Latest news with #immunology
Yahoo
a day ago
- Business
- Yahoo
Bristol Myers Squibb and Bain Capital Create New Company Dedicated to Developing Innovative Immunology Therapies that Address the Unmet Medical Needs of Patients
Five immunology assets in-licensed from BMS with potential to address unmet needs for patients with autoimmune diseases, including late-stage asset for lupus Bain Capital leads $300 million financing commitment PRINCETON, N.J. & BOSTON, July 28, 2025--(BUSINESS WIRE)--Bristol Myers Squibb (NYSE: BMY, "BMS") and Bain Capital today announced the creation of a new independent biopharmaceutical company ("NewCo") focused on developing new therapies for autoimmune diseases that address significant unmet needs of patients. The newly formed company launches with five immunology assets in-licensed from BMS and a $300 million financing commitment that was led by Bain Capital. The NewCo has a broad pipeline consisting of three clinical-stage and two Phase 1-ready investigational medicines that each target promising mechanisms in autoimmune diseases. The most advanced assets in the NewCo's portfolio are afimetoran, an oral, potential best-in-class TLR7/8 inhibitor that is currently being studied in a Phase 2 clinical trial for systemic lupus erythematosus (SLE), and BMS-986322, an oral TYK2 inhibitor, which successfully established proof-of-concept in a positive plaque psoriasis Phase 2 trial. Other licensed assets include BMS-986326, a novel, potential best-in-class, IL2 fusion protein that is currently being studied in Phase 1 clinical trials for SLE and atopic dermatitis, and BMS-986481 and BMS-986498, two Phase 1-ready biologics targeting the IL18 and IL10 pathways respectively. The assets licensed to NewCo reflect the strength of BMS's scientific innovation and hold promise to address unmet needs for patients with autoimmune diseases. As part of the agreement, BMS will retain a nearly 20 percent equity stake in NewCo and will be entitled to royalties and milestones tied to the success of each asset. Robert Plenge, MD, PhD, Executive Vice President and Chief Research Officer at BMS, will also serve on NewCo's Board of Directors. This transaction reflects BMS's strategic shift in Immunology research to focus on assets that have the potential to reset the immune system and promote tissue repair. It also further demonstrates the company's sharpened strategy to invest in areas where BMS is best positioned to lead, while enabling the continued development of promising medicines. "These assets have significant potential, and we are confident that this new company will drive their development to ensure greater impact for patients," said Julie Rozenblyum, Senior Vice President, Business Development at BMS. "Bain Capital's exceptional track record in building successful life science companies by providing focused development and dedicated resources makes them ideally suited to advance these assets to realize their full promise." Daniel S. Lynch will serve as the Executive Chairman of the Company's Board of Directors and interim CEO. Mr. Lynch is an accomplished biopharmaceutical industry leader with decades of strategic, management and operational experience at companies spanning many stages of growth. Nicholas Downing, MD, Adam M. Koppel, MD, PhD, and Andrew Kaplan from Bain Capital will also join Mr. Lynch and Dr. Plenge of BMS on NewCo's Board of Directors. "We are excited to partner with BMS and we share their commitment to improving lives through science," said Adam Koppel, a Partner at Bain Capital Life Sciences. "We look forward to working together and leveraging our company creation experience to build out this new platform and advance these distinct assets in an effort to bring innovative, high-quality therapies to patients with autoimmune diseases." "This is a unique opportunity to build an innovative biotech company with a strong scientific foundation and differentiated development capabilities," said Mr. Lynch. "I'm thrilled to have the opportunity to leverage my background and experience to contribute to the success of the company as it seeks to develop much-needed new therapies, and I look forward to supporting BMS and Bain Capital in the build-out of the company's operations." Bain Capital is investing in NewCo through its Life Sciences and Private Equity teams, drawing on over 40 years of supporting the growth and innovation of healthcare companies globally. Canada Pension Plan Investment Board also joined the investment. About Bristol Myers Squibb: Transforming Patients' Lives Through ScienceAt Bristol Myers Squibb, our mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. We are pursuing bold science to define what's possible for the future of medicine and the patients we serve. For more information, visit us at and follow us on LinkedIn, X, YouTube, Facebook and Instagram. Bristol Myers Squibb Cautionary Statement Regarding Forward-Looking StatementsThis press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 regarding, among other things, the research, development and commercialization of pharmaceutical products, the creation of NewCo and the agreement with NewCo. All statements that are not statements of historical facts are, or may be deemed to be, forward-looking statements. Such forward-looking statements are based on current expectations and projections about our future financial results, goals, plans and objectives and involve inherent risks, assumptions and uncertainties, including internal or external factors that could delay, divert or change any of them in the next several years, that are difficult to predict, may be beyond our control and could cause our future financial results, goals, plans and objectives to differ materially from those expressed in, or implied by, the statements. These risks, assumptions, uncertainties and other factors include, among others, that the expected benefits of, and opportunities related to, the creation of NewCo and the agreement with NewCo may not be realized by Bristol Myers Squibb or may take longer to realize than anticipated, that the assets described in this press release, may not achieve their primary study endpoints or receive regulatory approval for the indications described in this release in the currently anticipated timeline or at all and, if approved, whether such assets will be commercially successful. No forward-looking statement can be guaranteed. Forward-looking statements in this press release should be evaluated together with the many risks and uncertainties that affect Bristol Myers Squibb's business and market, particularly those identified in the cautionary statement and risk factors discussion in Bristol Myers Squibb's Annual Report on Form 10-K for the year ended December 31, 2024, as updated by our subsequent Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and other filings with the Securities and Exchange Commission. The forward-looking statements included in this document are made only as of the date of this document and except as otherwise required by applicable law, Bristol Myers Squibb undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events, changed circumstances or otherwise. About Bain CapitalFounded in 1984, Bain Capital is one of the world's leading private investment firms. We are committed to creating lasting impact for our investors, teams, businesses, and the communities in which we live. As a private partnership, we lead with conviction and a culture of collaboration, advantages that enable us to innovate investment approaches, unlock opportunities, and create exceptional outcomes. Our global platform invests across five focus areas: Private Equity, Growth & Venture, Capital Solutions, Credit & Capital Markets, and Real Assets. In these focus areas, we bring deep sector expertise and wide-ranging capabilities. We have 24 offices on four continents, more than 1,850 employees, and approximately $185 billion in assets under management. To learn more, visit Follow @BainCapital on LinkedIn and X (Twitter). corporatefinancial-news View source version on Contacts Bristol Myers Squibb Media Inquiries: media@ Investors: Bain Capital Scott Lessne / Charlyn LuskStantonslessne@ / clusk@ (646) 502-3569 / (646) 502-3549 Error while retrieving data Sign in to access your portfolio Error while retrieving data Error while retrieving data Error while retrieving data Error while retrieving data
Yahoo
a day ago
- Business
- Yahoo
Bristol Myers, Bain Capital form new company to develop immunology drugs
(Reuters) -Drugmaker Bristol Myers Squibb and private equity firm Bain Capital will launch an independent company focused on developing immunology drugs, backed by Bain's $300 million financing round, the companies said on Monday. The new company will work on five experimental drugs licensed from Bristol Myers, including a late-stage lupus treatment and a mid-stage psoriasis drug that has shown promise in trials. Bristol Myers will retain nearly 20% equity in the venture and is set to receive royalties and milestone payments based on the drugs' success. The collaboration allows the drugmaker to concentrate its immunology research on treatments aimed at resetting the immune system while ensuring the continued development of promising assets, the companies said. "These assets have significant potential, and we are confident that this new company will drive their development to ensure greater impact for patients," said Julie Rozenblyum, senior vice president of business development at Bristol Myers. Daniel Lynch, a seasoned pharmaceutical executive, will take on the roles of executive chairman and interim CEO of the new company, while Bristol Myers' chief research officer Robert Plenge is set to join the board alongside Bain Capital partners. Canada Pension Plan Investment Board also participated in the financing round. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Reuters
a day ago
- Business
- Reuters
Bristol Myers, Bain Capital form new company to develop immunology drugs
July 28 (Reuters) - Drugmaker Bristol Myers Squibb (BMY.N), opens new tab and private equity firm Bain Capital will launch an independent company focused on developing immunology drugs, backed by Bain's $300 million financing round, the companies said on Monday. The new company will work on five experimental drugs licensed from Bristol Myers, including a late-stage lupus treatment and a mid-stage psoriasis drug that has shown promise in trials. Bristol Myers will retain nearly 20% equity in the venture and is set to receive royalties and milestone payments based on the drugs' success. The collaboration allows the drugmaker to concentrate its immunology research on treatments aimed at resetting the immune system while ensuring the continued development of promising assets, the companies said. "These assets have significant potential, and we are confident that this new company will drive their development to ensure greater impact for patients," said Julie Rozenblyum, senior vice president of business development at Bristol Myers. Daniel Lynch, a seasoned pharmaceutical executive, will take on the roles of executive chairman and interim CEO of the new company, while Bristol Myers' chief research officer Robert Plenge is set to join the board alongside Bain Capital partners. Canada Pension Plan Investment Board also participated in the financing round.
Yahoo
6 days ago
- Health
- Yahoo
Citryll Announces Formation of Scientific Advisory Board
CITRYLL ANNOUNCES FORMATION OF SCIENTIFIC ADVISORY BOARD Oss, Netherlands – 24 July 2025 – Citryll, a biotech company pioneering a transformative approach to treating immune-mediated inflammatory diseases by targeting Neutrophil Extracellular Traps (NETs), today announces the formation of its Scientific Advisory Board (SAB). The Board will provide strategic guidance and scientific insight as Citryll advances the development of CIT-013, its first-in-class monoclonal antibody, through the clinic. The SAB brings together internationally recognised experts in NET biology, pre-clinical development, and immunology. The founding members include Dr. Tim Hammond, Professor John Hamilton, Dr. Christian Lood and Professor Paul Kubes. 'We are honoured to welcome this distinguished group of experts to Citryll's Scientific Advisory Board,' said Eric Meldrum, Chief Scientific Officer of Citryll. 'Their combined expertise will be invaluable as we advance CIT-013 in ongoing trials in rheumatoid arthritis and hidradenitis suppurativa. With their guidance, we aim to unlock the full therapeutic potential of targeting extracellular traps in a range of inflammatory diseases. This is an important step in strengthening our broader advisory network, as we also work to build a Clinical Advisory Board to support our next stage of clinical development.' Members of Citryll's Scientific Advisory Board include: Dr. Tim Hammond, PhD Tim brings over 35 years of experience in pharmaceutical drug discovery and development. He is currently Head of Safety at various companies and was formerly Vice President of Safety Assessment in the UK for AstraZeneca. He has been an independent consultant since 2012. Tim is a past President of the British Toxicology Society, is a Fellow of the Royal College of Pathologists, is a member of the American Society of Toxicology and was a founding member of the International Safety Pharmacology Society, which awarded him the Distinguished Scientist Award in 2007. He holds a PhD in Pharmacology and Toxicology from the University of Birmingham and an Honorary Professorship from the University of Liverpool. Professor John Hamilton, PhD John is internationally recognised for his expertise in macrophage biology and inflammation, with his research significantly contributing to the understanding of inflammatory mechanisms in diseases such as rheumatoid arthritis. He has received numerous honours, including the Australian Rheumatology Association Distinguished Service Medal, the American College of Rheumatology Distinguished Basic Investigator Award, and the International Association of Inflammation Societies Lifetime Achievement Award. He is a Professor in the Department of Medicine at the University of Melbourne and a Fellow of the Australian Academy of Science. He holds a PhD in Chemistry from the University of Melbourne. Dr. Christian Lood, PhD Christian is a leading researcher in neutrophil function, NET formation, and the role of innate immunity in autoimmune diseases such as systemic lupus erythematosus. His work has provided critical insights into how NETs contribute to autoimmune pathology and therapeutic intervention opportunities. He is currently an Associate Professor, Division of Rheumatology at the University of Washington with a focus in neutrophil biology in inflammatory and autoimmune conditions. He holds a PhD in Biomedicine from Lund University. Professor Paul Kubes, PhD Professor Paul Kubes is known internationally for his expertise in leukocyte recruitment and inflammation, with significant contributions to understanding immune cell function in inflammatory disease and tissue repair. He is a professor at Queen's University, where he recently accepted a Canada Excellence Research Chair. Prior to this, he was a Professor at the University of Calgary Cumming School of Medicine and the Founding Director of the Snyder Institute for Chronic Disease for 15 years. He also holds a Canada Research Chair in Leukocyte Recruitment in Inflammatory Disease. Professor Paul Kubes has received numerous awards, including the CIHR Investigator of the Year and the Henry Friesen Award, and has published in leading journals such as Cell, Science, and Nature. He holds a (Honours) in Biological Sciences, an M.S. in Physiology, and a Ph.D. in Physiology from Queen's University. -ENDS- About Citryll Citryll is pioneering a transformative approach to treating inflammatory diseases by targeting Neutrophil Extracellular Traps (NETs), a fundamental component of the inflammatory process that has yet to be addressed therapeutically. Citryll is developing the first NET-targeting therapy and potentially creating a new class of therapeutics with broad applications across immune-mediated inflammatory diseases. Our lead asset, CIT-013, is a first-in-class monoclonal antibody with a unique dual mechanism of action: it enhances the clearance of existing NETs and inhibits the formation of new NETs. By addressing this key driver of inflammation, CIT-013 has the potential to offer a differentiated and comprehensive treatment option for conditions such as rheumatoid arthritis and hidradenitis suppurativa, where current therapies often fall short of providing adequate disease control. Contacts CitryllSjoerd van Gorp, COOEmail: info@ Citryll Media ContactsICR HealthcareAmber Fennell, Stephanie Cuthbert, Lucy FeatherstoneEmail: citryll@ while retrieving data Sign in to access your portfolio Error while retrieving data Error while retrieving data Error while retrieving data Error while retrieving data
Associated Press
6 days ago
- Health
- Associated Press
Creative Biolabs Debuts Platforms for Smarter T Cell Stimulation
Creative Biolabs delivers tailored T cell activation solutions using hydrogel matrices, DNA scaffolds, and synthetic systems for precise and efficient immune modulation. Creative Biolabs, the global pioneer in immunotherapy, has developed novel artificial T cell-stimulating platforms —like hydrogel matrices, DNA scaffolds, and synthetic systems—to enhance CAR-T, TCR-T, and adoptive cell therapy research in oncology and immunology. Activation of T cells is also a key issue in cancer immunotherapy, especially as researchers seek more physiologically relevant conditions in which to optimize cell growth, survival, and activity. Creative Biolabs' artificial platforms replicate the most critical aspects of the original lymphoid microenvironment—enabling antigen-specific stimulation and controlled co-signal presentation that reduce activation-induced death and provide for long-lasting immunity. One of the newly announced technologies is a hydrogel-based artificial T cell-stimulating platform, which includes tunable formats such as artificial T cell-stimulating matrices (aTM), artificial lymph node scaffolds (aLN), and immunomodulatory macroporous hydrogels. The platforms enable the possibility of accurately modulating the stiffness of the matrix and biochemical ligand density, triggering localized immune activation with a low off-target effect. Complementing these is the DNA-based platform, which uses self-assembled DNA scaffolds to mimic dendritic cell architectures. With tunable conjugation protein ratios and high surface-to-volume efficiency, researchers can modulate multi-signal stimulation profiles to fit therapeutic design parameters. The platform further improves functional antibody display and allows for scalable stimulation approaches. 'Our tools bridge the gap between engineering precision and biological complexity,' said a Creative Biolabs senior R&D director. 'By simulating the critical immunological signals with synthetic and bioinspired materials, we're empowering scientists to accelerate discovery and improve cell product quality.' In addition to proprietary technology, Creative Biolabs offers end-to-end service customization in processes like DNA scaffold design, molecular engineering, protein functionalization, and in vitro / in vivo testing. Each workflow is supported by GLP-grade quality systems and high-throughput facilities to offer reproducibility and data integrity during the experimental stages. Customers are not only offered cutting-edge platforms but also professional advice and flexible project delivery. Creative Biolabs' team of specialists ranges from immunology, synthetic biology, and materials science to offer cross-functional support that is tailored to achieve every research goal. With applications from antigen-specific T cell screening to potency optimization and the development of novel therapeutics, artificial stimulation platforms hold the promise of transforming the evaluation and scaling of cell therapies. Creative Biolabs is leading innovation in this space, committed to enabling global partners to unlock the full potential of immune-based therapeutics. For additional information or to obtain a custom quote, visit About Creative Biolabs Creative Biolabs is a leader in immunotherapy, delivering customized artificial T cell-activating platforms for CAR-T and TCR-T studies. Their hydrogel, DNA, and synthetic platforms replicate critical immune signals, optimize activation efficiency, and facilitate scalable therapies—uniting engineering accuracy and biological sophistication to propel global cell therapy innovation. Media Contact Company Name: Creative Biolabs Contact Person: Candy Swift Email: Send Email City: Shirley State: New York 11967 Country: United States Website: Press Release Distributed by To view the original version on ABNewswire visit: Creative Biolabs Debuts Platforms for Smarter T Cell Stimulation
