
TMates Under Review: Affordable GLP-1 Medication Website to Buy Semaglutide, Tirzepatide, Phentermine & More
New York City, April 25, 2025 (GLOBE NEWSWIRE) —
In This Article, You'll Discover: Why traditional weight loss methods often fail due to metabolic resistance, hormonal imbalances, and emotional eating
How Semaglutide , Tirzepatide , and Phentermine work as medically supported weight loss options
, , and work as medically supported weight loss options What makes TMates one of the most affordable GLP-1 medication websites for prescription weight loss treatments
one of the for prescription weight loss treatments A step-by-step breakdown of how to get started with TMates, from health quiz to medication delivery
The unique benefits of TMates' full-service model including 24/7 coaching, telehealth consultations, and insurance integration
Transparent pricing, insurance compatibility, and national coverage across the U.S. and its territories
Real user testimonials and consistent results from a supportive, digital-first care platform
What to expect from GLP-1 medications, including side effects, safety precautions, and ongoing monitoring
TL;DR: TMates Under Review – Best GLP-1 Medication Website for Affordable Semaglutide, Tirzepatide & Phentermine
TMates is a fully virtual telehealth platform offering affordable and medically supervised access to GLP-1 medications like Semaglutide, Tirzepatide, and Phentermine. Designed to overcome the common frustrations of traditional weight loss methods, TMates simplifies the process with a 90-second health quiz, virtual consultations, and nationwide home delivery. Unlike basic online prescription sites, TMates provides full-service care, including 24/7 support, personalized coaching, and transparent pricing starting at $199/month. With oral and injectable medication options and major insurance compatibility, TMates is quickly becoming a top destination for people seeking long-term weight management without the hassle of in-person visits or expensive weight loss programs.
The Growing Frustration with Weight Loss Options
Losing weight isn't just about counting calories or spending hours in the gym. For many, it's a long-term battle with slow metabolism, food cravings, emotional eating, and the discouragement of minimal results despite significant effort. Traditional weight loss methods often fall short, especially for those facing biological or hormonal challenges.
Enter TMates: A Streamlined Solution Backed by Modern Science
In response to these common struggles, a new generation of medically supported solutions has emerged—most notably, GLP-1 medications like Semaglutide, Tirzepatide, and even oral options that target key metabolic processes. TMatesis positioning itself as a go-to provider in this space, offering affordable access to these therapies through a fully digital telehealth platform.
This article presents an in-depth TMates review, highlighting how it aims to be one of the most affordable GLP-1 medication websites to buy Semaglutide, Tirzepatide, Phentermine, and more. You'll learn how TMates works, what makes it different, who it's for, and all the important business and pricing details that make it an increasingly popular option for people seeking medically supported weight loss.
What You'll Learn in This Article
We'll cover: Why so many people are turning to GLP-1s for weight loss
How Semaglutide and Tirzepatide support long-term goals
What TMates offers beyond just medication access
Step-by-step guidance on getting started through the platform
Transparent pricing and available support systems
Whether you're just starting your journey or exploring better alternatives to current programs, this review will equip you with all the facts you need to decide if TMates is right for you.
Note: This article is for informational purposes only and does not constitute medical advice. Always consult with a licensed healthcare provider before beginning any weight loss program involving prescription medications.
Understanding the Struggle: Common Weight Loss Challenges
Why Traditional Approaches Often Fail
Many people embark on their weight loss journey with diets, gym memberships, and trendy supplements, only to see short-lived or minimal results. This frustration is not always a matter of willpower. In fact, common biological and environmental obstacles can block meaningful progress despite sustained effort.
Metabolic Resistance and Hormonal Factors
Your metabolism—how your body processes energy—plays a huge role in fat storage and energy use. Some individuals naturally burn fewer calories at rest, especially as they age or encounter hormonal shifts. For many, conditions like insulin resistance or sluggish thyroid activity make it harder to burn fat effectively. This is where newer therapies like GLP-1 receptor agonists, such as Semaglutide and Tirzepatide, have gained attention for targeting metabolic pathways directly.
Disclaimer: GLP-1 medications are prescription-based and should only be used under the supervision of a licensed medical professional.
Cravings, Emotional Eating, and Lifestyle Pressures
Modern lifestyles bring new challenges. Work-related stress, screen time, poor sleep habits, and limited access to healthy meals make long-term success difficult. Many individuals resort to quick fixes or extreme calorie restriction, which can backfire and lead to weight regain.
The Mental and Emotional Toll of Unsuccessful Dieting
The emotional burden of trying—and failing—to lose weight can be just as difficult as the physical challenge. Constantly comparing yourself to others or not seeing results despite your effort can lead to hopelessness and poor self-image.
Breaking the Cycle with New Support Systems
What's missing from many weight loss solutions is true personalization and long-term structure. Programs like TMates step in to address this gap by combining affordable GLP-1 medications with one-on-one support, coaching, and digital care—all managed through a secure online platform.
This tailored support system helps users stay accountable, navigate side effects, and feel guided every step of the way—making it more than just a place to buy Semaglutide or Tirzepatide online.
Unlock your potential with TMates! Our personalized care approach means you'll get exactly what you need to thrive. Don't wait any longer—begin your health transformation at TMates.
Introduction to GLP-1 Medications
What Are GLP-1 Receptor Agonists?
GLP-1 receptor agonists are a class of prescription medications that mimic the natural hormone glucagon-like peptide-1 (GLP-1). This hormone helps regulate blood sugar levels and appetite by signaling the brain when you're full, slowing digestion, and moderating insulin production. For individuals struggling with weight, this can translate into fewer cravings, more stable energy levels, and a reduced likelihood of overeating.
Among the most widely known GLP-1 medications are Semaglutide (the active ingredient in brands like Ozempic and Wegovy) and Tirzepatide (known for its dual action and use in Mounjaro and Zepbound). TMates offers access to both of these powerful compounds—delivered in convenient oral or injectable formats—through its digital platform.
Disclaimer: These medications require a prescription and are not intended for cosmetic weight loss. They are prescribed based on medical necessity and monitored by licensed professionals.
Why GLP-1 Medications Are So Popular in 2025
There's a major shift happening in the weight loss space. Rather than relying solely on willpower, consumers are looking toward metabolism-enhancing therapies, like GLP-1s, to support long-term changes. This surge in popularity is also fueled by social media success stories and increasing scientific validation.
A Brief Look at the Research
In multiple clinical studies, Semaglutide and Tirzepatide have shown significant results in reducing body weight among people with obesity or related conditions. Participants experienced improvements in appetite control, fat loss, and overall health markers—often without needing crash diets or excessive exercise.
However, results vary by individual, and these medications are not without risks. It's essential to undergo proper screening and receive a personalized treatment plan before starting any GLP-1 regimen.
Always consult a licensed healthcare provider before initiating any new weight loss program or medication, especially if you have existing medical conditions.
The Key Differences Between Semaglutide and Tirzepatide
While both medications fall under the GLP-1 category, they have slightly different actions: Semaglutide works by activating GLP-1 receptors to control appetite and regulate blood sugar.
works by activating GLP-1 receptors to control appetite and regulate blood sugar. Tirzepatide is a dual-action medication that targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide), offering potentially stronger effects for certain users.
TMates provides access to both options—oral and injectable—based on your unique profile and consultation with one of their medical professionals.
TMates – A Comprehensive Weight Loss Solution
What Is TMates?
TMates is a fully virtual healthcare platform offering access to affordable GLP-1 medications, including Semaglutide, Tirzepatide, and Phentermine, for qualified individuals seeking sustainable weight loss solutions. Designed with convenience, discretion, and affordability in mind, TMates eliminates many of the common hurdles associated with prescription weight loss treatments by delivering everything through a secure online system.
Their model integrates personalized medical evaluations, fast prescriptions, and full-service coaching into a single, monthly membership.
The TMates Experience: From Quiz to Care
TMates simplifies the journey into three straightforward steps:
Step 1: Take a 90-Second Health Quiz
The process begins with a short online quiz designed to screen for eligibility and understand your goals. The questions are medically informed and help determine if you're a candidate for GLP-1 therapy. Based on your responses, you may be invited to move forward with a virtual consultation.
Step 2: Get a Custom Treatment Plan
After the quiz, you'll have a telehealth visit with a licensed medical provider who will review your information and build a treatment plan. Depending on your health profile, this plan may include oral or injectable forms of Semaglutide or Tirzepatide. Every plan is medically supervised to ensure safety and maximize results.
Step 3: Receive Your Prescription + Ongoing Coaching
Once approved, your prescribed medications are shipped directly to your door. But that's not all. With TMates, you also gain access to: 24/7 Medical Team Support
Health Coaching via SMS
Nutrition & Exercise Guidance
Weekly Check-ins
Digital Progress Tracking
This integrated approach makes TMates more than just a place to buy GLP-1 medications online—it becomes a full-service weight management partner.
Note: All prescriptions are based on individual medical evaluations. Not everyone will qualify for medication, and results will vary.
Medication Options: Oral and Injectable Formats Available
TMates offers both oral and injectable options for Semaglutide and Tirzepatide. This flexibility is key for those who might be needle-averse or simply prefer the convenience of a pill. Oral Semaglutide is especially popular for newcomers to GLP-1 therapy.
is especially popular for newcomers to GLP-1 therapy. Injectable Semaglutide and Tirzepatide provide proven, longer-acting solutions for more advanced or tailored plans.
Additionally, TMates offers access to Phentermine, a well-known prescription appetite suppressant, when appropriate for a patient's profile.
Discover a world of personalized health solutions at TMates! Start your wellness journey today and experience quality medication delivered right to your doorstep. Don't wait—visit us at TMates now!
Pricing, Insurance, and Accessibility
Transparent Monthly Pricing With No Hidden Fees
One of TMates' biggest selling points is its clear, all-inclusive monthly pricing. Unlike traditional providers that charge separately for prescriptions, visits, and coaching, TMates offers a flat monthly rate—currently starting at $199 per month.
This monthly fee covers: Licensed provider consultations
Prescription medications (including Semaglutide, Tirzepatide, or Phentermine)
Health coaching and 24/7 support
Nutrition and exercise planning
Progress tracking via the TMates platform
There are no initiation fees or long-term contracts, and members can cancel anytime. Shipping is included at no extra cost.
Note: Prices are subject to change and may vary depending on location and specific medication prescribed.
Does TMates Accept Insurance?
Yes. TMates works with major insurance providers including: Aetna
Blue Cross Blue Shield
Cigna
UnitedHealthcare
Medicare (select states and plans)
However, coverage varies based on individual plans. If you're uninsured or prefer to self-pay, TMates offers cash-pay pricing that includes all services in one bundled cost.
This accessibility makes TMates one of the few GLP-1 medication websites to offer prescription weight loss support with or without insurance—a major advantage over in-clinic options or direct pharmacy purchases.
Disclaimer: TMates is not a pharmacy or insurance company. They coordinate access to licensed professionals and approved compounding pharmacies that dispense medications according to your state's regulations.
Available Across the U.S. and Territories
TMates operates across all 50 U.S. states, Puerto Rico, and other U.S. territories. Whether you live in a major city or a rural town, TMates delivers discreet, convenient access to prescription weight loss injections directly to your home.
This nationwide coverage is especially beneficial for people who may not have access to obesity specialists, endocrinologists, or weight clinics in their area.
Comparing TMates to Other Weight Loss Solutions
Traditional Weight Loss Programs: High Effort, Low Sustainability
Conventional weight loss strategies like calorie counting, fitness boot camps, and restrictive dieting often require extreme dedication with limited long-term success. Many people who try them experience rapid weight regain once they stop the program or hit a plateau. Gym memberships and personal trainers often exceed $200/month
Meal kits and diet food subscriptions can cost $400–$600/month
Time commitments are often incompatible with busy lifestyles
While these approaches may offer temporary results, they typically don't address deeper metabolic or hormonal imbalances.
The Supplement Dilemma
Over-the-counter weight loss pills and detox teas flood the market, but most lack scientific validation or long-term data. Even popular natural fat burners offer inconsistent results, and many are not FDA-regulated. Some can even come with unwanted side effects or stimulant-related risks.
TMates fills the gap by offering medically-supervised weight loss treatments like Semaglutide and Tirzepatide—supported by decades of clinical research—through a nationwide telehealth platform.
Note: TMates does not claim to replace exercise or healthy eating habits. Medications are part of a broader plan that includes nutrition and lifestyle coaching.
Online Competitors: What Sets TMates Apart?
With the rise of direct-to-consumer healthcare, several online platforms now provide GLP-1 medications. However, TMates stands out due to a few key differentiators:
1. Full-Service Support Beyond the Prescription
While other providers may stop at prescribing Semaglutide or Tirzepatide, TMates offers 24/7 access to licensed medical staff, SMS-based coaching, customized health plans, and digital check-ins to optimize results and user experience.
2. Pricing Clarity and Insurance Integration
Some platforms advertise low introductory rates that spike after the first month. TMates maintains consistent, transparent pricing and accepts major insurance, making it easier to continue long-term therapy without surprises.
3. Medication Options with Personalized Flexibility
TMates offers both oral and injectable GLP-1s, as well as access to Phentermine when medically appropriate—giving users and providers the flexibility to craft the best solution for each body type, preference, and lifestyle.
Disclaimer: Outcomes and plans are customized for each individual. No medication is guaranteed to work the same way for everyone.
Why TMates May Be the Better Fit
For those looking for an affordable GLP-1 medication website that doesn't just ship prescriptions but also provides full accountability and real-time care, TMates emerges as a unique and reliable option.
Why settle for less when you can have the best? TMates offers affordable and effective health solutions tailored to your unique needs. Experience the difference with us—start your journey now at TMates.
Safety, Side Effects, and Medical Oversight
Understanding the Importance of Supervised Treatment
Weight loss medications like Semaglutide, Tirzepatide, and Phentermine are powerful tools—but they are not one-size-fits-all. Without the proper medical oversight, they may lead to side effects, ineffective outcomes, or health risks, especially in people with underlying medical conditions.
This is why TMates emphasizes ongoing medical monitoring, offering continuous access to licensed professionals who can review your progress, adjust your dosage, or switch medications if needed.
Common Side Effects and What to Expect
GLP-1 medications—especially Semaglutide and Tirzepatide—are generally well tolerated, but like all prescription medications, they come with potential side effects.
The most commonly reported side effects include: Mild nausea or upset stomach
Constipation or diarrhea
Fatigue
Headache
Reduced appetite
These symptoms are usually temporary and manageable, particularly when the dose is gradually increased under supervision.
Disclaimer: TMates does not provide emergency medical care. Patients experiencing severe or persistent symptoms should contact their healthcare provider immediately.
How TMates Minimizes Risk
TMates provides a structure of accountability and safety that many other programs lack. Their process includes: A medical screening to assess your baseline health
A one-on-one video or asynchronous consultation with a licensed provider
Continuous oversight throughout your plan, with access to the care team 24/7
Adjustments to your protocol as needed, based on your progress and tolerability
This approach ensures that the medications are not only effective but also as safe and comfortable as possible.
Compounded Formulas and Regulatory Standards
Where available, TMates partners with licensed compounding pharmacies to provide access to cost-effective, high-quality formulations of GLP-1 medications. These pharmacies comply with state and federal guidelines for safety, purity, and efficacy.
Note: Compounded medications are not FDA-approved, but they are prepared under strict regulatory standards by credentialed pharmacies. TMates only works with certified providers to maintain high safety standards.
The Role of Personalized Care
Because each person's response to GLP-1 medications is unique, personalized dosing and follow-up are essential. TMates monitors your responses and makes changes based on side effect management, weight loss progress, and any emerging health concerns.
This level of supervision significantly reduces the risks associated with self-managed weight loss medications or unregulated sources.
Your health is your wealth! Invest in yourself by trying TMates' premium medication options. With our easy online assessment, getting started is a breeze. Take action now at TMates.
Customer Testimonials and Success Stories
Real People, Real Progress
Nothing communicates trust like hearing directly from those who've walked the path. TMates has quickly earned a loyal following by helping everyday people get access to prescription weight loss solutions that were once out of reach due to cost, geography, or complicated medical systems.
Users across the country—from busy parents to professionals and those in remote areas—have praised the TMates experience for being simple, empowering, and supportive throughout their journey.
Consistent Themes Across User Reviews
Here are some of the most common themes highlighted by TMates members:
1. Convenience and Time-Saving
For many, the idea of skipping a traditional clinic and handling everything online has been a major benefit. The ability to take a health quiz, meet with a doctor, and receive medication—all from home—has saved countless hours and travel time.
'I loved how everything happened so fast. I took the quiz and had my medication delivered within a few days. It's been a game-changer.' – TMates Member
2. Feeling Understood and Supported
Unlike programs that push one-size-fits-all protocols, TMates users often describe a sense of being truly heard. The coaching, weekly check-ins, and access to medical professionals provide reassurance and accountability that extend beyond the prescription itself.
'It didn't feel like a transaction. I actually felt cared for. The team answered my questions at 10 PM on a Sunday.' – Verified User
3. Gradual, Sustainable Weight Management
While results vary, many TMates members report feeling more in control of their hunger, energy levels, and mindset after beginning their prescribed program. With oral or injectable Semaglutide or Tirzepatide options, users are able to work with their provider to find what fits best.
'For the first time in years, I'm seeing the scale go down—without starving myself or killing myself at the gym. It's the structure that made the difference.' – TMates Subscriber
Disclaimer: Individual results will vary. TMates does not guarantee specific weight loss outcomes. All treatment plans are created and supervised by licensed medical providers.
The Power of Community
Beyond one-on-one support, TMates cultivates a digital wellness space where users share their stories, celebrate milestones, and offer encouragement. This sense of belonging adds a layer of emotional support that many traditional programs lack.
The TMates ecosystem is more than just a way to buy Semaglutide or Tirzepatide online—it's a movement toward accessible, guided, and compassionate health care.
How to Get Started with TMates
A Simple Path to Medical Weight Loss Support
Getting started with TMates doesn't require waiting rooms, referrals, or in-person visits. The entire process is designed to be fast, private, and user-friendly—ideal for people looking to begin a personalized GLP-1-based weight loss program from the comfort of their home.
Here's how the process works:
Step 1: Take the 90-Second Health Quiz
The journey begins with a short health quiz, accessible directly on the TMates website. This quick screening gathers information about your weight history, goals, lifestyle, and any existing medical conditions. It's designed to determine if you're a good candidate for Semaglutide, Tirzepatide, or Phentermine.
You don't need a prior prescription or primary care referral to qualify. If your answers align with TMates' treatment criteria, you'll be prompted to schedule a virtual consultation with a licensed provider.
Step 2: Consult with a Licensed Healthcare Provider
Once you pass the screening, you'll meet with a medical professional either via video call or asynchronous telehealth. During this session, your provider will: Review your health history and quiz responses
Discuss your weight loss goals
Recommend a personalized treatment plan
Answer your questions about medication options and expectations
If approved, you'll be prescribed either oral or injectable GLP-1 medication—or Phentermine if that's a better fit. Your first shipment is typically processed soon after the consultation.
Note: All prescriptions are issued based on medical necessity and provider judgment. Not every applicant will qualify for medication.
Step 3: Receive Your Medications and Start the Program
Your prescription is shipped directly to your door. No need to visit a local pharmacy. Once you receive your medication, you'll also unlock: Weekly progress check-ins
Access to certified health coaches
24/7 medical support via chat
Personalized nutrition and fitness tips
This robust support system helps you stay on track and manage any adjustments as your journey progresses.
Contact and Customer Support Info
If you have questions before enrolling, TMates offers support through their website's chat feature and help desk. Once you're a member, you'll have round-the-clock access to their medical and coaching teams. Website: https://try.tmates.com/
Support Contact: Available through secure portal and live chat
Available through secure portal and live chat Location: Services available across all 50 U.S. states, Puerto Rico, and U.S. territories
Conclusion – Why TMates Is Worth Considering
A Smarter Way to Approach Weight Loss in 2025
Weight loss is no longer about fad diets, punishing exercise routines, or empty promises from supplement bottles. With advancements in metabolic science and the accessibility of prescription-based care, solutions like GLP-1 receptor agonists are transforming the health journeys of people across the country.
TMates represents a modern approach to sustainable weight loss—delivering prescription medications like Semaglutide, Tirzepatide, and Phentermine through a full-service, digital-first model. By combining licensed medical care, around-the-clock support, and transparent pricing, TMates empowers users to take control of their health on their own terms.
Whether you're tired of one-size-fits-all weight loss plans or you're just now exploring GLP-1 medications as a solution, TMates offers one of the most affordable, personalized, and supportive experiences available today.
Is TMates Right for You?
If you're: Seeking medically supervised weight loss support
Looking for an affordable GLP-1 medication website
Tired of traditional programs that don't deliver results
Interested in starting a prescription weight loss program without insurance hassles
…then TMates may be the platform you've been looking for.
While individual results will vary and medical evaluation is always required, TMates provides a structure and system that makes long-term weight management more attainable than ever before.
Final Thoughts
The decision to pursue prescription weight loss is deeply personal—and should be made with care and guidance. TMates simplifies that journey by offering access to trusted medical providers, proven therapies, and real human support in a fully online format.
If you're ready to take the first step, start by visiting try.tmates.com and taking the 90-second health quiz to see if you qualify.
Disclaimer: This article is for informational purposes only and does not substitute for medical advice. Always consult a licensed healthcare provider before beginning any new prescription-based health program.
Experience the power of customized health solutions with TMates! Our scientifically backed products can help you achieve your wellness goals. Don't wait—begin your transformation at TMates today!
1. What is TMates and how does it work?
TMates is a fully virtual platform offering access to affordable GLP-1 medications like Semaglutide, Tirzepatide, and Phentermine. It connects users with licensed healthcare providers through telehealth consultations and delivers personalized prescription treatments directly to their homes.
2. Can I buy Semaglutide or Tirzepatide online without a prescription?
No. Both Semaglutide and Tirzepatide are prescription-only medications. However, TMates simplifies the process by offering an online consultation with a licensed medical provider who can prescribe them if you qualify.
3. Is TMates a legit place to buy GLP-1 weight loss medications?
Yes, TMates is a legitimate telehealth platform operating across all 50 U.S. states, Puerto Rico, and U.S. territories. It provides medical oversight, personalized plans, and ongoing support, making it a trusted source for GLP-1 prescriptions.
4. How much does TMates cost each month?
TMates offers a flat-rate monthly plan starting at $225, which includes the cost of your medication (Semaglutide, Tirzepatide, or Phentermine), medical consultations, health coaching, and home delivery.
5. Does TMates accept insurance for GLP-1 medications?
Yes. TMates accepts most major insurance plans, including Aetna, Cigna, UnitedHealthcare, and Blue Cross Blue Shield. Uninsured users can opt for a cash-pay plan that includes medication and full support.
6. What are the side effects of Semaglutide or Tirzepatide?
Common side effects include mild nausea, changes in appetite, and digestive discomfort. TMates provides continuous medical support to help manage these effects safely. Always speak with a healthcare provider about risks before starting.
7. How is TMates different from other weight loss clinics or online providers?
TMates combines fast prescription access with full-service weight loss support, including 24/7 medical access, digital coaching, and flexible options for oral or injectable medications. It's a full solution—not just a prescription.
8. What if I don't qualify for GLP-1 medications through TMates?
If you're not eligible for Semaglutide or Tirzepatide, TMates may recommend an alternative like Phentermine. If no medications are appropriate, your provider will explain why and may guide you toward other options.
9. How long does it take to receive my medication from TMates?
Once approved, most users receive their first shipment within a few business days. TMates offers fast, discreet delivery and continuous support throughout your program.
10. Can I cancel my TMates plan at any time?
Yes. TMates offers flexible month-to-month billing with no long-term commitment. You can cancel or pause your membership at any time through your account dashboard or by contacting support.
Ready to elevate your health regimen? TMates offers innovative products tailored to your specific needs, with fast delivery and no hidden fees. Start your wellness journey now at TMates. Company : TMates
: TMates Address : 777 SW 9th Ave, Suite 102, Miami FL 33130
: 777 SW 9th Ave, Suite 102, Miami FL 33130 Email : [email protected]
: [email protected] Order Phone Support: +1-833-359-8332
Disclaimers and Disclosures
Medical Disclaimer:
The content presented in this article is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment. The information regarding Semaglutide, Tirzepatide, Phentermine, and other GLP-1 medications is intended to provide general understanding and awareness of available prescription-based weight loss options. Readers are strongly advised to consult a licensed healthcare professional before starting any weight loss program or using any prescription medication discussed herein. TMates is not a pharmacy and does not manufacture or dispense medication directly. All prescriptions are issued solely at the discretion of licensed medical providers following a clinical assessment. Individual results may vary, and no outcomes are guaranteed.
Affiliate Disclosure:
This article may contain affiliate links, which means the publisher or its representatives may receive a commission at no additional cost to the reader if a purchase or enrollment is made through the provided links. The inclusion of affiliate links does not influence the editorial content, opinions, or product evaluations presented in this article. All products and services referenced are chosen based on independent research, consumer interest, and relevance to the topic.
General Content Accuracy Disclaimer:
Every effort has been made to ensure the accuracy of the information provided in this article at the time of publication. However, due to the evolving nature of telehealth regulations, medication pricing, insurance acceptance, and clinical research, certain details may change over time. Neither the publisher nor the author assumes responsibility for outdated, incomplete, or incorrect information. Readers should verify all details directly through TMates or their licensed healthcare provider before taking action.
Liability Waiver for Publishers and Syndication Partners:
Syndication partners and third-party publishers are not liable for any damages, losses, or claims arising from the use or misuse of information presented in this article. All parties involved in the publication and distribution of this content disclaim any and all liability related to its interpretation or application by readers. This content is published in good faith, with the intention to inform, not to replace the advice of qualified medical professionals.
Disclaimer: The above press release comes to you under an arrangement with GlobeNewswire. Business Upturn takes no editorial responsibility for the same.

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77% of patients (150 mg Q4W) treated with barzolvolimab who had angioedema at baseline were angioedema free at Week 52 (150 mg Q4W) Data further support barzolvolimab clinical benefit to patients with CSU HAMPTON, N.J., June 14, 2025 (GLOBE NEWSWIRE) — Celldex Therapeutics, Inc. (NASDAQ:CLDX) today announced data demonstrating that barzolvolimab profoundly improves angioedema at 52 weeks in the Company's Phase 2 clinical trial in chronic spontaneous urticaria (CSU). Angioedema, characterized by swelling of the deeper dermal layers of the skin and mucous membranes, is a painful, debilitating symptom of CSU that has significant impact on quality of life. It commonly affects the face (lips and eyelids), hands, feet, and genitalia but can also involve the tongue, uvula, soft palate, and pharynx1. 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Over 70% of patients had a weekly urticaria activity score (UAS7) greater than 28 at baseline and reported very high rates of angioedema at baseline. Barzolvolimab demonstrated rapid, robust and durable improvements in angioedema symptoms over the treatment period. At Week 52, an 86% mean reduction from baseline was reported for 150 mg Q4W arm and an 82% reduction was reported for the 300 mg Q8W. Up to 77% of patients treated with barzolvolimab who had angioedema at baseline were angioedema free (AAS7=0) at Week 52. Patients treated with barzolvolimab were angioedema free up to 72% of the time over the 52 week treatment period. Up to 87% of patients reported clinically meaningful improvement ( > 8 point) in AAS7 at Week 52. 1 DermNet . About Barzolvolimab Barzolvolimab is a humanized monoclonal antibody that binds the receptor tyrosine kinase KIT with high specificity and potently inhibits its activity. KIT is expressed in a variety of cells, including mast cells, which mediate inflammatory responses such as hypersensitivity and allergic reactions. KIT signaling controls the differentiation, tissue recruitment, survival and activity of mast cells. In certain inflammatory diseases, such as chronic urticaria, mast cell activation plays a central role in the onset and progression of the disease. Barzolvolimab is currently being studied in chronic spontaneous urticaria (CSU), chronic inducible urticaria (CIndU), prurigo nodularis (PN), eosinophilic esophagitis (EOE) and atopic dermatitis (AD), with additional indications planned for the future. About the Phase 2 CSU Study The randomized, double-blind, placebo-controlled, parallel group Phase 2 study evaluated the efficacy and safety profile of multiple dose regimens of barzolvolimab in patients with CSU who remain symptomatic despite antihistamine therapy, to determine the optimal dosing strategy. 208 patients were randomly assigned on a 1:1:1:1 ratio to receive subcutaneous injections of barzolvolimab at 75 mg every 4 weeks, 150 mg every 4 weeks, 300 mg every 8 weeks or placebo during a 16-week placebo-controlled treatment period. After 16 weeks, patients then entered a 36-week active treatment period, in which patients receiving placebo or the 75 mg dose were randomized to receive barzolvolimab 150 mg every 4 weeks or 300 mg every 8 weeks; patients already randomized to the 150 mg and 300 mg treatment arms remained on the same regimen as during the placebo-controlled treatment period. After 52 weeks, patients entered a follow-up period for an additional 24 weeks. Barzolvolimab achieved the primary efficacy endpoint of the study—a statistically significant mean change from baseline to Week 12 in UAS7 (weekly urticaria activity score) compared to placebo at all dose levels. For additional information on this trial (NCT05368285), please visit About the Phase 3 Program Celldex is currently conducting a global Phase 3 Program for barzolvolimab in CSU, consisting of two Phase 3 trials (EMBARQ-CSU1; NCT06445023 and EMBARQ-CSU2; NCT06455202) designed to establish the efficacy and safety of barzolvolimab in adult patients with CSU who remain symptomatic despite H1 antihistamine treatment. The studies also include patients who remain symptomatic after treatment with biologics. Enrollment is underway. About Chronic Spontaneous Urticaria (CSU) CSU is characterized by the occurrence of hives or wheals for 6 weeks or longer without identifiable specific triggers or causes. The activation of the mast cells in the skin (release of histamines, leukotrienes, chemokines) results in episodes of itchy hives, swelling and inflammation of the skin that can go on for years or even decades. Current therapies provide symptomatic relief only in some patients. About Celldex Celldex is pioneering new horizons in immunology to deliver life-changing therapies. We are relentless in our pursuit of novel antibody-based treatments that engage the human immune system and directly affect critical pathways to improve the lives of patients with allergic, inflammatory and autoimmune disorders. Visit Forward Looking Statement This release contains 'forward-looking statements' made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These statements are typically preceded by words such as 'believes,' 'expects,' 'anticipates,' 'intends,' 'will,' 'may,' 'should,' or similar expressions. These forward-looking statements reflect management's current knowledge, assumptions, judgment and expectations regarding future performance or events. Although management believes that the expectations reflected in such statements are reasonable, they give no assurance that such expectations will prove to be correct or that those goals will be achieved, and you should be aware that actual results could differ materially from those contained in the forward-looking statements. Forward-looking statements are subject to a number of risks and uncertainties, including, but not limited to, our ability to successfully complete research and further development and commercialization of Company drug candidates, including barzolvolimab (also referred to as CDX-0159), in current or future indications; the uncertainties inherent in clinical testing and accruing patients for clinical trials; our limited experience in bringing programs through Phase 3 clinical trials; our ability to manage and successfully complete multiple clinical trials and the research and development efforts for our multiple products at varying stages of development; the availability, cost, delivery and quality of clinical materials produced by our own manufacturing facility or supplied by contract manufacturers, who may be our sole source of supply; the timing, cost and uncertainty of obtaining regulatory approvals; the failure of the market for the Company's programs to continue to develop; our ability to protect the Company's intellectual property; the loss of any executive officers or key personnel or consultants; competition; changes in the regulatory landscape or the imposition of regulations that affect the Company's products; our ability to continue to obtain capital to meet our long-term liquidity needs on acceptable terms, or at all, including the additional capital which will be necessary to complete the clinical trials that we have initiated or plan to initiate; and other factors listed under 'Risk Factors' in our annual report on Form 10-K and quarterly reports on Form 10-Q. All forward-looking statements are expressly qualified in their entirety by this cautionary notice. You are cautioned not to place undue reliance on any forward-looking statements, which speak only as of the date of this release. We have no obligation, and expressly disclaim any obligation, to update, revise or correct any of the forward-looking statements, whether as a result of new information, future events or otherwise. Company ContactSarah CavanaughSenior Vice President, Corporate Affairs & Administration(508) 864-8337 [email protected]


New York Post
20 hours ago
- New York Post
Hairstylists, medical expert confirms this side effect for Ozempic users
Side effects from GLP-1s can vary, but one lesser-known reported outcome of the popular weight-loss medications is hair loss or thinning. Some hairstylists have confirmed an uptick in clients who complain about losing hair while on weight-loss journeys. Advertisement This includes Ashley DiMatteo, owner of Ashley Lauren Beauty Lounge in Westchester, New York, and Briana Delvecchio, a color specialist and hairdresser at DiMatteo's salon. The two spoke with Fox News Digital in an on-camera interview. 'There has definitely been an increase in clients coming in with hair loss,' DiMatteo said, noting that it ranges from gradual to fast, and from thinning out to completely losing hair. Delvecchio agreed that she's had 'a few' clients come in reporting thinner and drier hair, which she suspects could be due to weight-loss drugs. The hairstylist, who herself takes a GLP-1 drug, said there may be a few reasons for hair changes, including new medications, vitamin deficiencies, and weight loss, which can put stress on the body. Advertisement Becky Watt, an Ohio hairstylist with more than 20 years of experience, said she's also noticed clients losing hair while taking weight-loss drugs. 'I've seen thinning and shedding, and a lot of hair coming out very easily when being washed,' she told Fox News Digital. 'I have not noticed any bald spots.' 6 Some hairstylists have confirmed an uptick in clients who complain about losing hair while on weight-loss journeys. blackday – She's had some clients, however, who are taking the medications without any hair loss, Watt added. Medical factors Advertisement In a separate interview, Dr. Philip Rabito, an endocrinologist in New York City, said this reaction, called telogen effluvium, is a stress response to weight loss that affects the hair follicle. The response is only temporary, he noted. The hair will fall out, then grow back once the weight loss stabilizes after a few months. 'It's a response to severe physical stress, and weight loss is considered starvation,' Rabito said. 'It is the rapidity of the weight loss that correlates with the amount of hair loss.' 6 Ashley DiMatteo, owner of Ashley Lauren Beauty Lounge in Westchester, New York, and Briana Delvecchio, a color specialist and hairdresser at DiMatteo's salon, have noticed that some of their clients' hair has been thinning due to their weight loss journey. FOX News Digital Advertisement Before weight-loss drugs, traditional bariatric surgery would lead to the loss of 70% of excess body weight in about six months, Rabito said, which was often followed by hair loss within six to nine months. 'Your body doesn't understand that this is healthy weight loss — your body thinks it's starving,' he reiterated. 'It happens to almost everyone, to some people more than others.' Those who lose weight more repetitively are at higher risk of hair loss, Rabito said, as well as those who have an underlying thyroid issue or micronutrient deficiency, typically in iron, B12, or vitamin D. These vitamin deficiencies can worsen as weight loss occurs, so it's important to work with a medical professional to balance these levels, according to the doctor. 6 Delvecchio said that she's had 'a few' clients come in reporting thinner and drier hair, which she suspects could be due to weight-loss drugs. FOX News Digital 'From what I have learned from talking to these specific clients, it seems that the clients that are still eating don't have the hair loss,' Watt observed. 'It seems that my clients who say they don't have any appetite whatsoever are the ones losing the most hair,' she continued. 'I believe that's possibly due to lack of nutrients and protein, although I'm no doctor.' Tips for managing hair loss Advertisement DiMatteo and Delvecchio agreed they 'always' advise their clients to see their doctor for a vitamin level check. 'And we will also then taper their hair routine,' DiMatteo said. 'Basically, less is more during hair loss.' The salon owner suggested keeping up with scalp treatment, reducing the use of heat, brushing from the bottom up, and avoiding going to bed with wet hair. 'Check in with your weight-loss doctor or your endocrinologist prior to coming to us to rule out iron, vitamin D, or anything that you're lacking — we need to rule that out before we can help you,' Delvecchio said. Advertisement 'Then we'll tell you we need to work on your scalp health; we'll give you shampoo and conditioner that may be a little gentler for your hair.' 'Scalp stimulation is huge,' DiMatteo added. 'Rinsing with cool water helps as well. Try not to do harsher treatments in the sense of lightening or coloring — spread it out as much as possible.' Rabito noted that losing hair is 'part of the game.' He said he always warns his patients before starting their weight-loss journey that this will most likely occur and is a 'mark of success.' Advertisement 6 Dr. Philip Rabito (not pictured), an endocrinologist in New York City, said this reaction, called telogen effluvium, is a stress response to weight loss that affects the hair follicle. Wild Awake – 'They're going to lose hair,' he said. 'It's going to get worse before it gets better.' 'But as long as you get the vitamins controlled, get them adequately repleted — when the patient plateaus and the weight is stable for a month or two, the body doesn't sense starvation anymore, and the body is less stressed, then the hair grows back better than ever.' Watt said she often recommends a hair vitamin to her clients struggling with weight loss. 'Diet also has a lot to do with it,' she noted. Advertisement 6 When previously contacted, Novo Nordisk — the maker of Ozempic and Wegovy — confirmed that hair loss is an identified risk for semaglutide, and is listed as a side effect in the product information. mbruxelle – She also recommended using a shampoo and conditioner that are formulated to resist thinning and hair loss, along with a bond-building hair product. DiMatteo and Delvecchio assured those who are experiencing hair loss that regrowth does take time, and that there's no need for excessive hair growth treatments. Delvecchio added, 'The hair loss is temporary. It's a positive stress, and it's worth it.' When previously contacted by Fox News Digital, Novo Nordisk — the maker of Ozempic and Wegovy — confirmed that hair loss is an identified risk for semaglutide, and is listed as a side effect in the product information. 6 DiMatteo and Delvecchio assured those who are experiencing hair loss that regrowth does take time, and that there's no need for excessive hair growth treatments. doucefleur – 'In clinical trials of Wegovy, hair loss was reported in 2.5% of Wegovy-treated adult patients versus 1.0% of placebo-treated adult patients,' the company spokesperson said at the time. 'Hair loss was reported more frequently in patients with greater weight loss (≥20%), suggesting that the events of hair loss were potentially related to the magnitude of weight loss.' 'Patient safety is of utmost importance to Novo Nordisk,' the statement continued. 'We are continuously monitoring the safety profile of our products and collaborate closely with authorities to ensure patient safety, including adequate information on hair loss.'
Yahoo
a day ago
- Yahoo
ThinkCareBelieve: Week 21 of America's Progress under President Trump
Washington D.C., June 14, 2025 (GLOBE NEWSWIRE) -- You can find the article here: has published an article on the 21st week of America under the leadership of President Donald J. Trump. America is making strong progress toward prosperity and ThankCareBelieve's article shows this weeks numbers and indicators supporting that. Prices are going down. Tariffs are working. Inflation is gone. The economy is strong and once the One Big Beautiful Bill is passed, the economy will be booming. The article has a report by Maria Bartiromo that the CPI (Consumer Price Index) is out and the numbers are better than expected, surprising everyone. The trade deal with China is now complete, allowing China's markets to open up for American products which will help American business soar. The article shows this week's Los Angeles riots have sparked several investigations where they actually were paid anarchy by those wanting to disrupt American 21st week ends on Flag Day, the 25th Anniversary of the U.S. Army and the Birthday of President Donald J. Trump. The article shows how strong America has become with record number of enlistments and re-enlistments, President Trump attended an Invest in America Event and the President signing an end to costly and impractial EV Mandates. The Halt Fentanyl Act has been passed and is ready to be signed. The article also covers Secretary Kennedy's huge steps to restore public trust by appointing a new board to the Advisory Committee for Immunization Practices (ACIP), including the appointment of Dr. Robert Malone, M.D. is an outlook. ThinkCareBelieve's mission for Peace advocacy facilitates positive outcomes and expanded possibilities. To achieve Peace, we will find the commonalities between diverse groups and bring the focus on common needs, working together toward shared goals. Activism is an important aspect of ThinkCareBelieve, because public participation and awareness to issues needing exposure to light leads to justice. Improved transparency in government can lead to changes in policy and procedure resulting in more fluid communication between the public and the government that serves them. America needs hope right now, and Americans need to be more involved in their government. ### CONTACT: CONTACT: Joanne COMPANY: ThinkCareBelieve EMAIL: joanne@ WEB: in to access your portfolio