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What you need to know about electrolytes

What you need to know about electrolytes

Irish Times28-07-2025
There is a large, growing and very competitive market for electrolyte powders, drinks and tablets. In 2024, the electrolyte drink market was valued around €32 billion.
The products are designed to be consumed before, during and after exercise – and manufacturers claim they'll optimise your hydration, health and performance. There are even options to supplement your daily hydration, whether or not you are exercising.
But do you really need to replenish the electrolytes lost in your sweat?
And are sports drinks, electrolyte powders and salty supplements actually the best way to do it?
READ MORE
What do electrolytes do?
Electrolytes are minerals – such as sodium, potassium, calcium and magnesium – that carry an electrical charge that influences how water moves in your body.
'They help maintain the fluid balance,' explained Dr Amy West, a sports medicine physician. They help move fluid into and out of your cells and regulate blood pressure, heart rhythm, muscle and nerve function.
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While they're found in supplements and sports drinks, they're also in the foods we eat every day. 'When we talk about potassium, it's in a banana,' says Heidi Skolnik, a nutritionist. 'When you eat a pretzel, there's sodium on it.'
As you sweat, you lose both fluid and electrolytes and if you lose enough fluid, you can become dehydrated. The volume of blood in your body drops and 'your heart has to pump harder to get the same amount of blood circulating,' Skolnik says.
Do you really need to replace them?
When you lose an exceptionally large quantity of water and electrolytes, as you might if you're having a serious bout of diarrhoea, you need to replace both. In those situations, doctors often recommend a rehydration solution such as dioralyte, which typically has more sodium and potassium than your average sports drink.
But experts say you probably don't need to reach for a sports drink during your regular workouts. Even if those workouts are strenuous or happen in hotter weather, drinking water when you're thirsty is enough to keep you hydrated. The sugar and carbohydrates found in many sports drinks certainly may help competitive athletes maintain their energy, but the electrolytes have little impact.
In the 1990s, standard medical advice recommended sodium-rich drinks for athletes during any exercise that lasted more than an hour. But more recent research has found that even as you lose sodium through sweat and urine, your body maintains the concentration of sodium in your blood. In several small studies athletes didn't tend to report a performance difference between working out with water and electrolyte-infused drinks, even after five hours of running in heat.
It's been well-established for at least a decade that electrolytes don't do much for performance, says Ricardo Da Costa, an associate professor in sports dietetics at Monash University in Australia. 'But the marketing strategies from the sports drinks companies are more potent than the researchers.'
'Everybody thinks that they need to replace lost electrolytes right away,' says Tamara Hew-Butler, a sports medicine scientist. 'You don't. You will make it up generally in your meals.'
Most of the time, you are fine just drinking water when you're thirsty. If you're spending hours outside in the heat for several days and start feeling dehydration symptoms, like lightheadedness, you might reach for a sports drink or supplement, especially if you aren't getting enough electrolytes in your diet, says Robert Kenefick, a professor of biomedical and nutritional sciences at the University of Massachusetts-Lowell.
In rare cases, you can have too much fluid, but not enough sodium in your blood, a condition called hyponatremia, which can cause nausea, fatigue and, in the most severe cases, seizures or death. It's more likely to happen if you have certain medical conditions such as heart, liver or kidney problems.
For athletes, it can happen if they drink so much fluid before, during and after long workouts that it dilutes the electrolytes in their blood. However, most sports drinks don't contain enough sodium to prevent it, says Dr Da Costa.
Is there a downside?
Aside from the cost, experts say there's little downside to consuming electrolyte drinks. As long as you're otherwise healthy, they do not have enough electrolytes to overload your system (called hypernatremia), says Dr Kenefick. And the sweet taste could motivate you to hydrate.
Like most supplements, however, electrolyte products are not well regulated and can even be contaminated, says Dr Hew-Butler. In 2015, she and her team found unsafe levels of arsenic in Muscle Milk and Gatorade powders that had been provided to college athletes. The athletes showed no signs of having been harmed by the exposure.
You won't see 'arsenic' on a supplement label, but you should check for the amount of sugar in the drinks, which can be almost as high as some sodas. As you are reading the label, Dr Kenefick cautioned buyers to be sceptical of what it promises.
'The beverage market is very competitive and everyone's looking for an edge,' he says. 'A lot of the beverages that are out there are using electrolytes as a marketing tool.'
– This article originally appeared in the
New York Times
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A hero among hormones: Why cortisol is something to celebrate rather than stress about
A hero among hormones: Why cortisol is something to celebrate rather than stress about

Irish Times

time2 hours ago

  • Irish Times

A hero among hormones: Why cortisol is something to celebrate rather than stress about

Of all the hormones produced by the body, cortisol is the most misunderstood. It's essential to any number of biological processes, and yet commonly typecast as 'the one to do with stress' – an evolutionary adaptation for different times, wildly unsuited to modern living, something to reduce with meditation, reset with ice baths or regulate with red-light therapy. Personal trainers will tell you to avoid long runs in case they result in 'cortisol belly', while influencers diagnose 'cortisol face' as a sign of too much pressure in the office. To top it all, social media has recently seen the rise of the 'cortisol cocktail' – a combination of coconut water, orange juice, salt and lemon that TikTokers claim can reduce stress and help with weight loss. But how much of this has any kind of scientific validity ? And is worrying about your cortisol levels doing you more harm than good? The first thing to understand is what cortisol is, and what it actually does: and yes, that does include helping to manage our response to external stressors. In situations that the body perceives as fight-or-flight, it helps the body to produce immediate energy – as well as suppressing non-essential functions such as digestion or repair (we'll get to whether this is a bad thing or not shortly). READ MORE 'Cortisol plays a vital role in blood-sugar regulation, by prompting the liver to produce glucose and helping ensure a steady supply of fuel to the brain and body,' says Hannah Alderson, a nutritionist, hormone specialist and author of Everything I Know About Hormones. 'It also helps modulate inflammation, keeping immune responses in check and preventing them from going into overdrive. It's key in how we metabolise fat, protein and carbohydrate.' It also regulates blood pressure, can act as a mood buffer, and kicks in to help fight infection if we're recovering from an acute illness. But one of its most vital roles is also its least talked-about. 'It's the hormone that gets us out of bed,' says Angela Clow, emeritus professor of psychophysiology at the University of Westminster. 'You get this burst of it in the morning, which is called the 'cortisol awakening response'. That's not a bad thing or a stress response – it's the body's way of waking up and promoting cognitive function. 'You've probably experienced a time when you have an early flight or a busy day ahead, and your body anticipates it and wakes you up without needing an alarm clock. That's cortisol priming your brain to be more alert and more active, preparing you for the day ahead.' Research published earlier this year confirmed that cortisol is already increasing from its lowest point about three hours before you wake up – putting to rest any idea that getting up itself is stressful for the body, and suggesting instead that rising cortisol levels are part of what gets us ready for the day. Like every other higher organism on the planet, we've evolved to live in an environment that's dark for (roughly) half of every day, and so our body needs a way to switch from restoration into activity, which seems to be one of cortisol's key roles. [ Why bobs, perms and beehive hairstyles reveal the stories of women's lives Opens in new window ] 'A very large proportion of the genes in your body are sensitive to cortisol,' says Stafford Lightman, a professor of medicine at Bristol Medical School and co-author on the recent research. 'And so cortisol has a daily rhythm, and that daily rhythm regulates multiple genes in multiple tissues; in your brain, your liver and your immune system.' As part of this process, cortisol levels gradually decline throughout the day, with periodic bursts approximately every 90 minutes helping to maintain proper bodily function. This certainly isn't a bad thing, but it does make gauging it difficult: you could take two measurements 30 minutes apart and get two wildly differing numbers. Under laboratory conditions, researchers take cortisol readings from blood or saliva multiple times a day to obtain a general picture of how volunteers' levels fluctuate and respond to stressors. At-home tests are much less useful: if you're only testing yourself once or twice a day, the only thing you might notice is that your levels are very high or very low. So what about the idea that the minor stresses of everyday life are constantly keeping our cortisol levels perilously high? One common characterisation of the way this might work is that our bodies, evolved to deal with sabre-tooth tiger attacks and flash floods, can't easily distinguish between those sorts of immediate, physical threats and more psychological ones – an argument on the school run, say, or a nasty email from a client. Social stressors, the theory goes, can be insidious: they're basically ever-present, especially if we're prone to catastrophise, and if our bodies' restorative systems switch themselves off every time we encounter them, we'll never have time for rest and repair. In baboon troops – which are very social and hierarchical – this effect is visible, with the lower-pecking-order males suffering with worse immunity and shorter lifespans, as their fight-or-flight systems are constantly prioritised over the rest-and-digest ones. But baboon lives tend to be genuinely far more stressful than human ones – if you're kicked out of the troop or can't find a mate, you're facing a genuine, near-immediate threat to your genes' survival, rather than just feeling a bit put out. There's speculation, of course, that our bodies can't make this sort of distinction, and that we still internally respond to having our birthday forgotten at the office like we would to banishment on the savannah. But is that really true? As it turns out, probably not. To test the effect of short-term bursts of stress, psychologists have developed all sorts of unpleasant laboratory procedures – from cold-water immersion to problem-solving under time pressure, to the Trier Social Stress Test, where volunteers are tasked with delivering a speech and mental arithmetic task in front of an unresponsive panel of evaluators. And the effect isn't as pronounced as you might have been led to believe. 'Trying to stress a human is really difficult,' says Lightman. 'Even plunging your hand into freezing-cold water has very little effect. If you've got a really important job interview that is going to govern the rest of your life, then yes, that's probably going to be stressful. But it's very subjective – some people, of course, actually like giving presentations in front of a crowd. With things like the Trier test, you might get a reaction the first time, and then you won't again – just understanding what the test is about is enough to destroy the effect.' If you're chronically stressed, that's something to deal with for health reasons, but it's not necessarily a question of artificially finding ways to keep your cortisol down – it's more holistic than that. The most important thing is to look after yourself, rather than reaching for an expensive supplement or a cortisol cocktail — Niamh Martin This means you're unlikely to be suffering spikes in cortisol from the odd snippy Zoom call or altercation at the self-checkout – and, even if your body sees those situations as a threat to your wellbeing, there are other systems that kick in first. 'It's not just cortisol that goes up in stressful situations,' says Dr Thomas Upton, a clinical research fellow who also worked on the recent study. 'There are other hormones – like catecholamines, your adrenaline and noradrenaline – that play key roles in the immediate part of the fight-or-flight response. This is what helps you 'fight the lion' and get yourself out of the situation, followed up by cortisol release if the stress is strong enough or long enough. What you're feeling in a very stressful situation like a jump scare is a rush of adrenaline that makes your heart pound and your mouth go dry and all the rest of it.' Brief, short-term stress is probably not doing you any harm, then. But does this mean heightened cortisol becomes more of an issue when you're continuously stressed over the long term – for instance, from worrying about a family problem or the mortgage – or even deliberately putting yourself through too many difficult workouts? 'That's a bit trickier,' says Prof Clow. 'If you just have a short burst of perceived stress, you will have a little burst of cortisol. That's fine: your body will speedily return to normal cortisol secretion. But if you're chronically stressed, repeatedly getting these bursts, that can affect the regulation of your underlying circadian pattern, which is regulated by your biological clock. So that, instead of having a healthy dynamic pattern of cortisol secretion over each 24 hours, you get 'flatlining', which is not able to regulate other processes adequately.' [ A US animal lawyer in Wexford: 'There's a real social cost here: if you're not fun, you're gonna pay' Opens in new window ] Constant stress, then, is probably bad for your cognitive function and health. But cortisol is unlikely to change how you look, unless there are larger problems at play. 'If you had Cushing's syndrome, which is a rare condition where cortisol levels in the body are very high, for example due to a tumour of the adrenal gland, then yes, you might gain extra weight around the stomach, or notice that your face becomes round and puffy,' says Niamh Martin, a professor of endocrinology at Imperial College London. 'But that tends to be with very, very high cortisol levels.' And, while it's true that something like a long run can elevate cortisol levels over the short term, that doesn't mean there's any need to ditch your plans for a new personal best. 'Doing, say, a marathon is a massively stressful situation for the body,' says Upton. 'You need a cortisol response in that situation, and there's nothing wrong with it: if you didn't have that response, the results would probably be terrible. You might actually die.' The good news, then, is that you can happily ignore the most outlandish advice about keeping cortisol in check with cocktails or cold plunges. Unless you're suffering from a clear medical issue, you probably also don't need to worry about how your cortisol's changing on a daily or hourly basis. Several companies are working on methods for continuously monitoring cortisol levels as you go about your everyday life – but even these could do most people more harm than good. 'Something that we've seen with glucose monitors is that they create a lot of 'worried well' people who put one on, have their breakfast and say, 'oh hell, my blood sugar's gone up too much',' says Lightman. 'And then they start worrying about doing all sorts of things and make themselves ill. If you're an Olympic sprinter or something, continuous monitoring might be useful. But, among most people, there's so much individual variation that the range we call 'normal' is huge.' There's one more obvious question here, though: if cortisol isn't the culprit, why does stress seem to go hand in hand with poor health, immune-system disruption and weight gain? 'It's very difficult to unpick,' says Martin. 'For instance, many of us have a complex relationship with food – and there are behavioural reasons why we eat besides being hungry – so it's easy to blame cortisol if we notice that we're gaining weight, but it might also be that, because we're stressed, we're eating in a different way. Similarly, you might be having a tough time at work and that means you don't have time to exercise, or you're not sleeping well because you're stressed and that's negatively affecting your cortisol levels, rather than the relationship going the other way. Part of the issue is that we still don't fully understand the chronic stresses that modern life involves and what their impact is on our bodies over a long period of time.' So what does all this mean for you and your life – stressful or otherwise? 'I think the most evidence-backed approach is to treat cortisol as something like a bystander, rather than blaming it for any issues you're having,' says Martin. 'If you're chronically stressed, that's something to deal with for health reasons, but it's not necessarily a question of artificially finding ways to keep your cortisol down – it's more holistic than that. The most important thing is to look after yourself, rather than reaching for an expensive supplement or a cortisol cocktail or anything like that.' 'There are a few things that seem to help keep cortisol well regulated,' says Clow. 'The research suggests, for instance, that the earlier you wake – within reason – promotes a healthy and dynamic cortisol rhythm. So getting plenty of sleep and then getting up relatively early seems to be very good for you. There's increasing evidence that night-time light exposure inhibits your melatonin secretion, which liberates cortisol and allows it to rise while you sleep.' It's worth mentioning, though, that getting enough sleep – and on a regular schedule – might be more important. Physical exercise seems to keep cortisol well regulated but, if you can't face the gym, that's not necessarily a bad thing. 'Gentle exercise, like walking, stretching or pilates, can regulate cortisol far better than an hour-long Hiit class on an empty stomach,' says Alderson. 'Breath work is amazing and you can do it anywhere. Micromoments of joy are a lot simpler to weave in than grand gestures like weeklong yoga retreats – and, even if they're not directly affecting your cortisol, they matter more than people realise. A laugh, a hug, a walk in nature: this stuff really matters.' Finally, it's important to remember that, even if modern living does occasionally nudge your hormones outside optimal levels, cortisol is on your side. Your body's stress response to most things should be good for you. Try to get some exercise every day, sleep on a regular schedule, and eat as sensibly as you can. Don't worry about the other stuff: you really don't need the stress. – Guardian

‘A slow-moving car crash': Novo Nordisk's troubles keep mounting
‘A slow-moving car crash': Novo Nordisk's troubles keep mounting

Irish Times

timea day ago

  • Irish Times

‘A slow-moving car crash': Novo Nordisk's troubles keep mounting

Things just keep getting worse for Novo Nordisk . Shares were already battered before the recent profit warning, as US competition in the weight loss market intensified. The warning wiped another quarter off its rapidly falling market value. Novo, which reports earnings on Wednesday, has now lost two-thirds of its value in little over a year. Talk of Europe's first stock market trillionaire is long gone, with Novo's market capitalisation collapsing to $170 billion (€149 billion). Novo's latest troubles stem from copycat compounded versions of its flagship Wegovy drug and stronger rivals from US-based Eli Lilly. READ MORE Lilly's Mounjaro and Zepbound have gained market share, delivering greater weight loss with reportedly fewer side effects. As a Barclays analyst put it, it's been a 'slow-moving car crash'. Early supply shortages pushed patients to competitors, while Novo's cautious marketing lagged behind Lilly's aggressive, consumer-focused approach. Despite this, new CEO Maziar Mike Doustdar says the market opportunity and pipeline remain huge. The stock certainly looks cheap, trading at under 14 times trailing earnings and about 12 times projected earnings. In contrast, Lilly trades at 62 times trailing earnings and 34 times forward earnings. Still, Novo has looked cheap for a while, but investors who caught the proverbial falling knife have learned an expensive lesson: cheap stocks can stay cheap for a good reason.

Liver cancer: ‘The saddest part is that most of the cases are preventable'
Liver cancer: ‘The saddest part is that most of the cases are preventable'

Irish Times

timea day ago

  • Irish Times

Liver cancer: ‘The saddest part is that most of the cases are preventable'

Liver cancer kills more than 700,000 people each year. However, three in five cases could be prevented, according to a comprehensive analysis published in the journal Lancet. The research found that prevention could be accomplished by addressing the disease's major causes – hepatitis B, hepatitis C, alcohol -associated liver disease and liver disease linked to metabolic risk factors such as obesity . With nearly 900,000 new cases globally each year, liver cancer is the sixth most common cancer and the third leading cause of death from cancer. If cases continue to rise at the current rate, the number of new annual diagnoses will almost double, rising to 1.5 million globally in 2050, the study predicted. There are two broad categories of liver cancer – primary liver cancer and metastatic (secondary) liver cancer. About 370 people are diagnosed with primary liver cancer each year in Ireland. It is twice as common in men than it is in women. READ MORE The researchers estimated that liver disease from alcohol use and metabolic dysfunction together would account for nearly a third of new liver cancer cases by 2050. The findings align with what liver specialists have seen in their clinics for years. 'Liver cancer is common. It causes immense suffering and death, and the saddest part for me as a physician is that most of the cases are preventable,' said Dr Brian Lee, an associate professor of medicine, who was not involved in the study. Improved screening, vaccination and treatment in recent years have helped stem viral hepatitis. But the threat of liver cancer from heavy alcohol use and metabolic dysfunction-associated steatotic liver disease, or MASLD, formerly known as nonalcoholic fatty liver disease, 'has been underrecognised and underestimated,' said Dr Ahmed Kaseb, a professor of gastrointestinal medical oncology. A vast majority of liver cancers arise in people with cirrhosis, says Dr Hashem El-Serag, chairman of the department of medicine at Baylor College of Medicine in Texas and one of the authors of the new study. Cirrhosis, or advanced and largely irreversible scarring of the liver, damages healthy tissue and prevents the organ from working normally. [ Doctors share 19 tips for looking after your liver: Don't drink alcohol every day, but do drink coffee, and lose weight Opens in new window ] The hepatitis B and C viruses cause inflammation that, if left untreated, can scar and damage the liver, potentially leading to cirrhosis. And both alcohol and metabolic dysfunction lead to abnormal deposits of fat in the liver, which can also result in inflammation. Dr Lee says the accumulation of fat and inflammation acts as a 'highway' to liver scarring, which in turn can injure DNA and lead to cancer. 'There could be multiple ramps to get on to that highway,' he said. The new paper found that the share of liver cancers resulting from hepatitis B and hepatitis C is expected to drop to 63 per cent in 2050, from 68 per cent in 2022. But the burden of liver cancers resulting from alcohol and MASLD is expected to grow. An estimated four in 10 adults worldwide have MASLD, a condition in which fat builds up in the liver. Risk factors include obesity and Type 2 diabetes. A subset of patients with MASLD will go on to develop an advanced form called metabolic dysfunction-associated steatohepatitis, or MASH, which has been described as a silent killer because it can progress to cirrhosis and liver cancer without being noticed. Current guidance recommends monitoring for liver cancers in patients who have a history of viral hepatitis or established cirrhosis. Patients with MASH typically don't meet that criteria, Dr Kaseb said, but they could have liver scarring without symptoms, and nobody would know. That's why screening for liver disease needs to begin at the primary care level, where cases can easily go undetected, said Dr Mary Rinella, a hepatologist at University of Chicago Medicine and the lead author of guidelines for the management of MASLD. She recommended that doctors use a metric called the Fib-4, which uses routine blood test results to estimate the amount of liver scarring, to screen high-risk patients. These include people who have Type 2 diabetes or obesity with at least one other metabolic risk factor, such as high cholesterol. [ 'A serious threat to public health': Doctors warn about delay to mandatory alcohol health labels Opens in new window ] MASLD is reversible with lifestyle changes, including a healthy diet and increased exercise, and weight-loss drugs have recently been shown to be effective at reversing scarring as well. 'If you stop the reason or the impetus for scarring and injury in the liver, then you're going to have less impetus for the development of cancer,' says Dr Rinella. There is no national liver cancer screening programme in Ireland, so it's important to talk to your doctor about surveillance if you have a liver disease such as hepatitis B or C, genetic haemochromatosis or liver cirrhosis, as the risk of liver cancer is higher. [ Parents facilitating a 16-year-old's 'prinks' is a sign of our weird relationship with alcohol Opens in new window ] Alcohol-related liver disease is also on the rise. In research published in July , Dr Lee and his colleagues showed that the risk of alcohol-related liver disease among heavy drinkers (at least 10 drinks per week for women and 15 for men) in the United States more than doubled between 1999 and 2020, despite similar alcohol use over that period. That suggests that heavy drinkers today may be more sensitive to the effects of alcohol on the liver than those in the past, Dr Lee said. In Ireland, while average alcohol consumption per adult has shown signs of falling, the incidence of binge drinking continues to be pronounced. Drinking heavily and having a metabolic condition such as obesity can independently damage the liver, but patients who fall in both categories are at an especially high risk. These trends are likely to continue. 'Alcohol use is increasing,' says Dr Rinella. 'Obesity and diabetes are increasing.' 'I expect that we're going to continue to see a high burden of liver disease,' she added. – This article originally appeared in the New York Times

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