Latest news with #Woburn
Yahoo
12 hours ago
- Business
- Yahoo
Replimune Presents New Analyses from the IGNYTE Study of RP1 plus Nivolumab in Anti-PD1 Failed Melanoma at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting
- RP1 plus nivolumab generated robust responses in both injected and non-injected lesions - - Deep/visceral injections, including into the liver and lung, resulted in numerically higher rates of response compared to superficial injections only and were generally well tolerated - WOBURN, Mass., June 01, 2025 (GLOBE NEWSWIRE) -- Replimune Group, Inc. (NASDAQ: REPL), a clinical stage biotechnology company pioneering the development of novel oncolytic immunotherapies, today presented two posters highlighting data updates for RP1 (vusolimogene oderparepvec) at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting taking place May 30-June 3 in Chicago. 'The new analyses we presented from the IGNYTE clinical trial of RP1 plus nivolumab in anti-PD-1 failed melanoma confirms our belief in the systemic activity of the combination, and also shows robust responses in injected liver and lung lesions with an acceptable safety profile,' said Kostas Xynos, M.D., Chief Medical Officer of Replimune. 'Additional data also presented at the meeting shows that RP1 can be handled safely with no additional biosafety protocols required confirming that standard disinfection procedures are sufficient for clean up.' Key findings are outlined below. Poster Presentation: Response analysis for injected and non-injected lesions and the safety and efficacy of superficial and deep RP1 injection in the registrational cohort of anti-PD-1-failed melanoma patients of the IGNYTE trial (Track: Melanoma/Skin Cancers; June 1, 2025, 9:00 am – 12:00 pm CDT; Location: Hall A, Board 20; Abstract: 9537) The poster included an analysis from the IGNYTE clinical trial of RP1 plus nivolumab in the cohort of anti-PD-1 failed melanoma patients (n=140). In the trial, the objective response rate (ORR) was 32.9% using RECIST 1.1. The complete response rate was 15.0% and landmark overall survival (OS) rates at 1, 2, and 3 years were 75.3%, 63.3%, and 54.8% respectively. Median OS has not been reached. Patients experienced numerically higher objective response rates after receiving deep injections (± superficial) compared with superficial injections only. Deep responses were observed in injected and non-injected lesions. The ORR by injection type using RECIST 1.1 was 29.8% when only superficial lesions were injected, 42.9% for deep/visceral plus superficial injections injected, and 40.9% when only deep/visceral lesions were injected. There was a ≥30% reduction in 93.6% (73/78) of injected lesions and 79.0% (94/119) of non-injected lesions. The kinetics of response were similar in injected vs non-injected lesions. Of the non-injected visceral organ lesions in responding patients, 96.2% (50/52) showed reduction from baseline, with 65.4% reduced by ≥30%. RP1 injections directly into the lung and liver were generally well tolerated and resulted in few organ-specific adverse events that were easily managed. Liver and lung injections had a tolerable safety profile. No bleeding events were reported after liver injection. Lung injections were associated with low rates of pneumothorax events, which were typically of low grade and manageable. Overall, these data support the safety and efficacy of deep/visceral injections and demonstrate the development of a robust systemic anti-tumor response following treatment with RP1 plus nivolumab. Poster Presentation: Biosafety analysis from the skin cancer cohorts in the IGNYTE clinical trial of RP1 (Track: Melanoma/Skin Cancers; June 1, 2025, 9:00 am – 12:00 pm CDT; Location: Hall A, Board 17; Abstract: 9534) RP1 was assessed in various samples taken from patients. This demonstrated that RP1 DNA is primarily detected at the injection site, consistent with RP1 replication in the tumor, and much more rarely on dressings, in blood, on mucous membranes or in urine. In all cases, live RP1 was only rarely if ever detected, demonstrating that while residual RP1 DNA may be present, this does not indicate the presence of live RP1 There were no systemic herpetic infections in patients or reports of HSV-1 infections in contacts. RP1 is completely neutralized using standard disinfectants within 30 seconds of contact, confirming that standard disinfection procedures are sufficient for RP1 clean-up. Collectively these data demonstrate that the likelihood of transmission of RP1 to patients' contacts or into the external environment is minimal, with no transmission having been reported to date. Both posters will be available on the Company website under Events and Presentations. About RP1RP1 is Replimune's lead product candidate and is based on a proprietary strain of herpes simplex virus engineered and genetically armed with a fusogenic protein (GALV-GP-R-) and GM-CSF intended to maximize tumor killing potency, the immunogenicity of tumor cell death and the activation of a systemic anti-tumor immune response. About RP2RP2 is based on a proprietary strain of herpes simplex virus engineered and genetically armed with a fusogenic protein (GALV-GP-R-) and GM-CSF intended to maximize tumor killing potency, the immunogenicity of tumor cell death and the activation of a systemic anti-tumor immune response. RP2 additionally expresses an anti-CTLA-4 antibody-like molecule, as well as GALV-GP-R- and GM-CSF. RP2 is intended to provide targeted and potent delivery of these proteins to the sites of immune response initiation in the tumor and draining lymph nodes, with the goal of focusing systemic-immune-based efficacy on tumors and limiting off-target toxicity. About ReplimuneReplimune Group, Inc., headquartered in Woburn, MA, was founded in 2015 with the mission to transform cancer treatment by pioneering the development of novel oncolytic immunotherapies. Replimune's proprietary RPx platform is based on a potent HSV-1 backbone intended to maximize immunogenic cell death and the induction of a systemic anti-tumor immune response. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response. The RPx product candidates are expected to be synergistic with most established and experimental cancer treatment modalities, leading to the versatility to be developed alone or combined with a variety of other treatment options. For more information, please visit Forward Looking StatementsThis press release contains forward looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, including statements regarding the design and advancement of our clinical trials, the timing and sufficiency of our clinical trial outcomes to support potential approval of any of our product candidates, the regulatory review process and timing of potential product approval, our goals to develop and commercialize our product candidates, patient enrollments in our existing and planned clinical trials and the timing thereof, and other statements identified by words such as 'could,' 'expects,' 'intends,' 'may,' 'plans,' 'potential,' 'should,' 'will,' 'would,' or similar expressions and the negatives of those terms. Forward-looking statements are not promises or guarantees of future performance, and are subject to a variety of risks and uncertainties, many of which are beyond our control, and which could cause actual results to differ materially from those contemplated in such forward-looking statements. These factors include risks related to our limited operating history, our ability to generate positive clinical trial results for our product candidates, the costs and timing of operating our in-house manufacturing facility, the timing and scope of regulatory approvals, the availability of combination therapies needed to conduct our clinical trials, changes in laws and regulations to which we are subject, competitive pressures, our ability to identify additional product candidates, political and global macro factors including the impact of the coronavirus as a global pandemic and related public health issues and the Russian-Ukrainian and Israel-Hamas political and military conflicts, and other risks as may be detailed from time to time in our Annual Reports on Form 10-K and Quarterly Reports on Form 10-Q and other reports we file with the Securities and Exchange Commission. Our actual results could differ materially from the results described in or implied by such forward-looking statements. Forward-looking statements speak only as of the date hereof, and, except as required by law, we undertake no obligation to update or revise these forward-looking statements. Investor InquiriesChris BrinzeyICR Media InquiriesArleen GoldenbergReplimune917.548.1582 media@ in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Associated Press
5 days ago
- Business
- Associated Press
Leading Industrial Manufacturer Selects HawkSearch to Power Digital Commerce Growth
WOBURN, MASSACHUSETTS / ACCESS Newswire / May 28, 2025 / Bridgeline Digital, Inc. (NASDAQ:BLIN), a leader in AI-driven marketing technology, announced today that a major industrial manufacturer has selected HawkSearch to power product discovery for its eCommerce site. The HawkSearch integration will enhance the manufacturer's current eCommerce site with scalable search capabilities, including Instant Engage, dynamic autocomplete, and personalized product recommendations. The deployment will also feature Bridgeline's Rapid UI framework and advanced merchandising tools to improve conversion rates and standardize the user experience. Instant Engage will display the most popular products, category pages, and content items as soon as the user clicks on the search bar. For example, a contractor interacting with the search bar on the manufacturer's site might see top-selling fittings like the 2" Elbow - Copper Press, links to category pages for Valves and Stainless-Steel Components, and featured resources such as installation guides or specification sheets. This kind of immediate applicability keeps users engaged, increases cart sizes, and lifts conversion rates, all leading to revenue growth. 'This integration is designed to drive measurable growth,' said Ari Kahn, CEO of Bridgeline. 'With HawkSearch, manufacturers gain AI-powered tools to deliver faster, more personalized shopping experiences that increase conversion rates and boost revenue.' About Bridgeline Bridgeline helps companies grow online revenue by increasing traffic, conversion rates, and average order value. To learn more, visit .Contact: Danielle Colvin SVP of Marketing Bridgeline Digital [email protected] SOURCE: Bridgeline Digital press release
Boston Globe
6 days ago
- Sport
- Boston Globe
Student photographers there to capture crowning achievements in sports
Advertisement Some of their pictures are down below in this week's photo gallery, along with some from 17 other high school photographers from around the state. We hope you enjoy them. The Falmouth boys' lacrosse team took the field for a game against visiting Sandwich on May 21, 2025, just four days after classmate Ava Lodico was killed in a single-car accident following the school's prom. Kody Pokraka/Falmouth High School Woburn captain Ryan Lush goes back to the dugout in the fourth inning in a game against visiting Reading on May 20, 2025. Billy LaTores/Woburn High School Tewksbury's Erin Costello poses with her family during Senior Night ceremonies on May 21, 2025. Khai Hieu/Tewksbury High School The Maynard softball huddles up before a game with visiting Fitchburg on May 21, 2025. Ryan Guiel/Maynard High School University of Florida fans cheer on Ashley Dyer as she carries the ball downfield during a 20-4 loss to North Carolina in the NCAA Division 1 women's lacrosse semifinals at Gillette Stadium on May 23, 2025. Paige Berry/Bishop Feehan High School An empty lacrosse goal, its net picked clean for souvenirs, symbolized victory for Tufts after a 25-8 victory over Dickinson in the NCAA Division 3 men's lacrosse national title game May 25, 2025, at Gillette Stadium. Daniel Murphy/Melrose High School North Carolina's Chloe Humphrey, who scored seven goals, takes a moment to sign a young fan's poster and lacrosse ball after the Tar Heels' 20-4 victory over Florida in the NCAA Division 1 women's lacrosse semifinals at Gillette Stadium on May 23, 2025. Paige Berry/Bishop Feehan High School Somerset Berkley's Jayden Cruz maneuvers into third base during a 5-2 win over visiting Durfee on May 20, 2025. Calder Troutman/Somerset Berkley High School Nantucket sophomore Eli MacIver gets the out at home during a 10-0 loss at Martha's Vineyard on May 24, 2025. Andrew Lavin/Nantucket High School Quabbin Regional junior Finn Leander follows through on a pitch during a 6-1 loss to visiting Worcester South on May 21, 2025. Maddy Hardy/Quabbin High School Natick's Colby Ciavarro makes a play at second during a 3-2 victory over visiting Walpole on May 19, 2025. Jack Polansky/Wilson Middle School Junior Justin Moskal kicks and fires during South Hadley's 5-1 win over visiting Ludlow on May 23, 2025. Brandon Bregu/South Hadley High School Dighton-Rehoboth senior Lucas Letournaeu takes a rip during a 1-0 loss to visiting Seekonk on May 21, 2025. Autumn Sylvester/Somerset Berkley High School Shrewsbury's Ryan Iagallo (right) high fives Owen Michalowski after scoring in the bottom of the second inning of a 4-2 win over visiting St. John's on May 21, 2025. Kailey Flynn/Shrewsbury High School Nantucket junior Ronald Del Rosario Gomez catches an infield fly during a 10-0 loss at Martha's Vineyard on May 24, 2025. Andrew Lavin/Nantucket High School Woburn's Tanners Emmett Vaughan lets fly in a game against visiting Reading on May 20, 2025. Billy LaTores/Woburn High School Holy Cross's Danny Macchiarola went the distance in Game 1 of the Patriot League championship series, a 12-1 win over visiting Army at Fitton Field on May 18, 2025. Jack Polansky/Wilson Middle School Maynard catcher Max Cedeño throws back to the pitcher during a 3-2 win over visiting Assabet on May 23, 2025. Ryan Guiel/Maynard High School Nashoba Valley Tech senior Chase Blaisdell watches a pitch go by during a 9-3 loss to visiting Assabet Valley on May 19, 2025. Sam Hesketh/Nashoba Valley Technical Somerset Berkley's Kyle Sherman chats with a Durfee player after a 5-2 home win on May 20, 2025. Calder Troutman/Somerset Berkley High School Somerset Berkley's Hayden Teasdale waits for his chance to bat during a 5-2 win over visiting Durfee on May 20, 2025. Calder Troutman/Somerset Berkley High School The South Hadley baseball team lines up before its 5-1 win over visiting Ludlow on May 23, 2025. Brandon Bregu/South Hadley High School Tewksbury's Aidan Kelley has some on the sideline during a 14-4 win over visiting Lowell Catholic on May 16, 2024. Khai Hieu/Tewksbury High School Westwood junior Sam Cochran stretched for the ball during a 19-3 win over visiting Holliston on May 23, 2025. Zac Ventola/Westwood High School Shrewsbury's Cam Moore looks for a pass during a 9-2 loss to visiting Grafton on May 21, 2025. Kailey Flynn/Shrewsbury High School Somerset Berkley's Gavin Rodrigues concentrates as he runs with the ball during a 5-4 loss at Greater New Bedford RVT on May 21, 2025. Calder Troutman/Somerset Berkley High School Concord-Carlisle senior Jason Swaim drives toward the net during a 16-2 win over visiting Belmont on May 23, 2025. Aidan Moroney/Concord-Carlisle High School Wayland's Braden Leichliter (left) denies a Dover-Sherborn player during a 13-7 home loss on May 23, 2025. Vanessa Taxiarchis/Wayland High School Senior Charlie Blake moves the ball upfield during an 18-7 win over visiting Cape Cod Academy on May 21, 2025. Hanna Thornton/Dennis-Yarmouth High School Westwood senior Aaron Wachob (29) celebrates a fourth-quarter goal during a 19-3 win over visiting Holliston on May 23, 2025. Owen Ziegler/Westwood High School The Concord-Carlisle boys' lacrosse team celebrates a goal during a 16-2 win over visiting Belmont on May 23, 2025. Aidan Moroney/Concord-Carlisle High School Tewksbury's Aidan Kelley gets a bath after his big Senior Night game, a 14-4 win over visiting Lowell Catholic on May 16, 2024. Khai Hieu/Tewksbury High School The Somerset Berkley boys' lacrosse team treks into Jeffrey E. Riley Stadium at Greater New Bedford RVT for a game on May 21, 2025. Calder Troutman/Somerset Berkley High School The seniors on the Shrewsbury High boys' lacrosse team pose during a Senior Night ceremony on May 21, 2025. Kailey Flynn/Shrewsbury High School Penn State sophomore Brendan Leary looks down in disappointment as the Cornell men's lacrosse team celebrates its 11-9 win in the NCAA Division 1 semifinals on May 24, 2025, at Gillette Stadium. Paige Berry/Bishop Feehan High School Penn State senior Matt Traynor takes a moment after scoring in the second quarter of the NCAA Division 1 men's lacrosse semifinal against Cornell on May 24, 2025, at Gillette Stadium. Daniel Murphy/Melrose High School Maryland senior Geordy Holmes high-fives jubilant fans after a 14-8 win over Syracuse in the NCAA Division 1 men's lacrosse semifinals on May 24, 2025, at Gillette Stadium. Daniel Murphy/Melrose High School Maryland junior AJ Larkin celebrates with friends and family following the Terrapins' 14-8 win over Syracuse in the NCAA Division 1 men's lacrosse semifinals at Gillette Stadium on May 24, 2025. Paige Berry/Bishop Feehan High School The North Carolina women's lacrosse team poses with the NCAA Division 1 national championship trophy following its 12-8 over Northwestern at Gillette Stadium on May 25, 2025. Paige Berry/Bishop Feehan High School North Carolina goalie Betty Nelson holds the NCAA Division 1 women's lacrosse national championship trophy after helping the Tar Heels to a 12-8 win over Northwestern at Gillette Stadium on May 25, 2025. Daniel Murphy/Melrose High School Tufts senior Braun Lippe hoists the trophy after a 25-8 win over Dickinson in the NCAA Division 3 men's lacrosse national title game at Gillette Stadium on May 25, 2025. Daniel Murphy/Melrose High School Members of the Tufts men's lacrosse team gather in celebration after their 25-8 victory over Dickinson to claim the NCAA Division 3 national title at Gillette Stadium on May 25, 2025. Paige Berry/Bishop Feehan High School Maryland's Daniel Kelly sits in disappointment following a 13-10 loss to Cornell in the NCAA Division 1 men's lacrosse national championship game at Gillette Stadium on May 26, 2025. Paige Berry/Bishop Feehan High School Cornell's Jack Cascadden (white) and Maryland's Shea Keethler battle for the ball in the opening faceoff of the NCAA Division 1 men's lacrosse championship game between Cornell and Maryland at Gillette Stadium on May 26, 2025. Daniel Murphy/Melrose High School Fireworks followed the conclusion of the "Star-Spangled Banner" before the NCAA Division 1 men's lacrosse championship game between Cornell and Maryland at Gillette Stadium on May 26, 2025. Daniel Murphy/Melrose High School John Vitti can be reached at
Associated Press
22-05-2025
- Business
- Associated Press
Online Wholesale Marketplace Selects HawkSearch to Power Personalized Search and Recommendations
API Integration with BigCommerce Supports Rapid Growth to 5 Million Products and 30 Million Annual API Calls WOBURN, MA / ACCESS Newswire / May 22, 2025 / Bridgeline Digital, Inc. (NASDAQ:BLIN), a leader in AI-driven marketing technology, announced that a leading online wholesale marketplace has selected HawkSearch to enhance its eCommerce experience with personalized search and product recommendations. The wholesale marketplace will use HawkSearch to power search and recommendations across a catalog expected to surpass 5 million products. With site traffic projected to grow significantly year over year, HawkSearch will ensure fast, reliable results at scale, no matter how many shoppers are online. Integrated via API with the company's BigCommerce platform, HawkSearch personalizes each experience with real-time recommendations and dynamic product prioritization based on trends, availability, and customer behavior, helping users quickly find the right products in vast and growing catalogs. For example, a user searching for 'wireless charging station for cell phone' will be shown compatible products from multiple top-tier brands, intelligently sorted based on availability, shopper behavior, and marketplace promotions. HawkSearch ensures even detailed or multi-attribute queries return precise and buyer-ready results. 'This launch demonstrates the power of HawkSearch to drive performance for high-volume marketplaces,' said Ari Kahn, CEO of Bridgeline. 'By scaling with usage, offering flexible deployment, and delivering AI-powered personalization, HawkSearch helps fast-growing brands deliver search experiences that convert.' About Bridgeline Digital Bridgeline helps companies grow online revenue by increasing traffic, conversion rates, and average order value. To learn more, visit Contact: Danielle Colvin SVP of Marketing Bridgeline Digital [email protected] SOURCE: Bridgeline Digital press release
BBC News
19-05-2025
- General
- BBC News
Endangered baby bongo born at UK safari park
Check out these pictures of an adorable baby bongo who was born at Worburn Safari Park in Bedfordshire earlier this month. The currently unnamed male calf has been seen dashing around its outdoor enclosure despite needing special treatment on his hips and rear legs shortly after birth. The physiotherapy seems to have worked well and the new calf is now said to be integrating with the rest of the herd. Under the overall care of the keepers at Woburn, the newborn is being fed and looked after by his mother Odongo and his father Sonny. The eastern mountain bongo's birth is great news for the species as it is classified as as critically endangered. Breeding programmes in zoos and safari parks like Woburn are said to be playing a key role in conservation male calf was born last October - they named him Djembe. He is the new calf's cousin as their mothers are twin have said the two youngsters have already formed a bond with nose-to-nose head of section Tom Robson said that after a six-year breeding gap "two healthy calves were born within months of each other, marking a major success" for the team."As a critically endangered species, every birth plays a vital role in securing the future of these beautiful animals."Odongo has embraced motherhood beautifully, it's just wonderful to see her offering her newborn the strongest possible start in life." What is a bongo? Bongos are a large species of African forest antelope, and are found in tropical forests and bamboo forests of stand out from other antelope species due to their distinctive stripes. An adult usually has between 10 and 16 stripes and most have a black belly. Males tend to have darker coats than females. They are vegetarian, eating mainly leaf tips, shoots, roots and the vines of a wide variety of other plants including bamboo, cassava and even sweet potato when in captivity. In the wild, their main threat is poaching - humans illegally hunt them for food and thier skins. Other predators include lions, pythons, leopards and is estimated that there are less than 100 bongos currently living in the wild.
