Latest in Health
Business Upturn
24 minutes ago
- Business
- Business Upturn
KIF18A Targeting Therapies FDA EMA Approval Clinical Trials By Indication Company Country Drug Class Report
Delhi, July 12, 2025 (GLOBE NEWSWIRE) — Global KIF18A Targeting Therapies Market Trends, Clinical Trials, Technology Platforms & Future Outlook 2025 Report Highlights & Findings: First KIF18A Targeting Therapy Commercial Availability Expected By 2030 Highest Phase Of Development: Phase-I/II KIF18A Targeting Therapies In Clinical Trials: > 10 Therapies KIF18A Targeting Therapies Clinical Trials Insight By Company, Country, Indication & Phase KIF18A Targeting Therapies Market Development Trends Insight KIF18A Therapies Technology Platforms Insight Download Report: The global KIF18A targeting therapies market is rapidly gathering momentum as KIF18A has emerged as a key vulnerability in cancers characterized by chromosomal instability. As a mitotic kinesin motor protein essential for chromosome alignment during cell division, KIF18A is overexpressed in malignancies such as ovarian and triple-negative breast cancers, making it a promising target for precision oncology with potentially lower toxicity than traditional chemotherapies. Although no KIF18A-targeted therapy is commercially available yet, the field is progressing quickly. Clinical pipelines include more than 10 therapies, with several in early clinical development. Among the frontrunners is ATX‑295 from Accent Therapeutics, an oral, best-in-class small-molecule inhibitor that recently entered a Phase I/II dose-escalation study in patients with advanced solid tumors, including ovarian and triple-negative breast cancer. It's employed with biomarker-enriched enrollment based on genomic instability markers like whole-genome doubling, and has received FDA Fast Track status—accelerating its path forward. The clinical landscape includes global contributions from leading biotechs such as Volastra Therapeutics, advancing multiple small-molecule inhibitors including Sovilnesib (AMG‑650) in Phase I for platinum-resistant ovarian cancer, and VLS‑1488 in Phase I/II across chromosomal instability-high tumors. Accent's ATX‑295 stands currently at the most advanced Phase I/II stage, with trials in the US and potentially Asia-Pacific, suggesting geographic development convergence. Technological innovation underpins expansion in this field. Development is dominated by small-molecule inhibitors designed to halt KIF18A's motor activity at kinetochores, causing mitotic catastrophe in cancer cells. Alternative approaches include disrupting upstream regulatory pathways like phosphorylation, and leveraging AI-driven drug discovery platforms. For example, Insilico Medicine's Chemistry42 and PandaOmics platforms generated a macrocyclic KIF18A inhibitor (ISM9682), showcasing the power of AI to enhance specificity and efficiency in drug design. Market trends demonstrate strong growth potential. The first commercial KIF18A-targeting therapy is expected by 2030, propelled by fast track designations and positive preclinical data. The rich pipeline, combined with precision biomarker strategies, supports a robust developmental roadmap, aligning with unmet clinical needs in CIN-high solid tumors and potentially extending to hematologic malignancies where KIF18A overexpression correlates with poor prognosis. Regional development trends show clinical leadership based in the US and Europe, where companies like Accent and Volastra are active, while China and other Asia-Pacific markets are engaging through global trial participation and local biotech collaborations. Multi-region trial footprints and biomarker-defined patient enrollment strategies are shaping global development dynamics. Our Global KIF18A Targeting Therapies Market Report offers detailed insights into this evolving therapeutic area. It profiles more than ten clinical-stage candidates by company, indication, country, and development phase, with a deep focus on ATX‑295 as the leading Phase I/II program. The report evaluates technology platforms, including small-molecule motor inhibitors and AI-enabled discovery, and analyzes biomarker-led patient selection models. Regional development trends and regulatory environments are mapped, and strategic partnerships and investments are examined. For pharmaceutical executives, biotech investors, and drug development leaders, this report provides a strategic foundation. It outlines market drivers, technological innovations, and clinical milestones that are poised to transform KIF18A from a promising target into an approved therapeutic by 2030, potentially offering new treatment options for patients with chromosomally unstable tumors. Disclaimer: The above press release comes to you under an arrangement with GlobeNewswire. Business Upturn takes no editorial responsibility for the same. Ahmedabad Plane Crash
Business Upturn
24 minutes ago
- Health
- Business Upturn
Dr. Anosh Ahmed Foundation Announces Aid for Texas Flood Victims Through America First Foundation
Chicago, IL, July 12, 2025 (GLOBE NEWSWIRE) — In response to the recent floods impacting communities across Texas, Dr. Anosh Ahmed, physician and founder of the Anosh Supports America First Foundation, has announced a relief initiative aimed at assisting affected families. The initiative will include direct financial assistance, support for grieving families, and home reconstruction efforts for uninsured residents Standing with Texas As rising waters displace thousands across the state, Dr. Anosh Ahmed has activated his foundation's emergency response team to work with local authorities and communities hardest hit by the disaster. His support will focus on: Direct financial assistance to families who have lost loved ones to families who have lost loved ones Shelter and essential supplies for displaced residents for displaced residents Home rebuilding assistance for uninsured families for uninsured families Collaboration with churches, community organizations, and first responders to ensure effective outreach 'When Americans suffer, we don't wait — we act,' said Dr. Anosh Ahmed. 'This is not just about recovery. It's about restoring dignity and security for our fellow citizens.' America First in Action Founded earlier this year, the Anosh Supports America First Foundation was created to uphold and support the pillars of American strength — the military, law enforcement including members of Department of Justice and ex-FBI agents and their families, first responders, and patriotic communities. Dr. Anosh Ahmed's latest move expands that mission into disaster relief, reinforcing his belief that helping those in need is one of the most American acts of all. 'Being a proud Republican and believer in America First means stepping up when our people need help — not just with words, but with real action,' he added. Rebuilding Lives, Not Just Structures Dr. Anosh Ahmed's Texas relief plan includes long-term support beyond the initial recovery. His foundation will: Fund home reconstruction for uninsured families Provide mental health and grief counseling resources Support first responders and veterans affected by the disaster Launch community rebuilding initiatives focused on resilience and preparedness A special 'Texas Strong: America First Gala' will be hosted by the foundation in Dallas to raise additional funds and awareness. Supporting Those Who Serve Dr. Ahmed emphasized that veterans, police officers, and military families will be given priority in the foundation's housing and aid programs. His long-standing appreciation for America's protectors is at the heart of every initiative he undertakes. 'Our heroes in uniform deserve more than just our thanks—they deserve action. This relief effort will ensure they are not left behind,' Dr. Anosh Ahmed stated. About Dr. Anosh Ahmed Dr. Anosh Ahmed is a physician, entrepreneur, and Republican philanthropist dedicated to the principles of service, patriotism, and community. Through his Anosh Supports America First Foundation , he works to uplift those who serve and strengthen American communities in times of need. #anoshAhmed #dranoshahmed #anoshahmedMD #dranoshahmedchicago #anoshahmedofficial #anoshIncfoundation #anoshahmedleadership #anoshahmedbook Disclaimer: The above press release comes to you under an arrangement with GlobeNewswire. Business Upturn takes no editorial responsibility for the same. Ahmedabad Plane Crash
Powys County Times
25 minutes ago
- Health
- Powys County Times
Powys girl climbs Brecon Beacons mountain for dad 'Benny'
A schoolgirl from hay-on-Wye hiked Pen y Fan on Father's Day in memory of her dad after he passed away earlier this year. Edee Morris, a 12-year-old from Hay-on-Wye, raised £640 for Wales Air Ambulance by hiking up the tallest peak in South Wales on Father's Day, as a tribute to her dad after he passed away from a brain bleed in January. Her father Karl, better known to friends and family as Benny, had the brain bleed at home but was taken by Wales Air Ambulance to the University Hospital of Wales in Cardiff, but despite the best efforts of medics he passed away three days later. In tribute to her father, Edee wanted to raise funds for the charity that helped get him to hospital and set herself the challenge of hiking Pen y Fan, supported on the day by friends and family to go above her fundraising target of £600. Edee's sister Georgie O'Hagan said: 'It was a fantastic day, none of us trained so it was a bit ruthless at times. But we were doing it in memory of Edee's dad and for the Wales Air Ambulance, which is a vital service, so it made it worthwhile. 'We're very proud of Edee, it was an emotional day and emotions were high, especially with it being on Father's Day. Benny's death is still very raw, but the fundraiser helped us all come together and we're very proud.' Benny was remembered as a caring man who continued to help people even after he passed away, with organ donations saving the lives of three people who spent years on the transplant waiting list. Hannah Bartlett, Individual Giving Manager for the Wales Air Ambulance, added: 'Congratulations to Edee for hiking Pen y Fan in memory of her father, Benny. What a lovely way to honour his memory. At just 13-years-old Edee has shown so much strength to want to raise funds for our charity just months after losing her father. 'Thank you to Edee for raising an incredible amount of money for the Wales Air Ambulance. Your support will help us to continue to be there for the people of Wales when they need us the most. We appreciate your support and we're sure your dad would be very proud of you. 'Thank you to everyone who supported Edee on the day and donated to her fundraiser.'
Western Telegraph
28 minutes ago
- Health
- Western Telegraph
28 Palestinians including children killed in Israeli airstrikes in Gaza
The children and two women were among at least 13 people who were killed in Deir al-Balah, in central Gaza, after Israeli airstrikes pounded the area starting late on Friday, officials in Al-Aqsa Martyr's Hospital said. Another four people were killed in strikes near a petrol station, and 15 others died in Israeli airstrikes in Khan Younis, in southern Gaza, according to Nasser Hospital. The Israeli military said in a statement that over the past 48 hours, troops struck approximately 250 targets in the Gaza Strip, including militants, booby-trapped structures, weapons storage facilities, anti-tank missile launch posts, sniper posts, tunnels and additional Hamas infrastructure sites. People inspect the wreckage of a petrol station destroyed in an Israeli airstrike in Deir al-Balah, central Gaza Strip, on Saturday (Abdel Kareem Hana/AP) The military did not respond to The Associated Press' request for comment on the civilian deaths. Hamas-led militants killed some 1,200 people in their October 7, 2023, attack on Israel and abducted 251. They still hold 50 hostages, fewer than half of them believed to be alive, after most of the rest were released in ceasefire agreements or other deals. Israel's offensive has killed more than 57,000 Palestinians, more than half of them women and children, according to Gaza's health ministry. The ministry, which is under Gaza's Hamas-run government, does not differentiate between civilians and combatants in its count. The UN and other international organisations see its figures as the most reliable statistics on war casualties. US President Donald Trump has said that he is closing in on another ceasefire agreement that would see more hostages released and potentially wind down the war. But after two days of talks this week with Israeli Prime Minister Benjamin Netanyahu there were no signs of a breakthrough.
BBC News
33 minutes ago
- Health
- BBC News
Norwich hedgehog rescuer asks for help to keep animals hydrated
A man who has rescued hedgehogs for 30 years has urged people to leave shallow bowls of water outside to help keep the animals hydrated during the Claxton, 79, from Norwich, said the high temperatures had led to an increase in dehydrated mother hedgehogs abandoning their also asked the public to check long grass for hedgehogs before using lawnmowers or grass strimmers."Hedgehogs are like all mammals, we're dependent on water. But hedgehogs are far more dependent than other mammals," Mr Claxton said. "If they don't get sufficient water taken on board each night, the risk is that [their] organs start to shut down."The UK is experiencing its third heatwave of the summer, with temperatures rising above 30C across the country. Mr Claxton set up TSA Rescue in Norwich and learned to care for hedgehogs after he found one that was injured 30 years later undertook training at Vale Wildlife Hospital. He said that dehydration and injuries from grass-cutting equipment were the two main reasons hedgehogs were being brought to him for treatment. "[Hedgehogs] need to take on fluid to feed their young because it gets to a stage whereby they can't [provide the fluids due to dehydration], then the mother will say, my survival comes first," he is currently hand-rearing four hoglets, believing their mother abandoned them due to a lack of in a 2022 State of Britain's Hedgehogs report estimated there had been a loss of between a third and three-quarters of the hedgehog population nationally in the last two decades "I get some [hedgehogs with] injuries [from grass-cutting equipment] where they remove part of the head - I get injuries where they remove part of the legs," he said it made him "angry" when he saw hedgehogs coming in with these kinds of injuries and urged people to check for sleeping hedgehogs before using a grass strimmer."Please don't just use the strimmer straight away because the injuries they cause are simply horrendous," he said. Follow Norfolk news on BBC Sounds, Facebook, Instagram and X.
