Latest news with #Helix
Yahoo
12 hours ago
- Business
- Yahoo
Helix releases pharmacogenomics tests for use in neurology and oncology
US-based genomics company Helix has released a new suite of pharmacogenomics (PGx) tests, widening its portfolio to offer personalised patient care in neurology and oncology. The suite includes a PGx Fluoropyrimidines DPYD test to detect individuals with dihydropyrimidine dehydrogenase (DPYD) gene variants at risk for side effects from certain chemotherapies, aligning with the recent guidelines from the National Comprehensive Cancer Network. The DPYD test provides insights into a patient's metabolism of cancer treatments. It targets therapies used in treating breast, pancreatic, head and neck, colorectal, and oesophageal cancers. Additionally, the suite includes the PGx APOE test to evaluate the status of apolipoprotein E (APOE) relevant to Alzheimer's drugs. It assesses the risk of serious adverse effects such as amyloid-related imaging abnormalities (ARIA) for individuals treated with Leqembi or Kisunla. These drugs have US Food and Drug Administration (FDA) boxed warnings for individuals with two copies of the APOE ε4 allele. With these tests, Helix now covers all neurology and oncology-associated PGx haplotypes cited in the agency's warnings. The company noted that its PGx tests offer accuracy across varied populations, utilising its Exome+ assay and comprehensive star allele caller. Its Sequence Once, Query Often model allows for exomes to be sequenced just once, with subsequent genetic tests not requiring additional samples. This facilitates rapid results, enabling genetic insights at the point of care. Helix's latest PGx tests encompass medications for cancer, cardiovascular diseases, pain management, gastrointestinal conditions, and anaesthesia guidance. These tests add to the company's existing PGx offerings for blood clotting, mental health, and immune suppression treatments. In addition, Helix has also developed the Helix Research Network in collaboration with its partners. This precision clinical research network comprises health systems focused on integrating genomics into routine care and advancing human health through genomics research. It also creates real-world evidence to support a wide range of initiatives, including studies showing the genomics' clinical use. Helix chief science officer Will Lee said: 'By focusing on patients with neurodegenerative conditions and cancer, and actively identifying those at higher risk for adverse outcomes, we can help providers treat vulnerable patients more precisely and effectively.' "Helix releases pharmacogenomics tests for use in neurology and oncology" was originally created and published by Medical Device Network, a GlobalData owned brand. The information on this site has been included in good faith for general informational purposes only. It is not intended to amount to advice on which you should rely, and we give no representation, warranty or guarantee, whether express or implied as to its accuracy or completeness. You must obtain professional or specialist advice before taking, or refraining from, any action on the basis of the content on our site. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Tom's Guide
15 hours ago
- Lifestyle
- Tom's Guide
Helix Dawn vs Helix Dusk Luxe: which mattress for back and stomach sleepers is right for you?
Type: HybridFirmness: FirmHeight: 11.5"Sizes: 8Sleep trial: 100 nightsWarranty: LifetimeSale price: from $1,099 at Helix Type: HybridFirmness: Medium / Medium-firmHeight: 13.5"Sizes: 8Sleep trial: 100 nightsWarranty: LifetimeSale price: from $1,899 at Helix The Helix line-up features a mattress for every sleep style: the Dawn and Dusk Luxe come from the back and stomach sleeper collection. If you lie prone or supine and need a new bed, these mattresses should be at the top of your list. So is the Helix Dawn or the Dusk Luxe mattress right for you? We've put them to the test and after our rigorous review process it was the incredible support that stood out in both beds, comparable to the best mattresses for all sleep styles. Below we'll be weighing up the price, design, comfort and performance of the Dawn and Dusk Luxe to decide which you should buy in the mattress sales. Some of the best mattresses in a box we've tested have come from Helix and that includes the Dawn and Dusk Luxe we're pitting against each other here. Our full comparison is below, but here are the headlines if you're short on time. Both the Dawn and Dusk Luxe mattresses have been designed to appeal to stomach and back sleepers. Both also feature a comparable build, with the foam and springs combo you'll find in the best hybrid mattresses. Despite that, these mattresses have some significant differences, particularly in feel and comfort. Here we'll be digging deeper into those characteristics. Our Helix Dawn mattress review team agreed this bed is all about firm support. The flat surface has minimal sink to keep the body lifted from head to toe. Our Helix Dusk Luxe mattress review team, on the other hand, found this bed a touch softer and much more cushioned (but still hugely supportive.) It's also more luxurious and, no coincidence, more expensive. The Dawn and the Dusk Luxe are both made by Helix Sleep so they have a lot in common. When it comes to benefits, they're identical: both mattresses come with a 100-night sleep trial and a limited lifetime warranty. Both are also subject to the same Helix mattress sales... most of the time. The standard Helix sale takes 20% off all mattresses, including both the Dawn and the Dusk Luxe. But on rare occasions, Helix boosts the sale to 25% and even 27% off. Again, this typically applies sitewide. But sometimes Luxe and Elite mattresses (like the Dusk Luxe) come with perks the Core mattresses (like the Dawn) miss out on. For example, over Memorial Day 2025, if you opted Luxe or Elite, you got a free bedding gift, something excluded from Core purchases. When it comes to price, the difference is more significant. The Dawn is part of the mid-range Core collection and typically sells for $1,099 a queen. It's a close competitor of the Plank Firm mattress and the DreamCloud Premier Hybrid. But the Dusk Luxe comes from the upgraded Luxe collection at Helix. In the standard sale, a queen Dusk Luxe sells for around $1,899, similar to the premium Saatva Classic mattress and the Purple Plus mattress. Helix Dawn Mattress: twin was $998.66 now $729.03 at HelixThe Core collection from Helix features mid-range mattresses for all sleep styles, including the firm Dawn for back and stomach sleeping. There's normally 20% off but for a limited time you can use code TOMS27 for a 27% saving, reducing a queen to $972.30 (was $1,332.) Helix Dusk Luxe Mattress: twin was $1,436 now $1,048.28 at HelixHelix's Luxe mattress line-up is more luxurious than its Core collection and more expensive. You'll often get a Dusk Luxe for $1,899 in the 20% off sale but in the extended Memorial Day deal you can use code TOMS27 to save 27% and reduce a queen to $1,732,54 (was $2,373.33.) And you'll get a free bedding bundle as well. There are some basic similarities to the design of the Helix Dawn and the Helix Dusk Luxe, beyond the distinctive colored stripe of Helix branding. Let's start at the base, as both mattresses sit on a layer of DuraDense foam to provide stability. From here, things diverge. As hybrid mattresses both feature a coil base made with individually wrapped springs, to enhance support while reducing motion transfer. But the Dusk Luxe builds on this support with stronger coils around the entire perimeter of the mattress and across the central third. The Dawn is only reinforced at the lengthwise sides. Next are the foams. The Dawn features four layers of foams: two firm response foams, topped by a latex-style dynamic foam (the best organic mattresses use latex foam to create buoyant pressure relief.) It's finished with a layer of gel memory foam for targeted relief. You'll find a similar construction on the Dusk Luxe but with softer foams. The two response layers have a medium feel while the dynamic foam is replaced with an adaptive foam for more pressure relief. The Dusk Luxe is also topped with a gel memory foam. In addition, the Dusk Luxe features a quilted pillow top, while the Dawn has a flatter cover. Helix creates mattresses for sleep styles. For example, the Helix Midnight Luxe is designed for side sleepers and this targeted comfort landed it the top spot among the best mattresses for side sleepers we've tested. The Dawn and Dusk Luxe are both designed for back and stomach sleepers, so we expect them to excel in one area in particular: lumbar support. The best mattresses for stomach sleepers support the lower back to prevent the hips from sinking into the bed, as this causes the spine to twist uncomfortably. Both the Dawn and Dusk Luxe perform strongly in this aspect, although they take different approaches. The Dawn is a firm mattress; we rated it 8 out of 10 on the firmness scale (10 indicating rock hard.) Like the best firm mattresses it keeps the body lifted, while the layer of dynamic response foam bounces into place whenever you move to ensure you never miss out on support. The Dusk Luxe is softer then the Dawn (we rated it medium-firm) but that doesn't result in the sink of soft beds. You lie on top of the dense cushioning and the zoned lumbar support holds your lower back up — the reinforced coils coming into effect. While the Dusk Luxe features multiple memory foam layers and a quilted pillow top, it doesn't hug the body (you should consider one of the best memory foam mattresses, if that's what you're after.) But you can feel this cushioning, primarily at the shoulders and hips. That means side sleepers, particularly those with a heavier build, should find some comfort on the Dusk Luxe. The Dawn, on the other hand, sacrifices cushioning for firmness. While you can feel the foams yielding beneath pressure points, there's not much contouring. Lie on your side and you might find your shoulder aches by morning. Neither the Dawn or the Dusk Luxe rank among our favorite cooling mattresses but both largely retain a neutral temperature when sleeping. However, our testers found both mattresses could hold onto warmth during particularly hot nights. Hot sleepers should consider the cooling upgrades offered by Helix. The Dawn comes with an optional GlacioTex pillow top, while you can add a cooling cover or a cooling cover plus heat wicking CoolForce bands to the Dusk Luxe. In terms of motion isolation, it's impossible to choose between the two. Both do a good job at absorbing movement. Bed sharers shouldn't be disturbed by tossing and turning. We expected the Dusk Luxe to come out on top when it comes to edge support, as it features reinforcement around the perimeter (the Dawn is only reinforced lengthwise.) However, the quilted cushioning of the Dusk Luxe means when you sit on the side there is a slight sinking sensation. The firm feel of the Dawn offers good support all round — another category we'd call a draw. ✅ You have a smaller budget: The Helix Dawn is excellent value for money. If you have a mid-range budget, this bed delivers full-body support and a reliable, high-quality finish. ✅ You want a flat finish: While you can upgrade to a quilted pillow top, the standard Dawn comes with a flat top to ensure even support and comfort from head to toe. ✅ You value firm support: Stomach and back sleepers often prefer a firm mattress to keep the entire spine supported. The firm Dawn holds the entire body in alignment to minimize aches and pain. ✅ You want cushioning at the hips and shoulders: With multiple layers of memory foam and a quilted pillow top, the Dusk Luxe has better pressure relief than the Dawn — you can feel it most at the hips and shoulders. ✅ You spend some of the night sleeping on your side: While we wouldn't recommend this mattress for most dedicated side sleepers, combination sleepers will appreciate the support (when back or front lying) and the cushioning (when you're on your side.) ✅ You like a luxurious finish: As a Luxe model, the Helix Dusk Luxe is a step up from the Core collection when it comes to look and finish. It's also taller, creating an indulgent feel.
Tom's Guide
2 days ago
- Health
- Tom's Guide
Side sleepers, it's your last chance to save up to 27% with these 3 Memorial Day mattress topper deals
Whenever I review a mattress that's too hard for side sleeping, I always use a plush mattress topper to soften it up once the testing period is over. That's why I've searched for the biggest Memorial Day mattress topper deals still live today, including your last chance to save 27% on the Premium Mattress Topper with GlacioTex at Helix with our exclusive code TOMS27. After looking back at the greatest mattress toppers we've tested, I've selected the best ones for side sleepers that are still discounted in the Memorial Day mattress sales — but probably not for long. These deals include both a dorm-friendly memory foam mattress topper from Sleepyhead and a luxury latex topper from Naturepedic, both great choices if you're not quite ready to browse our best mattress guide and find a whole new bed. 1. Naturepedic Adagio 2" Organic Latex Mattress Topper: queen was $749 now $599.20 at Naturepedic While the price may seem high, the Adagio 2" Organic Latex Mattress Topper is a much cheaper alternative if you have your eyes on a top-rated organic mattress (which would likely cost you upwards of $1,500 for a queen). Plus, now with code MEMORIAL20, you'll get 20% off and takes a queen to $599.20. The Adagio is not only ideal for those who want to add eco-luxury to their bed, but for any side sleepers who want to soften a hard bed. Our Naturepedic Adagio Organic Latex Mattress Topper review called the organic design "marshmallowy" soft and found that it provided a plush feeling perfect for soothing side-sleeping pressure points. Benefits include a 100-night sleep trial, free shipping and returns, and a 10-year limited warranty. Our review: ★★★★½ User score: ★★★★½ (32 reviews) 2. Helix Premium Mattress Topper with GlacioTex: queen was $498.66 now $364.03 with code TOMS27 at HelixThe Premium Mattress Topper with GlacioTex is brought to you by the brand behind our favorite mattress for side sleepers, so you know it's going to provide luxurious comfort. This topper is made with memory foam and a supportive layer of steel microcoils, it has a cooling cover made from heat-dissipating GlacioTex and in comes in two firmness levels: Luxury Plush or Luxury Firm. While you won't find any user reviews on Helix's website, we got the chance to test this topper for our Helix GlacioTex Premium Mattress Topper review. We loved how the topper provided cooling comfort to hard bed, even when testing it in a Luxury Firm. Right now, a 25% off Helix mattress sale is still live, but our code TOMS27 gets you extra money off. You'll also get a 100-night sleep trial, free shipping and a 1-year limited warranty. Our review: ★★★★ 3. Sleepyhead 3" Cooling Copper Topper: queen was $519 now $415.20 at AmazonWhile the Sleepyhead Cooling Copper Topper was designed for college students who want to refresh their dorm beds, the 3" memory foam mattress will add body-hugging softness to any mattress. I was the lead tester for our Sleepyhead Cooling Copper Mattress Topper review, and loved the thick slab of comfort this topper brought to my too-hard latex bed. While non-students won't be able to get the student discount offered at Sleepyhead, Amazon now has a time-limited 20% discount on the topper — along with fast, free delivery and 30-day returns. Our review: ★★★★User score: ★★★★½ (479 reviews)
Tom's Guide
3 days ago
- Health
- Tom's Guide
My 3 favorite Memorial Day mattress topper sales to make soft beds supportive for back sleepers
If your mattress is a little too soft to be supportive for back sleeping, today's Memorial Day mattress sales is a great time to invest in a mattress topper for spinal support. One standout saving is 27% off the Helix ErgoAlign mattress topper at Helix Sleep with the code TOMS27. That brings a queen down to $364 from $499, which is an excellent price on a topper that promotes healthy spinal alignment and laced with cooling tech. Even the best mattresses can lack in support if it's approaching the end of its lifespan, but adding an extra layer of support can help promote a healthy sleep position. I've picked out three mattress topper deals for helping to not only firm up your mattress, but also offer enough support to making back sleeping more comfortable. Today's Memorial Day mattress and bedding sales means there are plenty of options to choose from, but these three are top of my list. Let's look at them more closely... 1. Helix ErgoAlign Mattress Topper: from $373.73 $272.54 with code TOMS27 at HelixLike the best mattresses for back pain, Helix's ErgoAlign mattress topper is specifically designed to help ease back pain. The topper is divided into three sections, with softer foam at the head and foot to contour to your body. In the middle, you'll find a denser foam that provides pressure relief and lumbar support to keep your spine elevated. There's also a GlacioTex cooling cover to keep sleepers cool (you'll often find this in the best cooling mattresses.) Use the code TOMS27 for 27% off the topper, which brings a queen size down to $364.03 (MSRP $498.66). There's also a 100-night trial and free shipping. 2. Serta ThermaGel Cooling Mattress Topper: from $49 $46 at AmazonIf you're on a tighter budget, the Serta ThermaGel cooling mattress topper is a great deak, with a queen coming in at $59 from $74. Choose from 2" or 3" options for a topper that provides a decent amount of support and pressure relief. The breathable material also does a great job of preventing heat from building up, helping to dissipate it away from the body. Bear in mind that if you want the thicker topper, you'll be looking at $91.76 (was $116.80.) 3. Puffy Deluxe Mattress Topper: from $238 $202 at PuffyWe rate the Puffy Deluxe as one of the best mattress toppers on the market right now. It comes in two versions, firm and soft. For those looking to firm up their mattresses, we'd unsurprisingly recommend the firm version. We tested this in our Puffy Deluxe mattress topper review, finding that while the dense firm did contour to pressure points, the topper still provided plenty of support and structure to the mattress where needed. A queen size will cost you to $245 (MSRP $288) and you'll get a very generous 101-night trial, lifetime warranty and free shipping.
Forbes
4 days ago
- Business
- Forbes
The Best 135+ Memorial Day Sales To Shop Right Now
Memorial Day is officially here, and this year's sales do not disappoint. Our team of deals experts have been sifting through the best Memorial Day sales all weekend long—and we've seen some of the biggest savings drop today. Right now, you can save up to 83% across all categories or use several exclusive Forbes Vetted codes to unlock special prices. For instance, consider refreshing your sleep space with 27% off a Helix mattress or a Brooklinen sheet set with code FORBES27, or use code FORBES10 to stock up on Supergoop sunscreen and save an extra 10%. Today's prices are likely the lowest we'll see until 4th of July sales go live later this summer. Shop the best Memorial Day sales on appliances, tech, home goods and more. Whether you want to head to Wayfair for up to 70% off furniture and décor or opt for summer-ready styles from for up to 50% off, today's Memorial Day sales are worth checking out. 'Now that Memorial Day weekend is here, you're not likely to see prices drop much lower than they currently are,' says supervising deals and coupons editor Kara Cuzzone. 'So if a deal catches your eye, add it to your cart. We've spotted all-time-low prices on everything from Hoka sneakers to LED face masks.' With that in mind, we've listed all of the best offers below. DreamCloud Tuft and Needle During its Memorial Day Sale, Tuft & Needle is offering 20% off the Original Hybrid Mattress, which combines three types of foam and individually wrapped coils to relieve pressure, contour your body and isolate motion. It's also topped with a cooling cover to help ensure plenty of airflow while you snooze. Now through May 27, you can take 20% off this model and the Original Mattress, as well as 40% off bedding (excluding pillows and body pillow covers). Purple Nolah Mattress Brooklinen Owala Williams Sonoma West Elm Amazon Target ABT Amazon Lenovo J. Crew Good American Hanna Andersson Dermstore Supergoop Higher Dose BowFlex Calpak Away: Built for modern travel Just about every brand you can think of is running a sale this holiday weekend— you could easily spend hours shopping Memorial Day deals. To help you navigate these markdowns efficiently and effectively, our deals editors put together a few tips on how to make the most of Memorial Day sales. It's crucial to go into any major shopping event with a plan. Otherwise, you could forget about an important purchase or end up tempted by impulse buys. A wish list will help keep you focused and make you less likely to overspend. Most Memorial Day sales are live all weekend. Shopping deals as you find them ensures your favorite items won't go out of stock. Right now you can find special discounts on big-ticket items like mattresses and appliances, plus get limited-time savings on beauty products, clothing, tech and furniture. It can be tempting to get sucked in by the first big markdown you see on a product you've been eyeing. But we recommend doing a little extra research to make sure you can't get the same item for less somewhere else. Since many major retailers will be running sales this weekend, it's worth checking a few sites to ensure you're getting the best deal. Shopping through our Memorial Day deal lists is another way to get the best offer: We price-check every deal that we recommend to our readers. Memorial Day is today, May 26. The holiday always falls on the last Monday in May. Memorial Day is a great time to save on big-ticket home items like mattresses, patio furniture, major appliances and TVs. This weekend, we've also seen plenty of offers from fashion and beauty brands. In short, you can think of the holiday as sort of a mini Black Friday, where you can find deals across nearly all product categories. Yes, Amazon is running a Memorial Day Sale this year. During the event, you can save up to 35% on thousands of products from top brands like Bose, Dyson, Hydro Flask and much more. Most Memorial Day sales will wrap up at the end of the day on May 26. Some retailers may extend their offers through Tuesday, May 27, or even the entire week—but to be safe, we recommend shopping before the end of the day Monday, since extensions are never guaranteed. The Forbes Vetted deals team has over 15 years of combined experience researching the best deals online across all categories. Assistant deals editor Jordan Thomas, who wrote this article, has been covering major sale events at Forbes Vetted for nearly three years. Deals editor and co-author Maya Gandara brings over six years of experience as a shopping writer and editor. Before joining Forbes Vetted, she led the shopping vertical at StyleCaster.
