Latest news with #medicalAttention
Medical News Today
06-08-2025
- Health
- Medical News Today
Your FAQs around generalized pustular psoriasis
Generalized pustular psoriasis is a severe form of psoriasis that can cause body-wide symptoms and may require immediate medical pustular psoriasis (GPP), also known as von Zumbusch psoriasis, is a rare type of GPP affects an estimated 1 to 7 people out of every million. It features episodes or 'flares' of erythroderma, widespread skin inflammation and redness or other skin color changes. These flares develop with sterile (not caused by infection), fluid-filled blisters or a flare, pustules break open, and the skin can become dry and painful. It may crack, peel, or scale and may resemble a is an immune-mediated condition caused by dysfunction in the immune system. Unusual immune responses to triggers such as stress, medication use, or infections can set off a chain of severe inflammatory reactions throughout the body. GPP often has identifiable triggers, but it can also happen without any obvious people experience severe systemic symptoms in addition to skin inflammation, including fever, chills, muscle weakness, and fatigue. If left untreated, GPP can cause life threatening complications like organ on to find out the answers to some of your most pressing questions about is the outlook for generalized pustular psoriasis?GPP is a chronic condition. It can be managed, but it may never be fully cured. As many as 80% of people experience relapses, and most have at least one episode outlook during a flare depends largely on how quickly a person receives treatment. Severe inflammation can cause tissue damage and affect internal organs like the heart, lungs, or kidneys. In some cases, this may result in sepsis, a life threatening complication that requires urgent care. Seeking treatment as soon as possible can help shorten the duration of a GPP flare and lower the risk of serious between flares, GPP can affect long-term health. People with GPP have a higher risk of cardiovascular conditions and other systemic complications, which can affect quality of life and life to a 2025 study, people with GPP have about four times the risk of death from any cause compared to the general is the best treatment for generalized pustular psoriasis?Everyone living with GPP has different factors that can affect their treatment plan. A doctor will consider a person's age, family history, genetics, and other health conditions when recommending a flare, first-line treatments usually include medications that target the immune system. These drugs work by blocking or calming overactive inflammatory example is spesolimab (Spevigo), a monoclonal antibody that blocks interleukin-36 (IL-36) receptors. IL-36 is a pro-inflammatory molecule, known as a cytokine, that becomes overactive in GPP. It triggers systemic inflammation and stimulates the production of neutrophils, which accumulate in the skin and create spesolimab is the only medication approved by the Food and Drug Administration (FDA) specifically for the treatment of may also use other medications that modify immune responses or control inflammation, such as:infliximaboral retinoidsapremilastmethotrexatecyclosporineFor mild symptoms or when GPP is well managed, doctors may recommend more conservative treatments. These can include keeping the skin hydrated, using topical corticosteroids, and prescribing antibiotics if there is an a medication triggers the flare, stopping that medication is also an important part of the do you stop pustules from spreading?Immediate treatment helps stop GPP pustules from in GPP are sterile. They form because of overactive inflammatory processes in the body. Itching pustules or having pustules break open is not what causes pustules to spread (although this can increase the risk of secondary infection).Interrupting the inflammatory chain with medications like spesolimab during a flare will help bring pustules under control. Applying cool compresses, keeping skin clean and moisturized, and avoiding irritants like rough fabric can help improve the overall health of the skin and manage pustular psoriasis lead to sepsis?Generalized pustular psoriasis can lead to is a severe, life threatening inflammatory reaction to an infection that spreads through the bloodstream. It can cause symptoms such as: feverrapid heartbeatrapid breathinga dangerous drop in blood pressureconfusionorgan damageIn GPP, several factors can increase the risk of sepsis. Open skin from pustules, cracks, or scratching allows bacteria, viruses, or fungi to cross the skin barrier and enter the bloodstream. Medications that suppress the immune system, such as methotrexate or infliximab, can also make it harder for the body to fight these pathogens enter the bloodstream, they can travel throughout the body, triggering a widespread inflammatory response known as sepsis happen during every generalized pustular psoriasis flare?Sepsis can occur during a flare, but it does not happen every time a person with GPP experiences a in GPP are believed to be caused by a 'cytokine storm.' A cytokine storm happens when the immune system becomes overactive and releases too many pro-inflammatory molecules at once. Infection can trigger a cytokine storm, but it is not the only cause. Cytokine storms in GPP can happen any time the immune system is overactivated, even without an however, always results from an infection. It also involves a cytokine storm, but in this case, the overactivation of cytokines is a direct response to that infection. In conditions like GPP, existing cytokine dysfunction can make a sepsis-related cytokine storm more pustular psoriasis is a rare form of psoriasis that causes widespread areas of red, inflamed skin covered with sterile, fluid-filled pustules. GPP can be life threatening. It causes severe, body-wide inflammation that may damage tissues and lead to organ treatment can help slow the spread of pustules and lower the risk of serious complications. Doctors typically treat GPP with medications that interrupt or block overactive immune responses. Spesolimab (Spevigo) is the only drug currently approved by the FDA specifically for the treatment of GPP.
WebMD
20-06-2025
- Health
- WebMD
When Life Throws a Curve Ball: Managing Diabetes with an Injury
It may sound strange for me to connect a pulled back muscle with blood sugar regulation, but let me explain. About two weeks ago, I began to experience this sharp pain in my lower back every time I turned in a certain direction. Whether I sat or stood, after about five minutes it would be there. I couldn't sleep and it became almost unbearable. This lasted for two days until I decided that it was time for me to seek medical attention. I visited an urgent care center down the street from where I live to find out what was going on. My first idea about the pain was that it could be my kidneys, so I checked my blood sugar levels to see if they were elevated and they were not. Also, the pain was more in the middle of my lower back on the right, and I know that my kidneys are not located there. While at the care center, the doctor asked me to move in certain positions by stretching, and we discovered that I must have pulled a muscle in my back. I wasn't sure how this happened, because I work out daily for about 30 minutes. I didn't think I was doing anything too strenuous that would result in pulling a muscle, but here we are. The doctor told me that I had to postpone both weight and HIIT workouts. This startled me, because I know that the exercise has been helping my blood sugar levels to stay in range. At this point, I was trying to think about what type of physical activity I could do that would help me to maintain a fitness level at which my body could still benefit from blood sugar regulation. I asked the doctor what exercises I could do to maintain my fitness and blood sugar levels. The doctor told me not to do too much movement and to allow my back to heal, but that I could do light walking and some moving around in a swimming pool. The water will support my joints and keep me from putting any strain on my back muscles. To make a long story short, he said that it may take anywhere from 2 to 8 weeks for me to heal. I knew exactly what I needed to do. Since I wasn't doing any high-intensity workouts, I needed to take in fewer carbohydrates so that I can maintain a decent blood sugar level in the coming weeks. So over the past two weeks I have been eating fewer carbohydrates. I'm taking my prescribed muscle relaxers and an anti-inflammatory medication. I've actually done some marching in place inside my apartment and have even visited the pool to exercise once. I am proud to report that two weeks later, my back is feeling much better and I haven't had to deal with any hyperglycemia even though I'm doing less exercise. The moral of this story is that life can throw curveballs, but it doesn't mean that you can't get around them. Diabetes self management is a marathon and never a sprint, so you just have to take one day at a time because anything can happen. Learning how to deal with tough circumstances can help you learn how to adapt in any situation.
Reuters
10-06-2025
- Politics
- Reuters
Ukraine brings home new group of POWs, Zelenskiy says
KYIV, June 10 (Reuters) - Ukraine on Tuesday returned a new group of prisoners of war as part of an earlier agreement with Russia, Ukrainian President Volodymyr Zelenskiy said. "Today marks the first stage of the return of our seriously wounded and injured soldiers from Russian captivity. All of them require immediate medical attention. This is an important humanitarian act," Zelenskiy said on the Telegram messenger.
