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Time of India

Glacier-fed Ganga's microbes offer new hope in fight against superbugs: Neeri, NCL study

Nagpur: Researchers have unveiled the rich microbial diversity and antimicrobial potential of the glacier-fed upper stretch of the Ganges River, in a study published in Microbiology Spectrum. This groundbreaking work not only contributes to environmental microbiology but also holds promise for combating antimicrobial resistance (AMR) under the globally endorsed One Health framework. The study, titled 'Deciphering the Comprehensive Microbiome of Glacier-Fed Ganges and Functional Aspects: Implications for One Health', was led by Dr Krishna Khairnar, principal investigator and head of environmental epidemiology and pandemic management at CSIR-Neeri. Dr Khairnar coordinated this multi-institute project sponsored by the National Mission for Clean Ganga (NMCG). The research was conducted in close collaboration with Dr Mahesh Dharne and Dr Syed Dastager from CSIR-National Chemical Laboratory (CSIR-NCL), showcasing an exemplary inter-institutional partnership between CSIR-Neeri and CSIR-NCL. The project investigated microbial communities from sediment samples collected over two years along a 250km glacier-fed stretch of the Ganges, spanning Gomukh to Rishikesh. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Đây có thể là thời điểm tốt nhất để giao dịch vàng trong 5 năm qua IC Markets Tìm hiểu thêm Undo The findings revealed a rich diversity of bacteria, archaea, and bacteriophages. Notably, several microbes were found to possess biosynthetic pathways for important antimicrobial compounds such as streptomycin, penicillin, and cephalosporins. The study also documented bacteriophages with lytic potential against pathogens, including the clinically significant ESKAPEE group, offering insights into the river's long-attributed non-putrefying properties. "This research reinforces the Ganges River's ecological and biomedical significance," said Dr Khairnar. "Its pristine upper stretch is a natural reservoir of microbial diversity with untapped potential to combat AMR — an urgent global health challenge." This research was conducted as part of the doctoral thesis of Rachel Samson, who is registered with the Academy of Scientific and Innovative Research (AcSIR). Her dedicated effort in sampling, sequencing, and analysis played a key role in uncovering this microbial landscape. Thanks to the National Mission for Clean Ganga, this initiative not only contributed to the scientific understanding of the river's unique properties but also lays a foundation for future bioprospecting, phage therapy, and environmental conservation efforts, Dr Khairnar said.