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Walmart Recalls 850,000 Water Bottles After 2 People Suffer 'Permanent Vision Loss'

Walmart Recalls 850,000 Water Bottles After 2 People Suffer 'Permanent Vision Loss'

Yahoo2 days ago
Walmart has recalled 850,000 Ozark Trail 64 oz insulated water bottles due to a dangerous lid defect that can cause serious injuries, including permanent vision loss
The CPSC warns that the hazard arises when consumers store carbonated, perishable, or fermented beverages in the bottle for extended periods
Shoppers are advised to stop using the bottles, check for the Ozark Trail logo (model 83-662), and return them to Walmart for a full refundWalmart is taking the precautionary route and removing a water bottle brand from its shelves due to a newly discovered safety hazard it poses for consumers, especially children.
On Thursday, July 10, the U.S. Consumer Product Safety Commission (CPSC) published a press release announcing a recall for the Ozark Trail 64 oz stainless steel insulated water bottle, with a retail price of $15.
According to the notice, the lid of the bottle could cause serious injuries, including 'laceration hazards,' if a consumer attempted to open the bottle after storing food, carbonated or perishable beverages, including juice or milk, for an extended period of time.
'Walmart has received three reports of consumers who were injured when struck in the face by a lid forcefully ejected from these bottles upon opening,' the announcement reads. 'Two consumers suffered permanent vision loss after being struck in the eye.'
PEOPLE reached out to a Walmart and Group Director, Enterprise Communications at Walmart Molly Blakeman affirmed the company's top priority is "the health and safety of our customers."
"Walmart has fully cooperated with the U.S. Consumer Product Safety Commission and the manufacturer of the impacted product to remove it from our stores and notify consumers of the recall," stated Blakeman.
Multiple food and beverage cans suddenly eject an unattached lid, such as a carbonated soda or fermented foods and drinks like kombucha, sourdough, kimchi and wine.
The model number of the roughly 850,000 defective products is 83-662; however, this number does not appear on the bottles themselves. Instead, to confirm if they own one of the recalled bottles, consumers can look for the embedded Ozark Trail logo on the bottle.
Purchasers are encouraged to stop using the bottle if they have it in their possession and to contact Walmart or return it to the nearest location for a full refund.
Recently, Costco recalled several items due to their various potential hazards of causing serious injury and even death.
Among the recalled items are the Midea brand U-shaped window air conditioner (due to the potential mold growth from water pooling inside the appliance), a variety of Anker power banks (for fire risk from overheating) and the BowFlex 552 adjustable dumbbell, which can dislodge and injure the user or anyone in the nearby area.
Read the original article on People
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Takeda Announces Positive Results from Two Pivotal Phase 3 Studies of Oveporexton (TAK-861) in Narcolepsy Type 1
Takeda Announces Positive Results from Two Pivotal Phase 3 Studies of Oveporexton (TAK-861) in Narcolepsy Type 1

Yahoo

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Takeda Announces Positive Results from Two Pivotal Phase 3 Studies of Oveporexton (TAK-861) in Narcolepsy Type 1

– Both Phase 3 Studies Met all Primary and Secondary Endpoints Demonstrating Statistically Significant Improvements Across Symptoms at All Doses, Building Upon Phase 2b Results – Oveporexton was Generally Well-Tolerated in Phase 3 Safety Profile – Takeda is Rapidly Advancing Regulatory Submissions and Launch Preparedness with the Aim to Bring Oveporexton to People Living with Narcolepsy Type 1 as Quickly as Possible – These Results Mark a Major Advancement Toward Transforming the Standard of Care by Addressing the Underlying Cause of Narcolepsy Type 1 OSAKA, Japan & CAMBRIDGE, Mass., July 14, 2025--(BUSINESS WIRE)--Takeda (TSE:4502/NYSE:TAK) today announced that all primary and secondary endpoints were met in two Phase 3 randomized, double-blind, placebo-controlled studies of oveporexton (TAK-861), a potential first-in-class investigational oral orexin receptor 2 (OX2R)-selective agonist, in narcolepsy type 1 (NT1). NT1 is caused by the loss of orexin-producing neurons in the brain. Orexin agonists are designed to address this underlying orexin deficiency. For the first time, this mechanism of action has been validated in Phase 3 studies demonstrating significant improvement across a broad range of symptoms. These results reinforce the potential of oveporexton to transform the standard of care. "We are thrilled to reach this pivotal milestone for the oveporexton program. Oveporexton is a testament to Takeda's strength in discovering and developing a potential new class of medicines for difficult to treat diseases such as narcolepsy type 1," said Christophe Weber, president and chief executive officer at Takeda. "Our leadership in orexin biology and building a multi-asset orexin franchise with transformative potential will position Takeda for long-term future growth." The FirstLight (TAK-861-3001) and RadiantLight (TAK-861-3002) studies were two large, global Phase 3 studies conducted in 19 countries. Both studies achieved statistically significant improvement compared to placebo with p-values of <0.001 for all primary and secondary endpoints across all doses at week 12. The primary and secondary endpoints measuring objective and patient reported improvements in wakefulness, excessive daytime sleepiness, cataplexy, ability to maintain attention, overall quality of life and daily life functions demonstrate statistically significant and clinically meaningful improvements achieving near normal ranges across the broad range of symptoms investigated. Oveporexton was generally well-tolerated with a safety profile from the Phase 3 studies overall consistent with oveporexton studies to date including the Phase 2b study. No serious treatment-related adverse events were reported. The most common adverse events were insomnia, urinary urgency and frequency. More than 95 percent of the participants who completed the studies enrolled in the ongoing long-term extension (LTE) study. "We are grateful to the patients who took part in these clinical studies and to their families, the investigators and clinical staff. The studies were accelerated at an unprecedented pace with the aim to bring this potential treatment to people living with narcolepsy type 1 as quickly as possible," said Andy Plump, M.D., Ph.D., president of R&D at Takeda. "The comprehensive assessments from our Phase 3 studies build on the transformative results we saw with our Phase 2b study with most participants reaching normative ranges and reporting clinically meaningful improvement across a broad range of symptoms at the end of the 12-week treatment period. The positive results also reinforce the continued momentum for our late-stage pipeline, which we believe will deliver value to the patients we serve around the world." Takeda intends to present the results at upcoming medical congresses and plans to submit a New Drug Application with the United States Food and Drug Administration and additional global regulatory authorities in fiscal year 2025. Results from the Phase 3 studies have no significant impact on the full year consolidated forecast for the fiscal year ending March 31, 2026. About Narcolepsy Type 1 (NT1) and Orexin Science NT1 is a chronic, rare neurological disease that results in a range of debilitating symptoms including excessive daytime sleepiness (EDS), cataplexy, disrupted nighttime sleep, sleep paralysis and hallucinations upon falling asleep or waking. Additionally, individuals living with NT1 often report cognitive symptoms, including difficulty thinking clearly, remembering, concentrating and paying attention. NT1 is caused by loss of the orexin-producing neurons in the brain, which regulate wakefulness and sleep, and is also believed to be essential to other functions such as attention through activation of orexin receptors. Currently, the standard of care is limited to symptomatic therapies that may only partially address some of the symptoms people face. About Oveporexton (TAK-861) Oveporexton (TAK-861) is an investigational orexin receptor 2 (OX2R)-selective agonist, which selectively stimulates the OX2R to restore signaling and address the underlying orexin deficiency that causes narcolepsy type 1 (NT1). By activating OX2Rs, oveporexton is designed to promote wakefulness and reduce abnormal rapid eye movement (REM)-sleep like phenomena, including cataplexy, to address the broad spectrum of daytime and nighttime symptoms. About the FirstLight and RadiantLight Phase 3 Studies FirstLight (TAK-861-3001; NCT06470828) and RadiantLight (TAK-861-3002; NCT06505031) are global, multicenter, placebo-controlled studies to evaluate the efficacy, safety and tolerability of oveporexton compared to placebo in patients with narcolepsy type 1 (NT1) over 12 weeks. The studies were conducted in 19 countries with enrollment completed within six months. The FirstLight study enrolled 168 participants randomized to one of three dosing arms (high dose, low dose and placebo). The RadiantLight study enrolled 105 participants randomized to two dosing arms (high dose and placebo). The primary endpoint in both studies was improvement in excessive daytime sleepiness (EDS) as measured by the Maintenance of Wakefulness Test (MWT), a standard measure of wakefulness. Key secondary endpoints included improvement in EDS as measured by the Epworth Sleepiness Scale (ESS) and in the Weekly Cataplexy Rate (WCR), a measure evaluating cataplexy. The studies also evaluated the effect of oveporexton on participants' ability to maintain attention, participants' overall quality of life, the spectrum of narcolepsy symptoms and daily life functions, as well as the safety and tolerability of oveporexton. About Takeda's Orexin Agonists for Sleep-Wake Disorders Takeda is leading the field of orexin science with a multi-asset franchise. Orexin is a key regulator of sleep and wake patterns and contributes to other essential functions including attention, mood, metabolism and respiration. Oveporexton (TAK-861) is the lead investigational orexin receptor 2 (OX2R) agonist asset in Takeda's orexin franchise and received Breakthrough Therapy designation for the treatment of excessive daytime sleepiness in narcolepsy type 1 (NT1) from the U.S. Food and Drug Administration and the Center for Drug Evaluation of China's National Medical Products Administration. The company is also investigating other orexin agonists in populations with orexin levels in the normal range, including TAK-360, an oral OX2R agonist initially being investigated for the treatment of narcolepsy type 2 (NT2), idiopathic hypersomnia (IH), and other potential indications where orexin signaling is implicated. ​ About Takeda Takeda is focused on creating better health for people and a brighter future for the world. We aim to discover and deliver life-transforming treatments in our core therapeutic and business areas, including gastrointestinal and inflammation, rare diseases, plasma-derived therapies, oncology, neuroscience and vaccines. Together with our partners, we aim to improve the patient experience and advance a new frontier of treatment options through our dynamic and diverse pipeline. As a leading values-based, R&D-driven biopharmaceutical company headquartered in Japan, we are guided by our commitment to patients, our people and the planet. Our employees in approximately 80 countries and regions are driven by our purpose and are grounded in the values that have defined us for more than two centuries. For more information, visit Important Notice For the purposes of this notice, "press release" means this document, any oral presentation, any question-and-answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited ("Takeda") regarding this release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this press release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws. The companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, "Takeda" is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words "we", "us" and "our" are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies. Forward-Looking Statements This press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda's future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as "targets", "plans", "believes", "hopes", "continues", "expects", "aims", "intends", "ensures", "will", "may", "should", "would", "could", "anticipates", "estimates", "projects", "forecasts", "outlook" or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda's global business, including general economic conditions in Japan and the United States and with respect to international trade relations; competitive pressures and developments; changes to applicable laws and regulations, including tax, tariff and other trade-related rules; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic; the success of our environmental sustainability efforts, in enabling us to reduce our greenhouse gas emissions or meet our other environmental goals; the extent to which our efforts to increase efficiency, productivity or cost-savings, such as the integration of digital technologies, including artificial intelligence, in our business or other initiatives to restructure our operations will lead to the expected benefits; and other factors identified in Takeda's most recent Annual Report on Form 20-F and Takeda's other reports filed with the U.S. Securities and Exchange Commission, available on Takeda's website at: or at Takeda does not undertake to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda's future results. Medical Information This press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development. View source version on Contacts Japanese MediaYuko U.S. and International MediaRachel 擷取數據時發生錯誤 登入存取你的投資組合 擷取數據時發生錯誤 擷取數據時發生錯誤 擷取數據時發生錯誤 擷取數據時發生錯誤

Footage of Inmate Suicide Captures Dysfunction on Rikers Island
Footage of Inmate Suicide Captures Dysfunction on Rikers Island

New York Times

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Footage of Inmate Suicide Captures Dysfunction on Rikers Island

As calls mounted for a federal court takeover of the Rikers Island jail system in New York City, what happened to Michael Nieves stood out as a case study in that system's dysfunction. Mr. Nieves, 40, was being held in the troubled jails on arson and other charges — his trial date repeatedly delayed by the pandemic and a series of mental health assessments — when he used a shaving razor to cut himself near the jugular vein and bled out on the floor as jail staff members waited for medical assistance. The fatal episode was foreshadowed by other incidents in his recent past. While being held in the Bellevue Hospital Prison ward, Mr. Nieves, who had schizophrenia, had used another shaving razor to cut a gash in his neck — surviving only after emergency surgery. And he had been placed on suicide watch just months before he died, after he was heard saying he no longer wanted to live. New York Times reporters filed a freedom of information request for video of Mr. Nieves's death and other cases of preventable harm in the jails, seeking to learn more about how jail staff members responded during the incidents. The Times then sued the city to force compliance with the state's open records law. The city provided the videos three years later, with the faces of detainees blurred and some information redacted. Made public here for the first time, they offer a window into a jail system in the grips of crisis. Mr. Nieves was one of 19 Rikers Island detainees who died by suicide, overdose or medical emergency in 2022, with most of the deaths deemed preventable by oversight officials. A city medical examiner found that the officers' inaction contributed to Mr. Nieves's death, but that he could have died even if he had immediately received emergency aid. The State attorney general's office declined to charge the officers, noting in a report that the correction department's policy on tending to severely bleeding inmates was unclear. Three years later, the department is building out a new 'medical emergencies' curriculum, a spokesman said. Want all of The Times? Subscribe.

GSK seeks FDA nod for expanded use of RSV vaccine in adults
GSK seeks FDA nod for expanded use of RSV vaccine in adults

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GSK seeks FDA nod for expanded use of RSV vaccine in adults

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