FDA investigates patient deaths after treatment with Sarepta's gene therapy
June 24 (Reuters) - The U.S. Food and Drug Administration said on Tuesday that it is investigating reports of two deaths due to acute liver failure in non-ambulatory Duchenne muscular dystrophy patients after receiving Sarepta Therapeutics' (SRPT.O), opens new tab gene therapy, Elevidys.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Daily Mail
an hour ago
- Daily Mail
Nat Barr erupts over 'ridiculous' ambulance crisis after just 'one per cent' of the fleet were able to respond to calls and dozens of patients left stranded
Nat Barr has lashed out at the ambulance crisis in Victoria and labelled it 'ridiculous' after it emerged just one per cent of the fleet were able to respond to calls. The Sunrise host demanded authorities fix the issue immediately following revelations that 50 people were left waiting for emergency transport on Monday night. Ambulance data showed more than 25 crews were off the roads across Melbourne due to staff shortages, while at least another 110 crews were stuck ramped at hospitals by 7.15pm. Paramedics were forced to care for patients in the vehicle while waiting for a hospital bed to become available, meaning they couldn't get back out on the road and respond to more calls for help. Danny Hill, from the Victorian Ambulance Union, described it as 'the perfect storm'. 'We had a lot of dropped resources,' he told Barr. 'We had 22 advanced life support and eight mobile intensive care ambulances that actually didn't run on Monday night. 'Compounding that, we had a very busy workload and the hospitals were overwhelmed and, at one point, we believe about 100 crews were ramped at metropolitan hospitals across Melbourne, sometimes for up to ten hours. 'I'm informed it left one per cent of the metropolitan Melbourne ambulance fleet able to respond to anyone in an emergency.' Barr was stunned by the situation and said it needed fixing right away. 'This is an absolute cluster, this is absolutely ridiculous,' she said before asking Mr Hill what would be done about the problem. 'Taxpayers pay for their ambulance service to be there in a time of emergency,' Mr Hill said. 'Too often we see them logged off emergency work to work in hospital corridors, to organise GP appointments and to do social work instead of being free to respond to genuine emergencies. 'Just the other night an ambulance was called to someone complaining of gaming addiction. Paramedics don't have anything to offer that person.' Barr asked why paramedics were receiving calls like the one about the person with a gaming addiction. 'Why isn't someone saying "no" and redirecting them, surely?' she asked. 'Correct, and they're being sent to those calls, that's the problem,' Mr Hill said. 'The calls are coming through, and always will, and some of these patients do need help but not from ambulance paramedics.' Barr said a common-sense approach needed to be taken towards the unforgivable situation Ambulance Victoria found itself in on Monday night. 'Surely someone can fix this, it's just absolutely ridiculous,' she said. Data leaked to the Herald Sun exposed that more than ten major hospitals had wait times of more than two hours by 8pm, with some as high as ten hours. Premier Jacinta Allan said winter was to blame for the spike in demand for ambulances. 'We are clearly in the depths of winter where many people are suffering from the impacts of flus, and Covid is still around, and a lot of respiratory illnesses,' she said. Two Victorians died waiting for ambulances in June alone, including an elderly Blackburn man who bled to death after falling and hitting his head. He phoned for an ambulance twice, but it took almost five hours for one to arrive, while six crews were ramped at Box Hill Hospital, just one suburb away.
Daily Mail
2 hours ago
- Daily Mail
I'm always tired, so I tried a celebrity-loved injectable that promises to boost your energy and make you more productive - but does it work?
I know there are few things more boring than hearing about how tired and busy other people are, but let's just say that, as a full-time working mother with two kids under five, I am more tired and busy than I've ever been before. So when I had the opportunity to test out NAD+, a molecule that's had the wellness world buzzing with its promise to increase energy, super-charge focus, enhance your mood and improve your sleep, I was definitely interested. After having my second child I've been left with a brain fog that rarely lifts outside of work, and I've always been a terrible sleeper. Who wouldn't want to be a more productive, get-up-and-go version of themselves?
The Independent
3 hours ago
- The Independent
Tens of thousands of women forced to travel out of state for abortion care after Roe v Wade was overturned in 2022
Tens of thousands abortion patients have been forced to leave their home states to seek abortion care three years after the end of constitutionally protected abortion access in America. One out of every seven abortion patients, or roughly 155,000 people, left their home state for abortion care last year, according to the Guttmacher Institute, a reproductive health research group. That total is slightly fewer than the 170,000 people who traveled for abortion care in 2023, but it remains a remarkable spike in abortion-related travel compared to the years before the Supreme Court's June 2022 decision in Dobbs v Jackson Women's Health Organization, which overturned Roe v Wade and allowed states to criminalize abortion care and implement outright bans. Out-of-state travel for abortion care has virtually doubled since that ruling. Since the Dobbs decision, 13 states have outlawed abortions in virtually all circumstances, creating a patchwork of abortion access across the country, and balkanized legal constraints for patients and providers, who are shielded in some states and criminalized in others. The total number of abortions each year has also steadily increased in the wake of that decision. In 2024, 1.14 million abortions occurred in the United States, according to the Society for Family Planning. Roughly one in four abortions were performed through telehealth last year, with an average of 12,330 abortions per month performed through medication abortion, which typically requires a two-drug protocol that a patient can take at home. That's up from one in five in 2023 and one in every 20 in 2022. Medication abortion has accounted for the vast majority of abortions in recent years. Roughly 63 percent of all abortions are now medication abortions, according to Guttmacher. Mifepristone, one of two prescription drugs used in medication abortions, is approved for use by the FDA up to 10 weeks of pregnancy. From 2019 through 2020, nearly 93 percent of all abortions were performed before the 13th week, according to the Centers for Disease Control and Prevention. But the drug is at the center of legal challenges fueled by right-wing anti-abortion activist groups who have sought to strip the government's approval and implement sweeping federal bans on abortion care. President Donald Trump's administration has also pledged to revisit the drug's approval, using spurious reporting and junk science, in an apparent attempt to undermine the basis for the government's approval. Nearly half of patients who traveled for an abortion last year came from states where abortion is outlawed — including more than 28,000 Texas residents, more than any other state, Guttmacher found. 'While these findings show us where and how far patients are traveling, they are not able to capture the numerous financial, logistical, social and emotional obstacles people face,' according to Guttmacher Institute data scientist and study lead Isaac Maddow-Zimet. In the months after the Dobbs decision, sweeping anti-abortion restrictions across the deep South and neighboring states have effectively forced abortion patients to travel hundreds of miles to reach the nearest state where abortion access was legal. Florida, surrounded by anti-abortion states, was initially a key point of abortion access in the South within the first two years after the Dobbs decision. In 2023, more than 9,000 people traveled from other states to get an abortion there, according to Guttmacher. Roughly one in every two abortions nationwide and one in three abortions in the South were performed in Florida at that time. Last year, Florida banned abortion beyond six weeks of pregnancy, before many women know they are even pregnant, and the number of patients traveling to the state for abortion care was virtually cut in half. Another 8,000 people left the state to get an abortion elsewhere, often crossing as many as three states to get there, Guttmacher found. 'It was not just Floridians who were impacted, but also the thousands of out-of-state patients who would have traveled there for care,' according to Candace Gibson, Guttmacher Institute Director of State Policy. 'The most extreme abortion bans are concentrated in the South, which makes it disproportionately difficult for people living in that region to exercise their fundamental right to bodily autonomy,' she added.
