Latest news with #brainfunction
Yahoo
26-07-2025
- Business
- Yahoo
UPDATED: Klotho Neurosciences, Inc. to Expand Development Programs Beyond Neurology
Company to Pursue Technologies to Improve Brain Function, Muscle Strength, Bone Health, and Other Longevity Indicators NEW YORK, July 25, 2025 /PRNewswire/ -- Klotho Neurosciences, Inc. (NASDAQ: KLTO) (the "Company" or "Klotho") announced that it is evaluating the acquisition of several complementary technologies aimed at supporting healthy brain function, organ health, and longevity. In addition to its core programs targeting brain aging and neurodegenerative diseases such as ALS, Alzheimer's, and Parkinson's, the Company is now seeking to expand into adjacent technologies that complement its proprietary anti-aging Klotho platform. The goal is to slow biological aging and reduce the burden of age-related diseases—ultimately promoting a longer, healthier life. "As announced previously, we've begun manufacturing and development of KLTO-101 and KLTO-202," said Klotho CEO Dr. Joseph Sinkule. "We're also exploring other treatments that could support healthy aging and extend human longevity." The human Klotho gene is strongly linked to aging and longevity. Klotho levels decline with age, contributing to age-related disorders such as cardiometabolic disease, neurodegeneration, cancer, sarcopenia (muscle wasting), osteoporosis, and general fatigue. Silencing of the Klotho gene has been shown to accelerate multi-organ deterioration. "The Klotho gene is what we call a master gene," stated Shalom Hirschman, M.D., world-renowned physician and senior consultant to the Company. "The Klotho gene has pleotropic actions modulating many critical cellular pathways including insulin resistance, insulin-like growth factor-1, FOXO3 transcription factors, and Wnt signaling pathways leading to the reduction of inflammatory and mitochondrial oxidative stresses and other cell-damaging mechanisms that can be prevented by two alpha-Klotho protein isoforms – soluble Klotho and secreted-Klotho." "We're assembling a team of scientists, clinicians, and business leaders focused on identifying key longevity indicators," said Jeffrey LeBlanc, Klotho CFO. "This includes evaluating genes and proteins such as alpha-Klotho, beta-Klotho, FOXO3, anti-myostatin, and their isoforms." Dr. Sinkule added, "If people don't die of cancer or trauma, they often succumb to age-related diseases of the brain, heart, kidneys, liver, bone, or muscle. Our mission is to identify and develop complementary assets to delay these outcomes through targeted research and intervention." About Klotho Neurosciences, Inc. Klotho Neurosciences, Inc. (NASDAQ: KLTO), is a biogenetics company focused on the development of innovative, disease-modifying cell and gene therapies using a protein derived from a patented form of the "anti-aging" human Klotho gene (s-KL), and its novel delivery systems to transform and improve the treatment of neurodegenerative and age-related disorders such as ALS, Alzheimer's, and Parkinson's disease. The company's current portfolio consists of its proprietary cell and gene therapy programs using DNA and RNA as therapeutics and genomics-based diagnostic assays. The company is managed by a team of individuals and advisors who are highly experienced in biopharmaceutical product development and commercialization. Investor Contact and Corporate Communications - Jeffrey LeBlanc, CFO, ir@ Website: Forward-Looking Statements: This press release contains forward-looking statements. These statements are made under the "safe harbor" provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements generally are identified by the words "believe," "project," "expect," "anticipate," "estimate," "intend," "strategy," "future," "opportunity," "plan," "may," "should," "will," "would," "will be," "will continue," "will likely result," and similar expressions. Without limiting the generality of the foregoing, the forward-looking statements in this press release include descriptions of the Company's future commercial operations. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, such as the Company's inability to implement its business plans, identify and realize additional opportunities, or meet or exceed its financial projections and changes in the regulatory or competitive environment in which the Company operates. You should carefully consider the foregoing factors and the other risks and uncertainties described in the documents filed or to be filed by the Company with the U.S. Securities and Exchange Commission (the "SEC") from time to time, which could cause actual events and results to differ materially from those contained in the forward-looking statements. All information provided herein is as of the date of this press release, and the Company undertakes no obligation to update any forward-looking statement, except as required under applicable law. View original content to download multimedia: SOURCE Klotho Neurosciences, Inc. 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Daily Mail
14-07-2025
- Health
- Daily Mail
Doctor warns about the huge mistake millions make in the car every day: 'Your brain slows down'
A doctor has shocked millions of drivers after revealing that a common setting in your car could be quietly sabotaging your brain function. Dr Clay Moss has racked up more than 6.9million views on a video after issuing a blunt warning about the recirculation button - a familiar feature most drivers flick on without a second thought. 'Did you know there's a single button in your car that could be causing more harm than good?' the American expert began in the eye-opening video. 'You guys remember this little guy right here that we always love putting on?' he said, pointing to the well-known recirculation symbol, which is typically found on the dashboard near the air conditioning controls. 'That little recirculation symbol stops outside air from getting in, which is great when you're trying to quickly cool off the air on a hot day, but it can have unintended consequences over time,' he explained. It's not just smog it's stopping, it's your the brain from functioning at its best, too. While many hit the button to block pollution or get cool air flowing fast, Dr Moss says keeping the car in recirculation mode for too long can quietly poison the air inside. 'You see, when you're breathing in a sealed car, carbon dioxide builds up pretty quickly. Thirty minutes of recirculation and you could easily exceed 12,000 PPM [parts per million] of CO2, where your brain literally starts to slow down.' View this post on Instagram A post shared by Clay Moss, MD (@drclaymoss) With two or three passengers, the issue gets worse: 'You could easily hit 2500–3000ppm of carbon dioxide. That's when you start to get drowsy, foggy and irritable.' And he's not just talking hypothetically. In a 2018 study on U.S. driving conditions, the levels of carbon dioxide recorded were alarming. It found that under recirculation mode, even single-occupant drives can reach up to 2,500ppm in longer or multi-occupant trips, well above cognitive risk thresholds. According to Dr Moss, that's where cognitive performance drops, reaction time slows, and you're more prone to drowsiness and brain fog. Before you panic, Dr Moss says there's an easy hack that takes just seconds and could make a massive difference to your alertness behind the wheel. 'Now, the fix is super easy,' he said. 'You just either crack the window, or switch to the fresh air mode and turn off the recirculation mode for just two minutes. It flushes the CO2 out and keeps your brain sharp.' 'Your car's climate settings aren't just about comfort, they mess with your cognition too,' he added. 'So breathe better, drive safe.' The clip has sparked major debate online, with many drivers admitting they had no idea something so minor could affect their brain so dramatically. 'I drive to work two hours each way every day… is this why I get so sleepy by the time I get to my destination?' one person commented. 'I've actually never used it to cool off, but I've used it when driving through stuff that I don't want getting in my car (like truck exhaust, dust, dirt, grass, etc),' said another. 'Is that why I suffer from road rage?' Another joked. Others pointed out they use it 'all the time to avoid city smog,' while some confessed that they've never switched it off. However, in a silver lining, more modern cars have an automatic recirculation mode that have timers to effectively shut-off by themselves to keep drivers safe.
Yahoo
25-06-2025
- Health
- Yahoo
Longevity Experts Say That Mastering This One Skill Could Add Years to Your Life
A new study found that among four cognitive abilities tested in older adults, verbal fluency (the ability to use language quickly and effectively) was significantly associated with a longer life span. Experts believe verbal fluency may serve as a proxy for biological resilience, as it relies on multiple brain functions—including memory, attention, processing speed, and executive functioning—all working in sync. Improving verbal fluency is possible at any age with regular challenges like naming games, deep conversations, strategic board games, storytelling, and even learning a new language—all of which stimulate brain function and support healthy it comes to aging, research has shown that intelligence can predict your longevity. But intelligence is a vague concept, and it doesn't give us much of an idea of what we can do to exercise our brains. However, a new study published in the journal Psychological Science has pinpointed a more specific trait in people who live longer: verbal fluency. The researchers gave participants—aged 70 to 105—tests measuring four cognitive abilities: verbal fluency (mastery of language), perceptual speed (the ability to access patterns quickly), verbal knowledge (vocabulary), and episodic memory (ability to recall and remember personal experiences). They also developed a model that assessed their risk of death. After analyzing the data, researchers determined that out of the four cognitive abilities they tested, verbal fluency alone appeared to have a significant link to longevity—but they're not sure why. Although the link between verbal fluency and longevity is not yet understood, Paolo Ghisletta, PhD, lead author of the study, has two possible theories. The first is that the physical body is inextricably linked to mental, emotional, and cognitive processes. 'All of these domains are just declining together, whether it's cognition, personality, emotions, or biological, medical decline in general,' he said in a statement. In addition to that, Ghisletta recognizes that verbal fluency could be a good measure of well-being, because it's a complex process involving multiple cognitive abilities, potentially including long-term memory, vocabulary, efficiency, and visual memory. Dr. Kimberly Idoko, neurologist and medical director at Everwell Neuro, agrees, noting that verbal fluency utilizes multiple brain functions, like memory, attention, processing speed, and the ability to organize and express ideas quickly. It also depends on strong connections between different parts of the brain—especially the frontal and temporal lobes. 'When someone can find and use words with ease, it suggests that the brain's regions are connecting well,' Idoko says. 'And when fluency starts to decline, it often suggests broader issues in brain function. So, strong verbal fluency may reflect biological resilience.' Let's break it down a bit more. 'In order to express a word, you come up with an idea or a thought,' says Polina Shkadron, neurodivergent therapist and founder of Play to Learn Consulting. 'Then, to communicate that thought to someone else, you pull from your language resources to choose specific words in a particular order so that the listener is able to also comprehend what you are describing.' Essentially, you are using language to implant your idea into someone else's mind. 'As the speaker, you also have a feedback loop, meaning that once you express your idea, you are analyzing it simultaneously to make sure that the words are exactly what you wanted in that moment and in that context,' she explains. While having extensive knowledge of vocabulary is part of communicative interactions, it's not the only part. 'You also need to have knowledge of how language is formed and used,' Shkadron says. 'Language use, referred to as pragmatics, is the way in which we facilitate conversational interactions. We use specific terms depending on the situation and the people in that environment.' Verbal fluency is also determined by executive functioning capacities—especially verbal working memory—as well as impulse inhibition and cognitive flexibility, Shkadron notes. 'For instance, to have an extensive conversation with someone else, your brain needs the skills to hold onto specific information, process what the other person is telling you—without interrupting them—determine whether that information is relevant or irrelevant, and keep the conversation going based on the topic being discussed,' she explains. Related: Clear Brain Fog Instantly With These 12 Effective Strategies The good news is that you can start improving your verbal fluency today, and keep it up over the years. 'The most important ingredients are challenge, variety, and frequency,' Idoko says. To get you started, here are some suggestions from Idoko and Shkadron. Set a timer for one minute or 90 seconds, and pick a category—like animals, foods you'd find in a grocery store, or items you'd find outdoors in nature, things that start with the letter 'S'—and name as many as you can before the timer goes off. You can challenge yourself or others and make a game out of it. The person who named the highest number of things in the category wins. (It's also a perfect game for a road trip.) According to Idoko, this activity 'activate[s] the same circuits I test in clinical exams.' Both Idoko and Shkadron mentioned that staying verbally active through having conversations with others is a great way to stay social and keep up with your language skills. More specifically, Shkadron recommends conversations that are about individual interests. 'People who stay verbally active through conversation, reading, or teaching tend to live longer and maintain better cognitive function,' Idoko says. 'So verbal fluency may reflect how much someone is using their brain to stay connected.' According to Shkadron, strategic board games that require you to use all aspects of executive functioning are beneficial. She suggests Blokus, Ticket to Ride, Settlers of Catan, Rummikub, The Oregon Trail, and Bananagrams. 'The cognitive shifting and strategy that occurs involves language planning and deliberating your moves, as well as the moves of your opponents,' she explains. Related: Do Brain Games Really Work to Boost Cognitive Fitness? This ancient oral tradition is also a great way to flex your language skills, Idoko says. '[Storytelling] artistically uses language to develop all of the critical components involved in the communication process,' say the authors of a 2001 study on literacy techniques and storytelling. 'Storytelling develops listening skills, enhances verbal expression, increases comprehension, creates mental images, and highlights verbal reasoning.' Consider trying your hand at creative writing or journaling to get started—you don't have to be an expert to reap the benefits of storytelling. Do you regret not taking Spanish in high school? Have you always wanted to learn Japanese? Well, there's no time like the present, regardless of your age. A 2012 study found that learning a new language is associated with the growth of the hippocampus—an area of that brain that's involved with handling memories, learning, and dealing with emotion. This is important because the hippocampus is among the first parts of the brain affected by memory loss. Read the original article on Real Simple
Daily Mail
13-05-2025
- Health
- Daily Mail
Rising state pension age 'helps women maintain brain function and avoid disability in their 60s'
Retiring later can help women maintain brain function and prevent disability, according to a study. Research by the respected Institute for Fiscal Studies (IFS) found the effect was particularly pronounced for those who were single or had active jobs. However, hanging on longer in sedentary work can be 'actively harmful' for physical mobility. The paper, published in the Labour Economic Journal, considered the impact of the government continuing to push up the state pension age. That has led to some people delaying retirement and remaining in paid work for longer - with so-called 'WASPI' women furious that they were not given adequate warning. The team investigated the increase in employment of women aged 60–63 between 2010 and 2017 in England. Using data from a long-term survey, they concluded that working longer 'substantially' boosted performance on two cognitive tests. The survey featured people being read 10 words and asked to repeat them immediately, and then again five minutes later. On the 'immediate' test working women were found to remember 0.4 to 0.7 extra words, while for the delayed test it was 1.4 to 1.7 additional words The IFS said the effect was more pronounced for single women, which was 'consistent' with work being an 'important source of social interactions'. There were also 'large' improvements in measures of physical disability, with walking speeds higher and lower reports of mobility problems. But the report stressed that the effects depended heavily on the kinds of work women undertook, with sedentary occupations seen to reduce walking speed. David Sturrock, Associate Director at the Institute for Fiscal Studies and an author of the research, said: 'The government continues to increase the state pension age, with an increase from 66 to 67 starting in April next year. 'As a result, many people face a longer working life. While increasing the state pension age reduces state pension spending, thought needs to be given to the effect that later retirement can have on people's health. 'Our research shows that paid work can help to maintain cognitive functioning and physical mobility. 'This is particularly true for single women and those whose jobs involve some amount of movement. 'However, not all work is beneficial, with sedentary jobs being actively harmful for physical mobility. 'Whether longer working is good for health also depends on what people will do once they retire – if the government wants to promote health at older ages then encouraging social interaction and physical exercise among retirees would also be beneficial.'
