Latest news with #UCLInstituteofHealthyAgeing
NDTV
29-05-2025
- Health
- NDTV
Anti-Ageing Drug Combo Extends Mouse Lifespan By 30%, Sparks Hope For Human Longevity
Quick Read Summary is AI generated, newsroom reviewed. A study reveals rapamycin and trametinib can extend mouse lifespan by 30%. Treated mice showed improved health markers, including reduced inflammation. Combined drugs resulted in a greater lifespan increase than either alone. A groundbreaking study by the Max Planck Institute for Biology of Ageing in Germany has revealed that a combination of two FDA-approved drugs-rapamycin and trametinib-can extend the lifespan of mice by up to 30%. Beyond merely prolonging life, the treated mice exhibited improved health markers, including reduced inflammation, delayed tumor progression, and enhanced physical function. Rapamycin, commonly used to prevent organ rejection, and trametinib, a cancer treatment, target different cellular pathways involved in aging. Their combined effect resulted in a more significant lifespan extension than either drug alone. While rapamycin alone extended lifespan by 17-18% and trametinib by 7-16%, their combination achieved a remarkable 26-35% increase. As per a news release, although rapamycin and trametinib act on the same network, the combination achieves novel effects that are probably not solely due to an increase in dose. An analysis of gene expression in various tissues shows that the combination of the drugs influences the activity of the genes differently than is achieved by administering the drugs individually. There are specific changes in gene activity that are only caused by the combination of the two drugs. The researchers plan to determine the optimal dose and route of administration of Trametinib to maximise the health and life-prolonging effects while minimising unwanted side effects. As Trametinib is already approved for human use, it is possible to test it in clinical trials. "Trametinib, especially in combination with rapamycin, is a good candidate to be tested in clinical trials as a geroprotector. We hope that our results will be taken up by others and tested in humans. Our focus is on optimising the use of trametinib in animal models," explains Sebastian Gronke. Co-senior author Professor Dame Linda Partridge (UCL Institute of Healthy Ageing and Max Planck Institute for Biology of Ageing) said, "While we do not expect a similar extension to human lifespans as we found in mice, we hope that the drugs we're investigating could help people to stay healthy and disease-free for longer late in life. Further research in humans in years to come will help us to elucidate how these drugs may be useful to people and who might be able to benefit." These findings suggest potential for developing anti-aging therapies in humans. However, researchers caution that further studies and clinical trials are necessary to determine safety and efficacy in humans.
The Independent
25-02-2025
- Health
- The Independent
One thing that could help prevent motor neurone disease and dementia
New research suggests omega-3 fats could play a vital role in protecting people from motor neurone disease (MND) and a type of dementia. While previous studies linked a high consumption of omega-3 fatty acids with a lower risk of developing MND and a longer lifespan for those with the condition, until now, researchers have not understood why this occurs. A study led by the UK Dementia Research Institute and the UCL Institute of Healthy Ageing found the fats – which are found in oily fish, nuts and seeds – affect the conditions and may boost survival. In the new research, experts increased the levels of healthy fats in the brain cells of fruit flies carrying a genetic mutation called C9orf72, while also examining human brain cells. C9orf72 mutation is the most common genetic cause of MND and a rarer form of dementia known as frontotemporal dementia (FTD), which tends to affect younger people. The team found that, at the start of the study, levels of poly-unsaturated fatty acids, including omega-3 fatty acids, were significantly reduced in the MND/FTD flies. These fatty acids were also reduced in the brain cells of people with MND/FTD. Experts specifically looked at alpha linoleic acid (ALA), a type of omega-3 fatty acid found in flaxseed, walnuts and soybean and vegetable oils such as canola oil. They also looked at linoleic acid, a type of omega-6 fatty acid, found in similar foods. Scientists fed the flies linoleic acid and alpha linoleic acid to test whether this would impact on their survival. They found that increasing the amount of fatty acids in their diet led to a small improvement in the survival of the flies. Next, they delivered the fatty acids directly to the brain cells of the flies which increased the survival of the flies by 83 per cent, from 15 days to 27.5 days. They repeated the experiment in cells taken from people with MND/FTD and found that increasing levels of the fatty acids in the cells prolonged survival. The research, published in the journal Nature Neuroscience, was funded by Alzheimer's Research UK and the UK Dementia Research Institute. Study leader Professor Adrian Isaacs, from the UK Dementia Research Institute, said: 'Epidemiological studies suggest that people with a high intake of omega-3 fatty acids have a lower risk of developing motor neuron disease. 'Our study adds a deeper understanding of the mechanisms behind this. 'From our findings we can conclude that enhancing levels of omega-3 fatty acids in the brain may be beneficial in motor neuron disease. Of course, the next step is to test this in people. 'We first need to work out which specific fatty acid would be best to test in humans, and how we can deliver sufficient quantities to the brain. Then, we want to take these findings forward into a clinical trial.' The researchers also suggested the findings may also have implications for other neurodegenerative diseases. Dr Julia Dudley, head of research at Alzheimer's Research UK, said: 'With nearly one million people living with dementia in the UK, there is an urgent need to understand and treat the diseases that cause this condition, including rarer forms. 'Neurodegenerative diseases are complex, however some share similar genetic changes. 'This means that understanding how these changes affect the brain could ultimately lead to new treatment approaches for dementia. 'It is exciting to see findings which suggest that increasing levels of fatty acids, including omega-3 could be protective against motor neuron disease and frontotemporal dementia. 'We are excited to see the next steps for this research which we hope will play a key role in bringing us closer to a cure.' Last year, MND campaigner and Leeds Rhinos, Great Britain and England rugby league star Rob Burrow died from MND. His family said they were inundated with messages of support when he died, including a 'heartfelt' message from the Prince of Wales. MND, including its most common subtype amyotrophic lateral sclerosis (ALS), affects around one in 300 people in their lifetime and cannot be cured. Dr Nick Cole, head of research at the MND Association, said: 'The potential impact of healthy fats, like polyunsaturated fats such as omega-3s, on the risk of developing MND and the length of survival has been of interest to researchers for some time, but crucially the understanding of their impact has been limited. This research takes our knowledge on a step. 'So would giving people with MND the same type of fatty acid increase their survival rate? 'We don't know yet. But it is an avenue worth exploring. The researchers must now look at which fatty acids should be tested further, in what quantities they could be effective and how they should be administered, before they carry out a clinical trial. 'We hope that further research and testing in humans will paint a clearer picture on the impact of diet on MND and other neurodegenerative diseases. 'In the meantime, we would advise anyone with MND to speak to their healthcare professionals before making any changes to their diet.'
Yahoo
25-02-2025
- Health
- Yahoo
Omega-3s ‘could be vital in motor neurone disease and dementia protection'
Omega-3 fats could play a vital role in protecting people from motor neurone disease (MND) and a type of dementia, new research suggests. A study led by the UK Dementia Research Institute and the UCL Institute of Healthy Ageing found the fats – which are found in oily fish, nuts and seeds – affect the conditions and may boost survival. Previous studies have linked a high consumption of omega-3 fatty acids with a lower risk of developing MND and a longer lifespan for those with the condition. However, until now, researchers have not understood why this occurs. In the new research, experts increased the levels of healthy fats in the brain cells of fruit flies carrying a genetic mutation called C9orf72, while also examining human brain cells. C9orf72 mutation is the most common genetic cause of MND and a rarer form of dementia known as frontotemporal dementia (FTD), which tends to affect younger people. The team found that, at the start of the study, levels of poly-unsaturated fatty acids, including omega-3 fatty acids, were significantly reduced in the MND/FTD flies. These fatty acids were also reduced in the brain cells of people with MND/FTD. Experts specifically looked at alpha linoleic acid (ALA), a type of omega-3 fatty acid found in flaxseed, walnuts and soybean and vegetable oils such as canola oil. They also looked at linoleic acid, a type of omega-6 fatty acid, found in similar foods. Scientists fed the flies linoleic acid and alpha linoleic acid to test whether this would impact on their survival. They found that increasing the amount of fatty acids in their diet led to a small improvement in the survival of the flies. Next, they delivered the fatty acids directly to the brain cells of the flies which increased the survival of the flies by 83%, from 15 days to 27.5 days. They repeated the experiment in cells taken from people with MND/FTD and found that increasing levels of the fatty acids in the cells prolonged survival. The research, published in the journal Nature Neuroscience, was funded by Alzheimer's Research UK and the UK Dementia Research Institute. Study leader Professor Adrian Isaacs, from the UK Dementia Research Institute, said: 'Epidemiological studies suggest that people with a high intake of omega-3 fatty acids have a lower risk of developing motor neuron disease. 'Our study adds a deeper understanding of the mechanisms behind this. 'From our findings we can conclude that enhancing levels of omega-3 fatty acids in the brain may be beneficial in motor neuron disease. Of course, the next step is to test this in people. 'We first need to work out which specific fatty acid would be best to test in humans, and how we can deliver sufficient quantities to the brain. Then, we want to take these findings forward into a clinical trial.' The researchers also suggested the findings may also have implications for other neurodegenerative diseases. Dr Julia Dudley, head of research at Alzheimer's Research UK, said: 'With nearly one million people living with dementia in the UK, there is an urgent need to understand and treat the diseases that cause this condition, including rarer forms. 'Neurodegenerative diseases are complex, however some share similar genetic changes. 'This means that understanding how these changes affect the brain could ultimately lead to new treatment approaches for dementia. 'It is exciting to see findings which suggest that increasing levels of fatty acids, including omega-3 could be protective against motor neuron disease and frontotemporal dementia. 'We are excited to see the next steps for this research which we hope will play a key role in bringing us closer to a cure.' Last year, MND campaigner and Leeds Rhinos, Great Britain and England rugby league star Rob Burrow died from MND. His family said they were inundated with messages of support when he died, including a 'heartfelt' message from the Prince of Wales. MND, including its most common subtype amyotrophic lateral sclerosis (ALS), affects around one in 300 people in their lifetime and cannot be cured.
The Independent
25-02-2025
- Health
- The Independent
Omega-3s ‘could be vital in motor neurone disease and dementia protection'
Omega-3 fats could play a vital role in protecting people from motor neurone disease (MND) and a type of dementia, new research suggests. A study led by the UK Dementia Research Institute and the UCL Institute of Healthy Ageing found the fats – which are found in oily fish, nuts and seeds – affect the conditions and may boost survival. Previous studies have linked a high consumption of omega-3 fatty acids with a lower risk of developing MND and a longer lifespan for those with the condition. However, until now, researchers have not understood why this occurs. In the new research, experts increased the levels of healthy fats in the brain cells of fruit flies carrying a genetic mutation called C9orf72, while also examining human brain cells. C9orf72 mutation is the most common genetic cause of MND and a rarer form of dementia known as frontotemporal dementia (FTD), which tends to affect younger people. The team found that, at the start of the study, levels of poly-unsaturated fatty acids, including omega-3 fatty acids, were significantly reduced in the MND/FTD flies. These fatty acids were also reduced in the brain cells of people with MND/FTD. Experts specifically looked at alpha linoleic acid (ALA), a type of omega-3 fatty acid found in flaxseed, walnuts and soybean and vegetable oils such as canola oil. They also looked at linoleic acid, a type of omega-6 fatty acid, found in similar foods. Scientists fed the flies linoleic acid and alpha linoleic acid to test whether this would impact on their survival. They found that increasing the amount of fatty acids in their diet led to a small improvement in the survival of the flies. Next, they delivered the fatty acids directly to the brain cells of the flies which increased the survival of the flies by 83%, from 15 days to 27.5 days. They repeated the experiment in cells taken from people with MND/FTD and found that increasing levels of the fatty acids in the cells prolonged survival. The research, published in the journal Nature Neuroscience, was funded by Alzheimer's Research UK and the UK Dementia Research Institute. Study leader Professor Adrian Isaacs, from the UK Dementia Research Institute, said: 'Epidemiological studies suggest that people with a high intake of omega-3 fatty acids have a lower risk of developing motor neuron disease. 'Our study adds a deeper understanding of the mechanisms behind this. 'From our findings we can conclude that enhancing levels of omega-3 fatty acids in the brain may be beneficial in motor neuron disease. Of course, the next step is to test this in people. 'We first need to work out which specific fatty acid would be best to test in humans, and how we can deliver sufficient quantities to the brain. Then, we want to take these findings forward into a clinical trial.' The researchers also suggested the findings may also have implications for other neurodegenerative diseases. Dr Julia Dudley, head of research at Alzheimer's Research UK, said: 'With nearly one million people living with dementia in the UK, there is an urgent need to understand and treat the diseases that cause this condition, including rarer forms. 'Neurodegenerative diseases are complex, however some share similar genetic changes. 'This means that understanding how these changes affect the brain could ultimately lead to new treatment approaches for dementia. 'It is exciting to see findings which suggest that increasing levels of fatty acids, including omega-3 could be protective against motor neuron disease and frontotemporal dementia. 'We are excited to see the next steps for this research which we hope will play a key role in bringing us closer to a cure.' Last year, MND campaigner and Leeds Rhinos, Great Britain and England rugby league star Rob Burrow died from MND. His family said they were inundated with messages of support when he died, including a 'heartfelt' message from the Prince of Wales. MND, including its most common subtype amyotrophic lateral sclerosis (ALS), affects around one in 300 people in their lifetime and cannot be cured.
