Latest news with #DKA
Hans India
07-08-2025
- Health
- Hans India
Study explores role of brain in treating type 1 diabetes
The brain might become the target of new type 1 diabetes treatments and pave a better way for insulin management, according to a study. Researchers had, over a decade ago, found that an acute complication of type 1 diabetes - diabetic ketoacidosis (DKA) - can be resolved with the hormone leptin, even in the absence of insulin. In the analysis, published in the Journal of Clinical Investigation, the team explained how leptin affects the brain and how it might be used in future therapeutics. DKA happens when the body is unable to make insulin and begins to break down fat for fuel. This can lead to a life-threatening buildup of sugar (glucose) and ketoacids in the blood. Doctors have typically administered insulin to address the complication. But evidence now shows that, when insulin is insufficient, the brain plays a key role in driving DKA, explained researchers from the University of Washington in the US When the pancreas can't make insulin, 'the brain gets the message that the body is out of fuel, even if it's not. This information is being communicated in part by a low blood level of the hormone leptin,' said Dr. Michael Schwartz, Professor of Medicine, at the University's School of Medicine.
News18
06-08-2025
- Health
- News18
Can The Brain Help Regulate Blood Sugar In Type 1 Diabetes? Here's What New Study Says...
Curated By : Satyaki Baidya Translation Desk Last Updated: August 06, 2025, 19:07 IST When insulin drops, leptin falls too, tricking the brain into sensing low energy despite glucose and fat. (Representative/AP) A recent study published in the Journal of Clinical Investigation has unveiled significant insights into the role of the brain in type 1 diabetes management. Type 1 diabetes is an autoimmune disease that halts insulin production, leading to elevated blood sugar levels. In the absence of insulin, the body resorts to breaking down fat for energy, causing a dangerous increase in blood sugar and ketoacids, a condition known as diabetic ketoacidosis (DKA), typically treated with insulin. The study highlights the importance of leptin, a hormone produced by fat cells, in regulating hunger and energy balance via the hypothalamus in the brain. It has found that when insulin levels drop, leptin levels also decrease, misleading the brain into thinking there is an energy deficit despite the presence of glucose and fat. This miscommunication prompts the brain to increase sugar and ketone production, resulting in DKA, the study suggested. In 2011, Dr. Michael Schwartz, a professor at Washington University in the US, and his team conducted an experiment where leptin was injected into the brains of type 1 diabetic mice and rats. Initially, there were no significant changes, but after four days, it was found that the animals' blood glucose and ketone levels normalised without insulin. This breakthrough suggested that the brain alone might regulate blood sugar levels, challenging the conventional belief that type 1 diabetes solely stems from a lack of insulin. The study highlighted that not only did the sugar level drop, but it also stayed balanced—indicating the brain can regulate blood sugar on its own. The scientific community initially met this discovery with scepticism. However, recent studies and analyses have strengthened the hypothesis that the brain plays a crucial role in managing type 1 diabetes. Dr. Schwartz now aims to seek approval from the US FDA for human trials to explore if leptin can yield similar results in humans. Swipe Left For Next Video View all The discovery of insulin 104 years ago marked a major step in diabetes treatment. Now, new research suggests leptin may also help regulate blood sugar, potentially reducing the need for daily insulin or frequent monitoring. According to the research, convincing the brain that the body has enough energy, or blocking the brain's signals that trigger glucose and ketone production, could help prevent diabetic ketoacidosis (DKA). This challenges the long-held belief that type 1 diabetes is solely caused by a lack of insulin. The News18 Lifestyle section brings you the latest on health, fashion, travel, food, and culture — with wellness tips, celebrity style, travel inspiration, and recipes. Also Download the News18 App to stay updated! view comments News lifestyle Can The Brain Help Regulate Blood Sugar In Type 1 Diabetes? Here's What New Study Says... Disclaimer: Comments reflect users' views, not News18's. Please keep discussions respectful and constructive. Abusive, defamatory, or illegal comments will be removed. News18 may disable any comment at its discretion. By posting, you agree to our Terms of Use and Privacy Policy.
Time Business News
16-07-2025
- Health
- Time Business News
What Your Breath Might Be Telling You
Breath is more than just an everyday function or the result of your last meal; it's often a clue about your overall health. From subtle changes to noticeable odors, the way your breath smells can indicate what's happening inside your body. Sometimes, it's as simple as forgetting to floss, but other times, it could be an early sign of underlying health conditions. Your breath can carry distinct odors, and their significance goes far beyond oral hygiene. Below are some common smells and the potential insights they offer about your health. When your breath has a fruity or sweet smell, it may seem pleasant, but it could indicate a serious condition called diabetic ketoacidosis (DKA). This condition occurs when the body doesn't have enough insulin and starts breaking down fat for energy, leading to a buildup of ketones in the blood. High levels of ketones can affect your breath, giving it a noticeable fruity aroma. If left untreated, DKA can be life-threatening, so this odor shouldn't be ignored. Breath with an ammonia-like smell, reminiscent of urine, could point to kidney issues. Kidneys play a crucial role in filtering waste from your blood and maintaining your body's overall balance. When the kidneys aren't functioning properly, waste products can build up in your body, including urea. This urea can break down into ammonia and result in a strong odor detectable in your breath. Bad breath, also known as halitosis, is often caused by poor oral hygiene or gum disease. However, if the smell is especially sulfuric, it might indicate an infection such as tonsillitis, sinusitis, or bronchitis. The bacteria causing these infections release compounds that result in a foul, rotting odor. The odors of your breath are often more than superficial; they can signal deeper health concerns. Here's how breath odors relate to specific medical conditions: Breath that smells fruity or sweet is commonly linked to diabetes, particularly Type 1 diabetes, when insulin levels are critically low. Diabetic ketoacidosis is a medical emergency and typically requires immediate intervention. Chronic kidney disease can cause a buildup of waste in your blood, leading to ammonia-smelling breath. Such odors may appear alongside fatigue, swollen feet, or difficulty concentrating. Liver disease can manifest as an odor often described as 'musty' or 'fishy.' The liver is responsible for detoxifying your body, and when it's compromised, certain compounds can escape into the bloodstream and the breath. Foul-smelling breath, particularly with a rotting undertone, could be indicative of lung infections like pneumonia or bronchitis. Respiratory issues can create the perfect environment for bacterial growth, leading to bad breath. Gastroesophageal Reflux Disease (GERD) If your breath smells sour or like vomit, GERD could be the culprit. Stomach acid flowing back into the esophagus can bring with it unpleasant odors. While occasional bad breath could simply mean it's time for a more thorough brushing, certain situations warrant professional advice. Consider seeing a doctor or dentist if: The odor persists despite good oral hygiene: Persistent bad breath might be a sign of underlying dental problems such as gum disease or cavities. Sometimes, dental issues may require interventions like dental implants, such as those offered in Pembroke Pines, to restore oral health. Persistent bad breath might be a sign of underlying dental problems such as gum disease or cavities. Sometimes, dental issues may require interventions like dental implants, such as those offered in Pembroke Pines, to restore oral health. There are other symptoms: Combine foul breath with symptoms like pain, unexplained weight loss, or fatigue, and it's time to consult a healthcare provider. Combine foul breath with symptoms like pain, unexplained weight loss, or fatigue, and it's time to consult a healthcare provider. You notice a specific odor, like fruity or ammonia: These smells are red flags for potential systemic health conditions, such as diabetes or kidney issues, and need immediate attention. Maintaining fresh breath means keeping your mouth clean, but it also involves taking care of your overall health. Here are some easy-to-follow tips: Brush and floss daily: Brush your teeth twice a day for at least two minutes and floss to remove food particles and plaque. Brush your teeth twice a day for at least two minutes and floss to remove food particles and plaque. Don't neglect your tongue: Bacteria love to hide on your tongue, so give it a good scrub with a tongue scraper or toothbrush. Bacteria love to hide on your tongue, so give it a good scrub with a tongue scraper or toothbrush. Stay hydrated: Dry mouth can exacerbate bad breath. Drinking water helps flush away bacteria and stimulates saliva production. Crunchy fruits and vegetables like apples, celery, and carrots help clean your teeth naturally. Limit sugary foods and drinks that can promote bacterial growth. Visit your dentist every six months for professional cleanings and checkups. Dentists can spot and treat issues before they escalate. From diabetes to GERD, systemic health conditions can affect your breath. Managing these conditions through medication, lifestyle changes, or other treatments can improve your breath, too. Your breath can reveal key insights into your health, from conditions like diabetes to the importance of oral hygiene. Unusual, persistent odors may signal bigger issues—don't ignore them. Fresh breath is the first step to better health! TIME BUSINESS NEWS
7NEWS
14-07-2025
- Health
- 7NEWS
Sozo Australia: The Aussie haircare brand born from a shock diabetes diagnosis — now loved by thousands
Sozo Australia is a haircare brand with a founder who knows all too well the struggles of hair loss firsthand. From July 13 to 19, Australia observes National Diabetes Week, a time to raise awareness of one of the country's most misunderstood chronic illnesses. For Isabella Charanduk, Founder of Sozo Australia, this week carries a deeply personal significance. Her own experience with an unexpected and life-threatening diagnosis of Type 1 Diabetes (T1D) changed the course of her life and led to the creation of an all-natural haircare range that is now transforming lives. In 2019, Isabella found herself in the Intensive Care Unit (ICU), fighting for her life. She had developed Diabetic Ketoacidosis (DKA), which is a serious and potentially fatal complication that often accompanies the initial onset of T1D when left undiagnosed. For two months prior, she had been unknowingly living with tell-tale symptoms of the autoimmune condition, unaware that her body was in crisis. 'I was extremely unwell and didn't know how close I was to serious, irreversible harm,' Isabella tells Best Picks. 'The symptoms were there, but I didn't recognise them for what they were.' Isabella's message today is simple but urgent: know the warning signs. The symptoms she experienced fall into a group commonly referred to as the four Ts: Tired: Experiencing extreme or unexplained fatigue. Thirsty: Excessive and unquenchable thirst. Toilet: Frequent urination, even during the night. Thinner: Sudden, unexplained weight loss. Type 1 Diabetes can strike anyone at any age, often without warning, and its early signs are too often mistaken or ignored. Following her diagnosis and recovery, Isabella faced a new challenge: telogen effluvium, a temporary form of hair loss triggered by physical stress and illness. As she watched her hair thin and shed in alarming amounts, she began searching for solutions, but the products she found either contained harsh chemicals or failed to deliver real results. This search sparked an idea: to develop a truly natural, effective haircare range tailored to restoring and maintaining hair health. That idea became Sozo Hair Health, a line of high-performance, all-natural hair products manufactured on the Gold Coast and now loved by thousands across Australia and beyond. 'I didn't set out to start a business, ' Isabella explains. 'I just wanted to understand my own hair health and feel good again. But through that journey, I found a calling — to help others feel the same.' Sozo Hair Health products are crafted with ingredients that are not only natural but also scientifically supported. From aloe vera and hyaluronic acid to beetroot extract, finger lime, and hydrolysed quinoa, each product is designed to nourish the scalp and strengthen the hair, without compromising on performance. Other potent botanicals like green tea and lavender oil are carefully selected to soothe the scalp, reduce inflammation, support hair growth, and boost shine — naturally. 'I noticed the difference in my hair, after just one week using these products,' one impressed shopper wrote. 'My hair is so much softer and feels so much healthier after using this haircare,' another person added. 'My hair is loving this, so much shinier and amazing results,' a third reviewer commented. Best picks:
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Business Standard
23-04-2025
- Politics
- Business Standard
Suspects can't contest CBI probes once FIR, investigation ordered: SC
The direction for a CBI probe after the registration of an FIR and subsequent investigation is not open to challenge by prospective suspects or accused, the Supreme Court said on Wednesday. The significant observations were made by a bench comprising Justices Dipankar Datta and Prashant Kumar Mishra in a judgement by which it upheld a Karnataka High Court order directing the CBI to conduct a thorough investigation into alleged murder of Bengaluru-based realtor K Raghunath in 2019. The apex court dismissed criminal appeals filed by several accused parties challenging the high court's decision. We are of the considered view that once an FIR is registered and investigation has taken place, direction for an investigation by the CBI is not open to challenge by the prospective suspect or accused. The matter for entrusting investigation to a particular agency is basically at the discretion of the Court, Justice Mishra, writing the judgement for the bench, said. The bench reaffirmed the discretionary power of courts to entrust investigations to specialized agencies like the CBI, especially in cases marred by suspicion and allegations of manipulation. The controversy stemmed from the death of K Raghunath, a reputed real estate developer and a close associate of late member of Parliament DK Adikeshavalu (DKA). Raghunath was found dead under mysterious circumstances, with his wife M Manjula, and son alleging foul play and implicating DKA's children and associates in the alleged murder. Despite an initial refusal by the local police to register a case, a private complaint filed by Manjula led to the registration of FIRs against the accused, including charges under Sections 302 (murder), 120B (criminal conspiracy), and several sections related to forgery and cheating. The high court, in a partial ruling on Manjula's petition, had quashed an earlier magistrate's direction to the HAL police station for further investigation, citing lack of jurisdiction. Instead, the high court asked the CBI to take over the probe, highlighting serious lapses in the initial inquiry and raising concerns about local interference. The CBI later registered fresh FIRs and initiated raids on the residences of several accused persons. The bench said the truth surrounding the death of K Raghunath needs to be settled after a complete and fair investigation, emphasizing that the seriousness of the case and the intricate property disputes warranted independent scrutiny. Referring to the facts of the case, the top court said the deceased, a close confidant of DKA, died a mysterious death and it was preceded by execution of two different wills, one in favour of his wife and and the other in favour of a respondent. There are civil proceedings relating to mutation and declaration of title as well as the allegations concerning forgery of stamp papers. The learned Magistrate while directing further investigation and the High Court, under the impugned order, has highlighted the glaring defects in the investigation which we have avoided to reiterate so that it does not influence the CBI investigation, the bench said. However, the fact remains that the truth surrounding the death of K Raghunath needs to be settled after a complete and fair investigation by the CBI which, in the facts and circumstances of the present case, has rightly been directed by the High Court, it said. We, accordingly, affirm the order of the High Court and dismiss the appeals, the bench added. The CBI shall conduct the investigation within a period of eight months and Karnataka shall render all possible assistance to the CBI to make a fair investigation into the crime, it said. The entire papers shall be handed over by the concerned police to the CBI within 15 days. If the CBI proceeds to file chargesheet, the same shall be submitted before the jurisdictional CBI Court in the State of Karnataka, the bench said.
