Deutsche Bank is now bullish on Cisco
Investing.com -- Deutsche Bank revealed in a note Monday that it has upgraded Cisco Systems (NASDAQ:CSCO) shares from Hold to Buy, citing improving growth visibility and strengthening AI-related demand.
The bank also raised its price target on the stock from $65 to $73, implying upside from the last closing price of $64.09.
The bank sees 'improved visibility towards durable mid-single-digit growth in upcoming years,' Deutsche Bank wrote, pointing to tailwinds across AI infrastructure, enterprise deployments, and sovereign spending.
'Tailwinds from AI (across webscale, enterprise and sovereign), a Campus portfolio refresh, more favorable near-term competitive dynamics in Networking and improved scale in Security' are all expected to support revenue momentum, the note said.
Cisco's earnings outlook is also strengthening, with Deutsche Bank now forecasting a 'high-single-digit (7-8%) EPS CAGR looking forward.'
This growth, the analysts noted, is underpinned by an increasingly attractive revenue mix, with 56% of total revenue now coming from subscription software and services. The shift is expected to support stable margins and allow for continued reinvestment.
The firm also sees Cisco's global supply chain strength as a key competitive advantage. 'Cisco's breadth of supply chain enables it to more deftly navigate incremental tariffs and re-invest in growth,' Deutsche Bank said, referring to ongoing trade tensions and the potential for increased cross-border duties.
The analysts believe that Cisco is showing 'increasing visibility towards delivering on targets.'
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12 minutes ago
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Vivoryon Therapeutics N.V. Q1 2025 Financial Results and Operational Progress
Vivoryon Therapeutics N.V. Q1 2025 Financial Results and Operational Progress Continued progress in advancing varoglutamstat in kidney disease based on encouraging data and expansion of IP portfolio Varoglutamstat's pre-clinical dataset showing synergistic effect in combination with an SGLT-2 inhibitor in different treatment regimens Novel composition of matter patent for varoglutamstat granted after accelerated review in the U.S.; patent term to provide exclusivity through 2044 with subsequent opportunity for patent term extension Varoglutamstat meta-analysis data presented in oral presentation at ERA 2025 Preparations ongoing for Phase 2b of varoglutamstat in diabetic kidney disease (DKD) Management to host a conference call today at 3:00 pm CEST (9:00 am EDT) Halle (Saale) / Munich, Germany, June 17, 2025 – Vivoryon Therapeutics N.V. (Euronext Amsterdam: VVY; NL00150002Q7) (Vivoryon), a clinical stage company developing small molecule medicines for inflammatory and fibrotic disorders, with a primary focus on kidney diseases, today announced financial results for the three-month period ended March 31, 2025, and provided an update on its corporate progress. 'We have started the year 2025 focused on rounding out the evidence to support the success of varoglutamstat in kidney disease,' said Frank Weber, MD, CEO of Vivoryon. 'Building on solid Phase 2 clinical evidence of varoglutamstat's beneficial impact on eGFR, we have developed a viable clinical development strategy, with a planned Phase 2b study in diabetic kidney disease as a first step. Beyond varoglutamstat as single agent, our clinical program also includes investigation of varoglutamstat in combination with SGLT-2 inhibitors for which we have generated very promising preclinical data. On the IP side, we have been able to significantly extend protection of our key asset varoglutamstat with a new composition of matter patent in the U.S. With the groundbreaking clinical data demonstrating varoglutamstat's unique impact on kidney function, a deeper understanding of its MOA in inflammation and fibrosis, and a strengthened IP portfolio, we believe we are well on track to deliver a novel therapy that addresses a significant unmet medical need for patients suffering from kidney disease. In particular, we strive to change the likely trajectory toward kidney failure for patients with advanced DKD, who currently have little to no treatment options to halt progression of kidney failure or improve kidney function.' Q1 2025 and Post-Period Updates Varoglutamstat Clinical Program Meta-analysis of VIVIAD and VIVA-MIND study data On January 14, 2025, the Company disclosed a meta-analysis of VIVIAD and VIVA-MIND data which confirmed that treatment with varoglutamstat at 600mg twice daily significantly improved eGFR kidney function in the overall study population. Statistically significant differences between varoglutamstat and placebo were first observed at week 24 and were sustained until week 96. The meta-analysis also confirmed a substantially larger effect size in study participants with diabetes compared to those without diabetes. Data for varoglutamstat were presented at the 62nd ERA Congress of the European Renal Association in Vienna, Austria, June 6, 2025, showing consistent improvement in both trials independently, replicated in the meta-analysis and pooled analysis, thus providing converging evidence for the findings. Synergistic effect of combination treatment with varoglutamstat and SGLT-2 inhibitors in pre-clinical animal model On April 29, 2025, Vivoryon disclosed preclinical data from a series of experiments in a chronic kidney disease animal model, analyzing different treatment regimens of varoglutamstat in combination with standard of care for kidney disease, the SGLT-2 inhibitor dapagliflozin. Data analysis revealed a synergistic in vivo effect for the combination treatment of dapagliflozin and varoglutamstat over a broad panel of markers, nearly normalizing pathology vs. control across the three key areas of inflammation, fibrosis and kidney function. Substantially de-risking the Company's DKD/CKD clinical development program, the strong synergistic effects observed on multiple outcome parameters suggest that QPCT/L inhibitors could be an ideal combination partner for patients treated with SGLT-2 inhibitors. Vivoryon is currently investigating additional animal models, including a DKD model, to provide further proof points. Proposed clinical development plan in DKD Vivoryon's key strategic priority for 2025 is to advance varoglutamstat in kidney disease and confirm the previously reported compelling data from two independent Phase 2 studies, VIVIAD and VIVA-MIND, by conducting a Phase 2b clinical study in patients with advanced diabetic kidney disease (DKD) stage 3b/4. Initiation of the Phase 2b and all future studies is subject to additional funding and/or partnership, which Vivoryon continues to actively explore. Expanding intellectual property portfolio in kidney disease treatment Vivoryon announced on May 27, 2025, that the United States Patent and Trademark Office (USPTO) has granted an additional patent covering the active polymorph of varoglutamstat. The new U.S. patent (US 12,312,335) was granted after an accelerated examination process and is expected to provide exclusivity through 2044 with subsequent opportunity for patent term extension of up to five years to 2049 under the Hatch-Waxman Act. Additional patents for medical use and dosing regimens under examination for varoglutamstat and related structures in kidney disease as monotherapy and in combination with SGLT-2 inhibitors. Pipeline Updates: Early-stage Pipeline The Company has enlarged its portfolio by nominating a novel, next generation QPCT/L inhibitor showing compelling pharmacological activity. This candidate, VY2149, is a potential fast follower in DKD or could also be explored for other inflammatory and fibrotic diseases including orphan diseases and chronic kidney disease (CKD). VY2149 is expected to enter formal, late-stage pre-clinical development within this year, subject to additional funding and/or partnership, which Vivoryon continues to actively explore. Corporate Development Updates In April 2025, Vivoryon entered into a Standby Equity Purchase Agreement (SEPA) withYorkville Advisors Global, LP, allowing for the purchase of up to EUR 15 million in ordinary shares over the next 36 months. Under the terms of this agreement, Yorkville has committed to acquiring these shares, providing Vivoryon with the right, but not the obligation, to sell them in individual tranches while excluding existing shareholders' pre-emptive rights. This agreement is expected to enhance Vivoryon's financial flexibility as the company seeks optimal funding solutions for its planned Phase 2b study in diabetic kidney disease. On April 29, 2025, the Company announced the appointment of Julia Neugebauer, PhD, as Chief Operating Officer (COO), effective May 1, 2025, heading investor relations and communications activities, spearheading market analysis, and overseeing various corporate functions. On May 13, 2025, Vivoryon announced that it will hold its 2025 Annual General Meeting on June 24, 2025. The full agenda and all relevant documents are available on the Company's website ( Financial Results for the First Quarter of 2025 Revenues were zero in the three months ended March 31, 2025, as well as in the three months ended March 31, 2024. Research and development expenses decreased by EUR 6.2 million to EUR 1.2 million in the three months ended March 31, 2025, compared to EUR 7.4 million in the three months ended March 31, 2024. This decrease was largely attributable to EUR 6.1 million lower third-party expenses consisting mainly of lower manufacturing cost (EUR 1.5 million) and lower clinical costs (EUR 4.5 million), predominantly due to the ramp-down of the VIVIAD and VIVA-MIND Phase 2b clinical studies. General and administrative expenses were EUR 1.3 million in the three months ended March 31, 2025, compared to EUR 2.1 million in the three months ended March 31, 2024. The decrease by EUR 0.8 million was largely attributable to lower expenses for personnel (EUR 0.3 million) as well as legal and consulting fees (EUR 0.2 million). Net loss for the three months ended March 31, 2025, was EUR 2.5 million, compared to EUR 9.3 million for the three months ended March 31, 2024. The Company held EUR 7.0 million in cash and cash equivalents as of March 31, 2025, compared to EUR 9.4 million, as of December 31, 2024. Outlook & Financial Guidance As published on April 29, 2025, the issuance date of its annual Financial Statements 2024, the Company expects, based on its most recent financial and business plan, that its existing cash and cash equivalents will be sufficient to fund its operating plans into January 2026, subject to the occurrence of unforeseen circumstances and without taking into account the SEPA as well as other potential additional financing transactions, if any. This cash runway guidance reflects an overall reduction in cash utilization including the conclusion of the VIVIAD and VIVA-MIND studies while prudently investing in preparing to execute on the Company's kidney disease strategy. The initiation of the Phase 2b DKD study is subject to further additional funding and/or partnership, which the Company continues to actively viability of the Company's business beyond its current guidance is dependent on its ability to raise additional funds to finance its operations which also depends on the success of its research and development activities such as those focusing on exploring opportunities in kidney Company expects to have continuing operating losses for the foreseeable future and the need to raise additional capital to finance its future operations. The Company has concluded that the ability to continue as a going concern in the financial year 2026, as stated in the Company's Annual Report 2024 published on April 29, 2025, depends on the ability to generate additional funding. Please refer to the Company's Annual Report 2024 for further information. Conference call and webcast Vivoryon will host a conference call and webcast today, June 17, 2025, at 3:00 pm CEST (9:00 am EDT). A Q&A session will follow the presentation of the first quarter 2025 results. A live webcast and slides will be made available at: To join the conference call via phone, participants may pre-register and will receive dedicated dial-in details to easily and quickly access the call via the following website: It is suggested participants dial into the conference call 15 minutes prior to the scheduled start time to avoid any delays in attendance. Approximately one day after the call, a slide-synchronized audio replay of the conference will be available on: ### About Vivoryon Therapeutics is a clinical stage biotechnology company focused on developing innovative small molecule-based medicines for the treatment of inflammatory and fibrotic disorders of the kidney. Driven by its passion for ground-breaking science and innovation, the Company strives to improve patient outcomes by changing the course of severe diseases through modulating the activity and stability of pathologically relevant proteins. Vivoryon's most advanced program, varoglutamstat, a proprietary, first-in-class orally available QPCT/L inhibitor, is being evaluated to treat diabetic kidney disease. press release includes forward-looking statements, including, without limitation, those regarding the business strategy, management plans and objectives for future operations of Vivoryon Therapeutics N.V. (the 'Company'), estimates and projections with respect to the market for the Company's products and forecasts and statements as to when the Company's products may be available. Words such as 'anticipate,' 'believe,' 'estimate,' 'expect,' 'forecast,' 'intend,' 'may,' 'plan,' 'project,' 'predict,' 'should' and 'will' and similar expressions as they relate to the Company are intended to identify such forward-looking statements. These forward-looking statements are not guarantees of future performance; rather they are based on the Management's current expectations and assumptions about future events and trends, the economy and other future conditions. The forward-looking statements involve a number of known and unknown risks and uncertainties. These risks and uncertainties and other factors could materially adversely affect the outcome and financial effects of the plans and events described herein. The Company's results of operations, cash needs, financial condition, liquidity, prospects, future transactions, strategies or events may differ materially from those expressed or implied in such forward-looking statements and from expectations. As a result, no undue reliance should be placed on such forward-looking statements. This press release does not contain risk factors. Certain risk factors that may affect the Company's future financial results are discussed in the published annual financial statements of the Company. This press release, including any forward-looking statements, speaks only as of the date of this press release. The Company does not assume any obligation to update any information or forward-looking statements contained herein, save for any information required to be disclosed by law. For more information, please contact: Investor ContactsVivoryon Therapeutics Manuela Bader, Director IR & CommunicationEmail: IR@ LifeSci AdvisorsSandya von der Weid Tel: +41 78 680 05 38Email: svonderweid@ Media ContactTrophic CommunicationsValeria Fisher or Verena SchossmannTel: +49 175 8041816 / +49 151 219 412 77Email: vivoryon@ Attachment 20250617_VVY Q1 2025_PRSign in to access your portfolio
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14 minutes ago
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ONWARD Medical Builds Commercial Momentum for the ARC-EX System and Reinforces its Brain-Computer Interface Leadership in Q1 2025
EINDHOVEN, the Netherlands, June 17, 2025 (GLOBE NEWSWIRE) -- ONWARD Medical N.V. (Euronext: ONWD and US OTCQX: ONWRY), the leading neurotechnology company pioneering therapies to restore movement, function, and independence in people with spinal cord injury (SCI) and other movement disabilities, today announces its Q1 2025 business update and year-to-date highlights: Commercial traction: Following FDA market authorization, the Company met its Q1 objective for the limited initial phase of its US launch of the ARC-EX® System, hiring, training and deploying a field organization, establishing a sales and service process, building a roster of reference clinics, and selling ten systems. Technology advancement: The Company's investigational ARC-IM® and ARC-BCI® platforms reached new milestones with the 4th and 5th successful BCI implants to restore thought-driven movement, and the first human implant of its investigational ARC-IM Lumbar Lead, which is designed to help restore mobility. Scientific leadership: Further expanding the body of clinical evidence supporting the ARC-EX System, Pathfinder2 study results published in Neuromodulation: Technology at Neural Interface showed that sustained access to ARC-EX Therapy can continue to drive functional improvements. Participants continued to make gains after one year of treatment. Financial highlights: The Company established a sponsored Level 1 American Depositary Receipt ("ADR") program to facilitate US investor trading and participation in its growth. "Our Q1 achievements reflect ONWARD's successful transition to a commercial organization that delivers breakthrough therapies to people with spinal cord injuries," said Dave Marver, Chief Executive Officer of ONWARD Medical. "The initial demand for our ARC-EX System and strong positive feedback we've received from users gives us confidence we can deliver against expectations in 2025.' Commercial traction ONWARD met its Q1 objective for the limited initial phase of its US launch of the ARC-EX System, hiring, training and deploying a field organization, establishing a sales and service process, building a roster of reference clinics, and selling ten systems. Strong early demand and positive feedback from users suggest the Company expects to meet its 1H sales target of approximately 30 systems and deliver a strong 2025. The Company also secured access to prominent US government online procurement platforms, enabling Veterans Affairs (VA) and other US government buyers to purchase the ARC-EX System. Technology advancement ARC-IM System In the first quarter, ONWARD announced the first human implant of its ARC-IM Lumbar Lead. The new lead is designed for placement in the lumbar region of the spinal cord, the optimal location for therapies targeting restoration of standing, stepping, and lower limb mobility. The Company's ARC-IM Thoracic Lead has been used in humans since early 2023. The Company also announced two new grants to support early clinical feasibility studies using its ARC-IM System to help people with Parkinson's disease. The Michael J. Fox Foundation for Parkinson's Research (MJFF) awarded the Company's research partner .NeuroRestore a USD 1M grant to explore how the ARC-IM System can address mobility challenges in Parkinson's disease. The US Department of Defense awarded a USD 1.5M grant to ONWARD and .NeuroRestore to support a clinical feasibility study to explore how the ARC-IM System can address blood pressure instability in Parkinson's disease. The Company continues to prepare for the initiation of Empower BP, a global pivotal study to assess the safety and efficacy of the ARC-IM System to address blood pressure instability after SCI. Commencement of the study is pending Investigational Device Exemption (IDE) approval from the US Food and Drug Administration (FDA). ARC-BCI System In June, ONWARD announced the 4th and 5th successful implants of its ARC-BCI technology in two additional individuals. These achievements further reinforce ONWARD's leadership in developing BCI-enabled movement solutions for people with SCI. Both procedures were performed at Centre Hospitalier Universitaire Vaudois (CHUV) in Lausanne, Switzerland, under the direction of Jocelyne Bloch, MD, Chief of Neurosurgery. The Company's innovations with BCI technology were featured on CBS 60 Minutes with Anderson Cooper, one of the most respected and longest-running US news programs. The segment highlighted the experience of study participants who received this breakthrough therapy. A companion segment, 60 Minutes Overtime, highlighted the Company's other advancements in SCI and Parkinson's disease. Scientific leadership In the first quarter, ONWARD announced the publication of positive results from the investigator-sponsored Pathfinder2 Study in Neuromodulation: Technology at Neural Interface. This peer-reviewed publication details findings from a one-year trial demonstrating that ARC-EX Therapy combined with activity-based rehabilitation delivered significant functional improvements when administered to people with SCI in community-based rehabilitation centers. Participants experienced gains in upper body strength, trunk control, and balance at one year of treatment, indicating no plateau in therapeutic benefit1. Financial highlights As part of the phased launch of the ARC-EX System in the US, the Company reported EUR 0.4M in revenue. The quarter ended with net cash of EUR 50.5M, in line with expectations. Facilitating greater access for US investors, in April the Company established a sponsored Level 1 American Depositary Receipt ("ADR") program through the Bank of New York Mellon ("BNY"). The ADRs trade on the OTCQX® Best Market under the symbol: ONWRY. Outlook Strong early demand for the ARC-EX System and positive feedback from initial users suggest ONWARD expects to meet its 1H sales target of approximately 30 systems and deliver a strong 2025 in line with expectations. The Company anticipates FDA clearance to market the ARC-EX System for home use. It also anticipates CE Mark authorization so it can begin marketing the device in Europe. The Company further expects to commence its Empower BP global pivotal study for the ARC-IM System. It also plans additional implants of its ARC-IM System and ARC-BCI to explore additional indications in SCI and Parkinson's disease. Webcast details ONWARD will hold a webcast today at 2:00PM CET / 08:00AM EST, hosted by CEO Dave Marver. To join the session, please register using this link. About ONWARD Medical ONWARD Medical is the leading neurotechnology company pioneering therapies to restore movement, function and independence in people with spinal cord injury (SCI) and other movement disabilities. Building on more than a decade of scientific discovery, preclinical research, and clinical studies conducted at leading hospitals, rehabilitation clinics, and neuroscience laboratories, the Company has developed ARC Therapy, which has been awarded ten Breakthrough Device Designations from the US Food and Drug Administration (FDA). The Company's ARC-EX System is cleared for commercial sale in the US. In addition, the Company is developing an investigational implantable system called ARC-IM with and without an implanted brain-computer interface (BCI). Headquartered in the Netherlands, the Company has a Science and Engineering Center in Switzerland and a US office in Boston, Massachusetts. The Company is listed on Euronext Paris, Brussels, and Amsterdam (ticker: ONWD) and its US ADRs can be traded on OTCQX (ticker: ONWRY). For more information, visit and connect with us on LinkedIn. To be kept informed about the Company's technologies, research studies, and the availability of therapies in your area, please complete this webform. For Media Inquiries: Sébastien Cros, VP communications media@ For Investor Inquiries: investors@ Disclaimer Certain statements, beliefs, and opinions in this press release are forward-looking, which reflect the Company's or, as appropriate, the Company directors' current expectations and projections about future events. By their nature, forward-looking statements involve several risks, uncertainties, and assumptions that could cause actual results or events to differ materially from those expressed or implied by the forward-looking statements. These risks, uncertainties, and assumptions could adversely affect the outcome and financial effects of the plans and events described herein. A multitude of factors including, but not limited to, delays in regulatory approvals, changes in demand, competition, and technology, can cause actual events, performance, or results to differ significantly from any anticipated development. Forward-looking statements contained in this press release regarding past trends or activities should not be taken as a representation that such trends or activities will continue in the future. As a result, the Company expressly disclaims any obligation or undertaking to release any update or revisions to any forward-looking statements in this press release as a result of any change in expectations or any change in events, conditions, assumptions, or circumstances on which these forward-looking statements are based. Neither the Company nor its advisers or representatives nor any of its subsidiary undertakings or any such person's officers or employees guarantees that the assumptions underlying such forward-looking statements are free from errors nor does either accept any responsibility for the future accuracy of the forward-looking statements contained in this press release or the actual occurrence of the forecasted developments. You should not place undue reliance on forward-looking statements, which speak only as of the date of this press release. Trademarks: ONWARD, ARC-EX, ARC-IM, ARC-BCI, and the stylized O-Logo are proprietary and registered trademarks of ONWARD Medical. Unauthorized use is strictly prohibited. 1ARC-EX Indication for Use (US): The ARC-EX System is intended to deliver programmed, transcutaneous electrical spinal cord stimulation in conjunction with functional task practice in the clinic to improve hand sensation and strength in individuals between 18 and 75 years old that present with a chronic, non-progressive neurological deficit resulting from an incomplete spinal cord injury (C2-C8 inclusive). Other Investigational Products: All other ONWARD Medical devices and therapies including ARC-IM and ARC-BCI are investigational and not available for commercial use.
Yahoo
16 minutes ago
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FirstFarms' top management is in position
The board has recruited internally for the CEO position. After a thorough assessment, the Board of Directors of FirstFarms A/S has appointed Søren Bredvig and Michael Hyldgaard as permanent Co-CEO's of FirstFarms with immediate effect. Søren Bredvig and Michael Hyldgaard have served as interim Co-CEO's since 1 May 2025. Both have, for a number of years in their respective roles as COO and CFO, demonstrated strong commitment, solid business understanding, and excellent leadership and collaboration skills. They will continue in their roles as COO and CFO while also taking on the overall responsibility for leading and operating the company. Chairman of the Board Asbjørn Børsting says:"We are pleased that it has been possible to recruit internally for such an important position. Søren and Michael are, with their deep knowledge of operations, organisation and economics, the right people to ensure the necessary continuity and continued operation of the company. Including not least the extensive reconstruction of milk production, which was hit by foot and mouth disease in the spring." In a joint statement, Søren Bredvig and Michael Hyldgaard say: "We thank the Board of Directors for the trust shown to us and look forward to continuing the close collaboration. We also look forward to continuing the collaboration with all our talented colleagues. Together, we will show that we are among the best operated companies in Europe, and we will build on the strong foundation that has been created in recent years." Best regards,FirstFarms A/S For further information:Please visit our website or by contacting chairman Asbjørn Børsting, Co-CEO's Søren Bredvig and Michael Hyldgaard on phone +45 75 86 87 87. About FirstFarms:FirstFarms is a Danish stock exchange listed company. We operate FirstFarms with responsibility for the surrounding communities, and we deliver highest quality which is primarily sold locally. We act on new opportunities, that create value for our investors and for the surroundings. Every day, we work on creating a more sustainable company. Attachment (24) FirstFarms top management is in positionError in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
