Latest news with #ThomasJensen
Associated Press
30-06-2025
- Business
- Associated Press
Allarity Therapeutics Receives Australian Patent Acceptance Notice for Stenoparib DRP® Companion Diagnostic
TARPON SPRINGS, Fla., June 30, 2025 -- Allarity Therapeutics, Inc. ('Allarity' or the 'Company') (NASDAQ: ALLR), a Phase 2 clinical-stage pharmaceutical company dedicated to developing stenoparib—a differentiated, dual PARP and WNT pathway inhibitor—as a personalized cancer treatment using its proprietary, drug-specific Drug Response Predictor (DRP®) patient selection technology—today announced that IP Australia, the Australian Government agency that administers intellectual property rights in the country, has formally accepted the Company's patent application for its DRP® companion diagnostic specific to stenoparib. The acceptance covers 40 claims and marks a key step in Allarity's global strategy to protect the potential international commercialization of its proprietary DRP® platform alongside the clinical development of stenoparib. The granted patent will be officially advertised in the Australian Official Journal of Patents on June 26, 2025, followed by a three-month opposition period. If unopposed, the patent is expected to be granted within 20 working days thereafter. Thomas Jensen, CEO of Allarity Therapeutics, commented: 'This latest patent acceptance from Australia represents another important achievement in our efforts to secure international IP protection for our DRP® technology. As we continue advancing stenoparib through Phase 2 trials toward U.S. regulatory approval, we are also building a robust intellectual property position in key global markets.' Allarity previously secured a European patent for the Stenoparib DRP® and holds 18 granted patents for drug-specific DRPs, including eight in the United States. Patent applications for the Stenoparib DRP® remain pending in the U.S., Canada, Japan, China, and India. About Stenoparib Stenoparib is an orally available, small-molecule dual-targeted inhibitor of PARP1/2 and tankyrase 1/2. At present, tankyrases are attracting significant attention as emerging therapeutic targets for cancer, principally due to their role in regulating the WNT signaling pathway. Aberrant WNT/β-catenin signaling has been implicated in the development and progression of numerous cancers. By inhibiting PARP and blocking WNT pathway activation, stenoparib's unique therapeutic action shows potential as a promising therapeutic for many cancer types, including ovarian cancer. Allarity has secured exclusive global rights for the development and commercialization of stenoparib, which was originally developed by Eisai Co. Ltd. and was formerly known under the names E7449 and 2X-121. About the Drug Response Predictor – DRP® Companion Diagnostic Allarity uses its drug-specific DRP® to select those patients who, by the gene expression signature of their cancer, may have a high likelihood of benefiting from a specific drug. By screening patients before treatment, and only treating those patients with a sufficiently high, drug-specific DRP score, the therapeutic benefit rate may be enhanced. The DRP method builds on the comparison of sensitive vs. resistant human cancer cell lines, including transcriptomic information from cell lines, combined with clinical tumor biology filters and prior clinical trial outcomes. DRP is based on messenger RNA expression profiles from patient biopsies. The DRP® platform has shown an ability to provide a statistically significant prediction of the clinical outcome from drug treatment in cancer patients across dozens of clinical studies (both retrospective and prospective). The DRP platform, which may be useful in all cancer types and is patented for dozens of anti-cancer drugs, has been extensively published in the peer-reviewed literature. About Allarity Therapeutics Allarity Therapeutics, Inc. (NASDAQ: ALLR) is a clinical-stage biopharmaceutical company dedicated to developing personalized cancer treatments. The Company is focused on development of stenoparib, a novel PARP/tankyrase inhibitor for advanced ovarian cancer patients, using its DRP® technology to develop a companion diagnostic that can be used to select those patients expected to derive the greatest clinical benefit from stenoparib. Allarity is headquartered in the U.S., with a research facility in Denmark, and is committed to addressing significant unmet medical needs in cancer treatment. For more information, visit Follow Allarity on Social Media LinkedIn: Forward-Looking Statements This press release contains 'forward-looking statements' within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements provide the Company's current expectations or forecasts of future events. The words 'anticipates,' 'believe,' 'continue,' 'could,' 'estimate,' 'expect,' 'intends,' 'may,' 'might,' 'plan,' 'possible,' 'potential,' 'predicts,' 'project,' 'should,' 'would' and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements include, but are not limited to, statements regarding the expected grant and scope of the Australian patent for the Stenoparib DRP®; the anticipated contribution of this patent to the Company's global intellectual property strategy; and the Company's ability to advance and commercialize stenoparib in Australia and other key markets. Any forward-looking statements in this press release are based on management's current expectations of future events and are subject to multiple risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, risks related to the potential for opposition to the patent grant; changes in regulatory timelines or requirements; failure to obtain regulatory approval for stenoparib or its companion diagnostic; and risks inherent in developing and commercializing biopharmaceutical products. For a discussion of other risks and uncertainties, and other important factors, any of which could cause our actual results to differ from those contained in the forward-looking statements, see the section entitled 'Risk Factors' in our Form 10-K annual report filed with the Securities and Exchange Commission (the 'SEC') on March 31, 2025, available at the SEC's website at and as well as discussions of potential risks, uncertainties and other important factors in the Company's subsequent filings with the SEC. All information in this press release is as of the date of the release, and the Company undertakes no duty to update this information unless required by law. ### Company Contact: [email protected] Media Contact: Thomas Pedersen Carrotize PR & Communications +45 6062 9390 [email protected] Attachment
Techday NZ
26-06-2025
- Business
- Techday NZ
Milestone & Genoa launch EU-compliant AI for smart cities
Milestone has commenced work on Project Hafnia in Europe, collaborating with the city of Genoa, Italy, to develop AI-driven solutions for traffic management and urban infrastructure using NVIDIA technology. The project's primary objective is to use artificial intelligence to enhance city operations by leveraging regulation-compliant video data, ensuring alignment with European legal frameworks, including GDPR and the EU's AI Act. Project Hafnia, after its launch in the United States, will provide high-quality video data that have been processed using NVIDIA NeMo Curator on the NVIDIA DGX Cloud platform. Milestone is adopting the NVIDIA Omniverse Blueprint for Smart City AI, which is a reference framework designed to optimise city operations through digital twins and AI agents. In addition to this, Milestone is expanding its proprietary data platform using NVIDIA Cosmos. This approach enables the generation of synthetic video data based on real-world inputs, combining both real and synthetic datasets to build and train vision language models (VLMs) responsibly. The company has engaged Nebius, a European-based cloud provider, to supply the GPU compute required for the training of these models. This partnership is intended to ensure that all data processing and storage remain fully compliant with European data protection regulations, while supporting digital sovereignty objectives and keeping sensitive public sector data strictly within EU jurisdiction. Urban AI applications Project Hafnia seeks to harness the potential of VLMs, which are AI models capable of mapping relationships between visual data—such as images or videos—and corresponding text. This enables the models to generate summaries and insights from visual sources, which can be applied across multiple domains including transportation, safety, and security within city environments. Emphasising the importance of regulatory compliance and ethical data sourcing, the project aims to support cities throughout Europe in building and refining computer vision and AI applications that align with the region's standards for privacy, transparency, and fairness. "I'm proud that with Project Hafnia we are introducing the world's first platform to meet the EU's regulatory standards, powered by NVIDIA technology. With Nebius as our European cloud provider, we can now enable compliant, high-quality video data for training vision AI models — fully anchored in Europe. This marks an important step forward in supporting the EU's commitment to transparency, fairness, and regulatory oversight in AI and technology — the foundation for responsible AI innovation," says Thomas Jensen, CEO of Milestone. The company states that the compliant and ethically sourced data library enabled by Project Hafnia provides the necessary foundation for developing advanced video analytics models and vision language models. The models are configured for optimal performance on NVIDIA GPUs and are compatible with NVIDIA AI Blueprint frameworks focused on video search and summarisation (VSS). Application in Genoa The first practical implementation from Project Hafnia is a European Visual Language Model purpose-built for transportation management. This VLM is developed using transportation data sourced directly from Genoa, Italy, ensuring that only compliant and responsibly gathered data are used. "AI is achieving extraordinary results, unthinkable until recently, and the research in the area is in constant development. We enthusiastically joined forces with Project Hafnia to allow developers to access fundamental video data for training new Vision AI models. This data-driven approach is a key principle in the Three-Year Plan for Information Technology, aiming to promote digital transformation in Italy and particularly within the Italian Public Administration," says Andrea Sinisi, Information Systems Officer, City of Genoa. The framework developed through Project Hafnia is designed for scalability, allowing it to extend across multiple domains and accommodate future technological developments. The resulting compliant data set and the fine-tuned VLM will be made available to participating cities under a controlled access licence model, facilitating broader AI adoption across Europe whilst upholding ethical standards. Nebius as cloud partner Nebius will provide the cloud infrastructure underpinning Project Hafnia in Genoa, ensuring that all processing power and data handling are carried out within the jurisdiction of the EU. This guarantees adherence to European data handling regulations and digital sovereignty imperatives. "Project Hafnia is exactly the kind of real-world, AI-at-scale challenge Nebius was built for," says Roman Chernin, Chief Business Officer of Nebius. "Supporting AI development today requires infrastructure engineered for high-throughput, high-resilience workloads, with precise control over where data lives and how it's handled. From our EU-based data centres to our deep integration with NVIDIA's AI stack, we've built a platform that meets the highest standards for performance, privacy and transparency." Milestone's approach with Project Hafnia positions it as an early adopter within the sector of European AI development, focusing on regulatory-compliant, ethically sourced, and technologically advanced infrastructure solutions for urban environments. Through partnerships with city administrations such as Genoa and technology providers including NVIDIA and Nebius, Milestone aims to facilitate responsible deployment of AI for urban improvement initiatives across Europe.
Scoop
26-06-2025
- Automotive
- Scoop
Smarter Streets Ahead: AI Platform Sets Blueprint For Urban Innovation
A breakthrough in AI-powered traffic management is putting the future of city infrastructure on the fast track — and it's a vision that could soon be applied across cities in Australia and New Zealand. Milestone Systems has unveiled a next-gen video data platform, Project Hafnia, developed in partnership with NVIDIA and now rolling out in European cities following its inception in the US. At its core, Hafnia is designed to power smarter, safer and more efficient cities through ethically sourced and regulation-compliant video AI models — a concept equally applicable in the Southern Hemisphere. With traffic congestion, pedestrian safety, and public surveillance emerging as key challenges for growing urban centres across ANZ, Project Hafnia offers a roadmap for leveraging AI responsibly. The system uses NVIDIA's advanced GPU platforms and large-scale video datasets — both real and synthetic — to train visual language models (VLMs) that can help city officials understand traffic flows, detect hazards, or summarise surveillance footage for faster response. 'Our cities don't just need more data, they need better, smarter data,' said Thomas Jensen, CEO of Milestone. 'With Project Hafnia, we're building the digital foundation for cities that are safer, more transparent, and AI-enabled — without compromising public trust or privacy.' While currently operational in Genoa, Italy, the platform is built to scale globally. The opportunity for ANZ councils lies in adapting this blueprint to local conditions, unlocking better traffic coordination, real-time monitoring, and urban planning insights — all with compliance and citizen protection at its heart.
Web Release
12-06-2025
- Business
- Web Release
Milestone revolutionizes urban infrastructure and traffic systems in Europe with NVIDIA and Project Hafnia, starting with Genoa
After launching in the USA, Milestone's Project Hafnia is now engaged in Europe with the city of Genoa, Italy. The aim is to develop AI-driven solutions to enhance traffic management systems and create smarter cities with high-quality, regulation compliant video data trained with NVIDIA NeMo Curator on NVIDIA DGX Cloud . Milestone is one of the early adopters of the newly announced NVIDIA Omniverse Blueprint for Smart City AI , a reference framework for optimizing city operations with digital twins and AI agents. Milestone is also expanding its data platform with NVIDIA Cosmos to generate synthetic video data from real world inputs. Leveraging both real and synthetic data, Milestone will build and train vision language models (VLMs) responsibly. European cloud provider Nebius will provide the required GPU compute to train the models. AI opens up new horizons for smarter, more efficient cities with Project Hafnia's data platform – from intelligent traffic and transportation management to better safety and security for people and property. VLMs learn to map the relationships between text data and visual data such as images or videos, allowing these AI-models to generate summaries and insights from visual inputs. Milestone Systems is working with NVIDIA to empower European cities like Genoa to build and fine-tune computer vision and AI applications on a foundation of fully compliant and ethically sourced data. The project is rooted in regulatory integrity, data diversity, and AI relevance, aligning with the EU's legal frameworks, including GDPR and the AI Act. This ensures both transparency and fairness in the development of AI technologies. 'I'm proud that with Project Hafnia we are introducing the world's first platform to meet the EU's regulatory standards, powered by NVIDIA technology. With Nebius as our European cloud provider, we can now enable compliant, high-quality video data for training vision AI models — fully anchored in Europe. This marks an important step forward in supporting the EU's commitment to transparency, fairness, and regulatory oversight in AI and technology — the foundation for responsible AI innovation,' says Thomas Jensen, CEO of Milestone. Milestone's Project Hafnia provides the missing link for developing video-centric AI innovation with a fully compliant and ethically sourced data library for fine tuning classical video analytics models and VLMs. The VLM's accuracy and performance optimizations are tuned for running on NVIDIA GPUs and in NVIDIA AI Blueprint for video search and summarization (VSS) . First service offering trained on transportation data from Genoa Project Hafnia now offers a fully European Visual Language Model for transportation management. The VLM is powered by NVIDIA and trained on a large volume of responsibly sourced and compliant transportation data from Genoa, Italy. 'AI is achieving extraordinary results, unthinkable until recently, and the research in the area is in constant development. We enthusiastically joined forces with Project Hafnia to allow developers to access fundamental video data for training new Vision AI models. This data-driven approach is a key principle in the Three-Year Plan for Information Technology, aiming to promote digital transformation in Italy and particularly within the Italian Public Administration,' says Andrea Sinisi, Information Systems Officer, City of Genoa. While the focus of these collaborations is initially on video data, the framework is designed to scale across multiple domains and modalities, enabling future expansion and adaptation improving the value of the data. Both the compliant dataset and the fine-tuned VLM will be made available to the cities using Project Hafnia through a controlled access license model, facilitating Europe's AI ambitions without compromising ethical standards. Nebius to serve as European cloud solution NVIDIA cloud provider, Nebius, will serve as the EU-based cloud solution for Project Hafnia's collaboration with Genoa. Choosing Nebius as a sovereign cloud provider ensures full compliance with European data protection regulations, supports digital sovereignty objectives and guarantees that sensitive public-sector data remains securely within EU jurisdiction. 'Project Hafnia is exactly the kind of real-world, AI-at-scale challenge Nebius was built for,' says Roman Chernin, Chief Business Officer of Nebius.'Supporting AI development today requires infrastructure engineered for high-throughput, high-resilience workloads, with precise control over where data lives and how it's handled. From our EU-based data centers to our deep integration with NVIDIA's AI stack, we've built a platform that meets the highest standards for performance, privacy and transparency.'
Techday NZ
12-06-2025
- Automotive
- Techday NZ
Milestone launches Project Hafnia for AI-driven city management
Milestone has commenced its Project Hafnia to develop AI-driven solutions for urban infrastructure and traffic management, with the first city being Genoa in Italy. The initiative is aimed at improving city operations by harnessing computer vision technologies, using high-quality video data that adheres to European regulatory frameworks, including GDPR and the AI Act. Video data used for the project is trained with NVIDIA's NeMo Curator on NVIDIA DGX Cloud. Collaboration and compliance Milestone is among the first companies to utilise the new NVIDIA Omniverse Blueprint for Smart City AI—a framework designed for optimising city operations through digital twins and AI agents. The company is also enhancing its data platform by generating synthetic video data via NVIDIA Cosmos, which processes real-world inputs. This combination of real and synthetic video data is used to build and train Vision Language Models (VLMs) in a manner that the company states is responsible and regulation-compliant. European cloud provider Nebius will supply the GPU compute for training these models, which is an element in keeping data processing anchored within European borders and compliant with regional data protection regulations. The application of AI within Project Hafnia spans smart traffic and transportation management, as well as improvements in safety and security for cities. VLMs establish connections between textual data and visual information from images or videos, enabling AI models to generate insights and summaries from visual sources. These efforts, the company asserts, are based upon regulatory integrity, data diversity, and relevance to European legal frameworks. "I'm proud that with Project Hafnia we are introducing the world's first platform to meet the EU's regulatory standards, powered by NVIDIA technology. With Nebius as our European cloud provider, we can now enable compliant, high-quality video data for training vision AI models — fully anchored in Europe. This marks an important step forward in supporting the EU's commitment to transparency, fairness, and regulatory oversight in AI and technology — the foundation for responsible AI innovation," says Thomas Jensen, CEO of Milestone. Genoa as a first Project Hafnia's first European service offering consists of a Visual Language Model specifically for transportation management, drawing on transportation data sourced from Genoa. The model is powered by NVIDIA technology and has been trained on data that is both responsibly sourced and compliant with applicable regulations. "AI is achieving extraordinary results, unthinkable until recently, and the research in the area is in constant development. We enthusiastically joined forces with Project Hafnia to allow developers to access fundamental video data for training new Vision AI models. This data-driven approach is a key principle in the Three-Year Plan for Information Technology, aiming to promote digital transformation in Italy and particularly within the Italian Public Administration," says Andrea Sinisi, Information Systems Officer, City of Genoa. The structure of Project Hafnia's collaborations allows for scalability, as the framework is designed to operate across multiple domains and data types. The compliant datasets and the fine-tuned VLMs will be supplied to participating cities via a controlled access licence model, supporting the region's AI ambitions within ethical standards. Role of Nebius Nebius has been selected as Project Hafnia's European cloud provider. The company operates EU-based data centres, facilitating digital sovereignty objectives and ensuring that sensitive public sector data remains within the jurisdiction of European data protection laws. "Project Hafnia is exactly the kind of real-world, AI-at-scale challenge Nebius was built for," says Roman Chernin, Chief Business Officer of Nebius."Supporting AI development today requires infrastructure engineered for high-throughput, high-resilience workloads, with precise control over where data lives and how it's handled. From our EU-based data centers to our deep integration with NVIDIA's AI stack, we've built a platform that meets the highest standards for performance, privacy and transparency." Project Hafnia data platform Project Hafnia acts as what Milestone refers to as a 'trusted librarian' of AI-ready video data, with the platform curating, tagging, and delivering video data that is described as ethically sourced and regulation-ready for AI model training. The emphasis is placed on maintaining precision, compliance, and citizen privacy throughout the process. According to Milestone, its network of customers, distributors, and technology partners enables the company to organise a comprehensive video data ecosystem that advances the development of AI in video analytics. Project Hafnia is positioned as a resource that companies can use to build AI models while meeting compliance and quality standards. The project will make both the compliant dataset and the fine-tuned Visual Language Model available to participating cities on a controlled basis as part of its effort to support AI development across Europe.
