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Heat health alerts extended into next week during fourth summer heatwave

Heat health alerts extended into next week during fourth summer heatwave

Yahooa day ago
Heat health alerts have been extended into next week for much of England following the fourth heatwave of the summer.
The UK Health Security Agency said yellow warnings will now be in place in Yorkshire and Humber, the East and West Midlands, London, the South East and South West and East of England until 6pm on Monday, August 18.
The warnings mean significant impacts on health and social care services are possible due to high temperatures, including a potential rise in deaths among the elderly or those with pre-existing health conditions.
Alerts were previously due to end at 6pm on Wednesday.
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Boy with fragile skin disorder given hope after new treatment
Boy with fragile skin disorder given hope after new treatment

Yahoo

time8 minutes ago

  • Yahoo

Boy with fragile skin disorder given hope after new treatment

A boy with a rare skin condition which can cause damage with even the smallest amount of friction has been given hope after taking part in a trial for the first potential treatment for the genetic disorder. Gabrielius Misurenkovas, 12, from east London, was diagnosed with an inflammatory disease called recessive dystrophic epidermolysis bullosa (RDEB) when he was a baby. Many symptoms of the painful condition have been alleviated thanks to a new trial in which he received certain stem cells via an intravenous drip. The rare genetic disease is severely debilitating. People with the condition have extremely fragile skin which is easily damaged, leading to blistering, deep wounds and scarring. About 150 children in the UK are affected by RDEB, which is painful and causes itchiness. With no disease-modifying treatment available, patients and their families manage symptoms by dressing wounds and applying eye ointments. Over time, the condition can lead to severe complications and many patients with the condition develop a type of skin cancer called squamous cell carcinoma when they are young adults – this is the most common cause of death for RDEB patients. Gabrielius has been under the care of medics at the world-renowned children's hospital Great Ormond Street (GOSH) since he was a baby. He said he jumped at the chance to join the clinical trial when it was suggested by his doctors. 'I wanted to take part in the trial as I was excited to see if it could help improve my condition and so I could do more of the things I enjoy, like playing football and spending time with my friends,' he said. The youngster, who can speak three languages and is a big fan of footballer Lionel Messi, needed his bandages changing three times a day, or more if he was injured. His mother, Jolita Cekaviciene, said: 'Gabrielius did really well on the trial. 'His wounds healed quicker, and his skin was less red and inflamed. 'His skin was also less itchy which also reduced him scratching. 'His sleep was also less disturbed as he didn't need to have his special wound dressings changed as often, so this was a great benefit.' She said Gabrielius has managed to do a few things that he was not able to before the treatment, including taking part in some sports at school, riding his bike in the park on the grass, and being able to play football with his friends, with a soft ball. Ms Cekaviciene said the trial has given her son more freedom than before, but he still needs to be careful in any activity to avoid falling over or bumps. Gabrielius was referred to GOSH as a baby after medics spotted a wound when he was born, and he was diagnosed with RDEB when he was two weeks old. Ms Cekaviciene said: 'The first two years were really hard as you had to watch him constantly – even rubbing his eyes could cause painful blistering. 'He couldn't even tell us how much pain he was in or where he was hurting.' RDEB is a genetic condition which is caused by a fault in the gene that makes a protein which holds layers of skin together – collagen VII. Medics wanted to assess whether regular infusions with mesenchymal stromal cells (MSC) improved symptoms for children with the condition, after studies suggested that MSC treatments could promote wound healing, reduce inflammation and stimulate tissue regeneration. In the trial, funded by NHS England, the National Institute for Health and Care Research and the charity Cure EB, children were given a treatment called CORDStrom, manufactured by INmuneBio. Gabrielius is one of 30 children who took part in the new clinical trial at GOSH and Birmingham Children's Hospital. Patients would go into hospital and have a drip which delivers the cells over 10 to 15 minutes. In the study patients were split into two groups, about half were given the treatment, which is made from umbilical cord tissue, as an infusion, twice over two weeks. The other half were given a placebo, also known as a dummy drug. They then had a nine-month gap, known as a wash-out period, where the group that were initially given the dummy drug were given the treatment, while the group that received therapy first were given a dummy drug. The study, published in the journal eClinicalMedicine, reported a positive outcome of the treatment. The largest effects were in children under the age of 10, and in the children with intermediate type of RDEB. Families involved in the study reported a positive impact on daily life and well-being, with a reduction in both pain and itching. The treatment was said to be well tolerated by the children. INmuneBio have agreed to provide CORDStrom free of charge for a year for all children who took part in the trial, so researchers can continue to study them, and patients are expected to get two infusions of the treatment every four months. The company is seeking regulatory approval for the treatment so it can be approved for use in the UK and other countries. Chief investigator of the study, Dr Anna Martinez, paediatric dermatologist at GOSH, said: 'Our study has demonstrated that CORDStrom was safe and can help reduce disease activity in some patients with RDEB. 'Administering the treatment early and at regular intervals appears to reduce itch and improve wound healing, which over time we hope will reduce inflammation, modify the condition and may reduce over time the future risk of squamous cell carcinoma. 'It's fantastic to see how the patients, like Gabrielius, had improvements in their symptoms and their quality of life.' She added: 'The 12-month open label study will allow us to collect more data to hopefully show an increased benefit from treatments administered in children and young people with RDEB, to continue research in support of the treatment being rolled out more widely.' Sharmila Collins, founder trustee of Cure EB, said: 'Since funding the first trial and by contributing to Mission EB we have been working towards bringing MSC infusions forward for all children in the UK with RDEB. 'We hope these cells will become part of routine clinical care to alleviate the significant suffering of children with this condition.'

Nike Founder Phil Knight Announces Historic $2 Billion Donation
Nike Founder Phil Knight Announces Historic $2 Billion Donation

Yahoo

time19 minutes ago

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Nike Founder Phil Knight Announces Historic $2 Billion Donation

Nike Founder Phil Knight Announces Historic $2 Billion Donation originally appeared on The Spun. Phil Knight, the co-founder and chairman of Nike, made a record-breaking donation this week that should make plenty of people smile. Knight and his wife, Penny, gifted $2 billion to the Oregon Health & Science University's Knight Cancer Institute. According to Thursday's press release, the plan is to invest in "cancer research, diagnosis, treatment, care, and some day, eradication." The Knight family's $2 billion investment will go down as the largest donation a U.S. educational institution has ever received. "This gift is an unprecedented investment in the millions of lives burdened with cancer, especially patients and families here in Oregon," OHSU President Shereef Elnahal said. "It is also a signal of trust in the superlative work that our clinicians, researchers and teammates at the Knight Cancer Institute do every day. Dr. Druker's vision around a multidisciplinary system of care — focused squarely on making the patient's experience seamless from the moment they receive a diagnosis — will now become reality. And thanks to the extraordinary generosity of Mr. and Mrs. Knight, Oregon will be the place to do it." Phil and Penny have worked with Brian Druker and the Knight Cancer Institute's team in the past, so they clearly felt confident giving them $2 billion. "Penny and Phil Knight have always challenged us to do what no one else is doing," Dr. Druker said. "It can seem impossible to navigate the health care system after being diagnosed with cancer. We're going to change that. We have revolutionized the way we detect and treat cancer. Now we are going to transform the way we care for patients while continuing to develop innovative treatments." Hopefully, this groundbreaking donation from the Knight family will be a game-changer for cancer research around the world. Nike Founder Phil Knight Announces Historic $2 Billion Donation first appeared on The Spun on Aug 14, 2025 This story was originally reported by The Spun on Aug 14, 2025, where it first appeared. Solve the daily Crossword

Berkshire Hathaway 13F Filing Reveals Warren Buffett's Secret Stock
Berkshire Hathaway 13F Filing Reveals Warren Buffett's Secret Stock

Yahoo

time20 minutes ago

  • Yahoo

Berkshire Hathaway 13F Filing Reveals Warren Buffett's Secret Stock

Warren Buffett's Berkshire Hathaway revealed a position in embattled healthcare giant UnitedHealth Group and reported smaller stakes in longtime holdings Apple and Bank of America, according to a regulatory filing Thursday. Berkshire (BRK.A, BRK.B) at the end of the second quarter held 5 million shares of UnitedHealth Group (UNH) valued at about $1.6 billion. The company has likely been accumulating shares since the fourth quarter of last year, when it first asked regulators to let it build a position in secret to avoid a price spike. Shares of UnitedHealth Group jumped more than 10% in extended trading Thursday. Berkshire also opened smaller new positions in security products provider Allegion (ALLE), homebuilder D.R. Horton (DHI), Lamar Advertising (LAMR), and steelmaker Nucor (NUE), all of which saw their stocks rise after hours. T-Mobile (TMUS) was Berkshire's sole exit. The conglomerate sold the entirety of its $1 billion stake in the telecommunications giant. It also offloaded nearly half of its Charter Communications (CHTR) holdings. Berkshire made smaller cuts to two of its largest holdings, selling 20 million of its 300 million Apple (AAPL) shares and 26 million of its 630 million Bank of America (BAC) shares. Buffett began paring Berkshire's stakes in both last year. Buffett scooped up 3 million shares of Chevron (CVX), another of his biggest holdings, and left stakes in longtime investments Coca-Cola (KO) and American Express (AXP) untouched. Berkshire slashed its exposure to banks in the first quarter, exiting its position in Citigroup (C) and trimming its holdings of Bank of America and Capital One (COF). On the flip side, the firm added to some of its food and beverage holdings, including alcohol maker Constellation Brands (STZ) and Domino's Pizza (DPZ). In the second quarter, the firm seemed to favor homebuilders. On top of entering D.R. Horton, Berkshire bought about 7 million shares of competitor Lennar (LEN), upping its stake from just 150,000 shares. Berkshire shares have shed about 11% of their value since Buffett announced in early May that he would step down as CEO at the end of 2025. Still, the stock is up almost 6% since the start of the year. Read the original article on Investopedia Fehler beim Abrufen der Daten Melden Sie sich an, um Ihr Portfolio aufzurufen. Fehler beim Abrufen der Daten Fehler beim Abrufen der Daten Fehler beim Abrufen der Daten Fehler beim Abrufen der Daten

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