Latest news with #Ungaro
Medscape
21-05-2025
- Health
- Medscape
Blood Test May Predict Crohn's Disease 2 Years Before Onset
SAN DIEGO — Crohn's disease (CD) has become more common in the United States, and an estimated 1 million Americans have the condition. Still, much is unknown about how to evaluate the individual risk for the disease. 'It's pretty much accepted that Crohn's disease does not begin at diagnosis,' said Ryan Ungaro, MD, associate professor of medicine at the Icahn School of Medicine at Mount Sinai, New York City, speaking at Digestive Disease Week (DDW) 2025. Although individual blood markers have been associated with the future risk for CD, what's needed, he said, is to understand which combination of biomarkers are most predictive. Now, Ungaro and his team have developed a risk score they found accurate in predicting CD onset within 2 years before its onset. It's an early version that will likely be further improved and needs additional validation, Ungaro told Medscape Medical News . 'Once we can accurately identify individuals at risk for developing Crohn's disease, we can then imagine a number of potential interventions,' Ungaro said. Approaches would vary depending on how far away the onset is estimated to be. For people who likely wouldn't develop disease for many years, one intervention might be close monitoring to enable diagnosis in the earliest stages, when treatment works best, he said. Someone at a high risk of developing CD in the next 2 or 3 years, on the other hand, might be offered a pharmaceutical intervention. Developing and Testing the Risk Score To develop the risk score, Ungaro and colleagues analyzed data of 200 patients with CD and 100 healthy control participants from PREDICTS, a nested case-controlled study of active US military service members. The study is within the larger Department of Defense Serum Repository, which began in 1985 and has more than 62.5 million samples, all stored at −30 °C. The researchers collected serum samples at four timepoints up to 6 or more years before the diagnosis. They assayed antimicrobial antibodies using the Prometheus Laboratories platform, proteomic markers using the Olink inflammation panel, and anti–granulocyte macrophage colony-stimulating factor autoantibodies using enzyme-linked immunosorbent assay. Participants (median age, 33 years for both groups) were randomly divided into equally sized training and testing sets. In both the group, 83% of patients were White and about 90% were men. Time-varying trajectories of marker abundance were estimated for each biomarker. Then, logistic regression modeled disease status as a function of each marker for different timepoints and multivariate modeling was performed via logistic LASSO regression. A risk score to predict CD onset within 2 years was developed. Prediction models were fit on the testing set and predictive performance evaluated using receiver operating characteristic curves and area under the curve (AUC). Blood proteins and antibodies have differing associations with CD depending on the time before diagnosis, the researchers found. The integrative model to predict CD onset within 2 years incorporated 10 biomarkers associated significantly with CD onset. The AUC for the model was 0.87 (considered good, with 1 indicating perfect discrimination). It produced a specificity of 99% and a positive predictive value of 84%. The researchers stratified the model scores into quartiles and found the CD incidence within 2 years increased from 2% in the first quartile to 57.7% in the fourth. The relative risk of developing CD in the top quartile individuals vs lower quartile individuals was 10.4. The serologic and proteomic markers show dynamic changes years before the diagnosis, Ungaro said. A Strong Start The research represents 'an ambitious and exciting frontier for the future of IBD [inflammatory bowel disease] care,' said Victor G. Chedid, MD, MS, consultant and assistant professor of medicine at Mayo Clinic, Rochester, Minnesota, who reviewed the findings but was not involved in the study. Currently, physicians treat IBD once it manifests, and it's difficult to predict who will get CD, he said. The integrative model's AUC of 0.87 is impressive, and its specificity and positive predictive value levels show it is highly accurate in predicting the onset of CD within 2 years, Chedid added. Further validation in larger and more diverse population is needed, Chedid said, but he sees the potential for the model to be practical in clinical practice. 'Additionally, the use of blood-based biomarkers makes the model relatively noninvasive and easy to implement in a clinical setting,' he said. Now, the research goal is to understand the best biomarkers for characterizing the different preclinical phases of CD and to test different interventions in prevention trials, Ungaro told Medscape Medical News . A few trials are planned or ongoing, he noted. The trial PIONIR trial will look at the impact of a specific diet on the risk of developing CD, and the INTERCEPT trial aims to develop a blood-based risk score that can identify individuals with a high risk of developing CD within 5 years after initial evaluation. Ungaro reported being on the advisory board of and/or receiving speaker or consulting fees from AbbVie, Bristol Myer Squibb, Celltrion, ECM Therapeutics, Genentech, Jansen, Eli Lilly, Pfizer, Roivant, Sanofi, and Takeda. Chedid reported having no relevant disclosures.
Buzz Feed
03-05-2025
- Entertainment
- Buzz Feed
18 Met Gala Wardrobe Malfunctions
Hot Topic 🔥 Full coverage and conversation on the Met Gala The Met Gala is the biggest night in fashion, but not everything is picture-perfect. Extravagent, expensive clothes are often delicate, which can lead to disaster. Here are 18 Met Gala wardrobe malfunctions: 1. The little zipper on Kylie Jenner 's Alexander Wang dress at the 2018 Met Gala was a controversial fashion choice, but it turns out, it wasn't actually supposed to be part of the look in the first place! In a 2020 Instagram story post, she said, "This dress wasn't supposed to have a zipper but it ripped as I was squeezing into it, so we added it on the way out the door." Here's a closer look. 2. At the 2019 Met Gala, Cara Delevingne accessorized her rainbow Dior outfit with a matching scepter. In an Instagram video she shared a year later, she had to fix the scepter in the back of the car on the way to the event. She captioned it, "It all looks great once we get to the carpet, but this was our journey to the Met Gala on this day last year. My scepter broke in the lobby of the hotel, some stranger gave us a glue gun, and I had a 10lb hair piece clipped to my head. We don't always have to feel or be perfect to look 100!" Here's the video. 3. At the 2018 Met Gala, Selena Gomez didn't have an issue with her Coach dress — the problem was her self-tanner! Three years later, she told Vogue, "I was getting ready, and we wanted to add some color. So [I] put on some of this tanning lotion, and it looked really beautiful and very even. As the evening kept going on, it was getting a little darker and darker, and I didn't notice it." "I'm at the Met Gala — basically one of the most prestigious, beautiful events — and I'm walking, trying to look all beautiful, and I look at a photo of myself when I sit down, and I am completely orange," she said. However, she was able to laugh about it. To beat online commenters to the punchline, she posted an Instagram video of herself running away from the ball with the caption, "Me when I saw my pictures from MET." 4. Lucy Liu suffered a zipper malfunction at the 2004 Met Gala. She told People, "I was wearing Ungaro, and Giambattista Valli was the designer at the time. [Valli] met me at the hotel, and he was like, 'Oh my God, the zipper won't work!' He had to sew me into the dress, and then I had to cut myself out of it. My stylist was there, too; they were both sewing. I could go to the bathroom; it was just that the side zipper didn't work. That happens when you have a dress that's very unique; it just starts to fall apart, unfortunately." "I still have the dress, actually. It's beautiful, but you would have to re-make it to wear it again. It's pretty chopped up. I could probably take parts of it and then add to the sides or remake it, but the material was very patterned and beautiful. That's a real story, and I have the evidence. It was great," she said. 5. At the 2014 Met Gala, Hayden Panettiere tripped down the stairs in her Dennis Basso gown. According to Us Weekly, when she got to the top of the steps, she said, "Hallelujah! I made it up the stairs!" Here's what her dress looked like when she was standing. 6. At the 2022 Met Gala, Katy Perry accessorized her Oscar de la Renta dress with Aquazarra heels. In an Instagram video shared by Derek Blasberg, YouTube's head of fashion and beauty, Katy said, "She is beauty, and she is grace. She's also got her foot stuck in a vent." Here's what her outfit looked like on the red carpet. 7. Kristen Stewart walked the 2021 Met Gala red carpet in her Chanel look without any problems, but when she got inside, it was another story. She told People, "So I go to the Met ball, and there's a new set of kids at the Chanel table. There was a beautiful young tennis player [Emma Raducanu] and a young actress [Whitney Peak]. I'm talking to them, saying, 'Welcome, I've done this a couple times,' and they look like I'm scaring them. I look down, and literally, my [nipple] is in their faces. I was like, 'Okay, sorry, I'll put that away now.' They're like, 'Who is this crazy old actress at the Met Ball?' This is going to be a story for them when they're older." 8. Anne Hathaway almost didn't make it to the 2014 Met Gala because of a last-minute issue with her Calvin Klein gown. On The Late Show with Stephen Colbert, she said, "I was about a block away from the Met, and I was like, 'Wow, this is amaz— achoo!' And I sneezed, and my dress, like, just straight up split open...I felt so terrible. So, I'm pulling up, and Francisco [Costa, the designer] was so proud of this dress. And I put the window down, and he's like, 'Baby, you look amazing.' I'm like, 'Thank you so much! My dress just broke.' And I've never actually seen someone turn green before, and he did." She continued, "I'm like, 'It's gonna be fine. I can go on the carpet. I'm gonna keep my arm down, and I'll hold it in place. And we'll get inside, and there's gonna be a needle and thread.' And he goes, 'Pull over!' So we pulled over, went to a hotel. They found a seamstress. She sewed me into it, and the big thing was, 'Are we gonna make it in time for the red carpet?' because it takes a minute. So we show up. There's nobody on the red carpet. I say, 'Oh my God, did they miss it?' And they said, 'You're just ahead of Rihanna! Go!' Apparently, the only rule you really can't break at the Met Ball is you cannot show up after Rihanna. That's just gauche." 9. At the 2024 Met Gala, Venus Williams's Marc Jacobs gown was covered in minuscule mirrors. She told E! News, "It's, you know, based off the theme of today. We're showing all these dresses that are too fragile to wear, and so he wanted to bring in the fragility of, like, mirrors. It's very fragile. I only broke one! I broke one zipping up. It was too late [to replace it] 'cause I was already running behind!" Jeff Kravitz / FilmMagic / Via Getty 10. When Anya Taylor-Joy wore a weighty Dolce & Gabbana gown to the 2018 Met Gala, Jimmy Fallon "saved [her] life." On The Tonight Show Starring Jimmy Fallon, she told the host, "I was wearing a dress that was ridiculously heavy, and I couldn't really move, and I was just kind of trying to get through the evening. And at the end of the night, I'm at the top of the stairs. The gorgeous Hailee Steinfeld walks past me, has a very complicated, like, three-train thing, and I get wrapped up in it. And I'm like, 'Oh, I'm gonna die. I'm gonna die on the steps of the Met, darling.' But literally, just out of nowhere, the 'hand of God' came out and pulled me out of it, and it was you. And you were just so sweet about it. You were like, 'Hey, I'm Jimmy. Nice to meet you.' I was like, 'Okay, thank you.'" Jamie McCarthy / Getty Images 11. At the 2023 Met Gala, Chloe Fineman wore a Wiederhoeft dress. She told Entertainment Tonight, "There might be a minor tear somewhere, but I'm not gonna tell you where. It's hard to sit in traffic in a is. It's really a challenge." Kevin Mazur/MG23 / Getty Images for The Met Museum/Vogue 12. At the 2024 Met Gala, Camila Cabello wore a Ludovic de Saint Sernin gown, and she carried a rose in a block of ice. She told Extra, "It was a purse, but then it broke like five minutes into being in line, so I called my stylist. I was like, 'What do I do?' I was like, '[Fuck it], I'll take it as a clutch.' So, you know, we're just trying things here. It's all we're doing." Kevin Mazur/MG24 / Getty Images for The Met Museum/Vogue 13. At the 2024 Met Gala, model and influencer Haley Kalil wore a Marc Bouwer gown. She told E! News, "One person made this dress in four days. One person by hand in four days — and this morning, the zipper broke. We had the classic zipper moment. I mean, it is the Met, so he had to fix the zipper, and here I am. It worked! We got it!" Kristina Bumphrey / WWD via Getty Images She also said that getting ready was "a lot of chaos," adding, "The behind-the-scenes of all of this is chaos, but it's fun chaos. There's a lot of running around. My nail broke. I had to run to a nail salon this morning. Oh, we've had all the issues, but all the issues mean we're gonna have a good rest of the day...I would make it here even if I lost an arm." WWD / WWD via Getty Images 14. At the 2022 Met Gala, Nicki Minaj liked the look of her Burberry gown, but she didn't like the fit. In 2023, she told Vogue, "I just realized just this moment that actually there was something good that came out of this. It's what really cemented the fact for me that I had to get my breast reduction. I did my fittings and stuff. I told him I loved this hat. I loved what the outfit was giving, but I said, 'You guys, listen, look, these boobs are gonna be spilling out.' And by the time we were ready to go, I looked in the mirror, I said, 'Guys, my boobs are still spilling out.' And Naomi Campbell was walking in and out of the room, looking at me, like, 'Girl, let's go.' I knew before we even left the room that the boobs were about to have a night of their own." Dimitrios Kambouris / Getty Images for The Met Museum/Vogue 15. At the 2018 Met Gala, Kim Kardashian wore a golden Versace gown. On SnapChat, she shared that it got caught on other attendees' outfits during the party. Sharing a video of her dress stuck on SZA's skirt, Kim said, "When your dress is connected to this beauty. We're stuck together!" Kim Kardashian / Via Here's Kim's dress on the red carpet. Jamie McCarthy / Getty Images 16. At the 2022 Met Gala, Kim Kardashian infamously wore the 60-year-old dress that Marilyn Monroe wore when she sang "Happy Birthday" to President Kennedy. She told Vogue that when she first tried it on, she "wanted to cry because [the dress] can't be altered at all." So, in a bid to fit into the dress, she lost a significant amount of weight in a short time through unhealthy measures. Dietician Elaina Efird told BuzzFeed, "My message for people wanting to attempt to do what Kim K did is DO NOT DO THIS. It is a terrible example that she is setting, and her behavior is perpetuating eating disorders." ANGELA WEISS / AFP via Getty Images In footage TMZ released after the Met Gala, during a fitting, Kim struggled to get the dress over her butt, and once it was on, it wouldn't zip all the way. She asked, "Can we use that tie and tie it and keep it open? What if we did that and put a fur over? Oh my God, we can maybe fake it?" Ultimately, she accessorized with a fur stole, covering the back of the dress. Gotham / Getty Images 17. Unfortunately for Kim, that wasn't the only thing that went wrong with her 2022 Met Gala look. She told Vogue that she wanted to debut a new Marilyn-inspired blonde at the event, so, though lightening hair typically takes months, she waited until the last minute. She said, "I did want a physical change, too, so I thought I would wait and do it for this, so I'm spending a day straight dyeing my hair — 14 hours straight! — to get it done." Many fans criticized the final results, calling her hair "botched." Mike Coppola / Getty Images 18. And finally, on her way to the 2023 Met Gala, Kim Kardashian got help from her daughter, North, when an issue arose with her Schiaparelli gown. Kim told Vogue, "Some [pearls] popped on the way, and I told my daughter to grab them all. They're real pearls, and she was putting them all in her purse.' Cindy Ord/MG23 / Getty Images After the event, when Kim got out of the car, she seemingly tripped over her Schiaparelli gown, breaking one of the strings and sending pearls everywhere. However, she kept her cool and kept going as if nothing was wrong. MIHA, NEDA / ALEXJR / BACKGRID
New York Times
06-03-2025
- Entertainment
- New York Times
The Queen of the Blouse
On the second floor of a 19th-century villa near the Bois de Boulogne, overlooking a garden housing a child's trampoline and various plastic scooters, there is a room filled with blouses. Hundreds of blouses. Lace blouses from the Victorian era and big-shouldered blouses from the 1980s. Blouses in paisley and leopard print. Blouses with familiar pedigrees — Ungaro, Yves Saint Laurent, Giorgio di Sant' Angelo — and blouses with no pedigree at all. A rainbow of blouses arranged according to color on six clothing racks. Welcome to the mind — or, rather, the home office — of Chemena Kamali, the creative director of Chloé. If you want to understand how, in only two seasons, she transformed Chloé from an earnest but increasingly minor women's wear house into one of fashion's hottest labels, not to mention the uniform of cool girls like Suki Waterhouse and Sienna Miller (and, during her run for president, Kamala Harris), you have to understand Ms. Kamali's obsession with the blouse. She has been collecting them for 25 years and has more than 1,500 blouses: at her parents' home in Germany, in storage in France, almost 500 in her house alone. For her, the blouse — that relatively unappreciated top, redolent of school uniforms, Edwardian nannies and 1970s career girls that lost its primacy of place in the woman's wardrobe to the T-shirt decades ago — is actually the Platonic ideal of a garment. 'The evolution of the blouse is the evolution of femininity in a way, and the evolution of fashion,' Ms. Kamali said recently, tucked into one of the two giant leather chairs in her office. Aside from the blouses, a big modular desk from the 1980s and some pottery and family tchotchkes are the only objects in the room. She and her husband, Konstantin Wehrum, and their two sons, ages 3 and 5, moved into the house when she got the job at Chloé last year — they had been on their way to California — and she has not had a lot of time to unpack. 'Historically, the blouse was a man's undergarment,' she said. When she talks about something she loves, you can hear her working through her ideas in real time: 'Then, in Victorian times, the blouse became feminized. Postwar, it got more tailored. In the 1970s, again, more fluid, and in the '80s, more powerful. It can be formal and strict or playful and romantic. It reflects personalities. It reflects all of the things that make us who we are as women.' That's a lot of meaning to load onto a garment, but to Ms. Kamali, the blouse is not just a bit of fabric with buttons. The Shirt on Her Back No one wears a blouse better than Ms. Kamali, not even converts like Karlie Kloss and Liya Kebede, who have begun to line the Chloé front rows in her lacy tops and wooden platforms. Ms. Kamali's typical uniform starts with a Chloé blouse of her own design or one from her collection, often in an aged ivory with a touch of embroidery to lend it a vaguely bohemian air. 'A blouse is so much easier than a dress,' she said. She pairs them with high-waist Chloé jeans, shredded at the hem, white Chloé high-top sneakers and a tangle of necklaces, some new, some sourced at the same vintage markets where she finds her blouses. With waist-length brown hair parted in the center and framing a face that seems makeup free, it creates a vibe that is both Venice Beach hippie — even though Ms. Kamali grew up mostly in Dortmund, Germany — and efficient. If Stevie Nicks had a day job at a venture capital fund, she might look like this. 'She's aspirational,' said the actress Rashida Jones, who met Ms. Kamali a year ago. 'But it doesn't feel unattainable. It feels grounded.' Kaia Gerber, who has modeled for Ms. Kamali and wears her clothes off the runway, put it this way: 'Chemena herself is a testament to holding your power without having to adhere to the judgments society makes about women based on the way they dress.' Ms. Kamali, 43, started collecting blouses in 2003, which was around the time she got her first job at Chloé. She knew she wanted to be a designer when she was a child, and in Germany, she said, that meant being like Karl Lagerfeld, the most famous German designer, who was then at Chloé. She went to the University of Applied Sciences in Trier, Germany, and talked her way into Chloé as an intern during the Phoebe Philo era. 'The first designer piece I ever bought, actually, was at the company's employee sale for 50 euros,' she said, pointing to a white T-shirt with a 'necklace' of silver teardrops woven into the front. 'That's when my vintage obsession started, because I remember members of the team coming back from trips with big duffel bags and unpacking treasures they'd found. I realized how certain source pieces can trigger a creative process that can flow into the concept of a collection.' She got a degree from Central Saint Martins, worked at Alberta Ferretti; Chloé again, under Clare Waight Keller; and then Saint Laurent before returning to Chloé in the top job. But wherever she went, Ms. Kamali kept buying blouses. She does not buy, as many collectors do, for historic or material value but rather according to details that catch her eye — 'the volume or the construction of the sleeve or yoke.' As a result, her pieces are not forbiddingly expensive. They range from 'super cheap to maybe $700,' she said, though the average is about $300. She sources them from eBay, vintage fairs like A Current Affair in Los Angeles and what has turned into an extended network of vintage dealers. 'You go to a store, you go to a market and you meet this person who says, 'OK, you want more of this, I have some stuff in my basement,'' she said. 'Then, connecting to this community, this group of obsessive people all about the rare find, becomes an addiction.' It also made her perfect for Chloé. All Blouses All the Time The blouse is such an important part of the Chloé aesthetic that when the Jewish Museum in New York held the first major retrospective devoted to Chloé in 2023, it dedicated an entire room to the blouse. As a garment, it encapsulates the easy-breezy-feminine tone set by the founder, Gaby Aghion, in 1952, and was replicated to varying extents by the designers who came after, including Mr. Lagerfeld, Stella McCartney, Ms. Keller and Gabriela Hearst. But while they all made blouses, none made them as central to their aesthetic as Ms. Kamali had. It is the way 'she connects to the fundamental values of the house,' said Philippe Fortunato, the chief executive of the fashion and accessories maisons at Richemont, the Swiss conglomerate that owns Chloe. Indeed, Ms. Kamali's first collection for Chloé was built around a blouse. Specifically, a piece Karl Lagerfeld designed for Chloé with a black capelet of sorts built into the top. The blouse, she said, got her 'thinking about how the cape is an iconic piece in Chloé's history.' Just as the lace in a Victorian blouse had inspired the lacy tiers of the last collection, which were visible not just in actual blouses, but also in playsuits with the affect of blouses and dresses that looked like longer versions of the blouses. And just as, for her third collection, to be unveiled March 6, Ms. Kamali was thinking about something Karl Lagerfeld once said about 'the basic idea being the simplest of all: a blouse and a skirt.' 'That kind of triggered in me the idea of really looking at the blouse not as a component of a look, but as the main component,' she said. That in turn led her to the idea of the blouse as a container of historical fragments: a dolman sleeve, say, or an exaggerated collar or shoulder. All of which made their way into the collection. 'It's not about copying,' she said. 'It's about using the blouse as a way to root things in the past or in tradition.' And signal that it has a place in the future. And as Lauren Santo Domingo, a founder of Moda Operandi, reports, it's working. Chloé is 'one of our fastest sellout designers,' Ms. Santo Domingo said, noting that sales of Chloé tops had grown 138 percent since Ms. Kamali's first collections appeared. For the photographer David Sims, who shoots the Chloé campaigns, Ms. Kamali has essentially created 'the representation of a new French kind of woman, with a play around nudity and embroidery that suggests ownership over a sexual energy and power that feels like an answer to so many of the questions that have sprung up recently.' Questions about gender and stereotype; questions about the male gaze. Doing that through the prism of a garment that was essentially relegated to the dustbin of fashion and old rock stars is, he said, kind of 'radical.' But that tension is actually the point of Ms. Kamali's Chloé, which has taken the Chloé girl and grown her into a woman. 'The term 'Chloé girl' is so connected to how the world perceived the house in the first place,' Ms. Kamali said. 'But the word 'girl' is reductive. I never want the Chloé woman to be only one thing. No woman is. She has shifting moods and feelings. Ease and optimism always exists with tension. These contrasts and these opposites are what makes everything interesting.' Including, maybe especially, the shirt on your back.
