Latest news with #SwissArmy
Business Wire
3 days ago
- Business
- Business Wire
Bruker Launches Revolutionary timsOmni TM Mass Spectrometer
BALTIMORE--(BUSINESS WIRE)--For the 73 rd Conference on Mass Spectrometry and Allied Topics (ASMS), Bruker Corporation (Nasdaq: BRKR) announced the launch of the timsOmni™ system, a transformative new timsTOF-based mass spectrometer designed for scientific, drug discovery, and clinical researchers, as well as for advanced QC on biologics, offering deep structural insights into the functional or pathological proteoforms or oligonucleotides. Multimodal eXd trapping with precise electron energy control, ion accumulation, and reaction time regulation is a cornerstone innovation of the timsOmni™ platform. This also enables CIU, further expanding the value of proteoform CCS information, followed by multiple electron-based (ECD, EID) and collision-based (CID) fragmentation techniques. The timsOmni uniquely enables protein researchers and biologics developers to tailor information-rich dissociation pathways for deeper insights - with high speed and high sensitivity. The 'Swiss-army knife' type flexibility of the timsOmni top-down capability enables the identification of low-abundant, aberrant proteoforms, the structurally altered versions of proteins arising from genetic mutations, alternative splicing, or post-translational modifications that deviate from normal physiological forms, disrupting protein function, misfolding, or aggregation, and often play critical roles in the onset and progression of human diseases, including cancer, neurodegeneration, cardiovascular disorders, and autoimmune conditions. Anders Giessing, PhD, Science Manager at Novonesis in Denmark, said, 'We use intact protein mass analysis to ensure performance, stability, and consistency of our diverse protein product portfolio. Introduction of the timsOmni, with its Swiss Army knife versatility, redefines intact mass and top-down analysis with the precision, speed, and confidence needed to provide definitive analytical support in the development and production of industrial enzymes.' The Omnitrap's signature high-sensitivity, high-speed, multimodal eXd capability is particularly powerful for mapping PTMs, such as histone proteoforms (H3:1K14ac) that play a crucial role in regulating gene expression by altering chromatin structure and controlling access to the DNA. Other PTMs like glycosylation critically influence protein folding, stability, transport, and cell signaling interactions, and detailed top-down or middle-down sequencing of complementarity-determining regions (CDRs) in humoral and therapeutic antibodies are important in cancer, autoimmunity and biologics development. Prof. Albert Heck, Professor of Chemistry and Pharmaceutical Sciences at Utrecht University and Scientific Director of the Netherlands Proteomics Center, commented, 'Proteomics will finally go 'protein-centric' by using the timsOmni. The multimodal eXd capability allows for comprehensive ion sequence ladders that are ideal for de novo sequencing and human plasma antibody repertoire profiling. Analyzing and monitoring circulating antibody levels is critical for characterizing the progression of a disease, identifying patients with delayed symptom onset, and predicting potential long-term immunity.' Frank H. Laukien, Ph.D., the CEO of Bruker Corporation, added, 'The timsOmni is a new lamppost for functional protein science, shining a light on functional and pathological proteoforms and truly enabling a new protein science paradigm for fundamental cell and molecular biology, signal transduction, cancer, neurodegeneration, and other disease research. The timsOmni will also be extremely valuable for biopharma drug discovery and development, as well as for biologics QC analysis, from therapeutic antibodies to antibody-drug conjugates.' The timsOmni is supported by OmniScape™, Bruker's next-generation top-down proteomics software that features state-of-the-art algorithms for de-isotoping complex spectra, automated charge state assignment, de novo protein sequencing support, and sequence confirmation. These key features provide unrivaled benefits for the accurate identification of proteoforms, post-translational modifications, and non-canonical proteins. OmniScape transforms complex eXd fragmentation spectra into actionable biological insights—empowering researchers to navigate the new world of functional proteoformics. Prof. Ole N. Jensen, Group Leader at the Protein Research Group of the University of Southern Denmark, observed, 'The timsOmni technology and OmniScape software already impacted our strategies for intact protein and proteoform analysis. Multimodal MS/MS fragmentation and MS3 afford very high amino acid sequence coverage and accurate localization of post-translational modifications in histones.' The timsOmni comes with the new NEOS off-line nanoESI for the extremely low infusion flow rates required for the study of protein complexes, allowing for extended analysis of scarce samples. The NEOS source works with coated and non-coated emitters. Additionally, the timsOmni retains the high sensitivity of the timsTOF Ultra 2 for nLC dia-PASEF high-throughput bottom-up 4D-proteomics. The timsOmni ushers in a new era of functional proteomics, setting the stage for landmark discoveries in ' Proteoformics ', and advancing a transformative new paradigm in protein research as it illuminates protein function through the deep sequencing of proteoforms, humoral and multi-specific antibodies, and other complex biomolecules. About Bruker Corporation – Leader of the Post-Genomic Era (Nasdaq: BRKR) Bruker is enabling scientists and engineers to make breakthrough post-genomic discoveries and develop new applications that improve the quality of human life. Bruker's high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular, and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity, and customer success in post-genomic life science molecular and cell biology research, in applied and biopharma applications, in microscopy and nanoanalysis, as well as in industrial and cleantech research, and next-gen semiconductor metrology in support of AI. Bruker offers differentiated, high-value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. For more information, please visit
Free Malaysia Today
3 days ago
- Climate
- Free Malaysia Today
Army searches for missing man after glacier debris buries Swiss village
Three rescue specialists were airlifted to the site, and the Swiss army has also been deployed to assist. (AP pic) WILER : The army was deployed and rescue specialists were airlifted in to search for a man still missing today after a huge chunk of glacier crashed down a mountain in Switzerland, burying much of a picturesque Swiss Alpine village. Blatten had already been evacuated more than a week earlier when part of the mountain behind the Birch glacier began to crumble but a 64-year-old man was thought to have been in the area of the deluge of ice, mud and rock on Wednesday. The debris has carved a grey gash into the wooded mountainside, stripping it bare of trees and leaving channels of water seeping over the mass of rock and earth below. A thin cloud of dust hung in the air over the Kleines Nesthorn mountain where the rockslide occurred and a helicopter buzzed overhead. Experts were concerned that the debris was blocking a nearby river, causing a new lake to form and posing a flood risk on top of the rest of the devastation. Three rescue specialists have been airlifted to the site, Swiss cantonal police and officials said. The army has also been deployed to the area to assist, they said. Swiss officials were struggling to come to terms with the scale of the landslide, which officials said blanketed around 90% of the village. 'This is the worst we could imagine. This event leaves us shocked,' Albert Roesti, the Swiss environment minister, said late on Wednesday at a press conference in the Valais canton, where the village is. The incident has revived concern about the impact of rising temperatures on Alpine permafrost, even if environmental experts have so far been cautious about attributing the glacier's collapse to the effects of climate change. The degeneration of part of the Birch glacier in the Loetschental valley occurred after sections of the mountain behind it began breaking off in the past few days, and ultimately brought down much of the ice mass with it. Christian Huggel, a professor of environment and climate at the University of Zurich, said that various factors were at play in Blatten where it was known that permafrost had been affected by warmer temperatures in the Alps. He added that the debris was damming up the Lonza river next to the village, saying this could pose a major challenge with up 1 million cubic meters of water accumulating there daily.
Time Business News
3 days ago
- Business
- Time Business News
What Is FEFCO 0201? A Complete Guide to the Most Popular Box Style in Packaging
Ever wondered about those sturdy boxes that keep your online orders safe? Meet FEFCO 0201, the unsung hero of the packaging world! This box style is like the Swiss Army knife of shipping containers – versatile, reliable, and found just about everywhere. Let's unpack why the FEFCO 0201 is such a big deal in the world of packaging and explore its impressive features that make it a favorite among businesses and consumers alike. Feature Description Design Simple rectangular box with folding flaps Versatility Suitable for various industries and product types Eco-friendliness Made from recyclable corrugated cardboard Cost-effectiveness Efficient production and storage Customization Available in various sizes and can be branded FEFCO stands for the European Federation of Corrugated Board Manufacturers. They're the folks who came up with a handy system to classify different box styles. The FEFCO 0201 is their star player – it's the most common box type you'll see in shipping and packaging, recognized globally for its efficiency and adaptability. Picture a simple rectangular box that can be folded flat. That's your FEFCO 0201! It's like origami for the packaging world – starts flat, but with a few folds, it's ready to protect your stuff. This design is a favorite because it's easy to make, store, and put together when needed. The genius of the FEFCO 0201 lies in its simplicity – it's a design that has stood the test of time and continues to meet the evolving needs of modern commerce. Let's break down what makes a FEFCO 0201 box special, examining its key components and structural features that contribute to its widespread use: Flaps: It has top and bottom flaps that fold to close the box. These flaps are crucial for creating a secure closure and protecting the contents inside. The design of these flaps allows for easy opening and closing, making it user-friendly for both packers and recipients. Score Lines: These are the creases that help the box fold neatly. Score lines are precision-engineered to ensure consistent folding and structural integrity. They allow the box to be collapsed flat for storage and transportation, saving valuable space in warehouses and during shipping. Dimensions: Can be made in pretty much any size you need! This flexibility is one of the FEFCO 0201's greatest strengths, allowing it to accommodate a wide range of products from small electronics to large appliances. Putting together a FEFCO 0201 box is a breeze. The flaps fold together like a puzzle, creating a secure package that's ready for shipping. This simple design is why it's so cost-effective to make and transport. The assembly process is intuitive, requiring minimal training for warehouse staff, which further contributes to its popularity in high-volume shipping operations. These boxes are everywhere! They're the go-to choice for many industries, showcasing their versatility and widespread adoption: E-commerce: Your online shopping probably comes in a FEFCO 0201. From books to clothing, these boxes are the backbone of online retail packaging, providing a balance of protection and cost-effectiveness for millions of daily shipments. Retail: Stores use them to stock and ship products. The FEFCO 0201's stackability makes it ideal for warehouse storage and easy transportation to retail outlets. Food Packaging: They keep your groceries safe and fresh. Many food items, especially those that don't require refrigeration, are packaged and shipped in FEFCO 0201 boxes due to their ability to protect contents from crushing and environmental factors. Electronics: Protecting delicate gadgets during shipping. The customizable nature of FEFCO 0201 boxes allows for the addition of internal cushioning or partitions, making them suitable for fragile electronic items. The FEFCO 0201 is like a chameleon – it can handle all sorts of items, from fragile glass to heavy books. That's why shipping companies love them for moving goods around the world. Its adaptability to different product types and sizes makes it a universal solution for packaging needs across various sectors. There are tons of reasons why businesses choose FEFCO 0201 boxes, making them a staple in the packaging industry: Cost-Effective: Simple design means cheaper production. The straightforward manufacturing process and efficient use of materials keep costs down, making FEFCO 0201 boxes an economical choice for businesses of all sizes. Strong and Durable: Keeps products safe during bumpy rides. The corrugated cardboard construction provides excellent protection against impacts and compression, ensuring that contents arrive intact. Eco-Friendly: Made from recyclable corrugated cardboard. In an era of increasing environmental awareness, the recyclable nature of FEFCO 0201 boxes aligns with sustainability goals and consumer preferences for eco-friendly packaging. These boxes are like the superheroes of the packaging world – they're tough, they're efficient, and they're kind to the planet. No wonder they're so popular! The combination of practical benefits and environmental responsibility makes FEFCO 0201 boxes a smart choice for businesses looking to optimize their packaging solutions. Choosing the right FEFCO 0201 box is like picking the perfect outfit – it needs to fit just right. Here are some expert tips to ensure you select the ideal box for your needs: Measure your product carefully. Consider not just the dimensions of your item, but also any additional space needed for protective packaging materials. Consider the weight of what you're shipping. Heavier items may require stronger corrugated cardboard or double-wall construction for added support. Think about how fragile your items are. Delicate products might benefit from custom inserts or additional padding within the FEFCO 0201 box. Factor in the shipping method and distance. Long-distance or international shipping might require more robust packaging to withstand extended handling and varying environmental conditions. You can even jazz up your FEFCO 0201 boxes with custom printing. Add your logo, some cool designs, or important information. It's like giving your box a makeover! Custom printing not only enhances brand visibility but can also include handling instructions or product information directly on the packaging. When it comes to materials, you've got options. Single-wall boxes are great for lighter items, while double-wall boxes offer extra protection for heavier or more delicate products. Check out Labelprint24's options to find the perfect fit for your needs. They offer a range of materials and customization options to ensure your FEFCO 0201 boxes meet your specific requirements. Let's see how the FEFCO 0201 stacks up against some other popular box styles, examining their unique features and best use cases: FEFCO 0401: This one has a lid and is great for heavier items. It offers enhanced stacking strength and is often used for archive storage or shipping bulky products. However, it's generally more expensive and less versatile than the 0201. FEFCO 0203: Similar to 0201, but with extra flaps for added strength. This design provides additional protection at the corners and edges, making it suitable for items that require a bit more cushioning. The trade-off is slightly more complex assembly and higher material costs. FEFCO 0427: A variation with a hinged lid, often used for display purposes or easy-access storage. While visually appealing and functional for certain applications, it's less suitable for shipping and more expensive to produce than the 0201. While these other styles have their place, the FEFCO 0201 remains the most versatile and widely used. It's like the Swiss Army knife of boxes – it can handle most jobs with ease. The 0201's balance of cost-effectiveness, ease of use, and adaptability makes it the go-to choice for a wide range of packaging needs across various industries. Box Style Strength Versatility Ease of Assembly Cost-Effectiveness Sustainability FEFCO 0201 Medium High Easy High High FEFCO 0401 High Medium Medium Medium High FEFCO 0203 High Medium Medium Medium High Ready to order some FEFCO 0201 boxes for your business? Here's a quick guide to help you navigate the procurement process: Decide on the size you need. Consider not just your product dimensions, but also any additional space required for protective materials or future growth in product sizes. Choose your material (single-wall or double-wall). This decision should be based on the weight and fragility of your products, as well as the shipping conditions they'll face. Figure out how many boxes you want. Consider ordering in bulk to take advantage of volume discounts, but be mindful of storage space and inventory turnover. Consider any custom printing or designs. This is an opportunity to enhance your brand visibility and provide important handling information directly on the packaging. Research suppliers and compare quotes. Look for manufacturers with a good reputation for quality and reliability in the packaging industry. Companies like Labelprint24 offer a range of FEFCO box options, including the 0201. They can help you customize your boxes to fit your exact needs, providing expert guidance on material selection, sizing, and custom printing options. When working with a supplier, don't hesitate to ask for samples or prototypes to ensure the boxes meet your quality standards before placing a large order. In today's world, being eco-friendly is super important. FEFCO 0201 boxes are leading the charge in sustainable packaging, aligning with global efforts to reduce environmental impact: Made from recyclable corrugated cardboard, which can be easily processed in most recycling facilities. Can be easily broken down and recycled after use, reducing waste in landfills. Often made from recycled materials themselves, contributing to a circular economy. The simple design minimizes material waste during production, further enhancing its eco-friendly profile. Lightweight nature reduces transportation emissions compared to heavier packaging alternatives. By choosing FEFCO 0201 boxes, you're not just getting great packaging – you're also doing your bit for the planet. It's a win-win! Many businesses are finding that using sustainable packaging like FEFCO 0201 boxes not only helps the environment but also resonates positively with environmentally conscious consumers, potentially boosting brand image and customer loyalty. So, there you have it – the FEFCO 0201 box in all its glory! It's the most popular box style for good reason, offering a combination of benefits that make it the go-to choice for businesses across various industries: Super versatile and can handle all sorts of products, from delicate electronics to robust hardware. Easy to make, store, and assemble, streamlining logistics and warehouse operations. Cost-effective for businesses of all sizes, offering a balance of quality and affordability. Environmentally friendly, aligning with growing consumer demand for sustainable packaging solutions. Customizable to fit specific product needs and branding requirements. Understanding FEFCO codes, especially the mighty 0201, is crucial for anyone in the packaging game. It helps you make smart choices that save money, protect products, and keep customers happy. The FEFCO 0201's widespread adoption across industries is a testament to its effectiveness and versatility in meeting diverse packaging needs. Next time you receive a package, take a moment to appreciate the humble FEFCO 0201 box. It's not just a box – it's a marvel of modern packaging engineering! Its simple yet effective design represents decades of innovation in the packaging industry, continuously evolving to meet the changing demands of global commerce and environmental responsibility. And if you're in the market for some top-notch packaging solutions, don't forget to check out what Labelprint24 has to offer. Your products (and the planet) will thank you! With their expertise in FEFCO box manufacturing and customization, you can find the perfect packaging solution tailored to your specific needs, ensuring your products are well-protected and your brand stands out in the competitive marketplace. TIME BUSINESS NEWS
Japan Times
3 days ago
- Climate
- Japan Times
Swiss residents in shock after glacier debris buries village
Residents struggled on Thursday to absorb the scale of devastation caused by a huge slab of glacier that buried most of their picturesque Swiss village, in what scientists suspect is a dramatic example of climate change's impact on the Alps. A deluge of millions of cubic meters of ice, mud and rock crashed down a mountain on Wednesday, engulfing the village of Blatten, and the few houses that remained were later flooded. Its 300 residents had already been evacuated earlier in May after part of the mountain behind the Birch Glacier began to crumble. Rescue teams with search dogs and thermal drone scans have continued looking for a missing 64-year-old man but have found nothing. Local authorities suspended the search on Thursday afternoon, saying the debris mounds were too unstable for now and warned of further rockfalls. With the Swiss army closely monitoring the situation, flooding worsened during the day as vast mounds of debris almost two kilometers across clogged the path of the River Lonza, causing a huge lake to form amid the wreckage and raising fears that the morass could dislodge. Debris and dust from a crumbling glacier that partially collapsed and tumbled onto the village of Blatten, Switzerland, on Thursday. | REUTERS Water levels have been rising by 80 centimeters an hour from the blocked river and melting glacier ice, Stephane Ganzer, head of the security division for the Valais canton, told reporters. Swiss President Karin Keller-Sutter is returning early from high-level talks in Ireland and will visit the site on Friday, her office said. "I don't want to talk just now. I lost everything yesterday. I hope you understand," said one middle-aged woman from Blatten, declining to give her name as she sat alone disconsolately in front of a church in the neighboring village of Wiler. Nearby, the road ran along the valley before ending abruptly at the mass of mud and debris now blanketing her own village. A thin cloud of dust hung in the air over the Kleines Nesthorn Mountain where the rockslide occurred while a helicopter buzzed overhead. A woman holds a sheep, which was carried by helicopter in Wiler, near Blatten, Switzerland, on Thursday. | REUTERS Werner Bellwald, a 65-year-old cultural studies expert, lost the wooden family house built in 1654 where he lived in Ried, a hamlet next to Blatten also wiped out by the deluge. "You can't tell that there was ever a settlement there," he said. "Things happened there that no one here thought were possible." The worst scenario would be that a wave of debris bursts the nearby Ferden Dam, Valais canton official Ganzer said. He added that the chances of this further mudslide were currently unlikely, noting that the dam had been emptied as a precaution so it could act as a buffer zone. Local authorities said that the buildings in Blatten that had emerged intact from the landslide are now flooded and that some residents of nearby villages had been evacuated. The army said around 50 personnel as well as water pumps, diggers and other heavy equipment were on standby to provide relief when it was safe. A crumbling glacier that partially collapsed and tumbled onto the village of Blatten, Switzerland, on Thursday. | REUTERS Authorities were airlifting livestock out of the area, said Jonas Jeitziner, a local official in Wiler, as a few sheep scrambled out of a container lowered from a helicopter. Asked how he felt about the future, he said, gazing towards the plain of mud: "Right now, the shock is so profound that one can't think about it yet." The catastrophe has revived concern about the impact of rising temperatures on Alpine permafrost where thawing has loosened some rock structures, creating new mountain hazards. For years, the Birch Glacier has been creeping down the mountainside, pressured by shifting debris near the summit. Matthias Huss, head of Glacier Monitoring in Switzerland, pointed to the likely influence of climate change in loosening the rock mass among the permafrost, which triggered the collapse. "Unexpected things happen at places that we have not seen for hundreds of years, most probably due to climate change," he said.
Irish Times
4 days ago
- Climate
- Irish Times
‘I lost everything': Swiss residents in shock after glacier debris buries village of Blatten
Swiss residents were struggling on Thursday to absorb the scale of devastation caused by a huge chunk of glacier that has buried most of their picturesque village, in what scientists suspect is a dramatic example of the impact of climate change on the Alps. A deluge of ice, mud and rock crashed down the mountain on Wednesday, engulfing some 90 per cent of the village of Blatten. Its 300 residents had already been evacuated earlier in May after part of the mountain behind the Birch Glacier began to crumble. However, rescue teams with search dogs were still scouring the area on Thursday for a missing 64-year-old man after an initial scan with thermal drones found nothing. As the Swiss army closely monitored the situation, some experts warned of the risks of flooding as vast mounds of debris almost two kilometres across were clogging the path of the River Lonza, causing a huge lake to swell amid the wreckage. READ MORE 'I don't want to talk just now, I lost everything yesterday. I hope you understand,' said one middle-aged woman from Blatten, declining to give her name as she sat alone in front of a church in the neighbouring village of Wiler. The scene on Thursday after the huge Birch Glacier collapsed the day before and destroyed the evacuated small village of Blatten in the Swiss Alps. Photograph: Fabrice Coffrini/AFP via Getty Images Nearby, the road ran along the valley before ending abruptly at the mass of mud and debris now blanketing her own village. Just a few roofs poked up through the sea of sludge. A thin cloud of dust hung in the air over the Kleines Nesthorn Mountain where the rockslide occurred, while a helicopter buzzed overhead. Martin Henzen, another Blatten resident, said he was still trying to process what had occurred and did not want to speak for others in the village, saying only: 'Most are calm, but they're obviously affected.' They had been making preparations for some kind of natural disaster but 'not for this scenario', he added, referring to the scale of destruction. But the immediate dangers might not be over. 'The water from the River Lonza cannot flow down the valley because there is an enormous plug,' Raphael Mayoraz, a cantonal geologist, told Swiss national broadcaster SRF. 'The worst case scenario is possible flooding.' Up to one million cubic meters of water are accumulating daily as a result of the debris damming up the river, said Christian Huggel, a professor of environment and climate at the University of Zurich. Matthias Ebener, a spokesman for local authorities, said some residents of neighbouring villages had been relocated as a precaution. The incident has revived concern about the impact of rising temperatures on Alpine permafrost, which has long frozen gravel and boulders in place, creating new mountain hazards. For years, the Birch Glacier has been creeping down the mountainside, pressured by shifting debris near the summit. Matthias Huss, head of Glacier Monitoring in Switzerland, pointed to the likely influence of climate change in loosening the rock mass in the permafrost zone, which triggered this week's collapse. 'Unexpected things happen at places that we have not seen for hundreds of years, most probably due to climate change,' he said. − Reuters
