Latest news with #ulcerativecolitis
Yahoo
16 hours ago
- Business
- Yahoo
This Stock Is Up by 800% This Year -- but Is It a Buy?
Key Points Abivax's shares skyrocketed following positive clinical trial results for its lead candidate, obefazimod. This investigational medicine could prove more effective than existing drugs for ulcerative colitis. There might be plenty of upside left if obefazimod produces more positive results in further trials. 10 stocks we like better than Abivax Société Anonyme › If you had invested money in Abivax (NASDAQ: ABVX) at the beginning of the year, you would be sitting pretty right now. The French biotech's shares recently skyrocketed and are up more than 800% year to date. As investors can probably guess, Abivax's gains are tied to impressive clinical progress for its leading pipeline candidate. However, some might worry that it's too late to buy the stock now. Is that the case? Let's look deeper into what's going on with Abivax and determine whether there's any upside left. A potential first-in-class drug Abivax's leading pipeline candidate is called obefazimod, a potential treatment for ulcerative colitis (UC). It could be a first-in-class drug, meaning a medicine that has a novel mechanism of action distinct from those of existing therapies targeting the same condition. First-in-class drugs sometimes prove more effective than standard existing treatments, so there is significant potential for a smaller biotech company working on a medicine like this one, if it can ace clinical trials. Abivax has just achieved exactly that, with strong results from a pair of phase 3 trials for obefazimod. The medicine led to a high rate of remission among participants with moderate to severely active UC, compared to a placebo. Importantly, the studies included patients who had never received any advanced therapy for UC, as well as some who had but had previously failed to achieve remission. According to Abivax, 47.3% of participants in these trials had an inadequate response to prior therapy. In other words, obefazimod succeeded in helping some patients achieve remission where other medicines had failed. And this isn't an obscure therapeutic area with just a couple of options, either: It's actually a highly competitive market. There are numerous advanced therapies for UC, including some produced by several of the world's largest pharmaceutical companies. That makes obefazimod's success all the more impressive. Why it may not be too late to buy the stock Abivax's market capitalization is now 3.7 billion euros (about $4.3 billion). Some analysts estimate that obefazimod could hit peak sales of about $4 billion. Of course, it won't get there anytime soon, even if it earns approval. Though the data looks strong so far, there is more to come. The recent results Abivax shared were from induction trials (to see whether a medicine can reduce the symptoms of a disease). The biotech has an ongoing maintenance study (to check whether it can keep the disease under control), the results of which it plans to share in the second quarter of 2026. If this data isn't up to Wall Street's liking, Abivax's shares might plunge. That's to say nothing of potential regulatory setbacks, which aren't that rare with smaller biotech companies and could also sink the company's stock price. So there are some risks involved, but the stock might be worth it for those who can stomach the volatility. Abivax has developed a medicine with a novel mechanism of action that performs well in clinical trials, and that ability speaks volumes about the company's innovative capabilities. Meanwhile, although funding was an issue at the start of the year, it should no longer be a problem. Abivax ended the first quarter with 103.6 million euros in cash ($120.1 million), which management thought would only last until the end of this year. Thanks to obefazimod's phase 3 results and the company's stock price soaring, Abivax announced a secondary offering, during which it expects to generate gross proceeds of 637.5 million euros ($747.5 million). That should be plenty of money for the company to keep the lights on, even beyond next year. There's still significant upside left if the ongoing phase 3 clinical trials for obefazimod in UC also yield strong results. Additionally, Abivax is testing its lead candidate as a monotherapy for Crohn's disease, as well as a potential combination treatment for UC. Consistent positive clinical and regulatory developments could lead to even more gains for patient investors. That's why it might still be time for those with above-average risk tolerance to initiate a small position in the stock. Should you buy stock in Abivax Société Anonyme right now? 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The Motley Fool has a disclosure policy. This Stock Is Up by 800% This Year -- but Is It a Buy? was originally published by The Motley Fool Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Daily Mail
4 days ago
- Health
- Daily Mail
Why so many older women suffer the agony of burning mouth syndrome: DR MARTIN SCURR reveals the likely causes – and how you can treat it
I've been diagnosed with burning mouth syndrome and it's extremely painful (it was caused by my ulcerative colitis). I've been put on gabapentin, but is this likely to help? Audrey Boyson, Merton.
Daily Mail
4 days ago
- Entertainment
- Daily Mail
Louise Thompson proudly displays her stoma bag in a yellow bikini as she admits she notices people staring at it and urges others to 'be kind'
Louise Thompson proudly displayed her stoma bag in a yellow bikini as she admitted she feels people staring at her and urged people to 'be kind'. The former Made in Chelsea star, 30, who nearly died when giving birth to her son in 2021, revealed last April that she had been fitted with a stoma after years of battling with ulcerative colitis. Ulcerative colitis is a chronic bowel condition where the colon and rectum become inflamed and small ulcers develop on the colon's lining, which can bleed. A stoma is a surgically-created opening made on the abdomen, which is made to divert the flow of body waste into a medical device, which the person can then empty. But taking to Instagram on Sunday, Louise admitted in a candid post that she us wearing less bikinis and switching to swimsuits, in part because she notices people looking at her stoma. Louise went on to say that she feels confident having her stoma on show now, but gave advice to those unfamiliar with them to 'be kind', not judge and let people with them wear what they want in peace. Sharing a snap and clip of herself in the yellow two-piece, Louise wrote: 'I'm not a big bikini girl these days. I don't think it's a confidence issue, I just really enjoy the comfort of a swimsuit. It's very practical and dare I say it - when you reach your mid 30s I think practicality equates to sophistication. 'There's another thing. I don't LOVE people looking at me that much. Stoma or no stoma. It doesn't happen to me often now I'm a bit older and a mother (gone are the days of men checking me out on the tube or the beach), but regardless of circumstances - you definitely get more attention with a random black or grey bag glued to your abs. Unsurprising really. 'I have no doubt that if I saw someone in a similar situation as me I'd look on in fascination/with curiosity/appreciation for what they might have gone through. It's natural. We are intrigued by uniqueness. We intrigued by medicine and health.' She continued: 'On the note of appreciation I've actually been serving myself lots of self-appreciation recently. Yesterday I got out of the shower and went straight to my phone to write down the words "remember you can get through TOUGH shit, ur tough as nails'" on a WhatsApp thread I have with myself (where I dump all my creative [thoughts]) because I really believed it. I wanted you to too. 'Regardless of the above I feel no shame when I look at my body. I don't attach much emotion to it at all. It just exists. That's the main thing. It's a privilege to exist. Literally. Metaphorically. 'But I fancied giving my tummy a bit of tan time/vit d on holiday… so here she is. The old bod. Me and Winnie hanging out. Wearing her with pride. I think I've still got it. I feel good. I roamed freely in the villa. I didn't feel the need to display my tummy in the beach clubs because tbh I'm not really a big lie down and tan kind of girl anymore. I think I dress really well and v freeely and vvvv ME regardless of my stomach situ.' Louise added: 'I don't feel held back at all, but I know some do and I want to remind anyone out there that doesn't really understand what this is that lots of normal and nice people in the uk have them (100k) and to be kind. 'Don't judge. Let people wear what they want. Ask nice questions if you really can't help it. You might learn something cool. #stoma.' In holiday snaps from earlier this month, Louise showed off her incredible figure in the two-piece, before slipping into a black swimsuit. Louise and fiancé Ryan Libbey have been enjoying a short trip 'just the two of them' at the luxurious Maslina Resort on Hvar island. Louise recently opened up about suffering a 'horrendously debilitating' stoma leak while out in central London. Since her diagnosis, Louise has continued to spread awareness and proudly show off her stoma, which she's nicknamed Winnie, in a hilarious reference to Winnie The Pooh. However, taking to her Instagram on Wednesday, she revealed she'd had a leak the day before, which left her in tears and needing some time out by herself. She explained she had headed to Marylebone with her fiancé Ryan on his motorbike for an appointment and a coffee, before going to record a podcast. However, Louise explained that despite their 'great start', she suddenly realised her stoma bag had unfortunately leaked, forcing her to rush to the nearest hospital for supplies. Sharing several selfies of her and Ryan on their bike journey before everything went wrong, she wrote: 'Yesterday I found myself in a really depressing situation. 'l had a great start to the day. I had a medical appointment at @ in the morning with Ryan... we biked there to get ahead of the traffic and managed to shave off 20 minutes from the journey. 'Then was off to record a podcast with 2x good friends which has been in the diary for ages. Had a lot of excited energy in my belly following a c**p week of of c**p health. 'We got off the bike in Marylebone blissfully happy and headed to @watchhouse for some delicious coffee and cookies pre-recording because we were a smidge early, but then I felt something a bit wet in my pocket. I looked down and had had the most horrendously debilitating stoma leak.' She recounted how she was left 'too overwhelmed' to explain the situation, but Ryan had stepped in, while she was left in a bathroom for an hour waiting for staff to try and source any new stoma bags, while 'covered in mess'. Louise said: ' I had to hobble to the nearest hospital which was a private one so a bit awkward. I was actually too overwhelmed to speak when we got to reception so thankfully Ryan who I was with handled it for me. 'I then literally waited locked in a bathroom for an hour sat on the loo covered in mess whilst they dug around to see if they had any stoma bags for any of their [sic] inpatients.'
Daily Mail
21-07-2025
- Health
- Daily Mail
Footy star reveals the simple diet change he used to beat horrible disease that is ruining the lives of tens of thousands of Aussies
Jake Waterman enjoyed one of his best seasons in a gold and blue guernsey in 2024. The 27-year-old was the West Coast's leading goal kicker, booting 53 goals for the year, which is a career high for the key forward. But rewind the tape back, and things were very different for Waterman, who had been unknowingly suffering from a horrible illness that over 180,000 people in Australia currently suffer from. He admitted he'd wake up in the morning suffering from severe pain in his abdomen and struggled to play footy. Prior to a game in 2023, the Eagles star had been feeling nauseous, had severe stomach cramps and was suffering from diarrhoea. 'I had to fly home and get myself into a hospital because I couldn't do anything, I was too ill,' Waterman told The Daily Telegraph. Waterman (right) was diagnosed with the illness back in 2023 after spending several weeks in hospital The footy star was subsequently diagnosed with ulcerative colitis (UC), after spending several weeks in hospital. UC is a bowel disorder that can cause inflammation and ulceration in a person's large intestine. Inflammatory bowel disease affects the inner lining of the large intestine and is a lifelong condition. The inflammation can cause redness, swelling and pain, while ulcers can also develop on the surface of the intestines. Other symptoms can include fatigue, diarrhoea and a loss of appetite. The cause of the illness is unknown, and while there is no known cure, it can be treated using medication, dietary changes and surgery. Spending several weeks in hospital felt like a 'blur' for the footy star, who revealed that he felt like he was stuck in a vicious cycle and didn't have 'much hope.' 'I woke up every day in pain, stuck on the couch trying to sleep again,' he explained. The illness sent him into a downward spiral, with Waterman explaining: 'I was down in the dumps, feeling horrible.' 'I just wanted to feel normal again.' Waterman played only 11 games during the 2023 season, a far cry from the 20 he featured in the previous year. But the resilient footballer was not going to let the illness get to him. He made some big changes to his diet and lifestyle, removing processed foods from his diet. He has begun to focus more on his nutrition in a bid to improve his gut health. The 27-year-old admitted that, even though he is an elite athlete, he had not been much of an expert in nutrition prior to being diagnosed. Now, Waterman is staying focused on refuelling with the right foods; a vital step in helping him perform at his best and manage the illness. And it sure has worked. Amid the tribulations of 2023, Waterman bounced back from a horrible period to enjoy an excellent 2024, earning himself his first All-Australian blazer. Waterman is also an ambassador for Chron's and Colitis Australia, and is helping to raise awareness of the illness. 'I feel like I've got an obligation to speak up and shine a light on these conditions,' he said. Agonisingly, Waterman has been ruled out for the remainder of the 2025 season after he dislocated his shoulder during the Eagles' Round 11 defeat by Adelaide. During his time away from the pitch, the 27-year-old has been using his time to speak to others who have the condition. 'I recently went to a Crohn's and colitis day, and I was able to speak to some young kids and parents about their struggles and hardships,' Waterman explained. 'My situation doesn't hold a candle to what they're going through… my heart breaks for them.' After his successful 2024 campaign, Waterman re-signed with the Eagles until 2029. It was a just reward for the work he did to help lift the West Coast, who have been battling their way through a torrid few seasons. And now, after Jack Darling's departure from the Mineral Resources Park, Waterman has stepped up to fill the void, while turning down offers from Geelong and Melbourne to lure the Western Australia-born star to Victoria. 'Now it's finally done, it's reality now, and I'm just happy that I'm locked away here for the next five years,' he said.
Health Line
14-07-2025
- Health
- Health Line
How to Live Beyond an Ulcerative Colitis Diagnosis
Getting diagnosed with ulcerative colitis means you can begin managing your symptoms and finding a treatment plan that works for you. Being diagnosed with ulcerative colitis (UC) can cause a range of emotions. On one hand, it's a relief to have an explanation for your symptoms and a plan to treat them. However, you may also worry about how this disease will affect your quality of life. Keep reading to learn how the condition may affect your routine and what simple steps you can take to regain control of your body and your lifestyle. Understand treatment options Other than surgery to remove your colon and rectum, there's no cure for UC. But several drugs can reduce the frequency of attacks and bring the disease into remission. Treating UC requires the care of an intestinal tract specialist, or gastroenterologist. There's no one-size-fits-all approach — your treatment plan will depend on whether your symptoms are mild, moderate, or severe. It's important to take your medication exactly as prescribed to benefit the most from treatment. Depending on the therapy, it can take weeks or even months for symptoms to improve. Let your healthcare team know if a medication isn't working. Some drugs are more effective than others, and your doctor may need to adjust your dosage or switch your medication. People respond differently to medications, so it's standard procedure to try more than one before you and your healthcare team figure out which is best for treating your UC. If you don't achieve remission with an anti-inflammatory or an immunosuppressant drug, you may be a candidate for biologics. This therapy — which targets the proteins that cause inflammation in your colon — can treat moderate to severe UC. If you have severe UC that doesn't respond to biologics, surgery to remove your colon may help. While it's a significant decision, surgery can provide long-term relief when other treatments haven't worked. Adjust or modify your diet There's no one diet to treat UC. The foods you eat don't cause the disease, but some may lead to a flare-up or worsen it. However, what affects one person may not affect another, which is why it's important to try to learn your food and drink triggers. If you can prevent or reduce the severity of a flare-up, you'll enjoy more of your favorite activities. Keeping a food diary can help you identify which foods trigger your symptoms, so you can make personalized adjustments that may reduce flare-ups and help you stay active and engaged in your daily life. Some people have found that eating a low fiber diet reduces loose stool and frequent bowel activity. Likewise, a lactose-free diet may decrease abdominal pain, gas, and diarrhea. Other diet and nutrition strategies to help you feel better and stay in control include: avoiding greasy or fried foods eating 5to 6 small meals daily eating foods rich in probiotics limiting caffeine, which can act as a laxative cutting out spicy foods to avoid irritating your intestinal tract Proper nutrition helps manage this disease, so talk with your doctor about taking multivitamins. A supplement can prevent vitamin deficiencies that result from removing certain foods from your diet. Be prepared when going out or traveling Flare-ups can occur unexpectedly, but they don't have to keep you from living your life. With some planning and preparation, you can stay active and enjoy the things you love. Whether you're headed to the movies, a restaurant, or another public place, it's helpful to know where the restrooms are, just in case. If you're worried about symptoms appearing suddenly, consider carrying a small kit with essentials like an extra pair of underwear and moist wipes. This kind of simple preparation can help you feel more confident and in control. If you're traveling, ensure you have enough medication to last for the duration of your trip. Forgetting your medication at home and skipping dosages can trigger a flare-up while away. If you'll be away for an extended time, consult your doctor about sending your prescription to a pharmacy in your destination city. Alternatively, get a referral to a local clinic in case you need professional healthcare while traveling. Join a support group A family history of UC increases the risk of developing the disease. But sometimes, there isn't a genetic link. If you're the only one in your family or circle of friends trying to manage UC, you may feel alone at times. Frequent bowel activity and diarrhea can cause feelings of embarrassment, and it's often easier to hide from others and avoid talking about what's going on. But shying away from social interactions can contribute to isolation. And the truth is, talking about your disease may help you feel better. If you share your feelings with people you trust and give them a chance to offer support, you may find it easier to resume activities. In addition to talking with friends and family, ask your doctor or gastroenterologist about local support groups or counseling. Connecting with others with UC can be helpful — not only for emotional support, but also for sharing practical tips and coping strategies. Maintain a positive outlook UC isn't caused by stress or anxiety, but emotional stress can sometimes worsen symptoms. Managing stress through mindful meditation, light exercise, journaling, or puzzling may help you feel calmer and more relaxed, ultimately reducing your stress levels. Even though living with UC can be challenging, having a support system and strategies for coping when flare-ups arise can make a difference. Being depressed or anxious can contribute to social isolation and the loss of interest in activities, and these feelings can occur if you're having difficulties managing your UC. If you are finding it difficult to cope with UC, talk with your healthcare team about options. They may recommend trying an antidepressant.
