Latest news with #Syndrome
Yahoo
4 days ago
- Business
- Yahoo
EXCLUSIVE: Telomir Pharmaceuticals Lead Drug Shows Promising Signs In Animal Study For Rare Premature Aging Disorder
Telomir Pharmaceuticals Inc. (NASDAQ:TELO) on Thursday released new preclinical data for its lead candidate, Telomir-1. The data demonstrated that Telomir-1, administered orally, significantly increases telomere length, reverses body weight and muscle loss, and resets cellular aging markers in a validated animal model of Werner Syndrome (WS)—a rare genetic disorder also known as adult-onset progeria. Adult progeria is a rare genetic disorder characterized by premature aging starting in late adolescence or early Syndrome is caused by mutations in the wrn gene, which plays a critical role in DNA repair and telomere maintenance. These findings confirm and build upon the company's previously reported results from a preclinical C. elegans study, which demonstrated that Telomir-1 restored lifespan and normalized physiological decline in animals with a wrn gene mutation. In this study, Telomir-1 reversed age-related hypomethylation at two chromosomal regions, restoring methylation patterns to above-normal wild-type levels. This suggests that Telomir-1 may help restore healthy gene regulation and reset the body's epigenetic aging clock, reducing the risk of dysfunction in key biological systems. Telomeres are the protective caps at the ends of chromosomes that shorten with each cell division and under stress. Telomere shortening is considered one of the hallmarks of aging. In the study, Telomir-1 increased telomere length by about three-fold compared to the shortened length in the mutated animals. At the higher dose, telomere length significantly exceeded wild-type (healthy) levels, suggesting restoration and potential enhancement of chromosomal integrity. In the wrn-mutant zebrafish model, animals exhibited a 50–60% reduction in body weight and muscle volume. After 14 days of Telomir-1 treatment, these physical markers were restored to levels statistically indistinguishable from healthy controls — indicating functional recovery and metabolic improvement. Reactive oxygen species (ROS), which damage cells and accelerate aging, were elevated in untreated animals. Telomir-1 reduced ROS levels by up to 50%, suggesting improved cellular resilience. Roughly 15% of untreated animals died during the 14-day study period, whereas no deaths occurred in any Telomir-1-treated groups. In March, Telomir Pharmaceuticals revealed preclinical findings demonstrating that Telomir-1 reduces tumor size by approximately 50% in a prostate cancer animal model with aggressive cancer cells. The company says that Telomir-1 actively suppresses cancer growth and protects against chemotherapy-induced toxicity and mortality when combined with Paclitaxel—a widely used chemotherapy but often associated with severe toxicity and side effects. Price Action: TELO stock closed at $2.11 on Wednesday. Read Next:Up Next: Transform your trading with Benzinga Edge's one-of-a-kind market trade ideas and tools. Click now to access unique insights that can set you ahead in today's competitive market. Get the latest stock analysis from Benzinga? This article EXCLUSIVE: Telomir Pharmaceuticals Lead Drug Shows Promising Signs In Animal Study For Rare Premature Aging Disorder originally appeared on © 2025 Benzinga does not provide investment advice. All rights reserved. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
22-05-2025
- Health
- Yahoo
Sens. Hickenlooper and Moran and Reps. DeGette and Hudson Reintroduce The DeOndra Dixon INCLUDE Project Act
Bipartisan Legislation for Transformative NIH Down Syndrome Research – A Legacy for GLOBAL Ambassador DeOndra Dixon Denver, May 22, 2025 (GLOBE NEWSWIRE) -- Sens. John Hickenlooper (D-CO) and Jerry Moran (R-KS) and Reps. Diana DeGette (D-CO) and Richard Hudson (R-NC) have reintroduced the DeOndra Dixon INCLUDE Project Act (S.1838/H.R. 3491). Also joining as original cosponsors are Sens. Cory Booker (D-NJ) and Markwayne Mullin (R-OK) and Reps. Tom Cole (R-OK), Rosa DeLauro (D-CT), Pete Stauber (R-MN), and Eleanor Holmes Norton (D-DC). The bill provides statutory authority for the trans-NIH INCLUDE 'Investigation of Co-occurring Conditions Across the Lifespan to Understand Down Syndrome' Project. As a result of Global Down Syndrome Foundation's advocacy, the INCLUDE Project was established in 2018 to investigate the co-occurring conditions that affect individuals with Down syndrome (e.g. Alzheimer's, autoimmune disorders) and their quality-of-life needs. It has focused on targeted research on chromosome 21, assembling a large study population of individuals with Down syndrome, and conducting clinical trials that include those with Down syndrome. 'Hundreds of thousands of Americans live with Down syndrome, and yet its research has been underfunded for decades,' says Senator Hickenlooper. 'This bill is named for my friend DeOndra Dixon, who lived a full, vibrant life and wanted the same for all people living with Down syndrome. We are determined to get this bill across the finish line for her, and for every American who will benefit from research on many different health conditions.' 'Research, supported by the NIH, has helped improve and extend the lives of individuals with Down syndrome, but there is still more to learn,' says Senator Moran. 'This legislation will invest in scientific studies on Down syndrome to help members of the Down syndrome community and their families find answers and solutions for the health challenges they face.' 'Down syndrome, the leading cause of developmental delay in the U.S. and worldwide, was the least funded genetic syndrome at the NIH for decades,' says Representative Diana DeGette. 'We have made tremendous strides in new federal investments in Down syndrome research to understand why those living with Down syndrome are so at risk for some diseases, such as Alzheimer's and autoimmune disorders, and protected from other diseases such as solid tumor cancers. Passage of the DeOndra Dixon INCLUDE Project Act will ensure these successful trans-NIH initiatives continue to make significant scientific advances to improve and extend the lives of people with Down syndrome and millions of other Americans as well.' 'People with Down syndrome enrich our world in many unique ways," says Representative Hudson. "The DeOndra Dixon INCLUDE Act ensures people with Down syndrome are valued, respected members of society and that NIH is supporting their health, enabling them to live their lives to their full potential – with no barriers or bias or obstacles standing in their way. I am honored to continue and grow research efforts so people with Down syndrome have the long and healthy lives they deserve.' The legislation is named in honor of the life and legacy of DeOndra Dixon, beloved Global Down Syndrome Foundation (GLOBAL) Ambassador and sister of Academy Award-winning and Grammy Award-winning talent Jamie Foxx. DeOndra was an inspiration behind GLOBAL's highest honor, the Quincy Jones Exceptional Advocacy Award and she traveled the world promoting awareness and advocacy. She was a talented dancer and musician who performed with her brother at the Grammy Awards. 'We are forever grateful to GLOBAL for creating such purpose for our little sister DeOndra,' says Jamie Foxx. 'My sister Deidra and I are so proud of the big difference she made through her advocacy in DC, and now with this bill she will continue to make a difference. There isn't a day that goes by that we don't miss her, but today I know she's dancing up in heaven because this legislation is named after her and will help millions of people with Down syndrome.' 'GLOBAL is truly overwhelmed by the strong bipartisan support for the DeOndra Dixon INCLUDE Project Act that will formally authorize the INCLUDE Project at the NIH and make the project more permanent,' says Michelle Sie Whitten, President and CEO of the Global Down Syndrome Foundation. 'We couldn't have come this far without the leadership of HELP Committee leaders Sens. John Hickenlooper and Markwayne Mullin, House Energy & Commerce leaders Reps. Richard Hudson and Diana DeGette, and our appropriation champions Reps. Tom Cole, Rosa DeLauro and Robert Aderholt. We also owe so much to Dr. Joaquin Espinosa for bringing scientific breakthroughs to the table, to Ambassador DeOndra's beautiful family, and to our original congressional champions, especially those who have children with Down syndrome such as Reps Cathy McMorris Rodgers, Pete Stauber and Eleanor Holmes Norton.' GLOBAL had advocated for a trans-National Institutes of Health (NIH) Down syndrome research program since its inception in 2009. In 2017, three GLOBAL leaders , including board member, Frank Stephens, testified at the hallmark House Appropriations Labor, Health and Human Services subcommittee hearing on Down syndrome research. Frank's testimony went viral that evening with 1 million views and today has over 200 million views. Shortly after the hearing, GLOBAL's long-time advocacy goal was fulfilled, and the NIH established the INCLUDE Project. Since the INCLUDE Project was established in 2018, the program has funded 389 unique awards within 21 of the 27 NIH institutes investing $434M. Thirteen of these institutes did not participate in Down syndrome research prior to this program. The INCLUDE Project has also supported the development of the clinical trial infrastructure. Prior to the program, there were only two NIH clinical trials focused on people with Down syndrome. In just seven years, the INCLUDE Project has funded fourteen promising clinical trials with possible immediate or short-term impact for people with Down syndrome. 'DSA of Central Oklahoma is a long-time supporter of the Global Down Syndrome Foundation, and their government advocacy work that resulted in the establishment of the trans-NIH Down syndrome research program called the INCLUDE Project,' says Sarah Soell, Executive Director of the Down Syndrome Association of Central Oklahoma. 'We know first-hand from our families that the increased research funding is making a difference. We see real progress in the treatment of the many co-occurring conditions that we see in people with Down syndrome, including autoimmune conditions, regression disorder, sleep apnea, Alzheimer's and more. Given the nearly twenty years of Down syndrome being the least funded genetic condition at the NIH prior to the INCLUDE Project, it is so important to pass this bill!' Formally authorizing the INCLUDE Project beyond an annual congressional directive will ensure that people with Down syndrome are not left behind when it comes to participating in clinical trials; it will improve health outcomes and improve their quality of life; and it will send a strong message that our society values and wants to invest in the future of our children and adults with Down syndrome and their families. GLOBAL urges advocates to contact Congress to urge them to co-sponsor and support passage of the DeOndra Dixon INCLUDE Project Act: GLOBAL Affiliate, the Crnic Institute for Down Syndrome, has multiple clinical trials specifically designed for persons with Down syndrome testing new therapies for Alzheimer's disease in Down syndrome, Down Syndrome Regression Disorder, and autoimmune conditions. To read about the impactful research that the INCLUDE Project has funded visit the NIH Down Syndrome Coordinating Center Website at: ### About Global Down Syndrome Foundation The Global Down Syndrome Foundation (GLOBAL) is the largest non-profit in the U.S. working to save lives and dramatically improve health outcomes for people with Down syndrome. GLOBAL has donated more than $32 million to establish the first Down syndrome research institute supporting over 400 scientists and over 2,700 patients with Down syndrome from 33 states and 10 countries. Working closely with Congress and the National Institutes of Health, GLOBAL is the lead advocacy organization in the U.S. for Down syndrome research and care. GLOBAL has a membership of over 100 Down syndrome organizations worldwide, and is part of a network of Affiliates – the Crnic Institute for Down Syndrome, the Sie Center for Down Syndrome, and the University of Colorado Alzheimer's and Cognition Center – all on the Anschutz Medical Campus. GLOBAL's widely circulated medical publications include Global Medical Care Guidelines for Adults with Down Syndrome, Prenatal & Newborn Down Syndrome Information and the award-winning magazine Down Syndrome WorldTM . GLOBAL also organizes the annual AcceptAbility Gala in Washington DC, and the annual Be Beautiful Be Yourself Fashion Show, the largest Down syndrome fundraiser in the world. Visit and follow us on social media (Facebook & Twitter: @GDSFoundation, Instagram: @globaldownsyndrome). ## end ## CONTACT: Anca E Call Global Down Syndrome Foundation (720) 320-3832 pr@ in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Indian Express
19-05-2025
- Health
- Indian Express
Second highest active cases in Maharashtra as Covid marks an uptick
Amid rising cases of Covid-19 across cities like Singapore and Hong Kong, Maharashtra has also recorded an uptick in active cases over the past week with the total number of cases logging a spike from 12 to 56 in one week. As of Monday, at least 257 active Covid cases have been recorded across the country with Maharashtra accounting for the second highest number of cases. At 95 active cases, the highest number of Covid cases have been reported in Kerala, wherein one death has also been reported. Speaking to The Indian Express, senior officials from the Brihanmumbai Municipal Corporation (BMC) confirmed that the cases of Covid have also registered a spike in Mumbai. 'While the cases have increased, the numbers are low and there is no cause for concern,' said Dr Daksha Shah, Executive Health officer at BMC. Recently, two deaths–of a 14-year-old woman and 54-year-old woman–were reported at the KEM hospital with some reports linking the mortality to Covid-19. However, the BMC on Monday clarified that the two patients died owing to serious comorbidity like Nephrotic Syndrome with Hypocalcemic seizures, cancers. The patients hailed from Sindhudurg and Dombivali. Even as officials maintained that no Covid deaths have been reported in the city thus far, the civic health department has enhanced its vigilance while increasing provision of special beds for the treatment of Covid patients. According to the BMC, 20 (MICU) beds have been reserved at Seven Hills hospital while 20 beds have been reserved for children and pregnant women each. At Kasturba hospital, meanwhile, two ICU beds and 10-beds in the ward have been earmarked for the treatment and guidance of Covid patients. Officials maintained that the capacity of beds will be increased across hospitals if the number of cases witness further spike. The spike in Covid cases have come at a time when the city is also experiencing an increase in the reports of respiratory ailments. 'Typically, Mumbai sees a rise in respiratory cases between March to May, besides November to December. However, since Covid tests are no longer a mandate, they are not conducted frequently unless someone specifically requires it,' an official from the civic health department told Express. Allaying fears, Dr Mohan Joshi, Dean, Sion Hospital, added, 'We are equipped with the essential drugs and testing labs. That said, there is no major cause for concern as nearly 99 per cent of our population have been vaccinated for Covid. Therefore, patients will largely experience mild symptoms like flarengitus.' Amid rising cases across the country, the Union health ministry on Monday said the cases reported in India are 'mostly mild, and 'not associated with unusual severity or mortality'. On Monday, the director general of health services chaired a meeting with experts from National Centre for Disease Control (NCDC), Emergency Medical Relief (EMR) division, the disaster management cell and Indian Council of Medical Research (ICMR) and Central government hospitals to take stock of the current situation. Maintaining that all cases are mild and require no hospitalisation, the Union health ministry said, 'A robust system for surveillance of respiratory viral illnesses including Covid-19 also exists in the country through the Integrated Disease Surveillance Programme (IDSP) and ICMR. The Union Health Ministry remains vigilant and proactive in monitoring the situation closely, ensuring that appropriate measures are in place to safeguard public health.'
Business Mayor
19-05-2025
- Entertainment
- Business Mayor
Eugene Daniels Talks Imposter Syndrome in Alma Mater Commencement Address (First Look)
Eugene Daniels departed Colorado State University in 2012 with a dream—and a B.A. in journalism. 13 years later, he's returning to his alma mater to address its graduating Class of 2025 as the co-host of MSNBC's The Weekend, one of the centerpieces of the network's revamped programming schedule. In between those tentpole life events, Daniels had a run at Politico and also served as president of the White House Correspondents' Association, emceeing its annual dinner this year. The long, challenging road to his current perch was one of the subjects that he addressed in his commencement speech. After exclusively revealing the news of Daniels' CSU return in March, TVNewser provides a first look at some of his prepared remarks, which were delivered to 5,500 graduating students on May 16 inside the the university's Canvas Stadium in Fort Collins, Colo. The Weekend co-host spoke about how graduates who hope to change the world need to also take care that the world doesn't change them first. Additionally, Daniels addressed the importance of navigating around the roadblock of imposter syndrome, using his own experience regularly showing up in the halls of power within Washington, D.C. as an example. Read exclusive excerpts from Daniels' commencement speech below: This month, I became the co-host of a national show at MSNBC. What I learned was that not everyone is going to get you. And that is okay. Because you all have come through the mean streets of FoCo, baby. You all have been tested and tested and you have come out on the other side rocking robes and tassels. The world is going to try and change you. People and institutions are going to try and bend you to their purpose and their expectations of you should be. They will challenge who you know you are, the person you've spent all this time discovering and excavating. But you have to remember that you, as is, belong in that meeting, in that research facility, in that doctor's chair, in whatever room you find yourself in… Now I'm not saying it's easy. Because trust me it is not. Imposter Syndrome is real and that little monster is always ready to rear his nasty little head. […] See when you accept every piece of yourself, when you accept all of your sharp edges and weird quirks, and you walk up into that room as your full self, you not only push past that fear, but you change the very nature and feel of that room.
Time of India
06-05-2025
- Science
- Time of India
Why do the people of this tribe have sparkling blue eyes
Where do people exceptionally possess blue eyes? What causes the change in the colour of eyes? Time and again, some facial features have been an attraction across cultures, like sparkling eyes, glowing skin, or thick hair. Blue eyes , in particular, have a near-mythical status, as they are often romanticised in songs, films, and poetry. In places like Bollywood, lyrics praising the charm of "neeli aankhen' are instantly adored. But what if a trait admired by the world comes not from lineage or chance, but from a rare genetic condition ?While blue eyes are globally rare, found in only a small percentage of the population, there's one place where they're surprisingly common, and that too in an eastern country on the Buton Island , located in Indonesia's Sulawesi province, an entire community seems to have been touched by a genetic miracle. Here, many members of the Buton tribe possess naturally vivid blue eyes that are so intense and bright that they often stop people in their tracks and give a mythical behind these magical eyes lies a deeper story of genetics, health complications, and the reality of living with a rare condition. These blue eyes are not just a symbol of inheritance, they are the result of a rare disorder, which carries challenges that go beyond first glance, the blue-eyed residents of Buton Island in Indonesiaseem to carry a rare and beautiful trait. Their trait of having luminous eyes stand out in a region where darker eye colours are the 'normal'. But this beauty comes with a hidden cost. These residents are part of the Buton tribe, and their unusual eye colour is linked to a rare genetic disorder known as Waardenburg Syndrome .Waardenburg Syndrome is an inherited condition that affects roughly 1 in 42,000 people. While it causes blue eyes and sometimes even one blue and one brown eye, it can also result in several health complications. These include hearing loss, changes in pigmentation of the skin and hair, and sometimes white patches on the blue eyes seen in the Buton tribe are the result of a mutation that occurs during fetal development, affecting melanocytes, the cells responsible for pigment. While the eyes may appear dazzling, the underlying syndrome affects more than just colour. In fact, people with Waardenburg Syndrome often face challenges with partial or complete hearing loss due to abnormalities in the inner these challenges, the tribe continues to live its traditional life on the island. The condition is not curable, but supportive therapies like hearing aids and early diagnosis can help manage its social media, the photographs of blue-eyed Buton children have gone viral. But experts remind us not to reduce their condition to a visual marvel. As beautiful as these eyes may be, the disorder is serious and deserves medical awareness and Syndrome isn't contagious and doesn't affect intelligence or life span, but early intervention can make a significant difference in quality of life. Many families on the island remain unaware of the exact cause of their condition due to lack of access to medical resources and genetic counseling.
