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Veradigm Advances GLP-1 Real-World Evidence Generation with AI-Driven EHR Data Curation
Veradigm Advances GLP-1 Real-World Evidence Generation with AI-Driven EHR Data Curation

Business Wire

time12-05-2025

  • Health
  • Business Wire

Veradigm Advances GLP-1 Real-World Evidence Generation with AI-Driven EHR Data Curation

CHICAGO--(BUSINESS WIRE)-- Veradigm ® (OTCMKTS: MDRX), a leading provider of healthcare data and technology solutions, announced today an advancement in the use of artificial intelligence (AI) to scale the generation of real-world evidence (RWE) for GLP-1 receptor agonists (GLP-1 RAs), including semaglutide and tirzepatide. By applying AI to electronic health record (EHR) deidentified data within the Veradigm Network, researchers can now surface rich, contextual insights—such as side effects, discontinuation reasons, and social determinants of health (SDoH)—that traditionally required intensive manual curation. 'AI-powered curation allows us to unlock clinically meaningful insights from millions of patient records—insights that have traditionally been hidden in unstructured and semi-structured fields of EHR systems." -Stuart Green, SVP & GM Veradigm Life Sciences Share GLP-1 therapies are transforming the management of type 2 diabetes and obesity, yet significant gaps remain in understanding real-world usage, especially in identifying reasons for discontinuation or capturing side effects hidden in physician notes. Veradigm's AI-driven approach enables scalable extraction of clinical signals from unstructured data, offering life science organizations deeper, real-time insight into patient experiences and outcomes. 'AI-powered curation allows us to unlock clinically meaningful insights from millions of patient records—insights that have traditionally been hidden in unstructured and semi-structured fields of EHR systems,' said Stuart Green, SVP & General Manager, Veradigm Life Sciences. 'This is especially critical for GLP-1 therapies, where understanding why patients discontinue, or which side effects matter most can significantly improve patient outcomes and therapeutic strategy.' Key Capabilities and Insights from Veradigm's AI-Driven Curation Include: Discontinuation Drivers – Automatically extracts reasons for stopping therapy (e.g., side effects, cost, perceived inefficacy) from clinician notes Side Effects Monitoring – Detects and stratifies severity of gastrointestinal and side effects, such as gallbladder issues or psychiatric symptoms, through contextual analysis of progress notes Off-Brand Use Identification – Flags mentions of compounded or unapproved formulations (e.g., 'semaglutide from weight-loss clinic'), supporting safety and market surveillance Outcome Tracking – Tracks comorbidities (e.g., cardiovascular events) and treatment responses not typically captured in structured EHR fields Social and Behavioral Context – Surfaces SDoH that influence adherence and health outcomes This new offering leverages the national footprint of Veradigm Network EHR Data, capturing both structured and unstructured data across diverse patient populations and geographies. By pairing AI with clinical validation, Veradigm ensures data accuracy and applicability for life science research, regulatory engagement, and value-based decision-making. Veradigm will present a research poster based on this data at ISPOR 2025 during Poster Session 2 on Wednesday, May 14, from 4:00–7:00 PM EDT. The poster will focus on GLP-1 persistence and the real-world reasons for therapy discontinuation. To learn more, view the poster abstract. About Veradigm® Veradigm is a healthcare technology company that drives value through its unique combination of platforms, data, expertise, connectivity, and scale. The Veradigm Network features a dynamic community of solutions and partners providing advanced insights, technology, and data-driven solutions for the healthcare provider, payer, and biopharma markets. For more information about how Veradigm is fulfilling its mission of Transforming Health, Insightfully, visit or find Veradigm on LinkedIn, Facebook, Twitter, Instagram, and YouTube. © 2025 Veradigm LLC and/or its affiliates. All rights reserved. Cited marks are the property of Veradigm LLC and/or its affiliates. All other product or company names are the property of their respective holders, all rights reserved.

Major intersection closure will divert 3 downtown streetcar routes all summer
Major intersection closure will divert 3 downtown streetcar routes all summer

CBC

time06-05-2025

  • CBC

Major intersection closure will divert 3 downtown streetcar routes all summer

Toronto's construction season is officially here, and with it comes new headaches for transit users on some of the city's busiest streetcar routes. On Sunday, a major rehabilitation project will get underway at the intersection of King Street E. and Church Street. The city will be tearing up the road and sidewalks to replace aging watermains, and the TTC will use that opportunity to do upgrades to streetcar tracks and other critical infrastructure. The work is expected to last until early September. That means diversions for three streetcar routes: 504/304 King, 503/303 Kingston Road and 508 Lake Shore. Collectively, more than 100,000 people ride these routes daily. "We absolutely understand that there is going to be inconvenience and that is frustrating, we get that," TTC spokesperson Stuart Green said Tuesday. The transit agency estimates the closure of the intersection will add roughly five minutes to the average trip on those streetcar routes for riders heading into and out of the downtown core, though that figure could fluctuate depending on the time of day. "As I say, it's that short-term pain for the longer-term gain that gives stability to both city infrastructure and TTC infrastructure," Green told CBC Radio's Metro Morning. Streetcars on the three impacted routes will be diverting in both directions on Queen, Richmond and Adelaide streets via York and Church streets. The diversions are in place between Spadina Avenue in the west and Broadview Avenue in the east. For the first six weeks or so of the project, the intersection of King and Church will remain open to vehicle traffic, so replacement buses will run along King from both the Distillery District and Broadview Station, all the way west to the Dufferin Gate Loop. If this is all a bit confusing, you can learn more from the TTC about the project timeline and diversions here and here. Green said the city will provide traffic wardens during the initial phases of the project to help avoid streetcar "bunching" (that's when a whole load of streetcars start stacking up at a particular stop) and keep traffic flowing as best as possible. "This will particularly be an issue during the afternoon and morning rush hours when we have more vehicles on the road," he said. "If things just aren't working, we will go in and we will readjust. We have the ability to be a bit flexible and we will keep an eye on things at the beginning." Asked why the TTC doesn't spread out its infrastructure upgrades over a longer period of time to limit the duration of any single closure or diversion, Green said it's become clear that finishing the complex work in one go is preferable for everyone.

Genting pledges £9.8 million for Westcliff casino restoration after Raac discovery
Genting pledges £9.8 million for Westcliff casino restoration after Raac discovery

Yahoo

time03-05-2025

  • Business
  • Yahoo

Genting pledges £9.8 million for Westcliff casino restoration after Raac discovery

A much-loved casino has pledged £9.8 million for the restoration of its venue in Westcliff after the discovery of crumbling concrete. Genting Casino has unveiled plans for a major refurbishment of its Westcliff site, committing nearly £10 million to ensure the venue's future. This comes after the presence of potentially dangerous RAAC (Reinforced Autoclaved Aerated Concrete) was found in its roof. Despite the scale of the works, the casino remains fully open to customers, with the restoration carefully phased to maintain access to gaming, dining, and live entertainment. Bookings are still currently being taken for forthcoming live events, including the Show Me Love Brunch on May 3 and a Take That Tribute on June 13. However, works are expected to continue until early 2026. Stuart Green, general manager of Genting Casino Westcliff, said: "We are delighted that we can continue to keep the casino open throughout the building works and offer customers the high-quality experience they associate with Westcliff, featuring the best in hospitality and entertainment. "Genting's financial commitment to the project is very welcome and will allow us to deliver an amazing outcome which we are sure our customers will love. "The project is running according to plan, and we look forward to sharing the first images of the new-look casino in the coming months." The first phase of the project is likely to be completed by the end of July. Building work is scheduled for weekday working hours to minimise the impact during evenings and at weekends when the casino is at its busiest. There are likely to be two single-day car park closures in June, which will be announced in due course. The restoration project aims to give Westcliff a stunning makeover, with popular performers set to entertain customers in an immersive lounge as the project moves into its second phase. The casino, which was built in the 1970s, has been serving the city of Southend for decades.

Tired of slow zones on the TTC? There could be more identified soon
Tired of slow zones on the TTC? There could be more identified soon

CBC

time26-04-2025

  • CBC

Tired of slow zones on the TTC? There could be more identified soon

The TTC is gearing up for another one of its annual track surveys meant to spot minor defects before they balloon into bigger issues, and help bring tracks across the transit system back to industry standard. Journalists were invited along to watch the preparations for this year's geometric track survey set to begin next week. "While we have no idea how many minor defects the survey might find (or slow zones may result), we assume it will find some," TTC spokesperson Stuart Green said in an email ahead of the tour. Last year's survey resulted in dozens of new slow zones being implemented to bring tracks across the transit system back to industry standard, while critics doubt whether more could be done to prevent the slow zones entirely. The number of slow zones has been reduced from 33 last summer to 12, but the Green already warned earlier this year that number will "never be zero." Trains drop down to 15 to 25 kilometres per hour in each slow zone, slowing down the service by two minutes per zone. How does a track survey work? During the survey, a specialized device takes laser-guided measurements of the distance between two rails on a track, as well as the elevation and wear and tear on the tracks — all to identify issues that wouldn't have been visible during a typical inspection, like a track misalignment as small as a few millimetres. The TTC started doing the survey in 2015, mapping out the whole subway network stretching over 140 kilometres. Slow zones could be placed in sections where the survey finds the track geometry falls outside the standard. The TTC says it will collect data twice on each line, something that will be done outside service hours on Line 1, but not for Lines 2 and 4. Each survey costs around $250,000 US, or about $347,000 Cdn., according to Fort Monaco, the TTC's chief operations and infrastructure officer. "We want more trains, we want more people, we want tighter headways. That comes at the cost of deterioration of assets," he said. The survey will kickstart April 28 and is expected to wrap up on May 5, according to the TTC. But the track survey might not be a cure-all for detecting issues that exist across the system. The TTC's maintenance reporting system was called out last year in a commissioned report, saying the system didn't properly document when certain components of its fleet needed to be inspected, maintained, or replaced. The TTC accepted all of the report's recommendations, according to staff. Critics say slow zones can't go on The slow zones are meant to reduce wear and tear so small deficiencies found along the tracks are less likely to turn into issues that cause bigger disruptions. The TTC says they try to prioritize areas where tracks can be fixed quickly and leverage weekend closures to limit the number of slow zones riders need to sit through. But Chloe Tangpongprush, a spokesperson for the advocacy group TTCriders, says riders are fed up with the state of despair. "These subway slow zones impact hundreds of thousands of riders every day, and it cannot be the new normal," she said. Monaco of the TTC says how long slow zones last depends on the severity of the issue, but the transit agency looks to clear them within an average of 22 to 25 days. He says Toronto can get to a world with zero slow zones if it took inspiration from cities like Boston, where the subway service can shut down for as long as three weeks for repairs — much longer than the weekend closures the TTC currently has. "I think the point is we need to increase our maintenance window and be a little bit more creative," he said. The TTC has long been plagued by maintenance issues. From the trains on Line 2 that will soon celebrate their 30th birthday, aging and faulty equipment causing fuel spills, and cracks in concrete that contribute to flooding, quite a lot of the TTC is aging as the transit system faces a roughly $8.2-billion repair backlog. That figure could go down by nearly 50 per cent, thanks to new sources of funding in this year's budget, according to an annual progress report. Tangpongprush said there's a need for more funding to repair the system as she appealed to federal parties to prioritize public transit ahead of election day. "We're asking for the federal government to chip in," she said. As the aging trains on Line 2 approach the end of their useful life, the city recently reached an agreement with the federal and provincial government to split the $2.3-billion bill for new ones.

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