Children more likely to engage with junk food posts from influencers
Cancer Research UK said that ministers must do more to protect young people from 'harmful marketing that could increase their risk of obesity and cancer in the future'.
New laws, which come into force next year, will end paid-for advertising, including online, of specific foods which are high in fat, sugar and salt.
The charity said that it is important for the implementation of the legislation to go ahead as planned after repeated delays.
And it warned that not all exposure to junk food will end when the new laws come into place as there will still be online advertising loopholes.
The charity surveyed 4,000 children and young people aged 11 to 21 across the UK and found:
– Half (52%) saw unhealthy food and drink products from either businesses or influencers on social media in the last month.
– Almost four in 10 (39%) said they engaged with these posts by commenting, liking or sharing.
– They were more likely to interact with a post from an influencer compared to a business.
Some reported that seeing content about food high in fat, salt and sugar made them feel tempted or hungry.
'A giant cookie bowl keeps showing up, when I see it, I feel like ordering a dessert and I feel really hungry,' an 11 year-old told the charity.
A 15-year-old said: 'I'd say at least every two minutes that I'm on Instagram I'd see at least one food-related post.'
Liv Cheek, prevention policy manager at Cancer Research UK, said: 'Being overweight or obese is the second biggest cause of cancer in the UK after smoking, and rates among young people are rising.
'Our survey shows more than half of young people regularly see unhealthy food and drink content online, often promoted by influencers.
'Advertising can shape what children eat, so the UK Government must help create an online environment that empowers, rather than undermines, healthy changes.
'Planned restrictions on junk food advertising online are a vital step to protect young people's health.
'However, these measures must be properly enforced and strengthened by closing any remaining gaps in the online marketing rules.
'We urge the UK Government and regulators to take bold action to shield young people from harmful marketing that could increase their risk of obesity and cancer in the future.'
Next month, experts will meet at the The International Food Addiction and Comorbidities Conference in London to discuss growing health concerns about food addiction.
The Daily Express reported organisers believe that some 10 million people in the UK are hooked on junk food including pizza, chocolate, crisps, biscuits and ice cream.
A Government spokesperson said: 'Obesity robs children of the best start in life and sets them up for a lifetime of health problems, which costs the NHS billions.
'The junk food advertising restrictions on TV and online are a crucial part of our Plan for Change to raise the healthiest generation of children ever.
'By reducing children's exposure to junk food advertising, we will remove up to 7.2 billion calories from UK children's diets each year and deliver around £2 billion in health benefits.'
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Vogue
43 minutes ago
- Vogue
These Are the Best Radio Frequency Devices to Stimulate Collagen Production
At-home access to the best radio-frequency devices is one of the chicest new perks in beauty tech. Beauty aficionados often trace the trend back to CurrentBody's 2024 RF debut—before then, you'd have to sit yourself in a dermatologist's chair for a skin-snatching appointment. And while radio frequency may sound like sci-fi jargon, the reality is far more enticing. London-based medical and cosmetics doctor Leah Totton notes that radio frequency boosts collagen production without harming the epidermis (a.k.a the skin's outermost layer). 'Heat penetrates deep into the skin's layers, triggering the body's natural healing response. This stimulates new cell production, while bolstering collagen and elastin production,' Totton tells Vogue. 'Consistent treatment can help skin to become noticeably firmer and tighter. Plus, radio frequency devices can also improve blood circulation and lymphatic drainage.' Vogue's Favorite Skin Care Devices Another perk of these at-home beauty devices? Saying so-long to down time. In-clinic RF treatments usually result in some post-treatment redness and soreness, whereas the lower energy levels of at-home devices reveal results over time. That said, there still aren't very many RF devices on the market—though we chatted with experts and derms for the seven of the best picks. Scroll to discover to more. In This Story Best Overall: Currentbody RF Radio Frequency Device Currentbody RF Radio Frequency Skin Tightening Device $385 CURRENTBODY Why We Love It : The at-home RF tool that arguably ignited the craze? CurrentBody's device. Designed to mimic the anti-aging wonders of professional treatments, it gently warms the skin to 104 degrees Fahrenheit. Plus, the gadget continuously self-adjusts to keep skin at the optimal in-clinic temperature for safe, effective results. According to Currentbody, 89% saw an improvement in skin tightness in eight weeks. 'It delivers a gentle heat as you glide it across your skin, and it never gets uncomfortably hot. The sensor maintains skin at 104 degrees Fahrenheit, the ideal temperature for collagen production, according to experts,' Vogue contributor Iman Balagam previously said.'I like to focus on my forehead, the 11s, crow's-feet, and around my laugh lines since I'm always hee-heeing in a corner somewhere.' : The at-home RF tool that arguably ignited the craze? CurrentBody's device. Designed to mimic the anti-aging wonders of professional treatments, it gently warms the skin to 104 degrees Fahrenheit. Plus, the gadget continuously self-adjusts to keep skin at the optimal in-clinic temperature for safe, effective results. According to Currentbody, 89% saw an improvement in skin tightness in eight weeks. 'It delivers a gentle heat as you glide it across your skin, and it never gets uncomfortably hot. The sensor maintains skin at 104 degrees Fahrenheit, the ideal temperature for collagen production, according to experts,' Vogue contributor Iman Balagam previously said.'I like to focus on my forehead, the 11s, crow's-feet, and around my laugh lines since I'm always hee-heeing in a corner somewhere.' Target Treatment Area: Full face Full face Treatment Time: 5–70 minutes 5–70 minutes Treatment per week : Once : Once Specs: FDA-cleared FDA-cleared Best For: Collagen production, firming, improving skin texture Collagen production, firming, improving skin texture How to Use: Apply Currentbody's radio frequency gel to clean, dry skin then glide the device in circular motions across the face. You can do this for up to 70 minutes maxoimum, or, follow one of the device's five-minute regimens. Best for Daily Use: Medicube Age-R Ultra Tune 40.68 Why We Love It: Surely you've heard of Medicube's viral Age-R Booster Pro, beloved by everyone from beauty editors to Hailey Bieber. Another device from the brand that deserves more hype is the Ultra Tune. A favorite amonst K-beauty devotees, this sleek tool pairs high-frequency energy with microcurrent technology to help sculpt and smooth the complexion. What makes it especially compelling is its safety for daily use (and doesn't require a specific gel)—the calibrated frequencies are gentle enough to support skin elasticity without triggering irritation, meaning you can reach for it regularly to achieve cumulative, long-term results rather than reserving it only for occasional treatments. Surely you've heard of Medicube's viral Age-R Booster Pro, beloved by everyone from beauty editors to Hailey Bieber. Another device from the brand that deserves more hype is the Ultra Tune. A favorite amonst K-beauty devotees, this sleek tool pairs high-frequency energy with microcurrent technology to help sculpt and smooth the complexion. What makes it especially compelling is its safety for daily use (and doesn't require a specific gel)—the calibrated frequencies are gentle enough to support skin elasticity without triggering irritation, meaning you can reach for it regularly to achieve cumulative, long-term results rather than reserving it only for occasional treatments. Target Treatment Area: Full face Full face Treatment Time: 5–10 minutes 5–10 minutes Treatment per week : Gentle enough for daily usage : Gentle enough for daily usage Specs: 40.68 MHz RF waves, three intensity levels, compact handheld build 40.68 MHz RF waves, three intensity levels, compact handheld build How to Use: After applying using your favorite hydrating serum or gel, glide in circular motions across the cheeks, forehead, and jawline. Ensure all six tips of the device are touching your skin. If you feel a hot sensation, remove the device and lower your settings. Best for Beginners: Foreo FAQ 101 LED Therapy & Massage Device Why We Love It: Combining RF with red light tools, and a soothing massage, this pick from Foreo is a true multitasker. 'This is a great option for gentle at-home maintenance and can complement in-office treatments nicely,' says Rufolo. Plus, double board-certified dermatologist Brendan Camp adds that this pick is a great choice for beginners. 'Perfect for individuals who are new to at-home skincare technology. It offers a gentle but effective combination of RF and pulsed red LED therapy to stimulate collagen production and improve skin tone and hydration,' he adds. Combining RF with red light tools, and a soothing massage, this pick from Foreo is a true multitasker. 'This is a great option for gentle at-home maintenance and can complement in-office treatments nicely,' says Rufolo. Plus, double board-certified dermatologist Brendan Camp adds that this pick is a great choice for beginners. 'Perfect for individuals who are new to at-home skincare technology. It offers a gentle but effective combination of RF and pulsed red LED therapy to stimulate collagen production and improve skin tone and hydration,' he adds. Target Treatment Area: Full face and neck Full face and neck Treatment Time: 10 minutes 10 minutes Treatment per week : Three to five times per week : Three to five times per week Specs: red LED, multiple massage modes, USB rechargeable red LED, multiple massage modes, USB rechargeable Best For: those seeking daily skin revival in a compact form those seeking daily skin revival in a compact form How to Use: Glide over clean, dry skin for 3 minutes, focusing on areas prone to dullness or fatigue. Best Multipurpose: Silk'n Titan Multiplatform Why We Love It: Call it a triple threat, this tool blends radio frequency, LED, and IR heat for an all-in-one rejuvenating treatment. 'This is a well-designed RF device that penetrates deeper into the skin to encourage collagen and elastin production,' Rufolo, noting patients often notice firmer skin with consistent use. 'This is a great option for those looking for deeper skin tightening and collagen stimulation at home,' adds Dr. Camp. 'It combines the three effective technologies of bipolar RF, near infrared, and low-level laser therapy to target dermal layers for firmer and smoother skin.' Best of all, there's a small RF platform, and attachment for larger areas. Call it a triple threat, this tool blends radio frequency, LED, and IR heat for an all-in-one rejuvenating treatment. 'This is a well-designed RF device that penetrates deeper into the skin to encourage collagen and elastin production,' Rufolo, noting patients often notice firmer skin with consistent use. 'This is a great option for those looking for deeper skin tightening and collagen stimulation at home,' adds Dr. Camp. 'It combines the three effective technologies of bipolar RF, near infrared, and low-level laser therapy to target dermal layers for firmer and smoother skin.' Best of all, there's a small RF platform, and attachment for larger areas. Target Treatment Area: Face, neck, and decolletage Face, neck, and decolletage Treatment Time: 10-15 minutes per treatment area 10-15 minutes per treatment area Treatment per week : Twice weekly : Twice weekly Specs: tri-polar RF, red LED, IR heat, USB rechargeable tri-polar RF, red LED, IR heat, USB rechargeable Best For: multitaskers who want multiple technologies in one device multitaskers who want multiple technologies in one device How to Use: Use with the brand's conductive gel, gliding evenly across the skin for 10–15 minutes per session. Best Travel-Friendly: Skin Gym Glowlit RF Tool Skin Gym GlowLIT RF Tool $130 REVOLVE Why We Love It: For RF on the go, Skin Gym's pick is perfectly portable, with a travel-friendly design that doesn't skip on results—and yes, it's another multipurpose beauty tool. 'This is an extremely versatile tool that integrates radio frequency, LED light therapy, and sonic massage,' says Dr. Camp. 'This is a great supplement to a skincare regimen focused on prevention and maintenance. Plus, it suits a variety of concerns from acne and redness, to pigmentation and early signs of aging.' Best of all, it's one of the more affordable picks of the bunch. For RF on the go, Skin Gym's pick is perfectly portable, with a travel-friendly design that doesn't skip on results—and yes, it's another multipurpose beauty tool. 'This is an extremely versatile tool that integrates radio frequency, LED light therapy, and sonic massage,' says Dr. Camp. 'This is a great supplement to a skincare regimen focused on prevention and maintenance. Plus, it suits a variety of concerns from acne and redness, to pigmentation and early signs of aging.' Best of all, it's one of the more affordable picks of the bunch. Target Treatment Area: Face Face Treatment Time: 10 to 15 minutes 10 to 15 minutes Treatment per week : Two to three : Two to three Specs: RF technology, LED indicator lights, portable size RF technology, LED indicator lights, portable size Best For: skincare minimalists who still want high-tech results skincare minimalists who still want high-tech results How to Use: After applying a hydrating gel, glide upward along the jawline, cheeks, and forehead. Best for Contouring: Amiro R3 Turbo Facial Device Amiro R3 Turbo Facial Device $320 AMAZON Why We Love It: No need to juggle multiple beauty devices—Amiro's RF tool merges the benefits of RF and microcurrentin one sleek device. 'This tool combines RF with EMS, which can give both a tightening effect and visible contouring of the face. It's a solid choice for people looking to maintain definition between professional treatments,' says Rufolo. Dr. Camp adds that it's particularly effective for those with skin laxity, under-eye bags, or concerns around jawline definition. No need to juggle multiple beauty devices—Amiro's RF tool merges the benefits of RF and microcurrentin one sleek device. 'This tool combines RF with EMS, which can give both a tightening effect and visible contouring of the face. It's a solid choice for people looking to maintain definition between professional treatments,' says Rufolo. Dr. Camp adds that it's particularly effective for those with skin laxity, under-eye bags, or concerns around jawline definition. Target Treatment Area: Face Face Treatment Time: Up to five minutes Up to five minutes Treatment per week : Two to three : Two to three Specs: FDA Approved, RF technology, EMS microcurrents, adjustable intensity levels FDA Approved, RF technology, EMS microcurrents, adjustable intensity levels Best For: time-pressed users seeking quick, noticeable results time-pressed users seeking quick, noticeable results How to Use: Apply a conductive gel and massage over the skin for 5–10 minutes, focusing on areas of concern. Best with LED: Althaea Skin CARA Multi-Modal Tool Kit Althaea Skin CARA Multi-Modal Tool Kit $350 ALTHAEA SKIN Why We Love It: Sure, other RF devices may offer an LED mode—but none with as many options as this Althaea Skin pick. We're talking three LED light settings to target different skin concerns, microcurrent technology for toning, and a massage function to boost circulation and ease facial tension. Essentially, it's a professional-level facial condensed into just a few minutes of daily ritual, making it effortless to keep your complexion refreshed and sculpted from the comfort of your home. Plus, it works with any (generously applied) serum—so you aren't beholden to using a single specific conductive gel. Sure, other RF devices may offer an LED mode—but none with as many options as this Althaea Skin pick. We're talking three LED light settings to target different skin concerns, microcurrent technology for toning, and a massage function to boost circulation and ease facial tension. Essentially, it's a professional-level facial condensed into just a few minutes of daily ritual, making it effortless to keep your complexion refreshed and sculpted from the comfort of your home. Plus, it works with any (generously applied) serum—so you aren't beholden to using a single specific conductive gel. Target Treatment Area: Face, jawline, and neck Face, jawline, and neck Treatment Time: 10 minutes 10 minutes Treatment per week : Three to five : Three to five Specs: RF, LED light modes, massage functionality RF, LED light modes, massage functionality Best For: skincare maximalists who love professional results at home skincare maximalists who love professional results at home How to Use: Select the desired mode and glide gently across the face for 5–15 minutes, adjusting technique to the function. Everything You Need To Know How do radio frequency devices trigger collagen production? AccordionItemContainerButton LargeChevron 'Radio frequency works by safely heating the deeper layers of your skin to stimulate collagen production. The heat has a tightening effect on existing collagen fibers and signals your body to start making new collagen and elastin over time,' says Rufolo. 'This helps your skin become firmer, smoother, and more youthful-looking, with results that continue to improve for several months after the treatment.' Are RF devices worth investing in? AccordionItemContainerButton LargeChevron 'As with most aesthetic treatments, not all radio frequency devices are created equal—some deliver much better results than others,' says Rufolo. Dr. Camp agrees, and while he notes these beauty tools absolutely can be effective, it's important to be realistic about results. Subtle skin tightening? Sure. Face lift contouring? No. 'Radio frequency devices are perfect for people seeking mild, non-surgical skin tightening, or improved skin texture—but you have to be willing to use them consistently,' he says. How often can you use an at-home RF device? AccordionItemContainerButton LargeChevron 'Although the usage of an RF device typically varies by brand, they are generally used around two to three times per week in the first few months of usage, then lowered to one to two times for maintenance,' says Dr. Camp, noting that when it comes to these devices, more is not always best. 'It's important not to overdo RF usage as this may lead to skin irritation such as dryness or redness when the skin barrier is disrupted.' Dr. Totton agrees, adding that a rest period of a day or two in-between sessions is ideal. 'It's worth bearing in mind that in-clinic radio frequency treatments are performed by an experienced aesthetic therapist and temperature is usually moderated throughout use for patient safety,' says Dr. Totten, adding thats it's all the more important to closely follow your devices specific instruction manual to ensure maximum safety. What's the difference between in-clinic and at-home RF? AccordionItemContainerButton LargeChevron 'In-clinic treatments that utilize radio frequency are an effective way to boost the production of collagen and elastin, offering a gentle alternative to more invasive options. They can reduce skin laxity on the face, neck and body, addressing sagging skin and fine,' says Dr. Totton, noting that while at-home devices work in the same way, they aren't as strong. 'Consequently, results from at-home devices will take longer and more consistent use to be achieved.' How long does it take to see results from at-home RF? AccordionItemContainerButton LargeChevron Remember, patience is key when experimenting with at-home radio-frequency devices. Dr. Totton reminds us that their effectiveness depends on consistent use over several weeks and months. 'All devices will vary in results depending on their energy levels, the specific skin concerns of the user, and also how effectively and consistently they are being used,' she says. 'However, in general users can expect to see and feel improvements to skin within a month, which should continue to improve as the months progress.' If you're the impatient type and want a clearer sense of when the results really kick in, board-certified dermatologist Dr. Nicole Ruth previously told Vogue that collagen production can take 12 to 16 weeks—or even longer—with at-home devices. Meet the Experts AccordionItemContainerButton LargeChevron Dr. Brendan Camp, MD, is a double board-certified dermatologist and dermatopathologist who sees patients in New York and Long Island. Natia Rufolo, FNP, NP-C is a board-certified aesthetic injector, PDO thread specialist, and founder of INJX BY NAT Aesthetics. Dr. Nicole Ruth is a board-certified dermatologist based in New York. Dr. Leah Totton, MBBS, MBCAM, is a London-based medical doctor and an award-winning cosmetic doctor with 11 years experience and a post-graduate diploma in dermatology. Totton is also the founder of Dr Leah Skin Clinics.
Yahoo
2 hours ago
- Yahoo
Medtronic lifts FY26 outlook amid 50% growth in cardiac ablation
Medtronic has raised its fiscal year 2026 (FY26) profit outlook to 4.5%, up from a previous target of 4%, amid strong growth in its cardiovascular portfolio due to the ongoing adoption of its pulsed-field ablation (PFA) systems and lower than expect tariff impacts. The Ireland-headquartered medtech giant's total sales reached $8.57bn in Q1 FY26, corresponding to an 8.4% rise on Q1 of FY25, which came in at $7.9bn. Medtronic now expects adjusted profits for FY26 to fall between $5.60 and $5.66 per share, up from $5.50 to $5.60 previously. Barring speciality therapies within its neuroscience portfolio, Medtronic achieved single-digit growth across all of its product lines. Cardiovascular was the company's strongest performing segment in FY26, with worldwide profits of $3.28bn, reflecting growth of 9.3% from around $3bn compared to the same period in the previous fiscal year. Cardiac Rhythm & Heart Failure witnessed the highest growth within Medtronic's cardiovascular portfolio, climbing to around $1.7bn, denoting an 11.5% rise on $1.53bn in Q1 of FY25. The uplift reflects the ongoing adoption of Medtronic's Affera mapping and ablation system featuring the Sphere-9 Catheter, and PulseSelect PFA for the treatment of atrial fibrillation (AFib). The systems gained US Food and Drug Administration (FDA) clearance in December 2023 and October 2024, respectively. Medtronic CEO Jeff Martha revealed in a post-earnings conference call that in Q1 of FY26, the company reached nearly 50% growth in cardiac ablation solutions on the rollout of its PFA systems. 'This performance is reflective of our execution capabilities, and we're excited that our growth momentum in this pivotal area is only just beginning,' Martha said. 'Looking this past quarter, I've witnessed Fara [Boston Scientific's Farapulse PFA system] and our competitors in action in several ablation cases, and I can tell you firsthand that the advantages that we're bringing to the market in terms of procedure time and ease of use are truly differentiated.' Martha added that physician feedback and utilisation levels of Medtronic's PFA equipment had been 'phenomenal', stating that the company now has 'more conviction than ever' that it has the right technology and product pipeline in place to progress towards a leadership position in cardiac ablation. In July, Boston Scientific's Q2 2025 financials revealed even stronger performance in its cardiovascular unit, with profits of $3.34bn, representing a 26.8% increase on the unit's Q2 2024 performance at $2.63bn. According to GlobalData analysis, months after separate approvals for Farapulse and PulseSelect, physicians in the US had already started displaying a much stronger preference for Boston's product over Medtronic's. Johnson and Johnson (J&J) received FDA approval for its Varipulse PFA system in 2024. In its Q2 2025 financials, J&J reported a 7.3% rise in its Medtech unit in Q2 2024 to around $8.54bn. Medtronic also lifted its FY2026 outlook due to a lower-than-expected impact from US President Donald Trump's tariffs. The company has revised the assumed impact of tariffs to $185m for the fiscal year, down from $200m to $350m previously. The move aligns with other recent tariff impacted revenue trims by companies including Zimmer Biomet and Philips. "Medtronic lifts FY26 outlook amid 50% growth in cardiac ablation" was originally created and published by Medical Device Network, a GlobalData owned brand. The information on this site has been included in good faith for general informational purposes only. It is not intended to amount to advice on which you should rely, and we give no representation, warranty or guarantee, whether express or implied as to its accuracy or completeness. You must obtain professional or specialist advice before taking, or refraining from, any action on the basis of the content on our site.
Yahoo
4 hours ago
- Yahoo
Rein Therapeutics Wins U.K. Approval to Launch Phase 2 Clinical Trial of LTI-03 in Idiopathic Pulmonary Fibrosis
AUSTIN, Aug. 19, 2025 (GLOBE NEWSWIRE) -- Rein Therapeutics ("Rein") (NASDAQ: RNTX), a biopharmaceutical company advancing a novel pipeline of first-in-class medicines to address significant unmet medical needs in orphan pulmonary and fibrosis indications, today announced that the UK Medicines and Healthcare products Regulatory Agency (MHRA) has authorized the Company to initiate its Phase 2 'RENEW' clinical trial of LTI-03, the Company's lead drug candidate for idiopathic pulmonary fibrosis (IPF). IPF is a serious, progressive lung disease that affects hundreds of thousands of people worldwide. It scars the lungs, leaving patients short of breath and with limited treatment options. Median survival after diagnosis is just 3–5 years. Rein's LTI-03 is a first-in-class therapy that is designed to directly target fibrosis while also protecting the lung's ability to regenerate healthy tissue. If successful, it could represent a major breakthrough in how pulmonary fibrosis is treated. Brian Windsor, Chief Executive Officer of Rein Therapeutics, commented, 'This MHRA approval marks an important milestone not only for Rein, but also for patients living with IPF. We are now working towards patient recruitment in the U.K., advancing LTI-03 into the next stage of development. Our approach is designed not only to slow disease progression, but also to preserve, and potentially restore, the lung cells that are critical to everyday breathing and quality of life. We believe LTI-03 has the potential to transform outcomes for patients while also creating substantial value for our shareholders.' Next Steps The RENEW trial is expected to enroll up to 120 patients worldwide, evaluating two dose groups of LTI-03 against a placebo. The primary objective of the trial is to assess safety and tolerability over 24 weeks of treatment. Secondary endpoints will include measures of lung function and imaging-based assessments of fibrosis progression. Rein is actively working with clinical sites in the UK to begin patient recruitment soon, with initial data expected in 2026. About Rein Therapeutics Rein Therapeutics is a clinical-stage biopharmaceutical company advancing a novel pipeline of first-in-class therapies to address significant unmet medical needs in orphan pulmonary and fibrosis indications. Rein's lead product candidate, LTI-03, is a novel, synthetic peptide with a dual mechanism targeting alveolar epithelial cell survival as well as inhibition of profibrotic signaling. LTI-03 has received Orphan Drug Designation in the U.S. and is in clinical development. Rein's second product candidate, LTI-01, is a proenzyme that has completed Phase 1b and Phase 2a clinical trials for the treatment of loculated pleural effusions. LTI-01 has received Orphan Drug Designation in the U.S. and E.U. and Fast Track Designation in the U.S. Forward-Looking Statements This press release may contain forward-looking statements of Rein Therapeutics, Inc. ("Rein", the "Company", "we", "our" or "us") within the meaning of the Private Securities Litigation Reform Act of 1995, including statements with respect to expectations for the Company's LTI-03 product candidate, the planned UK Phase 2 clinical trial of LTI-03 and the initial data readouts from the planned UK clinical trial. We use words such as "anticipate," "believe," "estimate," "expect," "hope," "intend," "may," "plan," "predict," "project," "target," "potential," "would," "can," "could," "should," "continue," and other words and terms of similar meaning to help identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including (i) the risk that the Company may not be able to successfully undertake the planned UK Phase 2 clinical trial of LTI-03, (ii) success in early phases of pre-clinical and clinicals trials do not ensure later clinical trials will be successful; (iii) the risk that the Company may not be able to obtain additional working capital with which to initiate and complete planned UK clinical trial, (iv) the risk that the Company may not be able to announce initial data readouts from the planned UK clinical trial in 2026 or, if it is able to do so, that the data may not be favorable and (v) those other risks disclosed in the "Risk Factors" section of the Company's Annual Report on Form 10-K for the year ended December 31, 2024, which is on file with the United States Securities and Exchange Commission (the "SEC") and in subsequent filings that the Company files with the SEC. These forward-looking statements should not be relied upon as representing the Company's view as of any date after the date of this press release, and we expressly disclaim any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law. Rein Investor Relations & Media Contact: Investor Relations IR@ in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data