Latest news with #Flatiron
Business Wire
4 hours ago
- Business
- Business Wire
Flatiron Health Triples Global Oncology Research Network, Unlocking Multinational Evidence Generation
NEW YORK--(BUSINESS WIRE)--Flatiron Health, a leading healthtech company dedicated to improving cancer care and advancing research using real-world data (RWD), today announced that its international oncology research network has tripled in size across the UK, Germany, and Japan over the past year—a milestone that marks an unprecedented acceleration in global cancer research collaboration and impact. In just five years, Flatiron established a global network of more than 30 leading academic medical centers, hospitals, universities, and community sites across Europe and Japan that contribute deidentified patient data to Flatiron's real-world database. Share Flatiron Health entered international markets to address the growing unmet need for high-quality, real-world oncology data that is reflective and representative of patient populations, practice patterns, and care settings globally. In just five years, Flatiron established a global network of more than 30 leading academic medical centers, hospitals, universities, and community sites across Europe and Japan that contribute deidentified patient data to Flatiron's real-world database. Notable partners include Leeds Teaching Hospitals NHS Trust, University Hospitals Of Leicester NHS Trust, and Newcastle Hospitals NHS Foundation Trust in the UK; Klinikum Stuttgart in Germany; and the National Cancer Center Hospital East, National Cancer Center Hospital, Nagoya University Hospital, Aichi Cancer Center Hospital, Institute of Science Tokyo Hospital in Japan. Furthermore, Flatiron also supports a broader group of data users to maximize the generation of impactful evidence, such as its collaboration with University Hospital Essen in Germany, where Flatiron multinational RWD was used for research published in Nature Cancer and presented at ASCO GU. "The unprecedented expansion of our global network will continue to support improvements to local cancer patients' care and novel multinational research—fundamentally changing what's possible for our partners and the patients they serve," said Nathan Hubbard, Chief Business Officer at Flatiron Health. 'Our partners are already unlocking answers to complex research questions—answers that traditional data sources can't support. By leveraging this expanded real-world evidence, which spans from understanding standards of care and treatment patterns to informing HTA and regulatory decisions, this momentum is improving cancer care for patients worldwide.' Flatiron has authored seven research studies incorporating its multinational RWD within the past two years powered by Flatiron's Trusted Research Environment (TRE) (Powered by Lifebit CloudOS)—a secure platform that enables access to patient-level data at scale. In research published in E SMO Real World Data and Digital Oncology, Flatiron Health researchers, software engineers, and medical oncologists local to each geography came together to characterize oncology RWD in the UK, Germany, and Japan. The work demonstrated how Flatiron's TRE enables cross-country cohort analyses, while maintaining local data control and compliance. The methods and approach described in this paper enable global researchers with the tools to investigate treatment patterns and outcomes across diverse healthcare systems, fostering high-quality, multinational evidence generation. 'Flatiron is committed to building research cohorts that are reflective and representative of the real-world oncology populations and local care standards,' said Hideaki Bando, MD, Chief, Division of Drug and Diagnostic Development Promotion at National Cancer Center Hospital East. 'Increased understanding of how different cancers impact different geographical areas is critical to generate robust evidence to inform targeted treatment strategies worldwide.' While Flatiron's international oncology network marks significant progress in enabling robust research across these regions, many countries outside the UK, Germany, and Japan still lack access to locally-available oncology datasets that are representative, methodologically sound, and recent enough for research needs. To help address these remaining gaps, Flatiron established Flatiron FORUM (Fostering Oncology RWE Uses and Methods), a global consortium that brings together biopharma and academic partners to collaboratively advance a portfolio of research studies focused on the transportability of oncology data across borders. Through Flatiron FORUM, participants co-develop concrete use cases, apply new methodologies, and rigorously validate the transportability of outcomes between regions and diverse healthcare systems—including countries beyond the UK, Germany, and Japan. This collaborative approach addresses critical challenges in regulatory science and access, ultimately supporting better evidence generation and improved outcomes for patients worldwide. 'Flatiron's real-world data is a powerful complement to the UK's cancer registries, adding new clinical depth and recency that help fill critical evidence gaps,' said Prof. Geoff Hall, Professor of Cancer Medicine & Digital Health and Consultant Oncologist at Leeds Teaching Hospitals NHS Trust, UK. 'Through the combined strength of Flatiron's global oncology research network and Flatiron FORUM, we are unlocking richer insights for both local innovation and multinational research—ultimately supporting more informed clinical breakthroughs, regulatory decisions, and better outcomes for patients across the UK and worldwide.' Flatiron is committed to expanding research access to increasingly representative oncology patient cohorts across the UK, Germany, and Japan, complementing its already extensive US cohorts. This expansion supports a growing set of use cases for researchers, clinicians, and policymakers to answer critical questions about cancer care—driving the next era of global oncology research. For more information about Flatiron's global network and research initiatives, visit Flatiron Health is a healthtech company expanding the possibilities for point of care solutions in oncology and using data for good to power smarter care for every person with cancer. Through machine learning and AI, real-world evidence, and breakthroughs in clinical trials, we continue to transform patients' real-life experiences into knowledge and create a more modern, connected oncology ecosystem. Flatiron Health is an independent affiliate of the Roche Group. @FlatironHealth
Reuters
11-07-2025
- Health
- Reuters
Health Rounds: New autism discovery paves way for personalized care
July 11 (Reuters) - The discovery of four different subtypes of autism is a major step toward understanding the condition's genetic underpinnings and improving care, researchers reported in Nature Genetics, opens new tab. According to researchers, the four autism subtypes can be categorized as: Behavioral Challenges, Mixed Autism Spectrum Disorder with Developmental Delay, Moderate Challenges, and Broadly Affected. Each subtype exhibits distinct developmental, medical, behavioral and psychiatric traits, and importantly, different patterns of genetic variation, the researchers said. The findings are drawn from a study of more than 5,000 children with autism, ages 4 to 18, and nearly 2,000 of their nonautistic siblings. The study looked for nearly 240 traits in each individual, from social interactions to repetitive behaviors to developmental milestones. While the four subtypes may share some traits – like developmental delays and intellectual disability - the genetic differences suggest distinct mechanisms are behind what appear on the surface to be similar characteristics. The timing of genetic disruptions and the effects on brain development differ with each subtype, researchers found. As a result, some of the genetic impact of autism may occur before birth, while other effects may emerge as children grow, according to the study. 'What we're seeing is not just one biological story of autism, but multiple distinct narratives,' study co-leader Natalie Sauerwald of the Flatiron Institute in New York said in a statement. 'This helps explain why past genetic studies (of autism patients) often fell short,' she said. 'It was like trying to solve a jigsaw puzzle without realizing we were actually looking at multiple different puzzles mixed together. We couldn't see the full picture, the genetic patterns, until we first separated individuals into subtypes.' WEARABLES MAY IMPROVE CARE OF CHILDREN AFTER SURGERY Young children recovering at home after surgery might someday wear fitness trackers to speed detection of complications, new research suggests. Presently, surgeons must rely on the children themselves, or their parents, to describe new symptoms after hospital discharge. As a result, complications are not always caught at early stages. At the Ann & Robert H. Lurie Children's Hospital of Chicago, 103 children each received a Google Fitbit - a commercially available activity, sleep and heartbeat monitor worn on the wrist like a watch - to wear for three weeks starting immediately after appendectomy. Rather than just monitoring the usual metrics captured by the Fitbit, the researchers modified the devices' algorithms to look for deviations from the circadian rhythms of a child's activity and heart rate patterns. The new algorithms were 91% accurate at flagging early signs of postoperative complications, up to three days before the children's doctors would later diagnose them, the researchers found upon reviewing the data. The devices were 74% accurate at identifying kids who were free of complications, they reported in Science Advances, opens new tab. Eventually the researchers hope to develop a real-time system that analyzes data automatically and sends alerts to children's clinical teams. 'By using widely available wearables, coupled with this novel algorithm, we have an opportunity to change the paradigm of postoperative monitoring and care — and improve outcomes for kids in the process,' study coauthor Dr. Fizan Abdullah said in a statement. (To receive the full newsletter in your inbox for free sign up here)
Yahoo
28-06-2025
- Entertainment
- Yahoo
Ski-inspired Workout Nordic Strong Lands in New York
Skiing just became a summer sport. Nordic Strong, a Copenhagen-based ski workout concept, has made its way to New York. This summer, the brand will be hosting a pop-up fitness studio in Sag Harbor at 11 Bridge Street until Labor Day, followed by a permanent outpost in Flatiron at 35 West 21st Street in Manhattan in early September. A single drop in class costs $50. More from WWD Inside Puppy Sphere, the Endorphin-boosting Non-workout Yoga Class Inside Pride x Boom, New York Pride Weekend's Kick-off Party Watermill Center Unveils 'Upside Down Zebra,' a Celebration of Childhood Art and Contemporary Creativity Nordic Strong employs a patented machine, which the fitness brand now owns, that replicates cross-country skiing. The machine can create 50-plus low-impact, full-body workouts and can be customized in a variety of ways. 'We found our first location in Copenhagen and opened that two years ago as a proof of concept. We knew we wanted to take it to the U.S.,' saya Nordic Strong founder and chief executive officer Nicole Roth. 'All classes are centered around the machine, but because it's so versatile we use it in different ways. We do a strength class, a cardio class and a sculpt class that's Pilates-based.' Each class is 50 minutes and also may employ mat work, weights and Bala accessories. Inspired by its Copenhagen roots, the space incorporates a cozy, Nordic-esque design, while the classes feature custom color lights inspired by the Northern lights. Roth described the concept as 'rooted in the Nordic heritage, but still globally relevant.'
Forbes
18-06-2025
- Entertainment
- Forbes
The Longest Sushi Bar In New York Is Now Open In Flatiron
The stunning sushi bar is the longest in NYC. You can't swing a sashimi knife in Manhattan without hitting an omakase counter these days. But Aqua Kyoto, the Japanese dining room inside Aqua New York in Flatiron, isn't just adding to the pile. It's carving out something bigger—literally. They've opened what's now the city's longest sushi bar. It stretches a staggering 77 feet. Yes, feet. This thing could double as a runway during Fashion Week. The sushi bar anchors the Kyoto side of Aqua New York's dual-restaurant setup, which also includes Aqua Roma (Italian, naturally). The bar feels theatrical—expansive without being cold—and, surprisingly, doesn't overpower the food or the experience. You'd expect something this size to turn into a gimmick. It doesn't. At the 22-seat counter, Chef Mitsuru Hara serves up a ten-course omakase that's equal parts sharp technique and unfussy pleasure. It's $158 for the full ride, and nothing feels inflated—either in portion size or pretension. Things kick off with a spinach salad dressed tableside with toasted sesame. It's not showy, but it lands. Then comes a Tuna and Salmon Tartar with a hit of caviar, a bit of yuzu kosho, and some wonderfully crispy lotus root chips. It's precise, not precious. Sushi purists and skeptics alike will find something to like here. The Scallop & Caviar Crystal Sushi is a standout—not just for the glimmering jelly on top (which, yes, sounds ridiculous) but for the subtle flavor it brings. Then there's the Spicy Tuna Maki. You've had a thousand of them, sure. This one's better—clean, punchy, nothing dripping in sauce or buried under fried onions. The Prawn Tempura is textbook in the way you want it to be: crisp, greaseless, salted with matcha, and dipped in a ten-tsuyu that's warming but restrained. The Miso Black Cod? You've had it before, yes, but here it feels grown-up—less sweet, more elegant, with just enough char to remind you it's been tended to. And then there's dessert. "Forest Floor," it's called, and it sounds like a Pinterest board. But the execution is surprisingly restrained: Tonka bean panna cotta, chocolate brownie crumble, a matcha soil, and a tart raspberry sorbet that cuts through the sweetness like a sharp exit line. It's plated like something out of a Nordic tasting menu, but—mercifully—tastes like dessert. Optional sake pairings are available, and they're worth the extra cost. They're not overly explained or turned into a seminar, which is a blessing these days. Just well-matched pours that make sense with the food. But the bar—and the meal—are only part of what Aqua New York is offering. This is a dual-concept restaurant, after all, where Aqua Kyoto shares space with Aqua Roma, a modern Italian operation located just across the dining room. And here's where things get interesting: you can order from either side of the menu no matter where you sit. Sushi followed by osso buco? Absolutely. Uni with your burrata? Nobody will stop you. The Italian side, Aqua Roma, focuses on seasonal regional fare and features a strong wine program built around a newer generation of small-production Italian winemakers. The Japanese side leans into contemporary Kyoto-style cuisine with an emphasis on seasonality and clean flavors. It's not fusion. It's a culinary two-hander. And somehow, it all plays well together. It helps that the dining room is a spectacle. The sushi bar might be the longest, but the central oval cocktail bar—Aqua Spirit—makes a bid for the largest in the city. It's a vast, curving statement piece, and yet it doesn't make you feel like you've wandered into a casino. It just feels... generous.
Eater
17-06-2025
- Entertainment
- Eater
A ‘Top Chef' Winner's Flatiron Restaurant Closes After Less Than a Year
Flatiron's Time and Tide closes today following its debut in October 2024. The upscale Flatiron fish house from Kent Hospitality and Top Chef winner Danny Garcia will reopen as a new concept from the same team — but an unexpected residency will be in the space until then. After a kitchen fire closed neighboring Massara on June 11, the Southern Italian spot from chef Stefano Secchi and his partner, David Switzer, will pop up at 48 E. 26th Street, at Park Avenue South, starting Thursday, June 19, until further notice, while the original Massara location undergoes repairs at its 913 Broadway location. It will be called Massara on Park, with reservations available on Resy. The menu will feature many familiar signature dishes inspired by the coast of Campania as well as new ones — particularly with a focus on crudo for the summer. 'Kent Hospitality Group is lending a helping hand to its friends at Massara … after a fire caused their original location to close indefinitely,' a spokesperson told Eater over email. 'During this time, KHG and Chef Danny Garcia will reimagine the Time and Tide concept.' 'We are extremely grateful no one was injured and for the FDNY's rapid response,' said Secchi in a statement to Eater. 'As rebuilding Massara will likely take a few months, our entire team is grateful to our friends at Kent Hospitality Group.' The cause of the kitchen fire at Massara is still under investigation. For perspective on how long the repairs could take, a fire at New York's Gjelina shortly after it opened in 2023 shut down the famous restaurant from Los Angeles for almost two years. Time and Tide seemed to be struggling to get its sea legs, with Saga and Crown Shy restaurateur Jamal James Kent and Garcia originally collaborating on the restaurant before Kent's untimely death last June. The original fish and seafood-filled menu was based on Kent's summer memories of his grandmother's home in Sag Harbor and Garcia's summers in Fire Island, with elements of seaside memories woven throughout the restaurant. However, a menu overhaul last month added more international dishes like grilled dates and frena bread with labneh, chicken katsu, and skate muhammara. Time and Tide was the first solo project from Top Chef Winner Garcia, and the first restaurant opened by Kent Hospitality Group following the unexpected passing of its namesake founder. Time and Tide was one of the most anticipated restaurant openings of 2024. Since Kent's death, the restaurants from Kent Hospitality group have shifted to reflect emerging leaders, with Michelin-starred Crown Shy overseen by Jassimran Singh, two-star Saga overseen by Charlie Mitchell, and World's 50 Best bar with a spectacular view, Overstory from Harrison Ginsberg. The team's largest undertaking yet has been overseeing the operations for several hospitality projects inside the Financial District's luxurious new department store, Printemps, including Maison Passerelle and Salon Vert — both overseen by James Beard winner Gregory Gourdet. The group is also behind the newly opened Birdee, the Brooklyn bakery in the Domino development from pastry chef Renata Ameni. Earlier this year, the Times reported Billy Durney, of Hometown Bar-B-Que and Red Hook Tavern acclaim, has taken on investment from Kent Hospitality, and will open a restaurant with the group at 9 West 57th Street. And earlier this month, the group signed to open a place in the former Bistro Les Amis space in Soho, which will be a bar overseen by Ginsberg. The timing lines up for now: Garcia is reworking his first spot just as Massara loses its home, but it's anyone's guess whether the two will sync up again when it's time for the Italian restaurant to return. See More:
