Latest news with #TAKEDOWN
Scottish Sun
18-07-2025
- Health
- Scottish Sun
‘One-two-punch' cancer vaccine weaponises the immune system to attack ANY tumour – raising hopes of universal jab
Last year, scientists tested the jab on brain cancer patients and saw a strong immune response that fought the killer tumour TAKEDOWN 'One-two-punch' cancer vaccine weaponises the immune system to attack ANY tumour – raising hopes of universal jab A NEW experimental cancer jab could one day be used to fight any type of tumour, US scientists claim. Experts from the University of Florida say they've developed a powerful mRNA vaccine that trains the immune system to target and destroy cancer cells. 1 The discovery brings us closer to a universal cancer jab that could work across many tumour types Credit: Getty It's dubbed the 'one-two punch' after the powerful boxing move where a jab sets up a cross to knock the opponent down. This is because this jab also works in two steps: first by waking up the immune system, then helping it attack cancer cells more effectively. It does this by boosting the effects of immunotherapy, a type of cancer treatment that helps the immune system recognise and attack cancer cells. The groundbreaking discovery brings us closer to a universal cancer jab that could work across many tumour types, it is hope Research in mice showed that combining the jab with a common immunotherapy drug called an immune checkpoint inhibitor helped fight even resistant tumours. Dr Elias Sayour, the study's senior author, said: 'This paper describes a very unexpected and exciting observation: that even a vaccine not specific to any particular tumour or virus, so long as it is an mRNA vaccine, could lead to tumour-specific effects.' He added: 'This finding is a proof of concept that these vaccines potentially could be commercialised as universal cancer vaccines to sensitise the immune system against a patient's individual tumour.' Unlike previous cancer vaccines that try to hone in on a particular protein in the cell, the new jab works by simply firing up the immune system, tricking it into responding as if it were under viral attack. By boosting levels of a protein called PD-L1 inside tumours, it makes them more receptive to immunotherapy and helps immune cells recognise them as dangerous. Lead scientist Dr Duane Mitchell, co-author of the study, said: 'What we found is by using a vaccine designed not to target cancer specifically but rather to stimulate a strong immunologic response, we could elicit a very strong anticancer reaction. The signs and symptoms of cancer 'And so this has significant potential to be broadly used across cancer patients, even possibly leading us to an off-the-shelf cancer vaccine.' For the past eight years, Dr Sayour's lab has been developing cutting-edge vaccines using the same mRNA technology found in Covid jabs. Last year, they trialled a personalised version in four patients with glioblastoma - an aggressive and usually deadly brain tumour. They saw a fast and fierce immune response that helped fight off the cancer. 'Profound' The latest study, published today in Nature Biomedical Engineering, tested a more generalised version of the jab, not tailored to individual tumours, and still saw dramatic results. In mice with melanoma, a type of deadly skin cancer, combining the jab with an immunotherapy drug called a PD-1 inhibitor led to tumour shrinkage While in some skin, bone, and brain cancer models, the jab alone eliminated tumours completely. Dr Sayour explained: 'Even an immune response that is seemingly unrelated to the cancer may be able to activate T cells that weren't working before, allowing them to multiply and kill the tumour if the response is strong enough.' Dr Mitchell said: 'It could potentially be a universal way of waking up a patient's own immune response to cancer. 'And that would be profound if generalisable to human studies.' The team are now working to improve the formula and begin human trials as soon as possible.
Fox News
05-04-2025
- Automotive
- Fox News
WATCH: Dems dodge on calling Tesla attacks acts of 'domestic terrorism'
After taking to social media to announce he was ditching his Tesla because it was made by an "a--hole" he claimed is damaging the country, Sen. Mark Kelly, D-Ariz., refused to say whether Democrats' inflammatory rhetoric against Elon Musk is to blame for the ongoing spate of attacks against Tesla owners and dealers across the also refused to say whether the attacks — some of which have involved shooting at and throwing Molotov cocktails into dealerships — qualify as "domestic terrorism."The Arizona senator admitted that "it's certainly vandalism and it's a crime, a significant crime, especially if you firebomb a car or vandalize somebody's vehicle, or even key somebody's vehicle, you shouldn't be doing it."While Kelly said those responsible should be tried and prosecuted, pressed by Fox News Digital on whether the attacks qualify as terrorism, he responded, "I think we've got to tread lightly on the whole 'terrorist' word."OVER 200 'TESLA TAKEDOWN' PROTESTS ERUPT NATIONWIDE"Sometimes trying to expand this thing, it kind of loses its focus," he said. "But when folks are vandalizing people's vehicles or dealerships, it is wrong and it is dangerous. Somebody's going to get hurt. For that reason, we should let the full force of law enforcement get to this problem and prosecute it."There have been at least 80 acts of vandalism against Tesla vehicles in the U.S. and Canada, and at least 10 incidents of vandalism and arson against Tesla dealerships, charging stations and properties. U.S. Attorney General Pam Bondi has said the Justice Department is investigating the incidents as "domestic terrorism."Leading Democrats, however, have been largely silent on the issue, with few being willing to condemn the attacks as acts of LOUDEST SILENCE: TOP DEMOCRATS REMAIN MUM AMID VIOLENT ATTACKS ON TESLARep. Alexandria Ocasio-Cortez, D-N.Y., who, in a 2023 CNN interview, accused Republicans who criticized her of engaging in "stochastic terrorism" — that is, incitement of violent political action — also refused to say whether Democrats' anti-Musk rhetoric should be held responsible for the News Digital asked Ocasio-Cortez whether she sees a connection between language against Musk and the violent incidents across the began to answer, saying, "Yeah, I mean, again, I've seen Republicans call me 'communist' and that I 'hate this country,'" before trailing Rep. Summer Lee, D-Pa., refused to label the attacks as even violent, saying, "While I have no opinion on what's been going on, I actually haven't been following that much, but let's be precise about our language — 'violence' is against human beings."EXCLUSIVE VIDEO: AOC REFUSES TO SAY WHETHER DEMOCRATS' RHETORIC IS RESPONSIBLE FOR TESLA ATTACKSAsked about Democrats' rhetoric, Lee said it is important to "recognize the difference between the frustration of people that is maybe organic, but also the language that is coming from people who are in power.""Donald Trump is in power and he's abusing that and it's going to harm people and has already," she said. "Because of the rhetoric from the administration, because of the rhetoric from the right, we're seeing American citizens being picked up, we're seeing a lot of profiling that's happening, I think that that's incredibly dangerous and again those are being perpetrated against people."Rep. Steny Hoyer, D-Md., also attempted to turn the question around, saying President Donald Trump "in effect… told people to resort to violence" at his rally on Jan. 6, said he discourages anyone from resorting to violence but advocated for peaceful ways of telling Trump and Musk "how angry we are."TESLA HYPOCRISY: DEMS CONTINUE INVESTING IN ELON MUSK COMPANY DESPITE PAINTING HIM AS VILLAIN"Effectively, he [Musk] and Trump are both trying to profit from being president. And this is unheard of what Musk is doing," said Hoyer."I'm opposed to all violence, beginning with the Jan. 6th insurrection," Rep. Jamie Raskin, D-Md., told Fox News Jasmine Crockett, D-Texas, who has been warned by Bondi to "tread lightly" after seeming to threaten Musk by calling for him to be "taken down," refused to answer the question, while her security got into the face of the Fox News Digital in the meantime, hammered that the attacks are obvious examples of CROCKETT SAYS SHE WAS HIRED AS A PUBLIC DEFENDER BECAUSE SHE WAS BLACK "I think it's awful, they need to bust their a--," said Rep. Tim Burchett, R-Tenn. "Elon doesn't even own a majority share of it anymore. All you're doing is hurting Americans."CLICK HERE TO GET THE FOX NEWS APPRep. Addison McDowell, R-N.C., pointed out that "when we boycotted Bud Light over their support over these radical issues, we didn't just say, 'We're going to burn down Bud Light manufacturers.' We just didn't buy it." "What you see these woke, radical liberals doing to a car they used to want championed, is lighting them on fire, destroying property, that's not how adults behave," McDowell said, adding, "they're behaving like criminals."
