
Bharat Biotech's cholera vaccine successfully completes Phase-III trials
Bharat Biotech
International Ltd on Wednesday said its
oral Cholera Vaccine
Hillchol has successfully completed phase III clinical trials. The vaccine maker, in a press release, said it has demonstrated against both Ogawa and Inaba serotypes, proving non-inferior in healthy Indian adults and children, supporting its potential as an effective OCV.
Ogawa and Inaba are two serotypes of Vibrio cholerae O1, a bacterial species that causes cholera.
The findings of a double-blind, randomized phase III clinical trial evaluating the safety, immunogenicity, non-inferiority, and lot-to-lot consistency of the
Hillchol
oral cholera vaccine, compared to a comparator vaccine, were recently published in a journal. The study involved 1,800 participants, ranging from infants to adults, across 10 clinical sites in India, the release said.
Play Video
Pause
Skip Backward
Skip Forward
Unmute
Current Time
0:00
/
Duration
-:-:-
Loaded
:
0%
0:00:00
Stream Type
LIVE
Seek to live, currently behind live
LIVE
Remaining Time
-
-:-:-
1x
Playback Rate
Chapters
Chapters
Descriptions
descriptions off
, selected
Captions
captions settings
, opens captions settings dialog
captions off
, selected
Audio Track
default
, selected
Picture-in-Picture
Fullscreen
This is a modal window.
Beginning of dialog window. Escape will cancel and close the window.
Text
Color
White
Black
Red
Green
Blue
Yellow
Magenta
Cyan
Opacity
Opaque
Semi-Transparent
Text Background
Color
Black
White
Red
Green
Blue
Yellow
Magenta
Cyan
Opacity
Opaque
Semi-Transparent
Transparent
Caption Area Background
Color
Black
White
Red
Green
Blue
Yellow
Magenta
Cyan
Opacity
Transparent
Semi-Transparent
Opaque
Font Size
50%
75%
100%
125%
150%
175%
200%
300%
400%
Text Edge Style
None
Raised
Depressed
Uniform
Drop shadow
Font Family
Proportional Sans-Serif
Monospace Sans-Serif
Proportional Serif
Monospace Serif
Casual
Script
Small Caps
Reset
restore all settings to the default values
Done
Close Modal Dialog
End of dialog window.
Sponsored Links
Sponsored Links
Promoted Links
Promoted Links
You May Like
Паста за почистване на бели обувки - PasteWhiteShoes
Murzel Shop
Купете сега
Undo
The participants were divided into three age groups: adults over 18 years, children aged 5 to under 18 years, and infants aged 1 to under 5 years. They were randomized in a 3:1 ratio to receive either Hillchol or a comparator vaccine.
"This publication reaffirms our commitment to advancing vaccines built on rigorous research, thorough clinical trials, and reliable clinical data. It highlights our continued commitment to providing affordable, effective, and accessible vaccines for the populations who need them the most," said Krishna Ella, Executive Chairman of Bharat Biotech.
Live Events
Cholera is an acute diarrhoeal infection caused by ingesting food or water contaminated with Vibrio cholerae bacteria. Studies have estimated that 2.86 million cases and 95,000 deaths occur annually, the release further said.
Global demand for OCVs is close to 100 million doses a year, and given that only one manufacturer supplies them, there is a global shortage. Bharat Biotech's facilities in Hyderabad and Bhubaneswar have a capacity to produce up to 200 million doses of Hillchol, it added.
Hashtags

Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles


India Today
29 minutes ago
- India Today
Falcon-9's liquid-oxygen leak plagues Indian astronaut's space launch: What is it?
Hours before Indian astronaut Shubhanshu Shukla was planned to strap into the Dragon spacecraft for a historic launch to the International Space Station, the mission stands postponed with no next launch announced on Wednesday, hours before the planned launch, that the teams require more time to repair the LOx (Liquid-oxygen) leak identified during post-static fire booster inspections."Standing down from tomorrow's Falcon 9 launch of Ax-4 to the Space Station to allow additional time for SpaceX teams to repair the LOx leak identified during post static fire booster inspections. Once complete – and pending Range availability – we will share a new launch date," SpaceX The Ax-4 mission was initially planned to launch on May 29 but was delayed to June 8 and then to June 10. It was postponed to June 11 due to weather issues and high winds in the launch rocket's liquid oxygen leak delays launchLatest input by @imsktripathi #ITVideo #Space #ShubhanshuShukla #Axiom4 | (@Akshita_N) IndiaToday (@IndiaToday) June 11, 2025WHAT IS LIQUID-OXYGEN? Liquid oxygen (LOX) is a supercooled form of oxygen, stored at -183C, and is used as an oxidizer in rockets like SpaceX's Falcon space lacks atmospheric oxygen, rockets must carry their own oxidizer to burn fuel. Falcon 9 combines LOX with RP-1, a refined form of kerosene, to power its Merlin mixed and ignited, this combination produces the high-pressure thrust needed to lift the rocket into orbit. LOx is used as an oxidizer in rockets like SpaceX's Falcon 9. (Photo: SpaceX) advertisementLOX is highly reactive and supports rapid combustion, making it essential for efficient rocket propulsion. Any leak or malfunction involving LOX can seriously impact launch safety and THE ISSUE? SpaceX had noticed a leak from the booster during the static fire test that was conducted on June is worth mentioning that the Falcon-9 being used to launch the newly developed Dragon spacecraft, had launched previously. SpaceX used the booster to launch a batch of Starlink satellites a few weeks back. Following its landing, it was refurbished and integrated with the Dragon spacecraft before moving to the launch pad at the Kennedy Space Centre in initially stated that they were installing a purge to fix the leak, but it appears that it did not work.' #India Today's @imsktripathi explains the significance of this mission from India's perspective.@ISRO #Super6 | @Akshita_N IndiaToday (@IndiaToday) June 10, 2025Now, that the launch has been postponed, there are chances that SpaceX might need to remove the Falcon-9 entirely from the pad and get it horizontal to fix the issue. That would mean a bigger delay in the launch that could stretch into the next week."It is understood that LOX leakage was detected in the propulsion bay during the test. Based on the discussion between the Isro team and experts from Axiom and SpaceX, it has been decided to correct the leak and conduct necessary validation tests before clearing the launch. Hence the launch of Axiom-4 slated for 11th June 2025 for sending the first Indian Gaganyatri to ISS is postponed," Isro the moment, SpaceX has yet to give a final launch date for the Ax-4 InMust Watch


Indian Express
43 minutes ago
- Indian Express
Pickle juice: Carlos Alcaraz's quick fix to stave off cramps in French Open final
French Open champion Carlos Alcaraz took sips of pickle juice during the five-hour, 29-minute marathon men's final against Jannik Sinner on Sunday, the longest-ever at Roland Garros. Alcaraz is not the first nor will be the last athlete to take small portions of pickle juice, known to help stave off the onset of cramps. There are many examples, recent and from the aughts. Over two decades ago, when temperatures touched 43 degree Celcius in Texas, the American football team Philadelphia Eagles drank pickle juice to stay hydrated during a game against the Dallas Cowboys. The Indian women's hockey team which finished fourth at the 2020 Tokyo Olympics took shots of pickle juice at the onset of cramps. At last year's UEFA Euros, England full-back Kieran Trippier was seen sipping from a sachet of pickle juice after cramping during the game against Serbia. Decathlete Tejaswin Shankar, the national record holder, Asian Games and Asian Championship silver medalist, swears by pickle juice as a quick-fix solution for cramps. What is pickle juice? Pickle juice is a briny liquid made up of water, salt and vinegar used for pickling. Gherkins, baby cucumbers, are a popular choice for pickling. The acetic acid in vinegar, a byproduct of fermentation, helps provide immediate relief from cramps, experts say. Brine also contains sodium and potassium, electrolytes the body loses through sweating. With it gaining popularity, commercial pickle juice is available in small PET bottles and sachets which may also contain dill oil or starch extracts. What in pickle juice gives relief from cramps? Experts believe that it's the acetic acid which is most effective in stopping cramps. 'Nerve receptors in the mouth detect acetic acid in the pickle brine and provoke a neurological reflex in which the brain sends messages to the muscles telling them to relax,' Anita Bean, a sports nutritionist told The Times, London. Tejaswin, India's high jump and decathlon national record holder, reckons, going by his practical knowledge, that acetic acid is like a silver bullet for cramps. 'It is not just sodium or potassium. We know because it's in electrolyte drinks and when you have it the cramps don't stop immediately. Maybe the brine in the pickle juice, or the vinegar or the acetic acid — one of those triggers a neuro reflex that stops the cramping,' Tejaswin told The Indian Express. Tejaswin uses a band-aid analogy. 'This is like a quick fix. I can't address hydration in the middle of a competition because if I do oral hydration it is going to take time to show results. When you are cramping you need to have something quick, like a pickle juice which puts a band-aid or a pause on the cramping and then you can continue.' What do top athletes experience? Tejaswin usually drinks pickle juice just before or during the high jump, the fourth event in decathlon on the first day. He reasons it is because of two reasons — he is starting to get tired because he has completed three events and also because he is tense ahead of his strongest event. 'I usually cramp right before or during the high jump. If I am cramping too much, I consume two shots but when I run the 400 metres (the event that follows the high jump), I feel really weird in my stomach, and after I finish I throw up for at least 10 minutes. To avoid that I don't consume it, but just gargle it so it just hits the back of my throat and the cramping stops,' Tejaswin said. Other than lack of hydration and loss of electrolytes, Tejaswin says a stressed mind can result in tense muscles that can cause a cramp. 'It comes down to the fact that it is my most important event, and there is some amount of stress that I carry going into the high jump thinking, 'I have to maximise my score here'. When you are not relaxed, your body tends to stiffen up, and those tight spots contribute to make a cramp worse. I am also fatigued by the time I reach the high jump because I have already done three events. All these add up,' Tejaswin said. He also carries a 'dabba' of mustard sauce in his bag as an option because he feels it has a similar effect on cramps. Did the women's hockey team benefit? Yes, ahead of the 2020 Tokyo Olympics, the team's strength and conditioning coach Wayne Lombard went shopping for pickles with gherkin and vinegar. He carried one hundred servings of pickle juice. 'When it was back-to-back games, the girls would drink that after breakfast, or depending on when the game was. And then, at the onset of cramps they would have additional shots if required,' he had told this paper. The bronze-medal match, which India lost narrowly to Britain, was played when the temperature touched nearly 40 degree Celsius. 'There are two ways to consume it. You either have it as a shot or you can gargle so your membranes get it, and then you spit it out,' Lombard said.


News18
an hour ago
- News18
Bharat Biotech's Nasal Vaccine 'Can Adapt' To New COVID Strains, Regulatory Nod Awaited
Last Updated: Bharat Biotech told News18 that the company's COVID-19 vaccine platforms are enabled for 'adaptation'. However, restarting production needs regulatory agency approvals. Amid rising concerns over the JN.1 COVID-19 variant, Indian vaccine maker Bharat Biotech has stated its preparedness to address the emerging variant with its 'adaptable" vaccine platforms. However, production will only restart with regulatory approval. Suchitra Ella, Managing Director of Bharat Biotech, told News18 that the company is 'actively monitoring the ongoing situation" and remains prepared to respond, emphasising the adaptability of its vaccine platforms to evolving strains. 'We remain committed to ensuring that our vaccine platforms are adaptable and ready to respond to evolving strains," she said. As of 11 June, India has recorded 7,121 active COVID-19 cases, according to the Union Health Ministry's official COVID-19 dashboard. Delhi, Gujarat, Kerala, Maharashtra, and West Bengal report the majority of these cases. Highlighting the benefits of its nasal vaccine, iNCOVACC, Ella told News18 that its intranasal COVID-19 vaccine offers targeted upper respiratory tract protection, ease of administration without needles, and adaptability to circulating strains. The company affirms its proactive monitoring and preparedness: 'actively monitoring the situation and well-positioned to respond effectively if the need arises." iNCOVACC, India's first intranasal COVID-19 vaccine, is available as a booster dose for adults. Its needle-free design, with drops instilled into each nostril, eliminates the need for trained healthcare professionals for administration. Ella confirmed the adaptability of both the injectable and intranasal COVID-19 vaccine platforms. 'However, any decision to restart production is contingent upon regulatory agency approvals. We continue to work in close coordination with regulatory bodies to ensure preparedness always aligns with evolving scientific and safety standards," she explained in an emailed interview with News18. While several countries recommend booster doses for high-risk and vulnerable groups, experts in India have not yet issued such a recommendation. 'Booster doses have been recommended in several countries for high-risk and vulnerable populations. Booster doses in our country are subject to approval from national regulatory agencies." Ella clarified that COVID-19 vaccine production would only recommence if directed by the national regulatory body. She also revealed the extent of vaccine wastage due to declining demand: 'As of early 2022, production of COVAXIN was paused in response to reduced demand and the cancellation of issued purchase orders. Subsequently, we proceeded with the destruction of around 20 crore doses of bulk and almost 5 crore doses of vaccines in vials." A senior health ministry source informed News18 that the recent rise in COVID-19 cases is no cause for panic, likening the current trend to seasonal influenza. While no immediate vaccination is necessary, basic precautions are advised, especially for those exhibiting symptoms. 'Wear a mask if you have a cough or cold, and request those around you to do the same, and people with co-morbidities like diabetes or kidney disease should remain particularly cautious during this period." Although booster shots may not be currently necessary in India, given the mild, influenza-like illness caused by current variants, the preparedness of Indian vaccine companies and their adaptable platforms demonstrate the nation's capacity for rapid response should more severe COVID-19 variants or other pathogens emerge.