Metrion Biosciences Launches Na v 1.9 High-Throughput Screening Assay to Strengthen Screening Portfolio and Advance Research on New Medicines for Pain
Na V 1.9 is a voltage-gated sodium channel selectively expressed in peripheral sensory neurones that plays a key role in pain signalling. Mutations in Na V 1.9 are associated with both severe pain and pain insensitivity in humans. Despite its potential as a non-opioid therapeutic target, research has been limited by difficulties developing stable heterologous expression systems.
Metrion's new Na V 1.9 assay complements the Company's existing portfolio of efficacy and safety screening assays, adding new capabilities to accelerate and de-risk preclinical programmes, unlocking deeper insights into Na V 1.9 pharmacology. Designed using a stable and validated CHO cell line, the assay has been developed and optimised in-house for high reproducibility and low variability and is available using both human- and rat-derived clones, providing insights into species selectivity for the development of more efficacious therapeutics.
The assay completes the Company's full suite of pain-related sodium channel assays to provide selectivity profiling across Na V 1.1 to Na V 1.9. Metrion's offering features a comprehensive portfolio of off-target counter screens, including other pain related ion channel targets and a CiPA panel for cardiac safety risk assessment. The Company also provides access to manual clamp-based mechanistic and translational assays, and automated patch clamp using the Qube 384 to provide highly sensitive, rapid analysis of large candidate libraries. Additional support for hit-to-lead and lead optimisation, streamlining compound evaluation and reducing project timelines is also provided.
' The availability of effective assays to study the Na V 1.9 sodium channel has been a major stumbling block that has held back development of the next generation of non-opioid pain therapeutics,' said Dr Eddy Stevens, Chief Scientific Officer, Metrion Biosciences. 'Metrion is now able to offer a unique combination of sodium channel expertise, high-throughput screening solutions and research services. These cover the full suite of pain-related sodium channels. By facilitating streamlined compound evaluation and accelerated lead optimisation, this service offering has the potential to bring novel pain therapeutics to market rapidly and more cost-effectively. This important launch represents a major milestone for Metrion, a testament to the dedication and knowledge of our team and reinforces our position as leading the field in ion channel drug discovery. '
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Business Wire
10 hours ago
- Business Wire
FUN Investors Have Opportunity to Join Six Flags Entertainment Corporation Fraud Investigation With the Schall Law Firm
LOS ANGELES--(BUSINESS WIRE)-- The Schall Law Firm, a national shareholder rights litigation firm, announces that it is investigating claims on behalf of investors of Six Flags Entertainment Corporation ('Six Flags' or 'the Company') (NYSE: FUN) for violations of the securities laws. The investigation focuses on whether the Company issued false and/or misleading statements and/or failed to disclose information pertinent to investors. Six Flags announced its Q2 2025 financial results on August 6, 2025. The Company swung from a profit to a $100 million dollar loss for the quarter, and cut its full year guidance. The Company blamed bad weather for the downturn but also indicated lower sales of season passes contributed to poor results. Finally, the Company's CEO will step down at the end of the year. If you are a shareholder who suffered a loss, click here to participate. We also encourage you to contact Brian Schall of the Schall Law Firm, 2049 Century Park East, Suite 2460, Los Angeles, CA 90067, at 310-301-3335, to discuss your rights free of charge. You can also reach us through the firm's website at or by email at bschall@ The Schall Law Firm represents investors around the world and specializes in securities class action lawsuits and shareholder rights litigation. This press release may be considered Attorney Advertising in some jurisdictions under the applicable law and rules of ethics.
Business Wire
13 hours ago
- Business Wire
CUPE: Liberals reward Air Canada's refusal to bargain fairly by crushing flight attendants' Charter rights
TORONTO--(BUSINESS WIRE)--Air Canada asked the government to crush underpaid flight attendants' Charter rights, and Jobs Minister Patty Hajdu only waited a few hours to deliver. The Liberal government has invoked Section 107 of the Canada Labour Code to end a strike by Air Canada flight attendants fighting to end unpaid work and poverty wages. "The Liberals have talked out of both sides of their mouths. They said the best place for this is at the bargaining table. They refused to correct this historic injustice through legislation," said Wesley Lesosky, President of the Air Canada Component of CUPE. "Now, when we're at the bargaining table with an obstinate employer, the Liberals are violating our Charter rights to take job action and give Air Canada exactly what they want — hours and hours of unpaid labour from underpaid flight attendants, while the company pulls in sky-high profits and extraordinary executive compensation." CUPE came to the table with data-driven and reasonable proposals for a fair cost-of-living wage increase and an end to forced unpaid labour. Air Canada responded by sandbagging the negotiations. The Liberal government is rewarding Air Canada's refusal to negotiate fairly by giving them exactly what they wanted. This sets a terrible precedent. Contrary to the Minister's remarks, this will not ensure labour peace at Air Canada. This will only ensure that the unresolved issues will continue to worsen by kicking them down the road. Nor will it ensure labour peace in this industry — because unpaid work is an unfair practice that pervades nearly the entire airline sector, and will continue to arise in negotiations between flight attendants and other carriers.
Business Wire
13 hours ago
- Business Wire
'This government is anti-union and anti-worker': CUPE NS Denounces Use of Bill 107
HALIFAX, Nova Scotia--(BUSINESS WIRE)--CUPE Nova Scotia strongly condemns the federal government's decision to interfere in workers' right to collective bargaining and job action by invoking Section 107 of the Canada Labour Code. 'Clearly, this government is anti-union and anti-worker,' said Alan Linkletter, CUPE Nova Scotia President. 'Forcing workers back on the job instead of supporting free and fair collective negotiations directly contradictions workers' rights that are guaranteed under the Canadian Charter of Rights and Freedoms.' Air Canada has asked the government to crush striking workers' Charter rights, and Federal Labour minister Patty Hajdu is ready to deliver. Hajdu announced that the federal government will be invoking Section 107 at a press conference this afternoon, citing the financial welfare of Canadians and the economy at large as a deciding factor for this decision. 'She says this move is for the financial security of Canadians—are these workers not Canadians? Does their welfare not matter? How can you be financially secure when you don't even get paid for all of the hours you work?' Contrary to the Minister's remarks, this will not ensure labour peace in Canada. This will only push this fight onto the next group of workers in negotiations, while Air Canda's flight attendants continue to work for a billion-dollar company for free. Flight attendants are only paid when the plane is moving, and work as many as 35 unpaid hours a month performing vital duties that ensure the safe and smooth operation of each flight. Now, instead of paying flight attendants for all the hours they work, Air Canada has clearly sought help from the federal government to continue exploiting their employees. 'Minister Hajdu's comments indicate a clear lack of respect for workers' rights,' said Sherry Hillier, President of CUPE Newfoundland and Labrador and National General Vice President for Atlantic Canada. 'By using Section 107 to force workers back on the job yet again, they're setting a pattern. And that pattern is that Liberals don't care about Canadians.' Recent polling data indicates that 9 out of 10 Canadians support Air Canada flight attendants' fight for fair pay. 88% per cent of Canadians believe flight attendants should be paid for all work-related duties including boarding, delays, and safety checks. 76% support raising their pay to reflect the important safety role they play. 59% believe the federal government should respect flight attendants' right to take job action–even if it causes travel disruptions. CUPE represents over 10,000 Air Canada flight attendants across the country, and workers have been demonstrating at Halifax Stanfield International Airport since 6AM. 'Messages of support have been pouring in for these workers from across the country,' continued Linkletter. 'Canadians stand with us. Our elected representatives should, too.'
