logo
Third Trimester Vegetable Intake May Boost Kids' Cognition

Third Trimester Vegetable Intake May Boost Kids' Cognition

Medscape2 days ago

Children whose mothers consumed greater amounts of polyphenols in the last trimester of pregnancy scored significantly higher on several cognitive measures at 8 years of age than children of mothers with lower polyphenol intakes in the last trimester, according to data from a new study presented at the annual meeting of the American Society for Nutrition.
'Polyphenols are nonnutritive phytochemicals present in fruits and vegetables and are linked to improved cognitive health in adults,' said presenting author Chelsey Fiecke, PhD, a postdoctoral fellow at Arkansas Children's Nutrition Center and University of Arkansas for Medical Sciences, Little Rock, Arkansas, in an interview.
Chelsey Fiecke, PhD
Although prenatal fruit and vegetable intake has been linked to improvements in children's cognitive development, studies are needed to target critical prenatal and postnatal polyphenol exposure windows, said Fiecke.
Notably, data on associations between prenatal polyphenol intake at different points during pregnancy and cognitive development in school-age children are lacking, the researchers noted.
To examine these associations, Fiecke and colleagues enrolled 124 mother-child pairs at a single center. Participants were enrolled during pregnancy, and follow-up visits occurred when the children were 5 and 8 years old.
Prenatal polyphenol intake was estimated on the basis of 3-day food records. Cognitive development for 62 children was based on the Wechsler Abbreviated Scale of Intelligence-II at 8 years of age. For 85 children, the researchers used the Wide Range Achievement Test 4 to assess reading, spelling, and math skills at ages 5 and 8 years.
The researchers used linear mixed models for data available at both follow-up visits and generalized models when data were limited. They controlled for factors including maternal IQ, gestational age, and prenatal consumption of carotenoids, docosahexaenoic acid, choline, and vitamin A.
Overall, the participants' average prenatal polyphenol intake was 815 mg/d. In the first trimester, greater maternal polyphenol intake was negatively associated with verbal IQ, perceptual reasoning IQ, and full-scale IQ ( P = .057, P = .020, and P = .011, respectively) in their children.
Polyphenol intake during the second trimester was not significantly associated with any cognitive outcomes of offspring. However, during the third trimester, maternal polyphenol intake was positively associated with children's scores for reading, spelling, and verbal IQ ( P = .035, P = .052, and P = .067, respectively).
Greater polyphenol intake was also associated with higher scores on the Similarities subtest (a verbal reasoning component of verbal IQ; P = .029).
The suggestion of critical exposure windows for prenatal polyphenol intakes for optimal cognitive development was an especially interesting finding, Fiecke told Medscape Medical News . 'It suggests that polyphenols may have similar functionality to other nutrients that play roles in brain and cognitive development, such as docosahexaenoic,' she said.
The results of the study need to be expanded to more diverse longitudinal cohorts, said Fiecke. In addition, research is needed to identify the extent of in utero transfer of polyphenols and to better understand how polyphenols might support optimal cognitive development during other critical exposure windows, such as the early postnatal period, she said.
One Piece of the Food Puzzle
'It is well known that maternal nutrition during pregnancy has effects on both the mother and unborn child, with results implicating nutrition in overall neonatal health and newborn weight,' said Catherine Haut, DNP, CPNP-AC/PC, in an interview.
The current study highlights one substance found in fruits and vegetables, polyphenol, which is also found in other substances consumed by pregnant women, notably coffee, tea, and chocolate, said Haut, director of Nursing Research and Evidence Based Practice at Nemours Children's Health, Wilmington, Delaware Valley, who was not involved in the study.
The effect of healthy nutrition in the last trimester of pregnancy on infant brain development and subsequent childhood cognition is not unexpected, Haut told Medscape Medical News . 'However, it would be of interest to follow children's nutritional intake of polyphenol over the same period with and without considering maternal intake,' she said. 'Maternal nutrition will most likely reflect what is then fed to their children,' she added.
Takeaways and Research Gaps
The study findings support the current daily nutrition guidelines for all age groups to include appropriate portions of fruits and vegetables, said Haut.
The current study was limited by the focus on a single state and location, despite the longitudinal results, and the sample size was small relative to the number of children in the United States, she noted.
Looking ahead to a future study, 'it would be helpful to include more diverse populations and to inquire about daily fruit and vegetable intake in children starting at 6 months of age for infants, when solid food is typically introduced,' Haut added.

Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Dense Breast Tissue Can Hide Cancer. Now What?
Dense Breast Tissue Can Hide Cancer. Now What?

WebMD

time40 minutes ago

  • WebMD

Dense Breast Tissue Can Hide Cancer. Now What?

June 11, 2025 — Have you checked your annual mammogram off your health to-do list? That's a relief, for sure — but there's one more critical step to take after you get your results. Go over your report to see if you have dense breast tissue. For more than 40% of women, the answer is yes. And that means you may want to consider supplemental testing. The next step isn't always clear. But two new studies compared your options. Here's what to know. 1. Having dense breasts increases your risk of breast cancer. Why it matters: Not only is the risk higher, but it's also harder to detect cancer in dense breasts. What to know: Dense breasts have more fibrous tissue and milk glands than fat tissue. On a mammogram, the dense areas show up as white — the same color as cancer. That can make cancer harder to see, particularly when it's small. Federal law (since last fall) requires that you be notified whether your mammogram shows you have dense breasts. To be certain, check your patient portal report or call your doctor's office. You'll also want to find out if you have 'heterogeneously dense' or 'extremely dense' breasts. What's the difference? "Heterogeneously dense" means most of the breast is dense with some areas of fat, and "extremely dense" means the breast has almost no fatty tissue. Even if you don't have dense breasts now, they could become more dense as you age, so you need to recheck your report every year. Dense breasts can only be diagnosed with imaging — a physical exam can't tell. Bottom line: 'Women should know that if they have dense breasts, the mammogram might not see their cancer,' said Ruth Etzioni, PhD, a biostatistician at Fred Hutchinson Cancer Center in Seattle who specializes in analyzing benefit-harm tradeoffs in cancer screening tests. 2. If you have dense breasts, consider supplemental screening. Why it matters: Between 25% and 30% of cancers in heterogeneously dense breasts are missed on a standard mammogram. That number for extremely dense breasts is even higher, potentially topping 40%. What to know: Knowing your breast density type can help you understand how likely a mammogram would be to miss cancer in your breast. But that's only one part of the decision-making equation. For those with heterogeneously dense breasts, 'we typically will consider other risk factors in addition to breast density in order to decide whether to recommend supplemental screening,' said Pittsburgh-based radiologist and dense-breast expert Wendie A. Berg, MD, PhD. A list of risk factors, including family history and high BMI after menopause, is available at Bottom line: If you have extremely dense breasts, you should get supplemental screening, Berg said. If you have heterogeneously dense breasts, you should know your risk factors and talk to your doctor about what makes sense for you. 3. There are three types of supplemental screenings. Why it matters: Researchers compared these techniques — ultrasound, MRI, and contrast-enhanced mammogram — by randomly assigning them to women ages 50 to 70 with dense breasts whose mammograms didn't detect cancer. Results showed that MRI and the contrast-enhanced mammogram (using an iodine -based dye that helps reveal cancers) each found nearly five times as many cancers as ultrasound. What to know: Contrast-enhanced mammogram detected 19.2 cancers per 1,000 people scanned; MRI detected 17.4 per 1,000 scans; ultrasound detected 4.2 per 1,000. These detection rates were somewhat higher than in past studies, Berg and Etzioni said. They noted that women who get the scans repeated annually often see those detection rates drop over time. (That's because you're more likely to have an undetected past cancer than to develop a new one in the next year.) A separate study in JAMA Oncology recently showed that among women with a family history of breast cancer, just getting a slightly better scan than a standard mammogram — called a 3D mammogram — offered improved detection of advanced cancer in women with extremely dense breasts. 'That was compelling that we should really be doing [3D mammogram] as the routine screening, at least for the basic screening,' Berg said. Bottom line: If you have a family history of breast cancer, request a 3D mammogram for your initial annual screen, and when considering supplemental scans, know that some are better than others. 4. Your doctor may not automatically suggest supplemental screening. Why it matters: Berg's own doctor questioned her request to get an MRI after Berg learned that she has dense breasts. Ultimately, she got the MRI, which showed a small cancer that she said was easily treated and she has recovered. What to know: An advisory group called the U.S. Preventative Services Task Force that typically influences what insurance will cover doesn't recommend supplemental screening for people with dense breasts. Their reason: There is no multi-year clinical trial data examining whether extra screenings have drawbacks. Bottom line: It's OK to request supplemental screening, and knowing your risk factors will help during that conversation with your doctor. 'You still can't count on your doctor to provide all the information that you might need to make a decision for yourself about supplemental screening,' Berg said. 5. Not all supplemental screenings are covered by insurance. Why it matters: Not every state requires insurance to cover supplemental screenings — and in those that do, the law may not apply to every type of insurance. maintains a list of which states and plan types are required to cover it. What to know: Without coverage, out-of-pocket costs for an MRI can reach thousands of dollars, but a type called 'abbreviated' or 'quick' MRI can be lower — between $300 and $600 total. Contrast mammography and ultrasound are usually even less, and a 3D mammogram can sometimes cost an extra $40 or $50. MRIs where Berg works in Pittsburgh are booking six months out. A contrast-enhanced mammogram isn't a usual method used in the U.S., but Berg said some places are starting to offer it and testing the waters to see if insurance will cover it. The procedure only takes about 15 minutes, including the contrast dye injection, and uses a standard mammogram machine. Bottom line: 'If you have heterogeneously dense breasts, I think it really does come down to your own tolerance of other risk factors and whether your insurance will cover it, so it is more of a personal choice,' Berg said. 6. Think through your benefit/harm tradeoffs. Why it matters: Getting extra scans can be stressful, potentially expensive, and require a lot of time researching and communicating with your provider — not to mention taking time off work for appointments. What to know: Your risk calculation is complex, including the risk of missing a cancer detection. For example, ultrasound does have advantages (it's quick, noninvasive, and inexpensive), but tends not to spot cancer until the tumor is larger. There's also about a 10% risk of a false positive with most screening types. 'You have to poke a lot of people to find the people that you can help,' said Etzioni, who is an expert in data-driven medical decision-making, particularly when it comes to diagnostic testing and early cancer diagnosis. Bottom line: Deciding whether to get additional screening is personal and involves weighing your comfort with risk and the potential stress and cost of a false positive, Berg said. 'I think it's hard — you don't want to have any regrets either way. I don't know anybody who has regrets that their cancer was found too small. It's always better — if it's going to be there — to find it as early as possible.'

HHS reinstates more than 450 CDC employees fired in April reorganization
HHS reinstates more than 450 CDC employees fired in April reorganization

CNN

timean hour ago

  • CNN

HHS reinstates more than 450 CDC employees fired in April reorganization

Federal agencies Health care policyFacebookTweetLink Follow The US Department of Health and Human Services is reinstating more than 450 employees at the US Centers for Disease Control and Prevention who were fired as part of a massive reorganization in April, including workers focused on HIV, lead exposure and workplace safety. More than 200 employees had their firings rescinded at the CDC's National Center for HIV, Viral Hepatitis, STD and Tuberculosis Prevention, along with 158 at the National Center for Environmental Health, an HHS spokesperson confirmed. Another 71 were brought back in the Office of the Director and two dozen more at the Global Health Center. The reinstatements represent almost 20% of the 2,400 CDC employees who HHS said it was dismissing in a mass Reduction in Force, or RIF, in April. The cuts also affected employees across the US Food and Drug Administration, the US National Institutes of Health and the US Centers for Medicare and Medicaid Services, but an HHS spokesperson said Wednesday's reinstatements applied only to employees at the CDC. 'Under Secretary Kennedy's leadership, the nation's critical public health functions remain intact and effective,' HHS Director of Communications Andrew Nixon said in a statement. 'The Trump Administration is committed to protecting essential services – whether it's supporting coal miners and firefighters through NIOSH, safeguarding public health through lead prevention, or researching and tracking the most prevalent communicable diseases. 'HHS is streamlining operations without compromising mission-critical work,' he continued. 'Enhancing the health and well-being of all Americans remains our top priority.' The cuts had wiped out the CDC's Childhood Lead Poisoning Prevention and Surveillance Branch as it was in the midst of helping the city of Milwaukee address a lead exposure crisis in its public schools. The firings meant the CDC had to deny a request from the city for specialists to help.

HHS reinstates more than 450 CDC employees fired in April reorganization
HHS reinstates more than 450 CDC employees fired in April reorganization

CNN

timean hour ago

  • CNN

HHS reinstates more than 450 CDC employees fired in April reorganization

The US Department of Health and Human Services is reinstating more than 450 employees at the US Centers for Disease Control and Prevention who were fired as part of a massive reorganization in April, including workers focused on HIV, lead exposure and workplace safety. More than 200 employees had their firings rescinded at the CDC's National Center for HIV, Viral Hepatitis, STD and Tuberculosis Prevention, along with 158 at the National Center for Environmental Health, an HHS spokesperson confirmed. Another 71 were brought back in the Office of the Director and two dozen more at the Global Health Center. The reinstatements represent almost 20% of the 2,400 CDC employees who HHS said it was dismissing in a mass Reduction in Force, or RIF, in April. The cuts also affected employees across the US Food and Drug Administration, the US National Institutes of Health and the US Centers for Medicare and Medicaid Services, but an HHS spokesperson said Wednesday's reinstatements applied only to employees at the CDC. 'Under Secretary Kennedy's leadership, the nation's critical public health functions remain intact and effective,' HHS Director of Communications Andrew Nixon said in a statement. 'The Trump Administration is committed to protecting essential services – whether it's supporting coal miners and firefighters through NIOSH, safeguarding public health through lead prevention, or researching and tracking the most prevalent communicable diseases. 'HHS is streamlining operations without compromising mission-critical work,' he continued. 'Enhancing the health and well-being of all Americans remains our top priority.' The cuts had wiped out the CDC's Childhood Lead Poisoning Prevention and Surveillance Branch as it was in the midst of helping the city of Milwaukee address a lead exposure crisis in its public schools. The firings meant the CDC had to deny a request from the city for specialists to help.

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into the world of global news and events? Download our app today from your preferred app store and start exploring.
app-storeplay-store