Latest news with #Zydus
Business Wire
2 days ago
- Business
- Business Wire
Zydus Announces Completion of the Acquisition of an 85.6% Stake in Amplitude Surgical and Upcoming Filing of a Simplified Tender Offer
AHMEDABAD, India & VALENCE, France--(BUSINESS WIRE)--Regulatory News: Zydus Lifesciences Limited 1 (' Zydus '), on March 11, 2025, entered into agreements with PAI and two minority shareholders of Amplitude Surgical (Paris:AMPLI) to acquire blocks of shares representing in aggregate 85.6% of Amplitude Surgical's share capital and voting rights 2 at a price of €6.25 per share and a total consideration of €256.8mn (the ' Block Acquisition '). As all conditions precedent to the completion have now been fulfilled, and the Block Acquisition has been subsequently completed on July 29, 2025, Zydus now holds 85.6% of the share capital and voting rights of Amplitude Surgical. Olivier Jallabert will remain in his role as CEO of Amplitude Surgical, and, as part of the Block Acquisition, has invested into the company which has completed the Block Acquisition. In the context of the Block Acquisition, Amplitude Surgical has terminated with effect as of July 28, 2025 its liquidity contract entered into between Amplitude Surgical, Oddo BHF and Natixis dated June 19, 2018. Zydus will file a simplified mandatory tender offer (the ' Offer ') on July 30, 2025 for all the remaining outstanding shares of Amplitude Surgical at a price of €6.25 per share, at par with the price paid for the Block Acquisition. Considering the certain undertakings to tender received from seven shareholders representing in aggregate 4.7% of share capital and voting rights 3, Zydus will be able to secure more than 90% of the capital and voting rights of Amplitude Surgical upon completion of the Offer and will subsequently request the implementation of a squeeze-out. Subject to the French Financial Market Authority's (Autorité des marches financiers, AMF) clearance of the Offer, it is currently envisaged that the Offer may be opened in September 2025. No other regulatory approval will be required. On July 28, 2025, the Board of Directors of Amplitude Surgical unanimously welcomed the Offer and on the same date issued its reasoned opinion following receipt of the fairness opinion from Finexsi, appointed as independent expert for the purpose of the Offer. ***** About Zydus Lifesciences Zydus Lifesciences Ltd. with an overarching purpose of empowering people with freedom to live healthier and more fulfilled lives, is an innovative, global lifesciences company that discovers, develops, manufactures, and markets a broad range of healthcare therapies. The group employs over 27,000 people worldwide, including 1,400 scientists engaged in R&D, and is driven by its mission to unlock new possibilities in lifesciences through quality healthcare solutions that impact lives. The group aspires to transform lives through path-breaking discoveries. For more details visit ***** About Amplitude Surgical Founded in 1997 in Valence, France, Amplitude Surgical is a leading French player in the global market for surgical technologies for lower limb orthopaedics. Amplitude Surgical develops and markets high-end products for orthopaedic surgery, covering the main pathologies affecting the hip and knee. Working in close collaboration with surgeons, Amplitude Surgical develops numerous high value-added innovations to best meet the needs of patients, surgeons and care facilities. A leading player in France, Amplitude Surgical is expanding internationally through its subsidiaries and a network of agents and exclusive distributors in over 30 countries. As of June 30, 2025, Amplitude Surgical employed 429 people and generated revenue of nearly €111 million. ******* This press release must not be published, broadcast or distributed, directly or indirectly, in any countries in which the distribution of this information is subject to legal restrictions. Therefore, persons in countries where this press release is disseminated, published or distributed should inform themselves about and comply with any such restrictions. This release contains forward-looking statements that are based on assessments or assumptions that were reasonable at the date of the release, and which may change or be altered due, in particular, to random events or uncertainties and risks relating to the economic, financial , regulatory and competitive environment, the risks set out in the 2023/2024 Universal Registration Document, and any risks that are unknown or non-material to date that may subsequently occur. The Company undertakes to publish or disclose any adjustments or updates to this information as part of the periodic and permanent information obligation to which all listed companies are subject. This press release contains inside information within the meaning of Regulation No. 596/2014 of 16 April 2014 on market abuse. 1 Through its subsidiaries/affiliates 2 Directly and indirectly through the acquisition of holding companies Auroralux, Ampliman 1 and Ampliman 2, and excluding treasury shares held by assimilation and on the basis of a total number of shares and theoretical voting rights of 48,020,841 3 Press release of April 17, 2025
Time of India
24-07-2025
- Business
- Time of India
Zydus moves Delhi HC against order restraining sale of its cancer drug
Zydus Lifesciences on Thursday moved the division bench of the Delhi High Court against its single judge's earlier order that temporarily restrained the Ahmedabad-based drug maker from manufacturing, selling biosimilar of US pharma giant E.R. Squibb's patent Nivolumab , a therapeutic antibody used in the treatment of cancer. The Division Bench while refusing to stay the single judge's interim order sought response from the US pharma company, which had alleged patent infringement of its blockbuster anticancer drug Opdyta (nivolumab) branded as Opdivo in other countries. In India, Nivolumab is being imported and marketed as Opdyta. Explore courses from Top Institutes in Please select course: Select a Course Category PGDM Technology Digital Marketing Data Science Others Management Cybersecurity Healthcare Data Science Product Management Public Policy MBA others Design Thinking Finance Leadership Project Management CXO MCA Data Analytics Artificial Intelligence Operations Management healthcare Degree Skills you'll gain: Financial Analysis & Decision Making Quantitative & Analytical Skills Organizational Management & Leadership Innovation & Entrepreneurship Duration: 24 Months IMI Delhi Post Graduate Diploma in Management (Online) Starts on Sep 1, 2024 Get Details While Squibb alleged that Zydus was conducting clinical trials for nivolumab and had plans to launch it during is valid patent period, the Indian company denied the allegations, saying its product ZRC-3276 does not infringe upon the existing patents, was following the regulatory provisions and had applied for a marketing approval with the central drug regulatory agency. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Simoes Filho: Unsold Furniture Liquidation 2024 (Prices May Surprise You) Unsold Furniture | Search Ads Learn More Undo Zydus argued that its product, ZRC-3276, is bio-similar to Squibb Nivolumab, but bio-similarity by itself does not substantiate infringement as it is based upon product-to-product comparison, whereas, infringement required claim to product mapping. The generic drug maker claimed that process steps were already known from the prior art and even several techniques for the preparation of human anti-PD1 antibodies were well-known on the priority date of the suit patent. Live Events The post-grant opposition that was filed by its subsidiary Zydus Healthcare led to the recommendation for revocation of the suit patent by the Opposition Board, and the said recommendation clearly showed that such a method was commonly employed to produce antibodies, the Ahmedabad-based drug manufacturer claimed. On July 18, Justice Mini Pushkarna had noted that E.R. Squibb shall suffer irreparable loss in case an interim relief was not granted. Therefore, the single judge had restrained Zydus from selling a biosimilar of Nivolumab till the main suit was decided.
Business Upturn
24-07-2025
- Business
- Business Upturn
Zydus Lifesciences gets tentative approval from USFDA for Ibrutinib tablets
Zydus Lifesciences has received tentative approval from the USFDA to market Ibrutinib tablets in the 140 mg, 280 mg, and 420 mg strengths in the U.S. market. The drug is a generic version of Imbruvica® and is used in treating adult patients with Chronic Lymphocytic Leukaemia (CLL)/Small Lymphocytic Lymphoma (SLL) with 17p deletion, as well as Waldenstrom's Macroglobulinemia (WM). The tablets will be manufactured at Zydus' SEZ facility in Ahmedabad. According to IQVIA (MAT May 2025), Ibrutinib tablets clocked annual sales of USD 2.15 billion in the U.S. With this, Zydus now holds 420 approvals and has filed 484 ANDAs since it began filings in FY 2003-04. In the meantime, Zydus Lifesciences shares opened today at ₹962.95 and, at the time of writing, touched a high of ₹976.60 during the session. The stock also hit a low of ₹960.15 in intraday trade. Over the past year, Zydus shares have seen a 52-week high of ₹1,324.30 and a low of ₹795.00. Ahmedabad Plane Crash Aman Shukla is a post-graduate in mass communication . A media enthusiast who has a strong hold on communication ,content writing and copy writing. Aman is currently working as journalist at
Time of India
04-07-2025
- Health
- Time of India
Healthy outside, sick inside: The hidden danger of fatty liver
Representative Image In today's fast-paced life, it's easy to overlook what we can't feel. Fatty liver is one such condition — often silent, commonly missed, and rapidly becoming one of India's most widespread health issues. It is estimated that nearly one in three urban Indians may have fatty liver disease without being aware of it. What is fatty liver and why should you care? Fatty liver, now increasingly referred to as MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease), occurs when fat accumulates excessively within liver cells. While a small amount of fat is normal, too much can impair liver function and lead to long-term complications like inflammation, fibrosis, cirrhosis, and even liver cancer. Most patients do not experience any symptoms. The condition is usually discovered during routine checkups or imaging tests done for other reasons, — making early detection even more critical. Who is at risk of fatty liver? Are you overweight? Do you have a sedentary lifestyle? Do you often consume junk food or sugar-sweetened beverages? If yes, you may be at risk. Fatty liver is no longer a disease of the elderly or those who consume alcohol. It is increasingly found in non-drinkers, young adults, and even teenagers, — largely due to poor lifestyle habits. Those with diabetes, obesity, high cholesterol, or high blood pressure are particularly vulnerable. Zydus recently launched #LiverKiSuno, a public awareness initiative aimed at promoting healthy lifestyle habits for better liver health. Such campaigns play a vital role in increasing awareness about liver-related conditions and educating the public on effective prevention and management strategies. How does fatty liver progress over time? Can a little fat in the liver really harm you? The answer is yes. If not addressed early, fatty liver can silently progress over the years from a mild stage to serious liver damage. This damage may not be reversible in advanced stages and can ultimately lead to liver failure or cancer. That's why early diagnosis and lifestyle modification are the best ways to protect your liver. What can you do to reverse fatty liver? Is fatty liver treatable? Absolutely — especially in its early stages, and the first step is not a pill, but a lifestyle change. Exercise is key. Brisk walking, cycling, or swimming for at least 30–45 minutes most days of the week can significantly reduce liver fat. Gradual weight loss is effective — even losing 5 to 10 percent of body weight can make a measurable difference. Equally important is diet. Avoid junk food and ultra-processed items like chips, biscuits, and sugary drinks. Cut down on refined carbs like white bread and fried foods. Choose whole grains, fruits, vegetables, and home-cooked meals rich in fibere and low in saturated fats. Sleep also plays a vital role. Studies show that sleeping less than 6 hours regularly can worsen insulin resistance and liver health. Aim for a good 7 hours of quality sleep every night. Should you get tested? If you're at risk — even without symptoms — it's wise to get screened. A simple ultrasound and basic liver function tests can help detect fatty liver early. The Liver Never Complains — Until It's Too Late. Your liver quietly performs over 500 essential functions every day. It digests food, stores energy, filters toxins, and keeps you alive — all without making a sound. Don't wait for a problem to show up. Start today. Eat clean. Move more. Sleep well. And take charge of your liver health before it's too late. Author: Dr Rajiv Mehta Consultant Liver Specialist SIDS Hospital and Research Centre Surat The above is non-editorial content and TIL does not guarantee, vouch or endorse any of it. Please take all steps necessary to ascertain that any information and content provided is correct, updated, and verified.
Economic Times
23-06-2025
- Business
- Economic Times
Go on, pop the innovation pill: ₹5,000 cr push signals India's shift from copy to create
Stir things up Rollout of the ₹5,000-cr Promotion of Research and Innovation in Pharma MedTech Sector (PRIP) scheme signals a shift in how India approaches the sector's growth. This initiative, expected to begin disbursals by the end of 2025, could attract ₹17,000 cr in additional R&D investment. For an industry that has long been associated with generic manufacturing, this represents a paradigm shift towards innovation-led pharma world is approaching a 'patent cliff', and for Indian firms, it represents an unprecedented opportunity: 24 mega-selling drugs with combined annual sales exceeding $250 bn will lose patent protection by 2030. This means blockbuster medicines like Humira for rheumatoid arthritis, Keytruda for cancer treatment, Stelara for psoriasis, and Symbicort for asthma will soon be open for generic manufacturing. When these patents expire, drug prices fall by at least 50%. For a country where out-of-pocket (OoP) healthcare expenses are high, this holds immense significance alongside its commercial potential. Capturing these opportunities won't be easy. Indian firms will face tough competition from generics and must match the original drug standards. Success will hinge on investment in bioequivalence studies, regulatory compliance and resilient supply chains. Indian pharma companies are eyeing these opportunities. Zydus, Sun Pharma, and Bharat Serums and Vaccines (now part of Mankind Pharma) have invested in establishing world-class R&D centres, focusing on developing new chemical entities. The younger generation of scientists and entrepreneurs, bringing fresh perspectives, is accelerating the transition from a generic-focused industry to one that balances both generic excellence and innovative drug discovery. MNCs are also rethinking their view of the Indian market: Novartis, Novo Nordisk and Eli Lilly have chosen to out-license their brands to Indian firms rather than directly market them here. This trend reflects both the growing capabilities of domestic firms and the unique challenges of serving India's diverse and price-sensitive market. These partnerships benefit all. International companies can maintain a presence in India without the complexities of direct operations, while Indian firms gain access to established brands and molecules, leveraging deep market understanding and extensive distribution networks. However, building these relationships requires investment in compliance systems, quality infrastructure, and continuous capability upgrades to meet the exacting standards of international positives in the sector include: Exemption of 36 life-saving drugs from basic customs duty will benefit companies bringing in innovative medicines. Drugs like AstraZeneca's Selumetinib, Pfizer's Lorlatinib, Novartis' Ribociclib, and GSK's Mepolizumab will now be more affordable. Additionally, six more life-saving medicines have been added to the concessional 5% duty slab, primarily targeting cancer, rare diseases and other chronic conditions. The health budget has risen to over ₹95,000 cr for FY26, up 9.46%. More than a numbers game, it's about building a healthcare ecosystem fit for our vast population. 15,479 Jan Aushadhi Kendras provide generic medicines at prices up to 80% lower than branded equivalents. A heart medicine that once cost ₹500 is available for ₹100, bringing essential treatments within reach of ordinary citizens. Yet, ensuring consistent quality and maintaining reliable supply chains remain a challenge. Extension of PM Ayushman Yojana to people above 70 years creates a virtuous cycle - more people seeking treatment drives demand for medicines, which, in turn, encourages pharma companies to invest in better products and wider distribution. Development of healthcare infra in tier-2 and tier-3 cities is also helping. However, attracting and retaining qualified medical professionals in these locations remains a hurdle, requiring innovative approaches to compensation, career development and quality-of-life considerations. Again, the market for pharma products will, then, be able to expand. A 'nutraceutical revolution' is underway. With the market expected to grow from $4 bn in 2020 to $18 bn by December, nutraceuticals represent a significant growth avenue for companies willing to invest in quality and innovation. The convergence of multiple factors - patent opportunities, GoI support, infrastructure development and changing consumer behaviour - is creating unprecedented opportunities for the sector. Companies that embrace innovation, while maintaining traditional strengths in affordable healthcare delivery, will thrive. The writer is CEO, Mankind Pharma (Disclaimer: The opinions expressed in this column are that of the writer. The facts and opinions expressed here do not reflect the views of Elevate your knowledge and leadership skills at a cost cheaper than your daily tea. Second only to L&T, but controversies may weaken this infra powerhouse's growth story Looking for quick buck in unlisted shares? Better think twice! How Vedanta's Anil Agarwal bettered Warren Buffett in returns Rivers are moving more goods than before. But why aren't they making a splash yet? Stock Radar: Supreme Industries stock down by about 30%! 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