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Associated Press
19 hours ago
- Business
- Associated Press
Pharvaris Presents Data Supporting Ongoing Clinical Development of Deucrictibant in Bradykinin-Mediated Angioedema
ZUG, Switzerland, June 02, 2025 (GLOBE NEWSWIRE) -- Pharvaris (Nasdaq: PHVS), a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to help address unmet needs of those living with bradykinin-mediated diseases such as hereditary angioedema (HAE) and acquired angioedema due to C1 inhibitor deficiency (AAE-C1INH), today announced a summary of data that were presented at the 14th C1-Inhibitor Deficiency and Angioedema Workshop. 'Additional analyses of deucrictibant data demonstrate consistency in the clinical profile shown in both the prophylactic and on-demand treatment settings,' said Berndt Modig, Chief Executive Officer of Pharvaris. 'Deucrictibant's early-onset and durable treatment response in the on-demand setting, the maintenance of attack reduction for over a year and a half in the prophylactic setting, and the potential for deucrictibant to be used together in both the prophylactic and on-demand settings, if needed, provide additional evidence of deucrictibant's potential in the treatment of bradykinin-mediated angioedema. Pharvaris continues to diligently execute on the deucrictibant clinical program and is planning for two pivotal data readouts in the next 18 months.' Details of the presentations are outlined below: Prophylaxis Long-Term Safety and Efficacy of Oral Deucrictibant for Prophylaxis in Hereditary Angioedema: Data Snapshot Results of the CHAPTER-1 Open-Label Extension Study, an oral presentation by Emel Aygören-Pürsün, M.D. The ongoing Phase 2 CHAPTER-1 open-label extension (OLE) study provides further evidence on the long-term safety and efficacy of oral deucrictibant for prevention of HAE attacks. The attack rate has remained low, irrespective of baseline attack rate, for over a year and a half in OLE participants. When evaluating mechanism-on-mechanism responses, the response to icatibant for on-demand treatment of breakthrough attacks appeared to be maintained when used for breakthrough attacks during prophylactic treatment with deucrictibant. Peng Lu, M.D., Ph.D., Chief Medical Officer of Pharvaris, stated, 'Deucrictibant remains the only drug in development for bradykinin-mediated angioedema that has the potential to both prevent attacks and treat them when they occur. The data from the ongoing study further bolsters the potential value proposition of deucrictibant as it provides initial evidence that a bradykinin B2 receptor antagonist can effectively manage a breakthrough attack during treatment with a B2 receptor antagonist, if it were to occur. We believe further confirming these post-hoc open-label findings in our ongoing CHAPTER-3 study would provide additional evidence on the potential of deucrictibant to help address unmet needs of people living with bradykinin-mediated angioedema.' Long-Term Prophylactic Treatment with Oral Deucrictibant Improves Health-Related Quality of Life and Disease Control in Participants with Hereditary Angioedema: CHAPTER-1 Open-Label Extension Study, a poster presentation by Markus Magerl, M.D. The impact of deucrictibant treatment on health-related quality of life (HRQoL), disease control, and treatment satisfaction during the ongoing CHAPTER-1 OLE was evaluated. All of the participants who received deucrictibant reported clinically meaningful improvements in HRQoL at the end of the randomized portion of the trial, which was maintained at week 62 of the OLE. All of the participants in the OLE reported well controlled HAE and a high level of satisfaction with treatment. Sustained Therapeutic Exposure with Once-Daily Oral Deucrictibant XR Tablet for Prophylaxis of Hereditary Angioedema Attacks: Results of a Pharmacokinetics Study in Healthy Volunteers, a poster presentation by Zhi-Yi Zhang, Ph.D. To confirm its potential for once-daily prophylactic treatment, a Phase 1 pharmacokinetic study was conducted to compare the profile of the XR formulation (40 mg) to the immediate-release (IR) formulation (2 x 20 mg in a single administration), which was shown to be efficacious and well tolerated in the proof-of-concept CHAPTER-1 prophylaxis study. Deucrictibant extended-release (XR) tablet was well tolerated with no adverse events. Deucrictibant XR's pharmacokinetic profile demonstrated sustained exposure for over 24 hours, supporting once-daily dosing, and showed, on average, approximately a four-fold higher mean plasma concentration than therapeutic threshold (EC85) at 24 hours, supporting its further investigation as a potential oral once-daily prophylactic therapy for bradykinin-mediated angioedema. CHAPTER-3 Phase 3 Trial Design: Efficacy and Safety of the Oral Bradykinin B2 Receptor Antagonist Deucrictibant Extended-Release Tablet for Prophylaxis of Hereditary Angioedema Attacks, a poster presentation by Andrea Zanichelli, M.D., Ph.D. CHAPTER-3 is an ongoing, global, Phase 3 study designed to evaluate the efficacy and safety of once-daily, oral deucrictibant (40 mg/day) XR tablet for prophylaxis of attacks in adolescents and adults with HAE. Results from the Phase 2 CHAPTER-1 study support the CHAPTER-3 study design. On-Demand Durability Of Response to a Single Dose of Oral Deucrictibant for On-Demand Treatment of Hereditary Angioedema Attacks, a poster presentation by Anna Valerieva, M.D., Ph.D. A post-hoc analysis of the placebo-controlled RAPIDe-1 trial and the RAPIDe-2 extension study assessed the durability of effects in HAE attacks treated with a single dose of deucrictibant. In both studies, the majority of attacks were treated with a single dose of deucrictibant. In RAPIDe-1, 95-100% of the attacks and, in RAPIDe-2, 98-100% of the attacks that achieved symptom relief and resolution had a durable response without symptom reoccurrence. Dr. Lu continued, 'The ideal on-demand treatment for people living with HAE should offer both rapid symptom relief and complete symptom resolution with a single dose; this can only be achieved if the response to treatment is sustained without attack symptom reoccurrence. We believe the recently presented data on durability of response could be compelling to multiple stakeholders in the HAE community, including those living with HAE, their prescribing physicians, and the payor community. We aim to further evaluate deucrictibant's ability to rapidly and completely address bradykinin-mediated angioedema attack symptoms in our ongoing Phase 3 RAPIDe-3 clinical study.' Long-Term Safety and Efficacy of Oral Deucrictibant for Treatment of Hereditary Angioedema Attacks: Results of the RAPIDe-2 Extension Study, an oral presentation by Marc A. Riedl, M.D., M.S. Following the closure of Part A of RAPIDe-2, a Phase 2/3 study of deucrictibant for the on-demand treatment of HAE attacks, an analysis of 465 attacks from 19 participants, including 14 upper airway attacks from seven participants, was conducted. The final results from Part A of the RAPIDe-2 extension are consistent with the Phase 2 RAPIDe-1 randomized study. Deucrictibant continued to be well tolerated across all doses. The median time to onset of symptom relief was 1.1 hours, and 97.8% of attacks achieved onset of symptom relief in 12 hours. The median time to complete attack resolution was 10.6 hours, and 86.9% of attack achieved complete resolution at 24 hours. Eighty-nine percent of the attacks that achieved symptom resolution at 24 hours were treated with a single dose of deucrictibant. Safety and Efficacy of Oral Deucrictibant for Treatment of Upper Airway and Laryngeal Hereditary Angioedema Attacks: Results from the RAPIDe-2 Extension Study, a poster presentation by Ramón Lleonart, M.D. The final data from Part A of the RAPIDe-2 study showed that safety and efficacy outcomes of treatment with deucrictibant IR were consistent for both HAE attacks affecting the upper airways, including laryngeal attacks, and HAE attacks occurring in other locations. Deucrictibant was generally well tolerated with no treatment-related treatment-emergent adverse events reported across upper airway and non-upper airway attacks. Fourteen upper airway attacks were treated by 7 participants; the median time to onset of symptom relief, as measured by Patient Global Impression of Change (PGI-C) of 'a little better', was 1.4 hours (n=14) for upper airway attacks compared to 1.1 hours for non-upper airway attacks (n=451). Endpoint measurements taken throughout the span of an entire attack until and including complete resolution were similar for both upper airway and non-upper airway attacks. Importantly, 92.9% of the upper airway attacks were treated with a single dose of deucrictibant. Expansion Beyond HAE Clinical Validation of a Novel Biomarker Assay to Characterize Bradykinin-Mediated Angioedema in Prospective and Biobank Plasma Samples, an oral presentation by Evangelia Pardali, Ph.D. Assays for an early and accurate diagnosis of bradykinin-mediated angioedema are lacking. Cold activation of plasma from people living with HAE resulted in increased levels of bradykinin compared to cold-activated plasma of healthy volunteers, resulting in a qualified kinin assay that can be used to reliably characterize people with bradykinin-mediated angioedema and could become a key tool aiding identification, study, and management of bradykinin-mediated pathologies including angioedema. Further applications of this biomarker assay will be explored during Pharvaris' R&D call on June 4 ( register here ). Acquired Angioedema Due to C1-Inhibitor Deficiency: Patient Experience and Assessment of Patient-Reported Outcome Measures, a poster presentation by Andrea Zanichelli, M.D., Ph.D. There are currently no approved therapies for the treatment of AAE-C1INH attacks, nor patient-reported outcome measures validated in AAE-C1INH. Concept elicitation and cognitive interviews were performed to develop a conceptual model of AAE-C1INH that could reveal important disease concepts supporting a clinical outcome assessment strategy, as well as evaluating the comprehension and interpretation of PGI-C, PGI-Severity (PGI-S), patient global assessment of change (PGA-C), and PGA-Status (PGA-S), and explore perceptions of meaningful change using these measures. One hundred percent of participants considered PGI-C 'better' to be a meaningful change four hours post-treatment. Epidemiology of Bradykinin-Mediated Angioedema in the European Population, a poster presentation by Emel Aygören-Pürsün, M.D. A systematic literature review was conducted to summarize epidemiologic data on bradykinin-mediated angioedema, including HAE due to C1 inhibitor deficiency (HAE-C1INH Type 1 and Type 2), HAE due to other mutations in people with normal C1 levels and function (HAE-nC1INH), and AAE-C1INH, in the European Union (EU) and United Kingdom (UK). The review of 14 peer-reviewed scientific articles allowed to estimate the prevalence of HAE-C1INH (Type 1/2) as ranging between 0.05-0.33/10,000 individuals, the prevalence of HAE-nC1INH ranging between <0.01-0.07/10,000 individuals, and the prevalence of AAE-C1INH ranging between 0.01-0.02/10,000 individuals in European countries. The presentation slides and posters are available on the Investors section of the Pharvaris website at: About Deucrictibant Deucrictibant is a novel, potent, orally bioavailable small-molecule bradykinin B2 receptor antagonist currently in clinical development. Deucrictibant is being investigated for its potential to prevent the occurrence of bradykinin-mediated angioedema attacks and to treat the manifestations of attacks if/when they occur by inhibiting bradykinin signaling through the bradykinin B2 receptor. Pharvaris is developing two formulations of deucrictibant for oral administration: an extended-release tablet to enable sustained absorption and efficacy as prophylactic treatment, and an immediate-release capsule to enable rapid onset of activity for on-demand treatment. Deucrictibant has been granted orphan drug designation for the treatment of bradykinin-mediated angioedema by the U.S. Food and Drug Administration and orphan designation by the European Commission. About Pharvaris Pharvaris is a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to potentially address all types of bradykinin-mediated angioedema. Pharvaris intends to provide injectable-like efficacy™ and placebo-like tolerability with the convenience of oral therapies to prevent and treat bradykinin-mediated angioedema attacks. With positive data in both Phase 2 prophylaxis and on-demand studies in HAE, Pharvaris is currently evaluating the efficacy and safety of deucrictibant in a pivotal Phase 3 study for the prevention of HAE attacks (CHAPTER-3) and a pivotal Phase 3 study for the on-demand treatment of HAE attacks (RAPIDe-3). For more information, visit Forward Looking Statements This press release contains certain forward-looking statements that involve substantial risks and uncertainties. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including, without limitation, statements relating to our future plans, studies and trials, and any statements containing the words 'believe,' 'anticipate,' 'expect,' 'estimate,' 'may,' 'could,' 'should,' 'would,' 'will,' 'intend' and similar expressions. These forward-looking statements are based on management's current expectations, are neither promises nor guarantees, and involve known and unknown risks, uncertainties and other important factors that may cause Pharvaris' actual results, performance or achievements to be materially different from its expectations expressed or implied by the forward-looking statements. Such risks include but are not limited to the following: uncertainty in the outcome of our interactions with regulatory authorities, including the FDA; the expected timing, progress, or success of our clinical development programs, especially for deucrictibant immediate-release capsules and deucrictibant extended-release tablets, which are in late-stage global clinical trials; our ability to replicate the efficacy and safety demonstrated in the RAPIDe-1, RAPIDe-2, and CHAPTER-1 Phase 2 and Phase 3 studies in ongoing and future nonclinical studies and clinical trials; risks arising from epidemic diseases, which may adversely impact our business, nonclinical studies, and clinical trials; our ability to potentially use deucrictibant for alternative purposes, for example to treat C1-INH deficiency (AAE-C1INH); the outcome and timing of regulatory approvals; the value of our ordinary shares; the timing, costs and other limitations involved in obtaining regulatory approval for our product candidates, or any other product candidate that we may develop in the future; our ability to establish commercial capabilities or enter into agreements with third parties to market, sell, and distribute our product candidates; our ability to compete in the pharmaceutical industry, including with respect to existing therapies, emerging potentially competitive therapies and with competitive generic products; our ability to market, commercialize and achieve market acceptance for our product candidates; our ability to produce sufficient amounts of drug product candidates for commercialization; our ability to raise capital when needed and on acceptable terms; regulatory developments in the United States, the European Union and other jurisdictions; our ability to protect our intellectual property and know-how and operate our business without infringing the intellectual property rights or regulatory exclusivity of others; our ability to manage negative consequences from changes in applicable laws and regulations, including tax laws (including the Biosecure Act), our ability to successfully remediate the material weaknesses in our internal control over financial reporting and to maintain an effective system of internal control over financial reporting; changes and uncertainty in general market conditions; disruptions at the FDA and other agencies; political conditions, such as the current war between Russia and Ukraine; economic conditions, including continuing inflation concerns; and the other factors described under the headings 'Cautionary Statement Regarding Forward-Looking Statements' and 'Item 3. Key Information—D. Risk Factors' in our Annual Report on Form 20-F and other periodic filings with the U.S. Securities and Exchange Commission. These and other important factors could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management's estimates as of the date of this press release. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. While Pharvaris may elect to update such forward-looking statements at some point in the future, Pharvaris disclaims any obligation to do so, even if subsequent events cause its views to change. These forward-looking statements should not be relied upon as representing Pharvaris' views as of any date subsequent to the date of this press release. Contact Maggie Beller Executive Director, Head of Corporate and Investor Communications [email protected]
Associated Press
6 days ago
- Business
- Associated Press
CROSS Sets New Benchmark with Transparent and Fair Token Launch
CROSS Public Sale Concludes - A Bold Experiment in Tokenomics Democracy. Opengame Foundation Completes Public Sale of CROSS Token, Burns Unsold Supply to Ensure Transparency and Value Stability ZUG, CH / ACCESS Newswire / May 28, 2025 / Opengame Foundation (OGF), the non-profit organization behind the open blockchain gaming platform CROSS, has officially concluded its public token sale for the CROSS utility token. The public sale, which ran for one week starting May 15, drew attention across the Web3 industry for its unique commitment to fairness and transparency. Tokens were offered at a fixed price of $0.10, the same as in the private sale, ensuring that all participants-whether early backers or new supporters-had access under identical conditions. In total, 96 million CROSS tokens, representing 9.6% of the platform's total supply of 1 billion, were made available during the public sale on a first-come, first-served basis. Approximately 92% of the allocation was sold by the end of the sale period. The remaining unsold tokens will be permanently burned-a move designed to reinforce both the integrity of the token's value and the foundation's long-term commitment to transparency. Henry Chang, CEO of NEXUS and key contributor to the CROSS ecosystem, described the initiative as 'an unprecedented experiment.' In a post on X (formerly Twitter), he wrote: 'Another dot, placed. We've now completed an unprecedented experiment-offering the same price to private and public investors, including the founder and team ourselves. I appreciate the support and investment from all who believed in us. Time will reveal how this unfolds. As we head toward the next milestone, TGE, we'll keep doing what we've always done: Build-so that one day, we can connect the dots backward.' The Opengame Foundation plans to distribute CROSS tokens to public sale participants in accordance with the TGE timeline. Together with NEXUS, it will accelerate the growth of the CROSS ecosystem, bringing more developers and players into the open blockchain gaming space. About Opengame Foundation Opengame Foundation (OGF) is a non-profit organization committed to building an open and inclusive blockchain gaming ecosystem. As the steward of the CROSS Protocol, OGF aims to empower both developers and players by providing transparent infrastructure, fair tokenomics, and interoperable tools that support the next generation of Web3 games. With a focus on long-term sustainability, openness, and community participation, the foundation works to democratize access to digital assets and reshape how value is created and shared in the gaming world. Media Contact Organization: Opengame Foundation Contact Person Name: Doyi Kim Website: Email: [email protected] Country: Switzerland SOURCE: Opengame Foundation press release
National Post
6 days ago
- Business
- National Post
Galderma Buys Back Shares Worth CHF 233 Million in the Context of Accelerated Bookbuild Offering
Article content ZUG, Switzerland — Galderma (SIX: GALD), the pure-play dermatology category leader, today announced that it has agreed to repurchase 2.38 million shares at a price of CHF 97.75 per share for a total consideration of CHF 232.5 million in the context of the accelerated bookbuild offering ('ABO') of Galderma shares by Sunshine SwissCo GmbH ('EQT'), Abu Dhabi Investment Authority and Auba Investment Pte. Ltd. launched yesterday evening. The repurchase was made at the same price per share determined by the bookbuilding offering. Article content The repurchase, which is expected to settle on June 2, is being financed by Galderma's existing liquidity on hand and will not affect the company's ability to deliver on its strategic and financing priorities. Article content The shares will be held in treasury for future use in connection with Galderma's employee participation plans, business development opportunities and/or treasury management. Article content Following the closing of the ABO, the free float in Galderma's shares is expected to increase from 41.8% to 49.8%. Article content About Galderma Galderma (SIX: GALD) is the pure-play dermatology category leader, present in approximately 90 countries. We deliver an innovative, science-based portfolio of premium flagship brands and services that span the full spectrum of the fast-growing dermatology market through Injectable Aesthetics, Dermatological Skincare and Therapeutic Dermatology. Since our foundation in 1981, we have dedicated our focus and passion to the human body's largest organ – the skin – meeting individual consumer and patient needs with superior outcomes in partnership with healthcare professionals. Because we understand that the skin we are in shapes our lives, we are advancing dermatology for every skin story. For more information: Article content Certain statements in this announcement are forward-looking statements. Forward-looking statements are statements that are not historical facts and may be identified by words such as 'plans', 'targets', 'aims', ' believes', 'expects', 'anticipates', 'intends', 'estimates', 'will', 'may', 'continues', 'should' and similar expressions. These forward-looking statements reflect, at the time, Galderma's beliefs, intentions and current targets/ aims concerning, among other things, Galderma's results of operations, financial condition, industry, liquidity, prospects, growth and strategies and are subject to change. The estimated financial information is based on management's current expectations and is subject to change. By their nature, forward-looking statements involve a number of risks, uncertainties and assumptions that could cause actual results or events to differ materially from those expressed or implied by the forward-looking statements. These risks, uncertainties and assumptions could adversely affect the outcome and financial consequences of the plans and events described herein. Actual results may differ from those set forth in the forward-looking statements as a result of various factors (including, but not limited to, future global economic conditions, changed market conditions, intense competition in the markets in which Galderma operates, costs of compliance with applicable laws, regulations and standards, diverse political, legal, economic and other conditions affecting Galderma's markets, and other factors beyond the control of Galderma). Neither Galderma nor any of their respective shareholders (as applicable), directors, officers, employees, advisors, or any other person is under any obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. You should not place undue reliance on forward-looking statements, which speak of the date of this announcement. Statements contained in this announcement regarding past trends or events should not be taken as a representation that such trends or events will continue in the future. Some of the information presented herein is based on statements by third parties, and no representation or warranty, express or implied, is made as to, and no reliance should be placed on, the fairness, reasonableness, accuracy, completeness or correctness of this information or any other information or opinions contained herein, for any purpose whatsoever. Except as required by applicable law, Galderma has no intention or obligation to update, keep updated or revise this announcement or any parts thereof. Article content Article content Article content Article content Article content Contacts Article content For further information: Article content Christian Marcoux, Chief Communications Officer +41 76 315 26 50 Article content Richard Harbinson Corporate Communications Director +41 76 210 60 62 Article content Emil Ivanov Head of Strategy, Investor Relations, and ESG +41 21 642 78 12 Article content Article content Article content
Associated Press
6 days ago
- Business
- Associated Press
Impact Investing Solutions Announces the Legacy of Impact and Love Retreat to Discover Life's Purpose
05/27/2025, Zug, Switzerland // PRODIGY: Feature Story // This November, a rare and transformative event by Impact Investing Solutions (IIS) and BE SHIRO Foundation, is unfolding in the serene Swiss countryside, a private, weeklong ' Legacy of Impact and Love ' retreat designed specifically for seasoned investors ready to shift their capital and consciousness toward global impact. Limited to just 15 carefully selected participants, this immersive experience will take place at Kloster Fischingen, a historic monastery near the forest, from 22nd to 29th November 2025. It will offer the perfect backdrop for profound inner work and deeper personal realignment. Behind this initiative is a forward-thinking organization with a mission to accelerate the flow of capital into meaningful, world-changing causes. Drawing from ancient meditative practices, cutting-edge AI matchmaking, and years of experience in impact investing, the retreat will help participants align their resources with their deepest values, what the organizers call going beyond impact. Why this event? Because too many successful individuals, despite their financial achievements, still feel something is missing. 'Money doesn't make you whole,' says Sveta Banerjee, founder and CEO of IIS. 'You can have all the earthly possessions and still find yourself looking up at the stars, hoping for more. But when you look inward and realize what you truly want to bring to this world, that is what brings true fulfillment.' This retreat is for those who have built wealth and influence but are seeking a more authentic legacy. Attendees will work closely with a handpicked team of four facilitators, including Sveta, the co-founder Ben Banerjee, alongside Andreas Dudas and Antoinette Haering of BE SHIRO, a Swiss-based cluster dedicated to empowering individuals to turn their unique life purpose into impactful change. Together, they'll guide participants through soul-centered meditations, purpose discovery, and deep conversations about how to activate philanthropic or impact capital in alignment with their true selves. The retreat's exclusivity is deliberate. With only 15 spots available, the experience is highly personalized to ensure every participant has the space, time, and guidance to go inward and connect deeply with what truly matters. Using refined AI matchmaking systems and insights gathered from years of working at the intersection of wealth, purpose, and social change, the team behind this initiative believes now is the time. 'We're seeing more and more investors holding back capital, not because they don't want to make a difference, but because they're still trying to decide with their heads,' says Sveta. 'This retreat helps them decide with their hearts.' The idea behind this retreat is truly for participants to uncover their life's true mission and then channel their wealth, whether through investments or philanthropy, into causes that ignite that mission. That's how real change happens. That's how legacies are built. With a powerful team, ancient teaching, and an extraordinary setting, this retreat offers something truly unique: a bridge between wealth and purpose, between success and fulfillment. With the retreat taking place this November and demand already building, now is the time to apply. By securing their place, individuals can solidify their place in global impact. Media Contact: Name: Legacy of Impact and Love Retreat Team Email: [email protected] Source published by Submit Press Release >> Impact Investing Solutions Announces the Legacy of Impact and Love Retreat to Discover Life's Purpose
National Post
7 days ago
- Business
- National Post
Galderma Intends to Buy Back approximately 2.4 Million Shares in the Context of the Accelerated Bookbuild Offering by EQT, ADIA and Auba
Article content ZUG, Switzerland — Galderma Group AG (SWX:GALD): Article content Article content Galderma intends to repurchase approximately 2.4 million shares in the context of the accelerated bookbuild offering of Galderma shares by Sunshine SwissCo GmbH ('EQT'), Abu Dhabi Investment Authority ('ADIA') and Auba Investment Pte. Ltd. ('Auba') announced today The repurchased shares will be held in treasury and financed by existing liquidity at hand Article content Galderma (SIX: GALD), the pure-play dermatology category leader, today announced that it intends to repurchase approximately 2.4 million Galderma shares in the context of an accelerated bookbuilding offering ('ABO') of approximately 16.7 million Galderma shares (approximately 7% of Galderma's share capital) by EQT, ADIA and Auba. Galderma will participate in the ABO at the same price per share which will be determined in the bookbuilding. Article content The repurchased shares will be financed by Galderma's existing liquidity on hand and will not affect the company's ability to deliver on its strategic and financing priorities. Article content The shares will be held in treasury for future use in connection with Galderma's employee participation plans, business development opportunities and/or treasury management. Article content About Galderma Article content Galderma (SIX: GALD) is the pure-play dermatology category leader, present in approximately 90 countries. We deliver an innovative, science-based portfolio of premium flagship brands and services that span the full spectrum of the fast-growing dermatology market through Injectable Aesthetics, Dermatological Skincare and Therapeutic Dermatology. Since our foundation in 1981, we have dedicated our focus and passion to the human body's largest organ – the skin – meeting individual consumer and patient needs with superior outcomes in partnership with healthcare professionals. Because we understand that the skin we are in shapes our lives, we are advancing dermatology for every skin story. For more information: Article content Certain statements in this announcement are forward-looking statements. Forward-looking statements are statements that are not historical facts and may be identified by words such as 'plans', 'targets', 'aims', ' believes', 'expects', 'anticipates', 'intends', 'estimates', 'will', 'may', 'continues', 'should' and similar expressions. These forward-looking statements reflect, at the time, Galderma's beliefs, intentions and current targets/ aims concerning, among other things, Galderma's results of operations, financial condition, industry, liquidity, prospects, growth and strategies and are subject to change. The estimated financial information is based on management's current expectations and is subject to change. By their nature, forward-looking statements involve a number of risks, uncertainties and assumptions that could cause actual results or events to differ materially from those expressed or implied by the forward-looking statements. These risks, uncertainties and assumptions could adversely affect the outcome and financial consequences of the plans and events described herein. Actual results may differ from those set forth in the forward-looking statements as a result of various factors (including, but not limited to, future global economic conditions, changed market conditions, intense competition in the markets in which Galderma operates, costs of compliance with applicable laws, regulations and standards, diverse political, legal, economic and other conditions affecting Galderma's markets, and other factors beyond the control of Galderma). Neither Galderma nor any of their respective shareholders (as applicable), directors, officers, employees, advisors, or any other person is under any obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. You should not place undue reliance on forward-looking statements, which speak of the date of this announcement. Statements contained in this announcement regarding past trends or events should not be taken as a representation that such trends or events will continue in the future. Some of the information presented herein is based on statements by third parties, and no representation or warranty, express or implied, is made as to, and no reliance should be placed on, the fairness, reasonableness, accuracy, completeness or correctness of this information or any other information or opinions contained herein, for any purpose whatsoever. Except as required by applicable law, Galderma has no intention or obligation to update, keep updated or revise this announcement or any parts thereof. Article content Article content Article content Article content Contacts Article content For further information: Article content Christian Marcoux, Chief Communications Officer +41 76 315 26 50 Article content Richard Harbinson Corporate Communications Director +41 76 210 60 62 Article content Emil Ivanov Head of Strategy, Investor Relations, and ESG +41 21 642 78 12 Article content Article content Article content
