Latest news with #macrophages
The Independent
2 days ago
- Health
- The Independent
Pioneering new drug could replace aggressive cancer therapies
A new medicine, KCL-HO-1i, has been developed to improve cancer treatment by enhancing the effectiveness of chemotherapy. The drug works by dismantling a crucial defence mechanism used by tumours, specifically targeting the heme oxygenase-1 (HO-1) protein produced by macrophages that shield tumours. Initial trials conducted on mice demonstrated that KCL-HO-1i made chemotherapy-resistant tumours responsive to treatment. Researchers at King's College London, who developed the drug, are hopeful for human trials to begin within two years. This new medicine could potentially serve as a valuable companion drug to chemotherapy, sparing patients from more aggressive interventions.
Washington Post
21-06-2025
- Health
- Washington Post
People with COPD had more carbon in their lungs than smokers in study
The lung tissue of people with chronic obstructive pulmonary disease contains triple the sootlike particle buildup found in similar tissue in smokers' lungs, a recent analysis finds. The study found that COPD patients' alveolar macrophages — a type of lung cell that removes dust, particles and microorganisms from the lungs — contain more carbon than those of smokers. The carbon-containing alveolar macrophages in COPD patients' lungs were also larger than macrophages without visible carbon, the study found.
