cognitive dysfunction in the subset of people with autophagy-related symptoms. Before announcing the Catalyst Award funding, Solve supported this trial by helping recruit participants. A key strength of the study is tracking autophagy biomarkers to determine if these markers will help predict patients most likely to respond to this treatment. Early results from almost 80 participants are highly encouraging—rapamycin treatment is significantly lowering fatigue, post-exertional malaise, orthostatic intolerance, and sleep issues for participants. Now, Solve is awarding the research team more funds to enroll more participants and to collect more samples from more time points. "This funding from Solve M.E. will help us continue enrollment in our ongoing expanded phase in collaboration with AgelessRx and cover the cost of study drug and safety labs in this decentralized study," noted Simmaron CEO Dr. C. Gunnar Gottschalk. "Our goal is to develop a predictive test to identify which patients are more likely to benefit from rapamycin or other mTOR-targeted therapies." Solve has a long history of funding innovative research projects in pursuit of treatments and cures for ME/CFS and associated conditions. Through its Ramsay Research Grant Program, Solve M.E. has supported nearly 100 early-career investigators with seed funding—yielding a 34x return on investment in follow-on grants and external funding. Now, with its Catalyst Award program, Solve is helping existing studies reach completion faster. The 2025 Catalyst Awards reflect Solve M.E.'s continued dedication to accelerating scientific breakthroughs, bridging research between ME/CFS and Long Covid, and delivering hope and impact to millions worldwide. Learn more about the Catalyst Award to Simmaron here. Solve will host Simmaron CEO Dr. C. Gunnar Gottschalk and Dr. Avik Roy (Simmaron, chief scientific officer) for a free webinar about their Catalyst Award-winning rapamycin study on Thursday, September 4th at 3 pm PT /6 pm ET. Register here. About Solve M.E.:The Solve ME/CFS Initiative (Solve M.E.) is a non-profit organization that serves as a catalyst for critical research into diagnostics, treatments, and cures for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Long Covid, and other infection-associated chronic conditions and illnesses (IACCIs). Our work with the scientific, medical, and pharmaceutical communities, advocacy with government agencies, and alliances with patient groups around the world are laying the foundation for breakthroughs that can improve the lives of millions who suffer from various "long haul" diseases. For more information, visit About Simmaron Research:Simmaron Research is a 501c3 non-profit organization based in Incline Village, Nevada, with laboratory facilities at the University of Wisconsin Milwaukee. The foundation unites patients, doctors, and scientists in a quest for breakthroughs in ME/CFS, Long-Covid & neuroimmune disease. Simmaron drives treatment-focused research, identifying key treatable mechanisms and building groundbreaking animal models, all in a strategic effort to spur discovery and attract pharmaceutical investment in treatments. For more information, visit View original content to download multimedia: SOURCE Solve M.E. Sign in to access your portfolio
