Latest news with #StephanMartin
Yahoo
22-07-2025
- Health
- Yahoo
Study: Lost weight rebounds quickly after stopping weight-loss jabs
Yahoo is using AI to generate takeaways from this article. This means the info may not always match what's in the article. Reporting mistakes helps us improve the experience. Yahoo is using AI to generate takeaways from this article. This means the info may not always match what's in the article. Reporting mistakes helps us improve the experience. Yahoo is using AI to generate takeaways from this article. This means the info may not always match what's in the article. Reporting mistakes helps us improve the experience. Generate Key Takeaways Doctors around the world have been hailing "miracle" medications that make weight loss far easier, but new research suggests that after a person stops taking certain drugs, the weight tends to increase again rather quickly. People who received the medication lost significant weight during the therapy, and this even continued to a small extent for a few weeks after stopping the medication, according to a research team led by Han Wu and Wenjia Yang from Peking University People's Hospital. However, from the eighth week after the end of therapy, researchers said there was a marked weight gain that persisted for many weeks. The extent of weight gain varies depending on the medication and lifestyle changes, according to the study, but there is a clear trend towards weight gain after stopping the medication. This confirms existing findings, according to Stephan Martin, chief physician for diabetology and director of the West German Diabetes and Health Centre at the Association of Catholic Clinics in Düsseldorf, Germany. He said that some manufacturers of the medications had also demonstrated this themselves through randomized studies. Test subjects were given the active substances for 10 weeks, after which some were switched to a placebo. This group "then continuously regained weight," Martin reported. In the current study, the researchers from Beijing also referred to an investigation in which people who had completed a 36-week treatment with the active substance tirzepatide (GLP-1-RA) regained about half of the weight they had previously lost within a year of switching to a placebo. The newly published meta-analysis summarised the results of 11 independent studies from around the world, including those on the drug orlistat, the combinations naltrexone/bupropion and phentermine/topiramate, as well as the group of GLP-1 receptor agonists. The data came from a total of 1,574 people in treatment groups and 893 in control groups. GLP-1 receptor agonists (GLP-1-RA) are included in popular medications such as Wegovy and Ozempic. In some countries, they are approved for type 2 diabetes and some cases of obesity, and they are known as lifestyle drugs for achieving a slim figure. These active substances, which are injected regularly, primarily prolong the time food stays in the digestive tract, thereby increasing the feeling of satiety. Side effects include gastrointestinal complaints. One aspect of the study stands out: Those who initially experienced significant weight loss during therapy tended to regain more weight afterwards, even if they participated in programmes to change their lifestyle, such as eating and exercise habits. "This does not surprise me," says Anja Hilbert, professor of behavioural medicine at Germany's Leipzig University Hospital. Similar experiences are seen, for example, in people who follow a very low-calorie diet — they also tend to regain more weight after the diet ends than those who undergo moderate calorie limits. However, the expert noted that there were only a few participants for this aspect of the study. "The results of the study actually suggest that long-term, perhaps even lifelong use of the medication may be necessary to stabilise weight," Hilbert says. "It is a long-term therapy," diabetologist Martin emphasizes. Anyone who believes they can lose weight with this therapy and then everything will be fine is mistaken. "You need this therapy permanently." Some in the US health care system have raised concerns that many people may not be aware of this or may accept it. According to studies, two-thirds of people treated for obesity, most of whom pay for the treatment themselves, stopped using the medication within a year. "We don't know why: Maybe it becomes too expensive, maybe they have lost enough weight and believe it will now stay off," says Martin, who advocates for more overweight prevention rather than treating the consequences.
Medscape
17-06-2025
- Health
- Medscape
Weight Loss in 40s or 50s? Slash Your Chronic Disease Risk
People who reduce excess weight in midlife can roughly halve their risk of developing chronic disease later in life. That's the conclusion of three long-term studies from the UK and Finland, analyzed by a team led by Timo E. Strandberg, MD, PhD, professor of geriatrics at the University of Helsinki, Helsinki, Finland, and chief physician at its university hospital. The findings, based on more than 23,000 participants, were published in JAMA Network Open . Although the negative effects of obesity on health are well known, 'Few studies have examined long-term health benefits among individuals with sustained weight loss beyond its association with decreased diabetes risk,' wrote Strandberg and colleagues. Their analysis also looked at heart attack, stroke, cancer, asthma, chronic obstructive pulmonary disease, and overall mortality. No Weight-Loss Drugs or Surgery Needed 'This publication again powerfully demonstrates that people have a large degree of control over their own health and can protect themselves from many illnesses — including age-related diseases — by preventing or reducing excess weight,' said Stephan Martin, MD, chief physician for diabetology of the Catholic Hospital Group Düsseldorf and director of the West-German Centre of Diabetes and Health, Düsseldorf, Germany, in an interview with Medscape's German edition . 'Another encouraging takeaway is that these results were achieved without weight-loss injections or surgical interventions,' Martin added. Commenting on the analysis, Ga Eun Nam, MD, PhD, of Korea University College of Medicine in Seoul, Republic of Korea, and Yong-Moon Park, MD, PhD, of the University of Arkansas for Medical Sciences in Little Rock, Arkansas, noted that individuals who reached a healthy weight in midlife had long-term health outcomes comparable with those who maintained a healthy weight throughout adulthood. Martin put it more simply: 'It's always worth losing weight.' Even those who reach a normal weight at 50 — or later — can still see health benefits. Follow-Up Spanning Several Decades Strandberg and his team evaluated three longitudinal studies that included repeated measurements of height and weight: The Whitehall II Study, launched in 1985 (4118 participants; 72.1% men) The Helsinki Businessmen Study, launched in 1964 (2335 male participants) The Finnish Public Sector Study, with data starting from 2000 (16,696 participants; 82.6% women) The follow-up periods ranged from 12 to 35 years. Participants, with an average starting age of about 40, were divided into four groups: Those with consistently normal weight (BMI < 25) Those who reduced from overweight to normal weight Those who gained weight (normal to overweight) Those who remained overweight (BMI ≥ 25) Diabetes Risk Not the Only One Reduced In the Whitehall II Study, with an average follow-up of 22.8 years, a BMI reduction from ≥ 25 to < 25 over approximately 6 years in midlife was associated with a lower risk of developing chronic diseases. After adjusting for potential confounders such as smoking, blood pressure, and lipid levels, the researchers calculated a 48% lower risk for chronic illness compared to those who remained overweight. Remarkably, this association held even after excluding participants who developed diabetes during follow-up. In that case, the risk reduction was 42%. The Finnish Public Sector Study, with a 12.2-year follow-up, confirmed the findings, showing a 57% reduced risk for chronic illness. Effects Independent of Gender and Hormonal Status The Helsinki Businessmen Study, which had the longest follow-up (up to 43 years; mean, 35 years), showed that weight loss in midlife was associated with a 19% reduction in overall mortality. Separate analyses by sex revealed that the association held for both men and women. Even menopausal status did not significantly affect the outcomes: Similar protective effects were observed in women younger and older than 50 years. Midlife as a Critical Window for Intervention 'As we continue facing the global obesity epidemic, this study provides valuable epidemiologic evidence on long-term associations between weight management and major health outcomes,' wrote Nam and Park. While further research is needed to refine intervention strategies, 'these results highlight midlife as a potentially critical window for weight management and reinforce the importance of sustained weight management in chronic disease prevention and longevity.' The study was conducted in a time when neither surgical nor pharmacologic weight loss interventions were common. 'Sustained midlife weight loss compared with persistent overweight was associated with a decreased risk of chronic diseases beyond type 2 diabetes and decreased all-cause mortality,' Strandberg and colleagues concluded. Diet as the Main Lever Martin said the findings confirm the importance of lifestyle in achieving and maintaining a healthy weight. 'Most chronic diseases caused by obesity stem from lack of physical activity and poor diet,' he noted. Foods that spike blood glucose and insulin levels should be avoided. 'Insulin inhibits fat breakdown, so it contributes to weight gain,' he explained. A long-term strategy for staying lean and healthy, Martin said, includes minimizing intake of white bread, fries, chips, chocolate, soda, and other highly processed foods.
Yahoo
26-02-2025
- Science
- Yahoo
Here's Your Chance To See Every Planet In Our Solar System At The Same Time
This week presents a unique chance to see all of the seven other planets in our solar system in the sky at the same time. "What an opportunity to get outside, spend some time with your family, out in nature, underneath the night sky, communing with the universe," astronomer Stephan Martin said in a recent interview. (MORE: Astronomers Explain NASA's 2032 Asteroid Projections) Mars, Jupiter, Venus, Mercury and Saturn are potentially visible to the naked eye, but Mercury will be the hardest of those to spot. For Uranus and Neptune, you'll need binoculars or a telescope. "So what people will notice is that all the planets will be lined up almost like pearls on a string across the sky," said Martin. "In terms of alignment, they're all going to appear to be in a line because that's the line called the ecliptic, that the planets, the sun, the moon all follow because our solar system orbits the sun on the same plane, and we see that plane as a line throughout the sky." This parade of planetswill peak Friday night, with the best time to look being around sunset, or just after 6 p.m. EST. You'll need to look toward the western horizon, and those with a view low in the sky will have the best chance to spot the most planets. (MORE: When To See The Blood Moon) Of course, it all depends on the weather. From digital meteorologist Jonathan Belles: The bigger trouble spots for the planetary parade are going to be the Northeast and somewhere in the Southwest. Northeast: A quick-moving clipper system will slide from the Great Lakes to the Interior Northeast during the evening. Portions of the upper Midwest and Northern Plains may also have some leftover cloud cover. A low-pressure system and related jet stream will push clouds across parts of the Southwest and perhaps parts of Texas and Florida. This forecast is less certain being four days out. Some of the models have the system in California while others are in Nevada or New Mexico. Also, the stream of clouds that comes with the jet stream has some uncertainties: How far north will the clouds reach and will there be enough moisture for clouds closer to the Gulf? Stephan Martin was interviewed by producer and editor Caroline Aylward. senior writer Jan Childs covers breaking news and features related to weather, space, climate change, the environment and everything in between.
